ATE169918T1 - Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure - Google Patents

Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure

Info

Publication number: ATE169918T1
Authority: AT; Austria
Prior art keywords: separation; production; diastereomeric salts; folinic acid; salts
Prior art date: 1994-06-08

Application number

AT95921797T

Other languages

English (en)

Inventor

Ernst Felder

Giorgio Ripa

Carlo Distaso

Original Assignee

Bracco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-08

Filing date

1995-05-31

Publication date

1998-09-15

1995-05-31 Application filed by Bracco Spa filed Critical Bracco Spa

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE169918T1 publication Critical patent/ATE169918T1/de

Links

238000000034 method Methods 0.000 title abstract 3
238000000926 separation method Methods 0.000 title abstract 3
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title 1
MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 title 1
235000008191 folinic acid Nutrition 0.000 title 1
239000011672 folinic acid Substances 0.000 title 1
229960001691 leucovorin Drugs 0.000 title 1
150000001412 amines Chemical class 0.000 abstract 2
LHGUAFXRWOFNSK-ZEDZUCNESA-N NC(NC1=O)=NC(NCC2C3)=C1[N+]2=CN3C(C=C1)=CC=C1C(N[C@@H](CCC(Cl)=O)C([O-])=O)=O.Cl Chemical compound NC(NC1=O)=NC(NCC2C3)=C1[N+]2=CN3C(C=C1)=CC=C1C(N[C@@H](CCC(Cl)=O)C([O-])=O)=O.Cl LHGUAFXRWOFNSK-ZEDZUCNESA-N 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT95921797T 1994-06-08 1995-05-31 Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure ATE169918T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI941193A IT1270185B (it)	1994-06-08	1994-06-08	Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico

Publications (1)

Publication Number	Publication Date
ATE169918T1 true ATE169918T1 (de)	1998-09-15

Family

ID=11369074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95921797T ATE169918T1 (de)	1994-06-08	1995-05-31	Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure

Country Status (12)

Country	Link
EP (1)	EP0755397B1 (de)
JP (1)	JP4241925B2 (de)
KR (1)	KR100262684B1 (de)
AT (1)	ATE169918T1 (de)
AU (1)	AU2672695A (de)
DE (2)	DE69504189T2 (de)
ES (1)	ES2101665T1 (de)
GR (1)	GR970300023T1 (de)
IL (1)	IL114050A0 (de)
IT (1)	IT1270185B (de)
WO (1)	WO1995033749A1 (de)
ZA (1)	ZA954692B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2241711C2 (ru) *	2002-12-27	2004-12-10	Институт биохимии им. А.Н. Баха РАН	Способ получения кальция фолината
WO2013025203A1 (en) *	2011-08-16	2013-02-21	Watson Laboratories, Inc.	Resolution of tetrahydrofolic acid derivatives
CN103102350A (zh) *	2011-11-11	2013-05-15	重庆华邦胜凯制药有限公司	一种左亚叶酸盐的制备方法
CN113666931B (zh) *	2021-09-07	2023-11-03	浙江大为药业有限公司	一种高纯左亚叶酸钙的制备方法
CN117486884A (zh) *	2023-09-26	2024-02-02	湖州展望药业有限公司	一种亚叶酸钙的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH680731A5 (de) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
IT1254635B (it) *	1992-02-20	1995-09-28	Bracco Spa	Processo per la separazione degli stereoisomeri dell'acido folinico

1994
- 1994-06-08 IT ITMI941193A patent/IT1270185B/it active IP Right Grant
1995
- 1995-05-31 EP EP95921797A patent/EP0755397B1/de not_active Expired - Lifetime
- 1995-05-31 JP JP50033096A patent/JP4241925B2/ja not_active Expired - Lifetime
- 1995-05-31 DE DE69504189T patent/DE69504189T2/de not_active Expired - Lifetime
- 1995-05-31 AU AU26726/95A patent/AU2672695A/en not_active Abandoned
- 1995-05-31 ES ES95921797T patent/ES2101665T1/es active Pending
- 1995-05-31 DE DE0755397T patent/DE755397T1/de active Pending
- 1995-05-31 WO PCT/EP1995/002073 patent/WO1995033749A1/en not_active Ceased
- 1995-05-31 KR KR1019960706965A patent/KR100262684B1/ko not_active Expired - Lifetime
- 1995-05-31 AT AT95921797T patent/ATE169918T1/de not_active IP Right Cessation
- 1995-06-07 IL IL11405095A patent/IL114050A0/xx not_active IP Right Cessation
- 1995-06-07 ZA ZA954692A patent/ZA954692B/xx unknown
1997
- 1997-08-29 GR GR970300023T patent/GR970300023T1/el unknown

Also Published As

Publication number	Publication date
DE69504189T2 (de)	1998-12-24
EP0755397B1 (de)	1998-08-19
IL114050A0 (en)	1995-10-31
JP4241925B2 (ja)	2009-03-18
ES2101665T1 (es)	1997-07-16
DE755397T1 (de)	1997-09-25
ITMI941193A0 (it)	1994-06-08
ZA954692B (en)	1996-01-29
GR970300023T1 (en)	1997-08-29
WO1995033749A1 (en)	1995-12-14
ITMI941193A1 (it)	1995-12-08
JPH10500972A (ja)	1998-01-27
IT1270185B (it)	1997-04-29
DE69504189D1 (de)	1998-09-24
KR100262684B1 (ko)	2000-08-01
KR970703343A (ko)	1997-07-03
AU2672695A (en)	1996-01-04
EP0755397A1 (de)	1997-01-29

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Legal Events

Date	Code	Title	Description
1999-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties