ATE167874T1 - Polypeptid bombesin antagonisten - Google Patents

Polypeptid bombesin antagonisten

Info

Publication number: ATE167874T1
Authority: AT; Austria
Prior art keywords: phenyl; alkyl; hydrogen; moiety; 10alkyl
Prior art date: 1993-03-15

Application number

AT94912199T

Other languages

English (en)

Inventor

Andrew Victor Schally

Ren Zhi Cai

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1994-03-07

Publication date

1998-07-15

1994-03-07 Application filed by Univ Tulane filed Critical Univ Tulane

1998-07-15 Application granted granted Critical

1998-07-15 Publication of ATE167874T1 publication Critical patent/ATE167874T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000002790 bombesin antagonist Substances 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
-1 naphthyl-C1-10-alkyl Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Enzymes And Modification Thereof (AREA)

AT94912199T 1993-03-15 1994-03-07 Polypeptid bombesin antagonisten ATE167874T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/031,325 US5369094A (en)	1990-11-29	1993-03-15	Polypeptide bombesin antagonists

Publications (1)

Publication Number	Publication Date
ATE167874T1 true ATE167874T1 (de)	1998-07-15

Family

ID=21858823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94912199T ATE167874T1 (de)	1993-03-15	1994-03-07	Polypeptid bombesin antagonisten

Country Status (27)

Country	Link
US (1)	US5369094A (de)
EP (1)	EP0646127B1 (de)
JP (1)	JP3838656B2 (de)
KR (1)	KR100306506B1 (de)
AT (1)	ATE167874T1 (de)
AU (1)	AU666270B2 (de)
BR (1)	BR9404341A (de)
CA (1)	CA2135787C (de)
CZ (1)	CZ286750B6 (de)
DE (1)	DE69411342T2 (de)
DK (1)	DK0646127T3 (de)
EE (1)	EE03180B1 (de)
ES (1)	ES2120615T3 (de)
FI (1)	FI945378A7 (de)
HR (1)	HRP940164B1 (de)
HU (1)	HU218288B (de)
IL (2)	IL108851A (de)
NO (1)	NO313418B1 (de)
NZ (2)	NZ299913A (de)
PL (1)	PL180372B1 (de)
RU (1)	RU2114118C1 (de)
SI (1)	SI9420001B (de)
SK (1)	SK282267B6 (de)
TW (1)	TW325478B (de)
UA (1)	UA34456C2 (de)
WO (1)	WO1994021674A1 (de)
ZA (1)	ZA941767B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
US5723578A (en) *	1987-09-24	1998-03-03	The Administrators Of Tulane Educational Fund	Peptide analogs of bombesin
US5650395A (en) *	1995-03-13	1997-07-22	Hurel; Steven	Treatment of pulmonary hypertension
US6989371B1 (en)	1996-08-16	2006-01-24	Dabur Research Foundation	Bombesin analogs for treatment of cancer
EP0977579B1 (de) *	1997-04-22	2009-03-11	Curator Of The University Of Missouri	Konjugate aus peptiden, die liganden von gastrinrezeptoren sind
RU2172322C1 (ru) *	1999-12-27	2001-08-20	Энтофарм Ко., Лтд.	Аллофероны-иммуномодулирующие пептиды
AU2001214046A1 (en) *	2000-11-17	2002-05-27	Warner-Lambert Company Llc	Treatment of sexual dysfunction using bombesin antagonist
US7226577B2 (en) *	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US8420050B2 (en) *	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en)	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7850947B2 (en) *	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
AU2003303714B2 (en) *	2003-01-13	2009-02-19	Bracco Imaging S.P.A.	Improved linkers for radiopharmaceutical compounds
US20060239923A1 (en) *	2003-01-13	2006-10-26	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
CN101791409A (zh)	2003-04-22	2010-08-04	研究及应用科学协会股份有限公司	肽载体
US7795385B2 (en) *	2004-12-17	2010-09-14	Bexar Global, Inc.	Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
RU2281690C1 (ru) *	2005-08-19	2006-08-20	Евгений Иванович Гусев	Способ определения показаний для лечения ишемического инсульта в восстановительном периоде препаратом "нейромидин"
FR2918566B1 (fr) *	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP2100900A1 (de) *	2008-03-07	2009-09-16	Universitätsspital Basel	Bombesin-analoge Peptid-antagonistische Konjugate
EP2198878A1 (de) *	2008-12-18	2010-06-23	University Of Miami	Polypeptide Bombesinantagonisten
CA2773713A1 (en)	2009-10-07	2011-04-14	Merck Sharp & Dohme Corp.	Novel trpa1 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5084555A (en) *	1989-08-21	1992-01-28	The Administrators Of The Tulane Educational Fund	An octapeptide bombesin analog
WO1989002897A1 (en) *	1987-09-24	1989-04-06	The Administrators Of The Tulane Educational Fund	Therapeutic peptides
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
AU618029B2 (en) *	1987-11-02	1991-12-12	Imperial Chemical Industries Plc	Polypeptide compounds
GB8813356D0 (en) *	1988-06-06	1988-07-13	Ici Plc	Polypeptide compounds
GR1000608B (el) *	1988-07-21	1992-08-31	Erba Carlo Spa	Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
MC2144A1 (fr) *	1988-10-14	1992-02-19	Univ Tulane	Peptides therapeutiques
US5217955A (en) *	1989-09-15	1993-06-08	Biomeasure, Inc.	Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5244883A (en) *	1990-11-29	1993-09-14	The Administrators Of The Tulane Educational Fund	Nonapeptide bombesin antagonists

1993
- 1993-03-15 US US08/031,325 patent/US5369094A/en not_active Expired - Lifetime
1994
- 1994-02-23 TW TW083101048A patent/TW325478B/zh not_active IP Right Cessation
- 1994-03-03 IL IL10885194A patent/IL108851A/xx not_active IP Right Cessation
- 1994-03-07 NZ NZ299913A patent/NZ299913A/en not_active IP Right Cessation
- 1994-03-07 BR BR9404341-8A patent/BR9404341A/pt not_active Application Discontinuation
- 1994-03-07 DK DK94912199T patent/DK0646127T3/da active
- 1994-03-07 EP EP94912199A patent/EP0646127B1/de not_active Expired - Lifetime
- 1994-03-07 HU HU9403244A patent/HU218288B/hu not_active IP Right Cessation
- 1994-03-07 SK SK1364-94A patent/SK282267B6/sk unknown
- 1994-03-07 WO PCT/US1994/002511 patent/WO1994021674A1/en not_active Ceased
- 1994-03-07 KR KR1019940704104A patent/KR100306506B1/ko not_active Expired - Fee Related
- 1994-03-07 RU RU94046091A patent/RU2114118C1/ru not_active IP Right Cessation
- 1994-03-07 AT AT94912199T patent/ATE167874T1/de not_active IP Right Cessation
- 1994-03-07 CZ CZ19942807A patent/CZ286750B6/cs not_active IP Right Cessation
- 1994-03-07 NZ NZ263668A patent/NZ263668A/en unknown
- 1994-03-07 PL PL94306209A patent/PL180372B1/pl not_active IP Right Cessation
- 1994-03-07 JP JP52109194A patent/JP3838656B2/ja not_active Expired - Fee Related
- 1994-03-07 CA CA002135787A patent/CA2135787C/en not_active Expired - Fee Related
- 1994-03-07 ES ES94912199T patent/ES2120615T3/es not_active Expired - Lifetime
- 1994-03-07 SI SI9420001A patent/SI9420001B/sl not_active IP Right Cessation
- 1994-03-07 DE DE69411342T patent/DE69411342T2/de not_active Expired - Fee Related
- 1994-03-07 AU AU64446/94A patent/AU666270B2/en not_active Ceased
- 1994-03-07 UA UA94119008A patent/UA34456C2/uk unknown
- 1994-03-10 HR HR08/031,325A patent/HRP940164B1/xx not_active IP Right Cessation
- 1994-03-14 ZA ZA941767A patent/ZA941767B/xx unknown
- 1994-11-10 NO NO19944293A patent/NO313418B1/no unknown
- 1994-11-15 FI FI945378A patent/FI945378A7/fi unknown
- 1994-11-23 EE EE9400166A patent/EE03180B1/xx not_active IP Right Cessation
2003
- 2003-03-19 IL IL15499503A patent/IL154995A0/xx unknown

