IT1243404B - Derivati della partricina - Google Patents

Derivati della partricina

Info

Publication number: IT1243404B
Authority: IT; Italy
Prior art keywords: derivatives; partricin; same; basic nitrogen; group
Prior art date: 1990-12-03

Application number

IT02226890A

Other languages

English (en)

Other versions

IT9022268A1 (it

IT9022268A0 (it

Inventor

Tiberio Bruzzese

Massimo Signorini

Franco Ottoni

Original Assignee

Prodotti Antibiotici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-03

Filing date

1990-12-03

Publication date

1994-06-10

1990-12-03 Application filed by Prodotti Antibiotici Spa filed Critical Prodotti Antibiotici Spa

1990-12-03 Publication of IT9022268A0 publication Critical patent/IT9022268A0/it

1990-12-03 Priority to IT02226890A priority Critical patent/IT1243404B/it

1991-11-21 Priority to AT91119817T priority patent/ATE170529T1/de

1991-11-21 Priority to EP91119817A priority patent/EP0489308B1/en

1991-11-21 Priority to ES91119817T priority patent/ES2119750T3/es

1991-11-21 Priority to DE69130107T priority patent/DE69130107T2/de

1991-11-29 Priority to KR1019910021700A priority patent/KR100205933B1/ko

1991-12-03 Priority to US07/801,253 priority patent/US5298495A/en

1991-12-03 Priority to JP03347995A priority patent/JP3113880B2/ja

1992-06-04 Publication of IT9022268A1 publication Critical patent/IT9022268A1/it

1994-06-10 Application granted granted Critical

1994-06-10 Publication of IT1243404B publication Critical patent/IT1243404B/it

Links

125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
NVJUPMZQNWDHTL-MJODAWFJSA-N partricin Chemical class O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-MJODAWFJSA-N 0.000 abstract 2
PILBMRSRDPAALN-OUXUIHJTSA-N (4e,6e,8e,10e,12e,14e,16e)-3-[(2s,3r,4r,5r,6s)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-23,27,29,31,33,35,37-heptahydroxy-19-[5-hydroxy-7-[4-(methylamino)phenyl]-7-oxoheptan-2-yl]-18-methyl-21,25-dioxo-20,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,1 Chemical compound C1=CC(NC)=CC=C1C(=O)CC(O)CCC(C)C1C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)CC(O2)C(C(O)=O)C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)O1 PILBMRSRDPAALN-OUXUIHJTSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT02226890A 1990-12-03 1990-12-03 Derivati della partricina IT1243404B (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IT02226890A IT1243404B (it)	1990-12-03	1990-12-03	Derivati della partricina
DE69130107T DE69130107T2 (de)	1990-12-03	1991-11-21	Partricinderivate
EP91119817A EP0489308B1 (en)	1990-12-03	1991-11-21	Partricin derivatives
ES91119817T ES2119750T3 (es)	1990-12-03	1991-11-21	Derivados de partricina.
AT91119817T ATE170529T1 (de)	1990-12-03	1991-11-21	Partricinderivate
KR1019910021700A KR100205933B1 (ko)	1990-12-03	1991-11-29	파트리신 유도체
US07/801,253 US5298495A (en)	1990-12-03	1991-12-03	Partricin derivatives
JP03347995A JP3113880B2 (ja)	1990-12-03	1991-12-03	パートリシン誘導体

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02226890A IT1243404B (it)	1990-12-03	1990-12-03	Derivati della partricina

Publications (3)

Publication Number	Publication Date
IT9022268A0 IT9022268A0 (it)	1990-12-03
IT9022268A1 IT9022268A1 (it)	1992-06-04
IT1243404B true IT1243404B (it)	1994-06-10

Family

ID=11193919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT02226890A IT1243404B (it)	1990-12-03	1990-12-03	Derivati della partricina

Country Status (8)

