IT1261255B - Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. - Google Patents

Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Info

Publication number
IT1261255B
IT1261255B ITTO930661A ITTO930661A IT1261255B IT 1261255 B IT1261255 B IT 1261255B IT TO930661 A ITTO930661 A IT TO930661A IT TO930661 A ITTO930661 A IT TO930661A IT 1261255 B IT1261255 B IT 1261255B
Authority
IT
Italy
Prior art keywords
gastrinic
activity
procedure
preparation
acid derivatives
Prior art date
Application number
ITTO930661A
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO930661A0 publication Critical patent/ITTO930661A0/it
Priority to ITTO930661A priority Critical patent/IT1261255B/it
Priority to PCT/EP1994/002983 priority patent/WO1995007261A1/en
Priority to US08/605,162 priority patent/US5962502A/en
Priority to JP7508456A priority patent/JPH09502433A/ja
Priority to DE69412103T priority patent/DE69412103T2/de
Priority to CA002170648A priority patent/CA2170648A1/en
Priority to AT94927576T priority patent/ATE169002T1/de
Priority to EP94927576A priority patent/EP0717732B1/en
Priority to ES94927576T priority patent/ES2123827T3/es
Publication of ITTO930661A1 publication Critical patent/ITTO930661A1/it
Application granted granted Critical
Publication of IT1261255B publication Critical patent/IT1261255B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Sono descritti nuovi derivati dell'acido glutammico ed aspartico di formula (FORMULA I) I composti sono potenti antagonisti recettoriali della gastrina a livello periferico e antagonisti della colecistochinina a livello del sistema nervoso centrale.
ITTO930661A 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. IT1261255B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
DE69412103T DE69412103T2 (de) 1993-09-09 1994-09-07 Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel
US08/605,162 US5962502A (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
JP7508456A JPH09502433A (ja) 1993-09-09 1994-09-07 抗ガストリン活性を有するポリアミノ酸誘導体、その製造法および医薬用途
PCT/EP1994/002983 WO1995007261A1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
CA002170648A CA2170648A1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
AT94927576T ATE169002T1 (de) 1993-09-09 1994-09-07 Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel
EP94927576A EP0717732B1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
ES94927576T ES2123827T3 (es) 1993-09-09 1994-09-07 Derivados del acido poliamidico con actividad antigastrina, un metodo para su preparacion y su uso farmaceutico.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Publications (3)

Publication Number Publication Date
ITTO930661A0 ITTO930661A0 (it) 1993-09-09
ITTO930661A1 ITTO930661A1 (it) 1995-03-09
IT1261255B true IT1261255B (it) 1996-05-09

Family

ID=11411721

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Country Status (9)

Country Link
US (1) US5962502A (it)
EP (1) EP0717732B1 (it)
JP (1) JPH09502433A (it)
AT (1) ATE169002T1 (it)
CA (1) CA2170648A1 (it)
DE (1) DE69412103T2 (it)
ES (1) ES2123827T3 (it)
IT (1) IT1261255B (it)
WO (1) WO1995007261A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) * 1996-05-17 1997-11-27 Rotta Research Laboratorium S.P.A. Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
AU3258197A (en) * 1996-06-13 1998-01-07 Novartis Ag Peptides
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
BR112012021657B8 (pt) 2010-03-04 2022-06-07 Ea Pharma Co Ltd Composto, agente farmacêutico, agente para conferir kokumi , e, tempero
RU2693484C1 (ru) 2013-11-22 2019-07-03 СиЭль БАЙОСАЕНСИЗ ЭлЭлСи Антагонисты гастрина для лечения и профилактики остеопороза

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) * 1992-04-09 1996-07-30 Rotta Research Lab Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico

Also Published As

Publication number Publication date
DE69412103D1 (de) 1998-09-03
JPH09502433A (ja) 1997-03-11
ITTO930661A0 (it) 1993-09-09
EP0717732A1 (en) 1996-06-26
US5962502A (en) 1999-10-05
ITTO930661A1 (it) 1995-03-09
ES2123827T3 (es) 1999-01-16
EP0717732B1 (en) 1998-07-29
CA2170648A1 (en) 1995-03-16
ATE169002T1 (de) 1998-08-15
WO1995007261A1 (en) 1995-03-16
DE69412103T2 (de) 1999-04-22

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