Also Published As

Publication number	Publication date
NZ263668A (en)	1997-06-24
NO313418B1 (no)	2002-09-30
IL108851A0 (en)	1994-06-24
JPH07507330A (ja)	1995-08-10
TW325478B (en)	1998-01-21
KR100306506B1 (ko)	2001-12-01
AU6444694A (en)	1994-10-11
KR950701646A (ko)	1995-04-28
FI945378A0 (fi)	1994-11-15
DE69411342D1 (de)	1998-08-06
EP0646127A1 (de)	1995-04-05
SI9420001B (sl)	1999-08-31
AU666270B2 (en)	1996-02-01
IL154995A0 (en)	2003-10-31
WO1994021674A1 (en)	1994-09-29
CA2135787C (en)	2008-08-12
HRP940164B1 (en)	2000-02-29
JP3838656B2 (ja)	2006-10-25
SK136494A3 (en)	1995-08-09
HUT69727A (en)	1995-09-28
DK0646127T3 (da)	1999-04-12
SK282267B6 (sk)	2001-12-03
PL306209A1 (en)	1995-03-06
FI945378A7 (fi)	1994-11-15
UA34456C2 (uk)	2001-03-15
SI9420001A (en)	1995-08-31
ZA941767B (en)	1994-10-06
CZ286750B6 (en)	2000-06-14
DE69411342T2 (de)	1998-11-19
PL180372B1 (pl)	2001-01-31
NZ299913A (en)	2000-07-28
HRP940164A2 (en)	1996-08-31
HU218288B (en)	2000-07-28
US5369094A (en)	1994-11-29
CZ280794A3 (en)	1995-07-12
NO944293D0 (no)	1994-11-10
NO944293L (no)	1995-01-02
BR9404341A (pt)	1999-08-31
EE03180B1 (et)	1999-04-15
IL108851A (en)	2003-05-29
ES2120615T3 (es)	1998-11-01
EP0646127B1 (de)	1998-07-01
RU2114118C1 (ru)	1998-06-27
CA2135787A1 (en)	1994-09-29
RU94046091A (ru)	1996-09-27

Legal Events

Date	Code	Title	Description
1999-03-15	UEP	Publication of translation of european patent specification
2009-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE167874T1 (de)	1998-07-15	Polypeptid bombesin antagonisten
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
NO952744L (no)	1995-09-08	Cytokinbegrensende midler
GB1533077A (en)	1978-11-22	4-substituted enkephalin derivatives
GB1526367A (en)	1978-09-27	Polypeptide
GB1109086A (en)	1968-04-10	Polypeptides
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
ATE125548T1 (de)	1995-08-15	Peptide.
TW340849B (en)	1998-09-21	Novel cyclopeptides and pharmaceutical compositions as integrin inhibitors comprizing the same
GB1357121A (en)	1974-06-19	Peptide enzyme inhibitors
ES416516A1 (es)	1976-03-01	Un procedimiento para la preparacion de nonapeptidos.
ES418929A1 (es)	1976-03-01	Procedimiento para la preparacion de polipeptidos.
GB1363801A (en)	1974-08-21	Peptides and their preparation
GB1273873A (en)	1972-05-10	Corticotropically highly active octadecapeptides
TH17064B (th)	2004-06-18	ตัวปฏิปักษ์ต่อโปลีเปปไทด์บอมเบซิน
GB917013A (en)	1963-01-30	Cyclic decapeptides and process for their manufacture
GB1224658A (en)	1971-03-10	Cyclic decapeptides
GB1269898A (en)	1972-04-06	Amino acid derivatives
TH35998A (th)	1999-11-30	Lh-rh เป็ปไทด์ อะนาล็อก ประโยชน์ของสิ่งเหล่านั้นและองค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสิ่งเหล่านั้น
GB1039536A (en)	1966-08-17	Manufacture of highly active isomers of hypertensin ó and of its analogues