Country	Link
US (1)	US5298495A (it)
EP (1)	EP0489308B1 (it)
JP (1)	JP3113880B2 (it)
KR (1)	KR100205933B1 (it)
AT (1)	ATE170529T1 (it)
DE (1)	DE69130107T2 (it)
ES (1)	ES2119750T3 (it)
IT (1)	IT1243404B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1283149B1 (it) *	1996-07-12	1998-04-07	Prodotti Antibiotici Spa	Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
BR9704385A (pt) *	1996-08-19	1999-05-11	Hoechst Ag	Novas antibióticos de polieno 3874 h1 a h6 processos para a sua preparação e uso
IT1294740B1 (it) *	1997-09-16	1999-04-12	Prospa Bv	Derivati della partricina per il trattamento profilattico e/o curativo delle contaminazioni fungine di colture cellulari e di tessuti
IT1295042B1 (it) *	1997-09-19	1999-04-27	Prospa Bv	Uso di derivati della partricina nelle terapie antitumorali
US6121244A (en) *	1997-09-19	2000-09-19	Prospa B.V.	Antitumoral method by administration of partricin derivatives
IT1301807B1 (it) *	1998-06-25	2000-07-07	Tiberio Bruzzese	Formulazioni farmaceutiche iniettabili di derivati della partricina.
JP4571248B2 (ja) *	1998-12-08	2010-10-27	プロ・アパルツ・インベステイメントス・エ・コンサルトリア・リミターダ	パートリシン誘導体の投与による腫瘍抑制法
WO2001051061A1 (en)	2000-01-14	2001-07-19	Intrabiotics Pharmaceuticals, Inc.	Derivatives of polyene macrolides and preparation and use thereof
US6664241B2 (en) *	2000-05-31	2003-12-16	Micrologix Biotech Inc.	Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
ITMI20032280A1 (it) *	2003-11-24	2005-05-25	Tiberio Bruzzese	Formulazioni farmaceutiche contenenti derivati della partricina e loro uso orale per il trattamento di infezioni fungine e protozoarie localizzate
MX365184B (es) *	2010-12-21	2019-05-21	Centro De Investig Y De Estudios Avanzados Del I P N	Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2023285323A2 (en) *	2021-07-12	2023-01-19	Bioseutica B.V.	A process for the production of amcipatricin diascorbate and the use of the same for the treatment of invasive fungal infections resistant to traditional antifungal agents
KR102444918B1 (ko)	2022-07-21	2022-09-22	주식회사 삼우에코	에어나이프의 전후진 장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1406774A (en) *	1973-02-15	1975-09-17	Prodotti Antibiotici Spa	Esters of patricin and of partricin derivatives
PL122086B1 (en) *	1979-04-09	1982-06-30	Politechnika Gdanska	Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
FR2654339B1 (fr) *	1989-11-14	1994-10-28	Mayoly Spindler Laboratoires	Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
IT1237772B (it) *	1989-11-16	1993-06-17	Tiberio Bruzzese	Derivati di macrolidi polienici.
EP0431870A1 (en) *	1989-12-08	1991-06-12	Beecham Group p.l.c.	Amphotericin B derivatives
EP0431874A1 (en) *	1989-12-08	1991-06-12	Beecham Group p.l.c.	Novel compounds

1990
- 1990-12-03 IT IT02226890A patent/IT1243404B/it active IP Right Grant
1991
- 1991-11-21 ES ES91119817T patent/ES2119750T3/es not_active Expired - Lifetime
- 1991-11-21 AT AT91119817T patent/ATE170529T1/de not_active IP Right Cessation
- 1991-11-21 EP EP91119817A patent/EP0489308B1/en not_active Expired - Lifetime
- 1991-11-21 DE DE69130107T patent/DE69130107T2/de not_active Expired - Lifetime
- 1991-11-29 KR KR1019910021700A patent/KR100205933B1/ko not_active Expired - Fee Related
- 1991-12-03 JP JP03347995A patent/JP3113880B2/ja not_active Expired - Fee Related
- 1991-12-03 US US07/801,253 patent/US5298495A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR920012105A (ko)	1992-07-25
ES2119750T3 (es)	1998-10-16
DE69130107T2 (de)	1999-01-21
IT9022268A1 (it)	1992-06-04
US5298495A (en)	1994-03-29
JP3113880B2 (ja)	2000-12-04
ATE170529T1 (de)	1998-09-15
EP0489308B1 (en)	1998-09-02
IT9022268A0 (it)	1990-12-03
EP0489308A1 (en)	1992-06-10
JPH04300892A (ja)	1992-10-23
KR100205933B1 (ko)	1999-07-01
DE69130107D1 (de)	1998-10-08

Legal Events

Date	Code	Title	Description
1994-06-10	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971125

Publication	Publication Date	Title
IT1243404B (it)	1994-06-10	Derivati della partricina
FI895693A7 (fi)	1990-05-29	Parantuneen liukoisuuden omaavia kantaja/lääkeainekoostumuksia ja menetelmä niiden valmistamiseksi
FI890282L (fi)	1989-07-21	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
FI942913A7 (fi)	1994-08-17	Isatiinijohdannaiset, menetelmät niiden valmistamiseksi ja niitä sisäl tävät farmaseuttiset koostumukset
FI935920A7 (fi)	1993-12-29	Oksatsolidiinijohdannaiset ja niiden farmaseuttisesti hyväksyttävät suolat
FI94591B (fi)	1995-06-30	Menetelmä antiviraalisten ja immunostimuloivien farmaseuttisten koostumusten valmistamiseksi
FI891910A7 (fi)	1989-10-24	Menetelmä uusien terapeuttisesti käyttökelpoisten pyrido/1,2,3-de//1,4/bentsoksatsiinijohdannaisten valmistamiseksi
DE69915487D1 (de)	2004-04-15	Erythromycin-derivate mit antibiotischer wirkung
FI945780A7 (fi)	1994-12-08	Uudet biologisesti aktiiviset eburnameniinijohdannaiset, niitä sisältävät farmaseuttiset koostumukset ja menetelmä niiden valmistamiseksi
NO891389D0 (no)	1989-04-03	Peptidderivater.
FI943358A7 (fi)	1995-01-16	16-rengasatomisten makrolidiantibioottien amidijohdannaisia
IT1217437B (it)	1990-03-22	Sistema perfezionato di registrazione in posizione degli ugelli orientabili di una turbina a gas
NO931011L (no)	1993-10-04	7-okso-7h-pyrido(1,2,3-de)(1,4)benzoksacin-6-karbonsyrer og -estere
ES2079402T3 (es)	1996-01-16	Un proceso para la preparacion de hidrocloruro de ester metilico de alfa-l-aspartil-l-fenilalanina mediante el uso de anhidrido n-formil-aspartico aislado.
FI892420A7 (fi)	1989-11-21	Menetelmä terapeuttisesti käyttökelpoisten 2-aminoetanolijohdannaisten valmistamiseksi
DK0388049T3 (da)	1995-06-06	Penciclovirderivater til behandling af hepatitis B infektioner
FI893002L (fi)	1989-12-21	Menetelmä terapeuttisesti käyttökelpoisten peptidijohdannaisten valmistamiseksi
NO894594L (no)	1990-05-21	Farmasoeytiske sammensetninger omfattende labdan diterpenoid-derivater og pyrimido(6,1-a)isoquinolin-4-one-derivater.
FI903973A7 (fi)	1991-02-11	Uusia 2-okso-1-oksa-8-atsaspiro/4,5/dekaanijohdannaisia, niitä sisältäviä farmaseuttisia koostumuksia ja menetelmä niiden valmistamiseksi
ATE145333T1 (de)	1996-12-15	Hirudin enthaltende orale arzneimittel
IT9020160A0 (it)	1990-04-27	Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
FI941635A7 (fi)	1994-04-08	Androst-4-eno(4,5-b)pyrrolijohdannaiset ja menetelmä niiden valmistamiseksi
ITMI910618A0 (it)	1991-03-08	Azoto ossidi di derivati aza- e diaza-antracenedionici come farmaci antitumorali
ITTO920606A0 (it)	1992-07-16	Derivati di decaidro-8h-isochino/2,1-g/1,6/naftiridina e decaidrobenzo/a/pirrolo/2,3-e/chinolizina
DK0490311T3 (da)	1996-07-22	Derivater af 10,11,12,13-tetrahydro-desmycosin, fremgangsmåder til fremstilling deraf og anvendelse deraf til opnåelse af farmaceutiske præparater