ES8801313A1 - Un procedimiento para preparar derivados de alanil-prolina. - Google Patents
Un procedimiento para preparar derivados de alanil-prolina.Info
- Publication number
- ES8801313A1 ES8801313A1 ES553613A ES553613A ES8801313A1 ES 8801313 A1 ES8801313 A1 ES 8801313A1 ES 553613 A ES553613 A ES 553613A ES 553613 A ES553613 A ES 553613A ES 8801313 A1 ES8801313 A1 ES 8801313A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically active
- derivatives
- general formula
- independently selected
- dipeptide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010016626 Dipeptides Proteins 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- -1 CARBOXYL Chemical class 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ELANIL-PROLINA, DE FORMULA GENERAL (I), Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE Q Y Q1-Q8 SE SELECCIONAN INDEPENDIENTEMENTE ENTRE HIDROGENO Y ALQUILO; B ES UN GRUPO ALQUILO DE C1-6; E Y Z SE SELECCIONAN INDEPENDIENTEMENTE DE DERIVADOS DE CARBOXILO; Y (X) ES UN ANILLO DE BENCENO O UN SISTEMA DE ANILLO DE NAFTILO O INDOLILO. DICHA REACCION SE LLEVA A EFECTO MEDIANTE REDUCCION POR HIDROGENACION SOBRE UN CATALIZADOR, TAL COMO PALADIO SOBRE CARBONO, Y EN UN DISOLVENTE ADECUADO, TAL COMO METANOL. DE APLICACION EN EL TRATAMIENTO Y LA PROFILAXIS DE LA HIPERTENSION Y OTROS ESTADOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848422165A GB8422165D0 (en) | 1984-09-01 | 1984-09-01 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES553613A0 ES553613A0 (es) | 1988-01-01 |
| ES8801313A1 true ES8801313A1 (es) | 1988-01-01 |
Family
ID=10566163
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546595A Expired ES8703418A1 (es) | 1984-09-01 | 1985-08-30 | Un procedimiento para preparar derivados heterociclicos ni- trogenados |
| ES553612A Expired ES8801312A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-prolina. |
| ES553611A Expired ES8801311A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alamil-prolina. |
| ES553610A Expired ES8801310A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-protina. |
| ES553613A Expired ES8801313A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-prolina. |
| ES553614A Expired ES8801672A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-prolina. |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546595A Expired ES8703418A1 (es) | 1984-09-01 | 1985-08-30 | Un procedimiento para preparar derivados heterociclicos ni- trogenados |
| ES553612A Expired ES8801312A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-prolina. |
| ES553611A Expired ES8801311A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alamil-prolina. |
| ES553610A Expired ES8801310A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-protina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES553614A Expired ES8801672A1 (es) | 1984-09-01 | 1986-04-01 | Un procedimiento para preparar derivados de alanil-prolina. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0174162A3 (es) |
| JP (1) | JPS6183198A (es) |
| KR (1) | KR860002501A (es) |
| AU (1) | AU581455B2 (es) |
| CS (1) | CS621585A2 (es) |
| DD (1) | DD236522A5 (es) |
| DK (1) | DK396885A (es) |
| ES (6) | ES8703418A1 (es) |
| FI (1) | FI853336L (es) |
| GB (1) | GB8422165D0 (es) |
| GR (1) | GR852113B (es) |
| HU (1) | HUT39190A (es) |
| MC (1) | MC1695A1 (es) |
| PL (3) | PL255192A1 (es) |
| PT (1) | PT81055B (es) |
| ZA (1) | ZA856672B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT84378B (en) * | 1986-02-28 | 1989-01-24 | Wellcome Found | New compounds |
| HUT44579A (en) * | 1986-02-28 | 1988-03-28 | Wellcome Found | Process for preparing novel compounds and pharmaceuticals comprising them |
| US5346887A (en) * | 1987-10-06 | 1994-09-13 | Abbott Laboratories | Glaucoma treatment |
| US5036051A (en) * | 1987-10-06 | 1991-07-30 | Abbott Laboratories | Glaucoma treatment |
| US4927807A (en) * | 1987-10-06 | 1990-05-22 | Abbott Laboratories | Glaucoma treatment |
| US5187183A (en) * | 1988-06-15 | 1993-02-16 | Brigham & Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
