ATE170865T1 - Festfase bei oligonukleotidsynthese - Google Patents

Festfase bei oligonukleotidsynthese

Info

Publication number: ATE170865T1
Authority: AT; Austria
Prior art keywords: group; substituted; carbon atom; oligonucleotide synthesis; solid fiber
Prior art date: 1992-04-03

Application number

AT93907979T

Other languages

English (en)

Inventor

Michael Joseph Mclean

Andrew John Garman

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-03

Filing date

1993-04-02

Publication date

1998-09-15

1993-04-02 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE170865T1 publication Critical patent/ATE170865T1/de

Links

238000002515 oligonucleotide synthesis Methods 0.000 title abstract 2
239000007787 solid Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
230000000269 nucleophilic effect Effects 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93907979T 1992-04-03 1993-04-02 Festfase bei oligonukleotidsynthese ATE170865T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929207380A GB9207380D0 (en)	1992-04-03	1992-04-03	Compounds

Publications (1)

Publication Number	Publication Date
ATE170865T1 true ATE170865T1 (de)	1998-09-15

Family

ID=10713444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93907979T ATE170865T1 (de)	1992-04-03	1993-04-02	Festfase bei oligonukleotidsynthese

Country Status (11)

Country	Link
US (2)	US5681945A (de)
EP (1)	EP0633890B1 (de)
JP (1)	JPH07505386A (de)
AT (1)	ATE170865T1 (de)
AU (1)	AU671629B2 (de)
CA (1)	CA2131993A1 (de)
DE (1)	DE69320949T2 (de)
FI (1)	FI111371B (de)
GB (1)	GB9207380D0 (de)
NO (1)	NO306254B1 (de)
WO (1)	WO1993020091A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9207380D0 (en) *	1992-04-03	1992-05-13	Ici Plc	Compounds
US5869696A (en) *	1996-04-22	1999-02-09	Beckman Instruments, Inc.	Universal solid supports and methods for their use
US5998604A (en) *	1997-09-15	1999-12-07	The Perkin-Elmer Corporation	Polynucleotide purification method
US6451998B1 (en)	1999-10-18	2002-09-17	Agilent Technologies, Inc.	Capping and de-capping during oligonucleotide synthesis
US20040215010A1 (en) *	2000-06-13	2004-10-28	Viktor Kumarev	Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
AU2002217893A1 (en) *	2000-11-29	2002-06-11	Glen Research Corporation	Universal supports for oligonucleotide synthesis
WO2004011474A1 (en) *	2002-07-31	2004-02-05	Isis Pharmaceuticals, Inc.	Universal support media for synthesis of oligomeric compounds
US6653468B1 (en) *	2002-07-31	2003-11-25	Isis Pharmaceuticals, Inc.	Universal support media for synthesis of oligomeric compounds
US20040242897A1 (en) *	2002-07-31	2004-12-02	Guzaev Andrei P.	Universal support media for synthesis of oligomeric compounds
US7202264B2 (en) *	2003-01-31	2007-04-10	Isis Pharmaceuticals, Inc.	Supports for oligomer synthesis
US20050130736A1 (en) *	2003-12-12	2005-06-16	Lottofone, Inc.	Prepaid wagering card
JP5438922B2 (ja) *	2008-06-25	2014-03-12	日東電工株式会社	核酸の製造方法
JP5360763B2 (ja)	2009-10-21	2013-12-04	日東電工株式会社	核酸固相合成用リンカー及び担体
KR20140000696A (ko) *	2010-10-26	2014-01-03	스미또모 가가꾸 가부시끼가이샤	봉구재 및 세라믹스 허니컴 소성체의 제조 방법
EP2620444B1 (de)	2012-01-30	2015-05-06	Nitto Denko Corporation	Linker und Träger für die Festphasensynthese von Nukleinsäure
EP2666794A1 (de)	2012-05-23	2013-11-27	Nitto Denko Corporation	Festphasenträger für Oligonukleotidsynthese und Oligonukleotidsyntheseverfahren
JP6537338B2 (ja)	2015-04-24	2019-07-03	日東電工株式会社	核酸固相合成用リンカー及び担体
EP3601310B1 (de) *	2017-03-29	2021-04-14	Roche Innovation Center Copenhagen A/S	Schnelle unylinker-spaltung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA03606A (fr) *	1967-01-16	1971-03-30	Ciba Geigy	Procédé de préparation de nouveaux dérivés glucidiques.
EP0067597A1 (de) *	1981-05-29	1982-12-22	ens BIO LOGICALS INC.	Verfahren für Polynukleotidsynthese
WO1985001051A1 (en) *	1983-09-02	1985-03-14	Molecular Biosystems, Inc.	Oligonucleotide polymeric support system
US4775619A (en) *	1984-10-16	1988-10-04	Chiron Corporation	Polynucleotide determination with selectable cleavage sites
US5118605A (en) *	1984-10-16	1992-06-02	Chiron Corporation	Polynucleotide determination with selectable cleavage sites
US4818681A (en) *	1985-02-22	1989-04-04	Molecular Diagnostics, Inc.	Fast and specific immobilization of nucleic acids to solid supports
US5378825A (en) *	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
GB9021625D0 (en) *	1990-10-04	1990-11-21	Ici Plc	Synthesis of oligonucleotides
IE922316A1 (en) *	1991-07-17	1993-01-27	Smithkline Beecham Corp	Retroviral protease inhibitors
GB9207380D0 (en) *	1992-04-03	1992-05-13	Ici Plc	Compounds

1992
- 1992-04-03 GB GB929207380A patent/GB9207380D0/en active Pending
1993
- 1993-04-02 EP EP93907979A patent/EP0633890B1/de not_active Expired - Lifetime
- 1993-04-02 CA CA002131993A patent/CA2131993A1/en not_active Abandoned
- 1993-04-02 JP JP5517254A patent/JPH07505386A/ja active Pending
- 1993-04-02 DE DE69320949T patent/DE69320949T2/de not_active Expired - Lifetime
- 1993-04-02 AU AU38980/93A patent/AU671629B2/en not_active Ceased
- 1993-04-02 WO PCT/GB1993/000693 patent/WO1993020091A1/en not_active Ceased
- 1993-04-02 AT AT93907979T patent/ATE170865T1/de not_active IP Right Cessation
- 1993-04-05 US US08/041,591 patent/US5681945A/en not_active Expired - Lifetime
1994
- 1994-09-30 FI FI944567A patent/FI111371B/fi active
- 1994-09-30 NO NO943667A patent/NO306254B1/no not_active IP Right Cessation
1997
- 1997-05-09 US US08/853,673 patent/US5886193A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI111371B (fi)	2003-07-15
JPH07505386A (ja)	1995-06-15
EP0633890A1 (de)	1995-01-18
DE69320949T2 (de)	1999-05-12
NO943667L (no)	1994-09-30
WO1993020091A1 (en)	1993-10-14
US5886193A (en)	1999-03-23
AU671629B2 (en)	1996-09-05
DE69320949D1 (de)	1998-10-15
AU3898093A (en)	1993-11-08
FI944567L (fi)	1994-09-30
EP0633890B1 (de)	1998-09-09
NO306254B1 (no)	1999-10-11
FI944567A0 (fi)	1994-09-30
NO943667D0 (no)	1994-09-30
CA2131993A1 (en)	1993-10-14
US5681945A (en)	1997-10-28
GB9207380D0 (en)	1992-05-13

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Legal Events

Date	Code	Title	Description
1999-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties