DK0644878T3 - 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister - Google Patents

2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister

Info

Publication number
DK0644878T3
DK0644878T3 DK93913323T DK93913323T DK0644878T3 DK 0644878 T3 DK0644878 T3 DK 0644878T3 DK 93913323 T DK93913323 T DK 93913323T DK 93913323 T DK93913323 T DK 93913323T DK 0644878 T3 DK0644878 T3 DK 0644878T3
Authority
DK
Denmark
Prior art keywords
benz
azepines
dioxo
dihydro
receptor antagonists
Prior art date
Application number
DK93913323T
Other languages
English (en)
Inventor
Gregory David Harris
Marc Jerome Chapdelaine
Paul Francis Jackson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0644878T3 publication Critical patent/DK0644878T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK93913323T 1992-06-10 1993-06-09 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister DK0644878T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929212308A GB9212308D0 (en) 1992-06-10 1992-06-10 Therapeutic compositions
PCT/GB1993/001218 WO1993025534A1 (en) 1992-06-10 1993-06-09 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
DK0644878T3 true DK0644878T3 (da) 2002-03-18

Family

ID=10716859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93913323T DK0644878T3 (da) 1992-06-10 1993-06-09 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister

Country Status (18)

Country Link
US (3) US5492905A (da)
EP (1) EP0644878B1 (da)
JP (1) JPH09502157A (da)
KR (1) KR100298377B1 (da)
AT (1) ATE205480T1 (da)
AU (1) AU672799B2 (da)
CA (1) CA2137834A1 (da)
DE (1) DE69330754T2 (da)
DK (1) DK0644878T3 (da)
ES (1) ES2161718T3 (da)
FI (2) FI106714B (da)
GB (1) GB9212308D0 (da)
HU (1) HUT71404A (da)
NO (1) NO305168B1 (da)
NZ (1) NZ253252A (da)
PT (1) PT644878E (da)
RU (1) RU94046322A (da)
WO (1) WO1993025534A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
MY133587A (en) 2002-05-29 2007-11-30 Glaxo Group Ltd Aromatic sulfones and their medical use
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
HRP20140309T1 (hr) 2008-10-22 2014-05-09 Array Biopharma, Inc. SUPSTITUIRANI SPOJEVI PIRAZOLO[1,5-a]PIRIMIDINA KAO INHIBITORI TRK KINAZE
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
JPWO2016199789A1 (ja) * 2015-06-08 2018-03-29 国立大学法人名古屋大学 トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物
KR102566858B1 (ko) * 2016-05-18 2023-08-11 어레이 바이오파마 인크. (s)-n-(5-((r)-2-(2,5-디플루오로페닐)피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복사미드의 제조 방법
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB130538A (en) * 1918-12-13 1919-08-07 John Algernon Launder Improvements in or relating to Means for Supporting Garments and Garment Hangers.
GB1340334A (en) * 1970-07-06 1973-12-12 Rees A H Synthesis of benzazetropolones and hence of kynurenic acids
JPS5129522B2 (da) * 1972-07-13 1976-08-26
JPS5520970B2 (da) * 1972-07-15 1980-06-06
DE3269625D1 (en) * 1981-08-11 1986-04-10 Ciba Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3323568C2 (de) * 1983-06-30 1987-01-29 Bayerische Motoren Werke AG, 8000 München Heiz- und/oder Klimaanlage für Kraftfahrzeuge
US4477446A (en) * 1983-07-01 1984-10-16 Usv Pharmaceutical Corporation 1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
WO1991005549A1 (en) * 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
JPH05105292A (ja) * 1991-10-15 1993-04-27 Nec Corp ロール紙のカール解消装置
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles

Also Published As

Publication number Publication date
PT644878E (pt) 2002-02-28
FI945807A0 (fi) 1994-12-09
AU672799B2 (en) 1996-10-17
AU4343693A (en) 1994-01-04
RU94046322A (ru) 1996-11-10
EP0644878A1 (en) 1995-03-29
ATE205480T1 (de) 2001-09-15
FI20002725A7 (fi) 2000-12-12
US5712272A (en) 1998-01-27
DE69330754D1 (de) 2001-10-18
NO305168B1 (no) 1999-04-12
NO944781L (no) 1995-01-30
FI106714B (fi) 2001-03-30
NO944781D0 (no) 1994-12-09
NZ253252A (en) 1996-11-26
US5654295A (en) 1997-08-05
FI20002725L (fi) 2000-12-12
CA2137834A1 (en) 1993-12-23
GB9212308D0 (en) 1992-07-22
WO1993025534A1 (en) 1993-12-23
ES2161718T3 (es) 2001-12-16
US5492905A (en) 1996-02-20
DE69330754T2 (de) 2002-07-04
HUT71404A (en) 1995-11-28
KR100298377B1 (ko) 2001-12-01
EP0644878B1 (en) 2001-09-12
FI945807A7 (fi) 1994-12-09
JPH09502157A (ja) 1997-03-04

Similar Documents

Publication Publication Date Title
FI945807A0 (fi) 2,5-diokso-2,5-dihydro-1H-bents/b/atsepiinit NMDA-reseptorin antagonisteina
MY121047A (en) Bicyclo [2.2.1] heptanes and related compounds
NZ223772A (en) Substituted benzodiazepine derivatives and pharmaceutical compositions
MX9605023A (es) Compuestos substituidos de imidazolidin-2,4-diona como substancias farmaceuticamente activas.
UA29416C2 (uk) Похідні 1,5 - бензодіазепіну, що є антагоністами гастрину та холецистокініну, спосіб їх одержання, фармацевтична композиція
IL110436A (en) Acylated tricyclic benzazepines and similar compounds, their preparation and pharmaceutical vasopressin antagonist compositions containing them
MXPA01012445A (es) Antagonistas de receptor metabotropico de glutamato, y su uso para tratar enfermedades del sistema nervioso central.
BG104561A (en) Aryl fused azapolycyclic compounds
UA37259C2 (uk) Активна речовина для одержання лікарських засобів при лікуванні дисфункціональних маткових кровотеч
IL117824A (en) Pharmaceutical compositions containing 2-aryl-imidazol¬1,2-a¾pyridine-3-acetamide derivatives for treatment of neuropsychiatric syndromes associated with dysfunction of the neural circuits of the basal ganglia
MY120976A (en) 2-amino-6-(2-substituted-4-phenoxy)- substituted- pyridines
IL104853A (en) Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
IL101358A0 (en) Crystalline tiagabine hydrochloride monohydrate,its preparation and pharmaceutical compositions containing it
BR9803385A (pt) AtropisÈmeros de 2,3-dissubstituìdo-(5,6)-heteroaril condensado-pirimidin-4-onas.
IL113365A0 (en) 5-heterocyclo-1,5-benzodiazepine derivatives, their preparation and use and pharmaceutical compositions containing them
GR3034354T3 (en) IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL109076A0 (en) Imidazolo-quinoxalinones, their preparation and pharmaceutical compositions containing them
BG102229A (en) Endothelium receptor antagonists
ITTO930661A1 (it) Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
BG101849A (en) Bicyclic tachyquinine antagonists, their preparation and use in pharmaceutical compositions
TW218011B (da)
HUP0004362A2 (hu) Karbamazepint vagy származékait tartalmazó parenterális készítmények
BR9714184A (pt) Utilização de bonzoillquil-1,2,3,6-tetraidropiridinas
IL111246A0 (en) Tricyclic compounds and pharmaceutical compositions containing them
MX9804631A (es) Antagonistas quinazolin-4-ona del ampa.