| US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| US5059589A (en) * | 1988-09-08 | 1991-10-22 | Abbott Laboratories | Glaucoma treatment |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| CA2841832C (en) | 2011-07-12 | 2019-06-04 | Icu Medical, Inc. | Device for delivery of antimicrobial agent into a trans-dermal catheter |
| JP6546988B2 (ja) | 2014-05-02 | 2019-07-17 | エクセルシオール・メディカル・コーポレイションＥｘｃｅｌｓｉｏｒ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 防腐キャップのためのストリップパッケージ |
| DK3294404T3 (da) | 2015-05-08 | 2025-09-08 | Icu Medical Inc | Medicinske konnektorer konfigureret til at modtage emittere af terapeutiske midler |
| PL3525865T3 (pl) | 2016-10-14 | 2023-02-06 | Icu Medical, Inc. | Nasadki dezynfekcyjne dla łączników medycznych |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
| CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705907A (en) * | 1970-02-19 | 1972-12-12 | Sandoz Ltd | 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| DE3177130D1 (de) * | 1980-08-30 | 1990-01-11 | Hoechst Ag | Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung. |
| GR75019B (es) * | 1980-09-17 | 1984-07-12 | Univ Miami | |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| EP0080822A1 (en) * | 1981-11-27 | 1983-06-08 | Beecham Group Plc | Anti-hypertensive prolinol-based peptides |
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| EP0088350B1 (en) * | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
| EP0099709A3 (en) * | 1982-07-19 | 1985-11-13 | Imperial Chemical Industries Plc | Amide derivatives |
-
1984
- 1984-09-01 GB GB848422165A patent/GB8422165D0/en active Pending
-
1985
- 1985-08-22 MC MC851792A patent/MC1695A1/fr unknown
- 1985-08-30 PL PL25519285A patent/PL255192A1/xx unknown
- 1985-08-30 ES ES546595A patent/ES8703418A1/es not_active Expired
- 1985-08-30 PL PL1985265523A patent/PL265523A1/xx unknown
- 1985-08-30 PL PL1985265522A patent/PL265522A1/xx unknown
- 1985-08-30 EP EP85306144A patent/EP0174162A3/en not_active Withdrawn
- 1985-08-30 FI FI853336A patent/FI853336L/fi not_active Application Discontinuation
- 1985-08-30 CS CS856215A patent/CS621585A2/cs unknown
- 1985-08-30 GR GR852113A patent/GR852113B/el unknown
- 1985-08-30 DD DD85280184A patent/DD236522A5/de not_active IP Right Cessation
- 1985-08-30 AU AU46932/85A patent/AU581455B2/en not_active Expired - Fee Related
- 1985-08-30 ZA ZA856672A patent/ZA856672B/xx unknown
- 1985-08-30 HU HU853304A patent/HUT39190A/hu unknown
- 1985-08-30 DK DK396885A patent/DK396885A/da not_active Application Discontinuation
- 1985-08-30 KR KR1019850006298A patent/KR860002501A/ko not_active Ceased
- 1985-08-30 JP JP60191817A patent/JPS6183198A/ja active Pending
- 1985-08-30 PT PT81055A patent/PT81055B/pt unknown
-
1986
- 1986-04-01 ES ES553612A patent/ES8801312A1/es not_active Expired
- 1986-04-01 ES ES553611A patent/ES8801311A1/es not_active Expired
- 1986-04-01 ES ES553610A patent/ES8801310A1/es not_active Expired
- 1986-04-01 ES ES553613A patent/ES8801313A1/es not_active Expired
- 1986-04-01 ES ES553614A patent/ES8801672A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU4693285A (en) | 1986-03-06 |
| KR860002501A (ko) | 1986-04-26 |
| GB8422165D0 (en) | 1984-10-03 |
| MC1695A1 (fr) | 1986-07-18 |
| PL265522A1 (en) | 1988-05-12 |
| ES553613A0 (es) | 1988-01-01 |
| HUT39190A (en) | 1986-08-28 |
| EP0174162A2 (en) | 1986-03-12 |
| PL265523A1 (en) | 1988-02-04 |
| AU581455B2 (en) | 1989-02-23 |
| ES8801672A1 (es) | 1988-02-16 |
| EP0174162A3 (en) | 1988-07-27 |
| FI853336A0 (fi) | 1985-08-30 |
| ES8801311A1 (es) | 1987-12-16 |
| PT81055A (en) | 1985-09-01 |
| ES546595A0 (es) | 1987-02-16 |
| ES553614A0 (es) | 1988-02-16 |
| ES8703418A1 (es) | 1987-02-16 |
| DK396885A (da) | 1986-03-02 |
| ES553612A0 (es) | 1987-12-16 |
| ES553611A0 (es) | 1987-12-16 |
| DK396885D0 (da) | 1985-08-30 |
| GR852113B (es) | 1985-12-24 |
| PT81055B (en) | 1987-07-02 |
| DD236522A5 (de) | 1986-06-11 |
| ES8801312A1 (es) | 1987-12-16 |
| ES553610A0 (es) | 1988-01-01 |
| JPS6183198A (ja) | 1986-04-26 |
| FI853336A7 (fi) | 1986-03-02 |
| CS621585A2 (en) | 1989-08-14 |
| FI853336L (fi) | 1986-03-02 |
| PL255192A1 (en) | 1987-09-21 |
| ZA856672B (en) | 1987-05-27 |
| ES8801310A1 (es) | 1988-01-01 |
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