ITTO930661A0 - Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. - Google Patents

Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Info

Publication number
ITTO930661A0
ITTO930661A0 ITTO930661A ITTO930661A0 IT TO930661 A0 ITTO930661 A0 IT TO930661A0 IT TO930661 A ITTO930661 A IT TO930661A IT TO930661 A0 ITTO930661 A0 IT TO930661A0
Authority
IT
Italy
Prior art keywords
antigastrinic
activity
procedure
preparation
pharmaceutical use
Prior art date
Application number
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO930661A0 publication Critical patent/ITTO930661A0/it
Priority to ITTO930661A priority Critical patent/IT1261255B/it
Priority to AT94927576T priority patent/ATE169002T1/de
Priority to ES94927576T priority patent/ES2123827T3/es
Priority to CA002170648A priority patent/CA2170648A1/en
Priority to PCT/EP1994/002983 priority patent/WO1995007261A1/en
Priority to US08/605,162 priority patent/US5962502A/en
Priority to JP7508456A priority patent/JPH09502433A/ja
Priority to EP94927576A priority patent/EP0717732B1/en
Priority to DE69412103T priority patent/DE69412103T2/de
Publication of ITTO930661A1 publication Critical patent/ITTO930661A1/it
Application granted granted Critical
Publication of IT1261255B publication Critical patent/IT1261255B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ITTO930661A 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. IT1261255B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
PCT/EP1994/002983 WO1995007261A1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
ES94927576T ES2123827T3 (es) 1993-09-09 1994-09-07 Derivados del acido poliamidico con actividad antigastrina, un metodo para su preparacion y su uso farmaceutico.
CA002170648A CA2170648A1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
AT94927576T ATE169002T1 (de) 1993-09-09 1994-09-07 Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel
US08/605,162 US5962502A (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
JP7508456A JPH09502433A (ja) 1993-09-09 1994-09-07 抗ガストリン活性を有するポリアミノ酸誘導体、その製造法および医薬用途
EP94927576A EP0717732B1 (en) 1993-09-09 1994-09-07 Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
DE69412103T DE69412103T2 (de) 1993-09-09 1994-09-07 Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Publications (3)

Publication Number Publication Date
ITTO930661A0 true ITTO930661A0 (it) 1993-09-09
ITTO930661A1 ITTO930661A1 (it) 1995-03-09
IT1261255B IT1261255B (it) 1996-05-09

Family

ID=11411721

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO930661A IT1261255B (it) 1993-09-09 1993-09-09 Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Country Status (9)

Country Link
US (1) US5962502A (it)
EP (1) EP0717732B1 (it)
JP (1) JPH09502433A (it)
AT (1) ATE169002T1 (it)
CA (1) CA2170648A1 (it)
DE (1) DE69412103T2 (it)
ES (1) ES2123827T3 (it)
IT (1) IT1261255B (it)
WO (1) WO1995007261A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) * 1996-05-17 1997-11-27 Rotta Research Laboratorium S.P.A. Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
WO1997047593A2 (en) * 1996-06-13 1997-12-18 Novartis Ag Peptides
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
CN102781910B (zh) * 2010-03-04 2015-03-11 味之素株式会社 烷基胺衍生物
US10709714B2 (en) 2013-11-22 2020-07-14 Clifton Life Sciences LLC Gastrin antagonists for treatment and prevention of osteoporosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) * 1992-04-09 1996-07-30 Rotta Research Lab Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico

Also Published As

Publication number Publication date
DE69412103T2 (de) 1999-04-22
DE69412103D1 (de) 1998-09-03
EP0717732A1 (en) 1996-06-26
IT1261255B (it) 1996-05-09
ITTO930661A1 (it) 1995-03-09
ATE169002T1 (de) 1998-08-15
US5962502A (en) 1999-10-05
ES2123827T3 (es) 1999-01-16
JPH09502433A (ja) 1997-03-11
EP0717732B1 (en) 1998-07-29
CA2170648A1 (en) 1995-03-16
WO1995007261A1 (en) 1995-03-16

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