ATE170529T1 - Partricinderivate - Google Patents

Partricinderivate

Info

Publication number: ATE170529T1
Authority: AT; Austria
Prior art keywords: partricin; same; basic nitrogen; derivatives; group
Prior art date: 1990-12-03

Application number

AT91119817T

Other languages

English (en)

Inventor

Tiberio Bruzzese

Massimo Signorini

Franco Ottoni

Original Assignee

Prodotti Antibiotici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-03

Filing date

1991-11-21

Publication date

1998-09-15

1991-11-21 Application filed by Prodotti Antibiotici Spa filed Critical Prodotti Antibiotici Spa

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE170529T1 publication Critical patent/ATE170529T1/de

Links

NVJUPMZQNWDHTL-MJODAWFJSA-N partricin Chemical class O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-MJODAWFJSA-N 0.000 title abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
PILBMRSRDPAALN-OUXUIHJTSA-N (4e,6e,8e,10e,12e,14e,16e)-3-[(2s,3r,4r,5r,6s)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-23,27,29,31,33,35,37-heptahydroxy-19-[5-hydroxy-7-[4-(methylamino)phenyl]-7-oxoheptan-2-yl]-18-methyl-21,25-dioxo-20,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,1 Chemical compound C1=CC(NC)=CC=C1C(=O)CC(O)CCC(C)C1C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)CC(O2)C(C(O)=O)C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)O1 PILBMRSRDPAALN-OUXUIHJTSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91119817T 1990-12-03 1991-11-21 Partricinderivate ATE170529T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02226890A IT1243404B (it)	1990-12-03	1990-12-03	Derivati della partricina

Publications (1)

Publication Number	Publication Date
ATE170529T1 true ATE170529T1 (de)	1998-09-15

Family

ID=11193919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91119817T ATE170529T1 (de)	1990-12-03	1991-11-21	Partricinderivate

Country Status (8)

Country	Link
US (1)	US5298495A (de)
EP (1)	EP0489308B1 (de)
JP (1)	JP3113880B2 (de)
KR (1)	KR100205933B1 (de)
AT (1)	ATE170529T1 (de)
DE (1)	DE69130107T2 (de)
ES (1)	ES2119750T3 (de)
IT (1)	IT1243404B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1283149B1 (it) *	1996-07-12	1998-04-07	Prodotti Antibiotici Spa	Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
BR9704385A (pt) *	1996-08-19	1999-05-11	Hoechst Ag	Novas antibióticos de polieno 3874 h1 a h6 processos para a sua preparação e uso
IT1294740B1 (it) *	1997-09-16	1999-04-12	Prospa Bv	Derivati della partricina per il trattamento profilattico e/o curativo delle contaminazioni fungine di colture cellulari e di tessuti
IT1295042B1 (it) *	1997-09-19	1999-04-27	Prospa Bv	Uso di derivati della partricina nelle terapie antitumorali
US6121244A (en) *	1997-09-19	2000-09-19	Prospa B.V.	Antitumoral method by administration of partricin derivatives
IT1301807B1 (it) *	1998-06-25	2000-07-07	Tiberio Bruzzese	Formulazioni farmaceutiche iniettabili di derivati della partricina.
JP4571248B2 (ja) *	1998-12-08	2010-10-27	プロ・アパルツ・インベステイメントス・エ・コンサルトリア・リミターダ	パートリシン誘導体の投与による腫瘍抑制法
WO2001051061A1 (en)	2000-01-14	2001-07-19	Intrabiotics Pharmaceuticals, Inc.	Derivatives of polyene macrolides and preparation and use thereof
US6664241B2 (en) *	2000-05-31	2003-12-16	Micrologix Biotech Inc.	Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
ITMI20032280A1 (it) *	2003-11-24	2005-05-25	Tiberio Bruzzese	Formulazioni farmaceutiche contenenti derivati della partricina e loro uso orale per il trattamento di infezioni fungine e protozoarie localizzate
MX365184B (es) *	2010-12-21	2019-05-21	Centro De Investig Y De Estudios Avanzados Del I P N	Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2023285323A2 (en) *	2021-07-12	2023-01-19	Bioseutica B.V.	A process for the production of amcipatricin diascorbate and the use of the same for the treatment of invasive fungal infections resistant to traditional antifungal agents
KR102444918B1 (ko)	2022-07-21	2022-09-22	주식회사 삼우에코	에어나이프의 전후진 장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1406774A (en) *	1973-02-15	1975-09-17	Prodotti Antibiotici Spa	Esters of patricin and of partricin derivatives
PL122086B1 (en) *	1979-04-09	1982-06-30	Politechnika Gdanska	Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
FR2654339B1 (fr) *	1989-11-14	1994-10-28	Mayoly Spindler Laboratoires	Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
IT1237772B (it) *	1989-11-16	1993-06-17	Tiberio Bruzzese	Derivati di macrolidi polienici.
EP0431870A1 (de) *	1989-12-08	1991-06-12	Beecham Group p.l.c.	Amphotericin-B-Derivate
EP0431874A1 (de) *	1989-12-08	1991-06-12	Beecham Group p.l.c.	Neue Verbindungen

