EE03180B1 - Bombesiini antagonistpeptiidid, farmatseutiline kompositsioon ja kasutamine - Google Patents

Bombesiini antagonistpeptiidid, farmatseutiline kompositsioon ja kasutamine

Info

Publication number: EE03180B1
Authority: EE; Estonia
Prior art keywords: phenyl; alkyl; hydrogen; moiety; 10alkyl
Prior art date: 1993-03-15

Application number

EE9400166A

Other languages

English (en)

Estonian (et)

Inventor

Zhi Cai Ren

V. Schally Andrew

Original Assignee

The Administrators Of The Tulane Educational Fund

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1994-11-23

Publication date

1999-04-15

1994-11-23 Application filed by The Administrators Of The Tulane Educational Fund filed Critical The Administrators Of The Tulane Educational Fund

1999-04-15 Publication of EE03180B1 publication Critical patent/EE03180B1/xx

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
229940123804 Bombesin antagonist Drugs 0.000 title 1
239000002790 bombesin antagonist Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
-1 naphthyl-C1-10-alkyl Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EE9400166A 1993-03-15 1994-11-23 Bombesiini antagonistpeptiidid, farmatseutiline kompositsioon ja kasutamine EE03180B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/031,325 US5369094A (en)	1990-11-29	1993-03-15	Polypeptide bombesin antagonists

Publications (1)

Publication Number	Publication Date
EE03180B1 true EE03180B1 (et)	1999-04-15

Family

ID=21858823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400166A EE03180B1 (et)	1993-03-15	1994-11-23	Bombesiini antagonistpeptiidid, farmatseutiline kompositsioon ja kasutamine

Country Status (27)

Country	Link
US (1)	US5369094A (de)
EP (1)	EP0646127B1 (de)
JP (1)	JP3838656B2 (de)
KR (1)	KR100306506B1 (de)
AT (1)	ATE167874T1 (de)
AU (1)	AU666270B2 (de)
BR (1)	BR9404341A (de)
CA (1)	CA2135787C (de)
CZ (1)	CZ286750B6 (de)
DE (1)	DE69411342T2 (de)
DK (1)	DK0646127T3 (de)
EE (1)	EE03180B1 (de)
ES (1)	ES2120615T3 (de)
FI (1)	FI945378A0 (de)
HR (1)	HRP940164B1 (de)
HU (1)	HU218288B (de)
IL (2)	IL108851A (de)
NO (1)	NO313418B1 (de)
NZ (2)	NZ299913A (de)
PL (1)	PL180372B1 (de)
RU (1)	RU2114118C1 (de)
SI (1)	SI9420001B (de)
SK (1)	SK282267B6 (de)
TW (1)	TW325478B (de)
UA (1)	UA34456C2 (de)
WO (1)	WO1994021674A1 (de)
ZA (1)	ZA941767B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
US5723578A (en) *	1987-09-24	1998-03-03	The Administrators Of Tulane Educational Fund	Peptide analogs of bombesin
US5650395A (en) *	1995-03-13	1997-07-22	Hurel; Steven	Treatment of pulmonary hypertension
US6989371B1 (en)	1996-08-16	2006-01-24	Dabur Research Foundation	Bombesin analogs for treatment of cancer
WO1998047524A1 (en) *	1997-04-22	1998-10-29	Curators Of The University Of Missouri	Gastrin receptor-avid peptide conjugates
RU2172322C1 (ru) *	1999-12-27	2001-08-20	Энтофарм Ко., Лтд.	Аллофероны-иммуномодулирующие пептиды
WO2002040022A1 (en) *	2000-11-17	2002-05-23	Warner-Lambert Company Llc	Treatment of sexual dysfunction using bombesin antagonist
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US20060239923A1 (en) *	2003-01-13	2006-10-26	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7226577B2 (en) *	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US7850947B2 (en) *	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en)	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US8420050B2 (en) *	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
ATE435035T1 (de) *	2003-01-13	2009-07-15	Bracco Imaging Spa	Verbesserte linker für radiopharmazeutische verbindungen
US8709998B2 (en)	2003-04-22	2014-04-29	Ipsen Pharma S.A.S.	Peptide vectors
US7795385B2 (en) *	2004-12-17	2010-09-14	Bexar Global, Inc.	Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
RU2281690C1 (ru) *	2005-08-19	2006-08-20	Евгений Иванович Гусев	Способ определения показаний для лечения ишемического инсульта в восстановительном периоде препаратом "нейромидин"
FR2918566B1 (fr) *	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP2100900A1 (de) *	2008-03-07	2009-09-16	Universitätsspital Basel	Bombesin-analoge Peptid-antagonistische Konjugate
EP2198878A1 (de) *	2008-12-18	2010-06-23	University Of Miami	Polypeptide Bombesinantagonisten
CA2773713A1 (en)	2009-10-07	2011-04-14	Merck Sharp & Dohme Corp.	Novel trpa1 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5084555A (en) *	1989-08-21	1992-01-28	The Administrators Of The Tulane Educational Fund	An octapeptide bombesin analog
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
WO1989002897A1 (en) *	1987-09-24	1989-04-06	The Administrators Of The Tulane Educational Fund	Therapeutic peptides
AU618029B2 (en) *	1987-11-02	1991-12-12	Imperial Chemical Industries Plc	Polypeptide compounds
GB8813356D0 (en) *	1988-06-06	1988-07-13	Ici Plc	Polypeptide compounds
GR1000608B (el) *	1988-07-21	1992-08-31	Erba Carlo Spa	Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
JP2919889B2 (ja) *	1988-10-14	1999-07-19	アドミニストレイターズオブザテューレインエデュケイショナルファンド	治療用ペプチド
US5217955A (en) *	1989-09-15	1993-06-08	Biomeasure, Inc.	Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5244883A (en) *	1990-11-29	1993-09-14	The Administrators Of The Tulane Educational Fund	Nonapeptide bombesin antagonists

1993
- 1993-03-15 US US08/031,325 patent/US5369094A/en not_active Expired - Lifetime
1994
- 1994-02-23 TW TW083101048A patent/TW325478B/zh not_active IP Right Cessation
- 1994-03-03 IL IL10885194A patent/IL108851A/xx not_active IP Right Cessation
- 1994-03-07 JP JP52109194A patent/JP3838656B2/ja not_active Expired - Fee Related
- 1994-03-07 ES ES94912199T patent/ES2120615T3/es not_active Expired - Lifetime
- 1994-03-07 DK DK94912199T patent/DK0646127T3/da active
- 1994-03-07 AT AT94912199T patent/ATE167874T1/de not_active IP Right Cessation
- 1994-03-07 BR BR9404341-8A patent/BR9404341A/pt not_active Application Discontinuation
- 1994-03-07 NZ NZ299913A patent/NZ299913A/en not_active IP Right Cessation
- 1994-03-07 CZ CZ19942807A patent/CZ286750B6/cs not_active IP Right Cessation
- 1994-03-07 NZ NZ263668A patent/NZ263668A/en unknown
- 1994-03-07 CA CA002135787A patent/CA2135787C/en not_active Expired - Fee Related
- 1994-03-07 KR KR1019940704104A patent/KR100306506B1/ko not_active Expired - Fee Related
- 1994-03-07 UA UA94119008A patent/UA34456C2/uk unknown
- 1994-03-07 DE DE69411342T patent/DE69411342T2/de not_active Expired - Fee Related
- 1994-03-07 PL PL94306209A patent/PL180372B1/pl not_active IP Right Cessation
- 1994-03-07 SI SI9420001A patent/SI9420001B/sl not_active IP Right Cessation
- 1994-03-07 RU RU94046091A patent/RU2114118C1/ru not_active IP Right Cessation
- 1994-03-07 EP EP94912199A patent/EP0646127B1/de not_active Expired - Lifetime
- 1994-03-07 SK SK1364-94A patent/SK282267B6/sk unknown
- 1994-03-07 WO PCT/US1994/002511 patent/WO1994021674A1/en not_active Ceased
- 1994-03-07 AU AU64446/94A patent/AU666270B2/en not_active Ceased
- 1994-03-07 HU HU9403244A patent/HU218288B/hu not_active IP Right Cessation
- 1994-03-10 HR HR08/031,325A patent/HRP940164B1/xx not_active IP Right Cessation
- 1994-03-14 ZA ZA941767A patent/ZA941767B/xx unknown
- 1994-11-10 NO NO19944293A patent/NO313418B1/no unknown
- 1994-11-15 FI FI945378A patent/FI945378A0/fi unknown
- 1994-11-23 EE EE9400166A patent/EE03180B1/xx not_active IP Right Cessation
2003
- 2003-03-19 IL IL15499503A patent/IL154995A0/xx unknown

Also Published As

Publication number	Publication date
RU94046091A (ru)	1996-09-27
HUT69727A (en)	1995-09-28
WO1994021674A1 (en)	1994-09-29
TW325478B (en)	1998-01-21
NO944293L (no)	1995-01-02
CZ286750B6 (en)	2000-06-14
DE69411342T2 (de)	1998-11-19
PL306209A1 (en)	1995-03-06
ZA941767B (en)	1994-10-06
DE69411342D1 (de)	1998-08-06
HRP940164B1 (en)	2000-02-29
JP3838656B2 (ja)	2006-10-25
FI945378A7 (fi)	1994-11-15
PL180372B1 (pl)	2001-01-31
NO944293D0 (no)	1994-11-10
CZ280794A3 (en)	1995-07-12
IL108851A0 (en)	1994-06-24
ATE167874T1 (de)	1998-07-15
EP0646127B1 (de)	1998-07-01
SI9420001A (en)	1995-08-31
NZ299913A (en)	2000-07-28
DK0646127T3 (da)	1999-04-12
CA2135787C (en)	2008-08-12
US5369094A (en)	1994-11-29
AU666270B2 (en)	1996-02-01
HU218288B (en)	2000-07-28
SK136494A3 (en)	1995-08-09
EP0646127A1 (de)	1995-04-05
KR950701646A (ko)	1995-04-28
NO313418B1 (no)	2002-09-30
CA2135787A1 (en)	1994-09-29
JPH07507330A (ja)	1995-08-10
IL154995A0 (en)	2003-10-31
HRP940164A2 (en)	1996-08-31
RU2114118C1 (ru)	1998-06-27
IL108851A (en)	2003-05-29
ES2120615T3 (es)	1998-11-01
KR100306506B1 (ko)	2001-12-01
FI945378A0 (fi)	1994-11-15
SK282267B6 (sk)	2001-12-03
UA34456C2 (uk)	2001-03-15
NZ263668A (en)	1997-06-24
AU6444694A (en)	1994-10-11
SI9420001B (sl)	1999-08-31
BR9404341A (pt)	1999-08-31

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2009-08-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20081123

Publication	Publication Date	Title
NO944293D0 (no)	1994-11-10	Bombesin antagonist-polypeptider
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
NO952744L (no)	1995-09-08	Cytokinbegrensende midler
AR034132A1 (es)	2004-02-04	Analogos de somatostatina, un proceso para su produccion y composicion farmaceutica
CA2272990A1 (en)	1998-06-04	Heptapeptide oxytocin analogues
FI892208A0 (fi)	1989-05-08	Foerfarande och mellanprodukt foer framstaellning av aggregationshaemmande peptider.
GB1533077A (en)	1978-11-22	4-substituted enkephalin derivatives
DE69422923D1 (de)	2000-03-09	Peptide mit endothelin antagonistischer aktivitaet. deren herstellung und pharmazeutische zusammensetzungen
TW340849B (en)	1998-09-21	Novel cyclopeptides and pharmaceutical compositions as integrin inhibitors comprizing the same
KR920701242A (ko)	1992-08-11	환원된 비가역성 봄베신 길항제
GB1357121A (en)	1974-06-19	Peptide enzyme inhibitors
GB1224576A (en)	1971-03-10	Novel tetrapeptide amides and the preparation thereof
SE9901773D0 (sv)	1999-05-17	Förebyggande av karies i tänderna
KR930012034A (ko)	1993-07-20	급성 췌장염 치료용 브래디키닌-길항제
GB1363801A (en)	1974-08-21	Peptides and their preparation
TH17064B (th)	2004-06-18	ตัวปฏิปักษ์ต่อโปลีเปปไทด์บอมเบซิน
TH15419A (th)	1995-01-27	ตัวปฏิปักษ์ต่อโปลีเปปไทด์บอมเบซิน
GB1273873A (en)	1972-05-10	Corticotropically highly active octadecapeptides
ES416516A1 (es)	1976-03-01	Un procedimiento para la preparacion de nonapeptidos.
ES248724A1 (es)	1960-01-01	Procedimiento para la obtenciën de nuevosdecapeptures ciclicos
GB1269898A (en)	1972-04-06	Amino acid derivatives
FR4219M (de)	1966-07-18