ATE169002T1 - Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel - Google Patents

Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel

Info

Publication number: ATE169002T1
Authority: AT; Austria
Prior art keywords: antigastrin; production; effect; acid derivatives; pct
Prior art date: 1993-09-09

Application number

AT94927576T

Other languages

English (en)

Inventor

Francesco Makovec

Walter Peris

Lucio Claudio Rovati

Luigi Angelo Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-09

Filing date

1994-09-07

Publication date

1998-08-15

1994-09-07 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169002T1 publication Critical patent/ATE169002T1/de

Links

239000004952 Polyamide Substances 0.000 title 1
239000002253 acid Substances 0.000 title 1
230000002614 anti-gastrin effect Effects 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
229920002647 polyamide Polymers 0.000 title 1
102100025841 Cholecystokinin Human genes 0.000 abstract 1
101800001982 Cholecystokinin Proteins 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
229940107137 cholecystokinin Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94927576T 1993-09-09 1994-09-07 Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel ATE169002T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITTO930661A IT1261255B (it)	1993-09-09	1993-09-09	Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Publications (1)

Publication Number	Publication Date
ATE169002T1 true ATE169002T1 (de)	1998-08-15

Family

ID=11411721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94927576T ATE169002T1 (de)	1993-09-09	1994-09-07	Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel

Country Status (9)

Country	Link
US (1)	US5962502A (de)
EP (1)	EP0717732B1 (de)
JP (1)	JPH09502433A (de)
AT (1)	ATE169002T1 (de)
CA (1)	CA2170648A1 (de)
DE (1)	DE69412103T2 (de)
ES (1)	ES2123827T3 (de)
IT (1)	IT1261255B (de)
WO (1)	WO1995007261A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1276462B1 (it) *	1995-07-03	1997-10-31	Rotta Research Lab	Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) *	1996-05-17	1997-11-27	Rotta Research Laboratorium S.P.A.	Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) *	1996-05-28	1997-12-04	Rotta Research Laboratorium S.P.A.	Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
WO1997047593A2 (en) *	1996-06-13	1997-12-18	Novartis Ag	Peptides
IT1286141B1 (it) *	1996-07-02	1998-07-07	Rotta Research Lab	Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
CN102781910B (zh) *	2010-03-04	2015-03-11	味之素株式会社	烷基胺衍生物
US10709714B2 (en)	2013-11-22	2020-07-14	Clifton Life Sciences LLC	Gastrin antagonists for treatment and prevention of osteoporosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1241029B (it) *	1990-12-11	1993-12-27	Rotta Research Lab	Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) *	1992-04-09	1996-07-30	Rotta Research Lab	Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico

1993
- 1993-09-09 IT ITTO930661A patent/IT1261255B/it active IP Right Grant
1994
- 1994-09-07 DE DE69412103T patent/DE69412103T2/de not_active Expired - Fee Related
- 1994-09-07 CA CA002170648A patent/CA2170648A1/en not_active Abandoned
- 1994-09-07 JP JP7508456A patent/JPH09502433A/ja active Pending
- 1994-09-07 ES ES94927576T patent/ES2123827T3/es not_active Expired - Lifetime
- 1994-09-07 WO PCT/EP1994/002983 patent/WO1995007261A1/en not_active Ceased
- 1994-09-07 EP EP94927576A patent/EP0717732B1/de not_active Expired - Lifetime
- 1994-09-07 US US08/605,162 patent/US5962502A/en not_active Expired - Fee Related
- 1994-09-07 AT AT94927576T patent/ATE169002T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69412103T2 (de)	1999-04-22
DE69412103D1 (de)	1998-09-03
EP0717732A1 (de)	1996-06-26
IT1261255B (it)	1996-05-09
ITTO930661A1 (it)	1995-03-09
US5962502A (en)	1999-10-05
ES2123827T3 (es)	1999-01-16
JPH09502433A (ja)	1997-03-11
EP0717732B1 (de)	1998-07-29
CA2170648A1 (en)	1995-03-16
ITTO930661A0 (it)	1993-09-09
WO1995007261A1 (en)	1995-03-16

Legal Events

Date	Code	Title	Description
1999-02-15	UEP	Publication of translation of european patent specification
2003-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
CA2118704A1 (en)	1993-04-01	Fused Tricyclic Nitrogen Containing Heterocycles as Substance P Receptor Antagonists
DK0561941T3 (da)	1995-03-06	N-Substituerede lactamer anvendelige som cholecystokinin-antagonister
DE59009351D1 (de)	1995-08-03	Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel.
DE69807587D1 (de)	2002-10-10	Quinazolin-4-on AMPA Antagonisten
DE69411260D1 (de)	1998-07-30	Thiazolidinederivate ihre herstellung und sie enthaltende medikamente
DE59002783D1 (de)	1993-10-28	Diphenylheteroalkylderivate, ihre Herstellung und daraus hergestellte Arzneimittel und Kosmetika.
ATE182333T1 (de)	1999-08-15	Heterocyclische verbindungen, ihre herstellung und verwendung
NO943133L (no)	1994-08-24	Benzodiazepinderivater egnet til bruk som CCK-reseptorantagonister
NZ300942A (en)	1998-12-23	1-aryl-2-acylamino-ethane derivatives as neurokinin 1 antagonists
DK0644878T3 (da)	2002-03-18	2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister
DK0711283T3 (da)	1999-11-22	Tetrahydro-1H-benzazepinoner og hexahydroazepinoner som selektive cholecystokinin-B-receptorantagonister
ATE169002T1 (de)	1998-08-15	Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel
PL316870A1 (en)	1997-02-17	Derivatives of 5-heterocyclo 1,5-benzodiazepine
DE59507539D1 (de)	2000-02-03	Pyrrolyl-tetrahydrobenzochinoxalindione, ihre herstellung und verwendung als glutamatrezeptor-antagonisten
NO952559D0 (no)	1995-06-26	N-acyl-pyrrolidiner og medikamenter for behandling eller prevensjon av cholecystokinin- og gastrin-relaterte mangler
ATE200277T1 (de)	2001-04-15	Substituierte phenylamidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE59402079D1 (de)	1997-04-17	Benzo[f]chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln
ES2123836T3 (es)	1999-01-16	Imidazo(1,5-a)quinoleinas para el tratamiento de la ansiedad y trastornos del sueño.