1990
- 1990-12-03 IT IT02226890A patent/IT1243404B/it active IP Right Grant
1991
- 1991-11-21 ES ES91119817T patent/ES2119750T3/es not_active Expired - Lifetime
- 1991-11-21 AT AT91119817T patent/ATE170529T1/de not_active IP Right Cessation
- 1991-11-21 EP EP91119817A patent/EP0489308B1/de not_active Expired - Lifetime
- 1991-11-21 DE DE69130107T patent/DE69130107T2/de not_active Expired - Lifetime
- 1991-11-29 KR KR1019910021700A patent/KR100205933B1/ko not_active Expired - Fee Related
- 1991-12-03 JP JP03347995A patent/JP3113880B2/ja not_active Expired - Fee Related
- 1991-12-03 US US07/801,253 patent/US5298495A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR920012105A (ko)	1992-07-25
ES2119750T3 (es)	1998-10-16
DE69130107T2 (de)	1999-01-21
IT1243404B (it)	1994-06-10
IT9022268A1 (it)	1992-06-04
US5298495A (en)	1994-03-29
JP3113880B2 (ja)	2000-12-04
EP0489308B1 (de)	1998-09-02
IT9022268A0 (it)	1990-12-03
EP0489308A1 (de)	1992-06-10
JPH04300892A (ja)	1992-10-23
KR100205933B1 (ko)	1999-07-01
DE69130107D1 (de)	1998-10-08

Legal Events

Date	Code	Title
1999-03-15	UEP	Publication of translation of european patent specification
2000-04-15	EEIH	Change in the person of patent owner
2005-04-15	EEIH	Change in the person of patent owner
2012-02-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE69130107D1 (de)	1998-10-08	Partricinderivate
PT1021456E (pt)	2003-08-29	Derivados macrociclicos de eritromicinas a e b de anel de 13 membros
FI890282L (fi)	1989-07-21	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
NZ298999A (en)	1999-01-28	4-benzyl-5-hydroxyoxazole derivatives acylated in position-1 by an amino acid, a dipeptide or an acyl group
IT1284871B1 (it)	1998-05-22	Composizione farmaceutica a base di macrolide in dispersione solida
NZ244914A (en)	1995-01-27	Water-soluble camptothecin derivatives and anti-tumour medicaments; methylene- or ethylenedioxyphenyl amine derivatives as intermediates
PT876388E (pt)	2004-07-30	Derivados de eritromicina triciclica
FI891910A7 (fi)	1989-10-24	Menetelmä uusien terapeuttisesti käyttökelpoisten pyrido/1,2,3-de//1,4/bentsoksatsiinijohdannaisten valmistamiseksi
EP0522173A4 (en)	1993-06-16	4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acceptable salt thereof
IL104158A (en)	1997-07-13	4, 13-dioxabicyclo £8.2.1\| tridecenone compounds and pharmaceutical compositions containing them
DE69915487D1 (de)	2004-04-15	Erythromycin-derivate mit antibiotischer wirkung
NO891389L (no)	1989-10-06	Peptidderivater.
FI943358L (fi)	1995-01-16	16-rengasatomisten makrolidiantibioottien amidijohdannaisia
HU9403502D0 (en)	1995-02-28	9 a-n-(n`-carbamoyl) and 9 a-n-(n`-thiocarbamoyl) derivatives 9-deoxo-9a-aza-9a-homoerythro-mycin a
NO931011L (no)	1993-10-04	7-okso-7h-pyrido(1,2,3-de)(1,4)benzoksacin-6-karbonsyrer og -estere
FI892420A7 (fi)	1989-11-21	Menetelmä terapeuttisesti käyttökelpoisten 2-aminoetanolijohdannaisten valmistamiseksi
FI883680L (fi)	1989-02-07	Foerfarande foer behandling av illamaoende med vissa substituerade fenylalkylamino (och aminosyra) derivat.
NO894594L (no)	1990-05-21	Farmasoeytiske sammensetninger omfattende labdan diterpenoid-derivater og pyrimido(6,1-a)isoquinolin-4-one-derivater.
PT90601A (pt)	1989-11-30	Processo para a preparacao de composicoes farmaceuticas com base em derivados de pirimido-(6,1-a)-isoquinolina-4-onas
ES2055030T3 (es)	1994-08-16	Antibioticos de 1-carbacefalosporina.
DK0490311T3 (da)	1996-07-22	Derivater af 10,11,12,13-tetrahydro-desmycosin, fremgangsmåder til fremstilling deraf og anvendelse deraf til opnåelse af farmaceutiske præparater
FI941635A7 (fi)	1994-04-08	Androst-4-eno(4,5-b)pyrrolijohdannaiset ja menetelmä niiden valmistamiseksi
PT99964A (pt)	1993-07-30	Derivados de partricina processo para a sua preparacao e composicoes farmaceuticas que os contem
FR2662941B1 (fr)	1993-01-15	Compositions therapeutiques a base de derives de la pyrrolo-pyridine.
IT8820026A0 (it)	1988-03-30	Composizioni farmaceutiche adattivita' antineoplastica.