ATE171042T1 - Verfahren und zusammensetzungen zur verbesserung der symptome von sepsis - Google Patents

Verfahren und zusammensetzungen zur verbesserung der symptome von sepsis

Info

Publication number
ATE171042T1
ATE171042T1 AT90911485T AT90911485T ATE171042T1 AT E171042 T1 ATE171042 T1 AT E171042T1 AT 90911485 T AT90911485 T AT 90911485T AT 90911485 T AT90911485 T AT 90911485T AT E171042 T1 ATE171042 T1 AT E171042T1
Authority
AT
Austria
Prior art keywords
sepsis
symptoms
compositions
improving
methods
Prior art date
Application number
AT90911485T
Other languages
English (en)
Inventor
Richard Ulevitch
Peter Tobias
Samuel D Wright
John D Mathison
Original Assignee
Scripps Research Inst
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Univ Rockefeller filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE171042T1 publication Critical patent/ATE171042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
AT90911485T 1989-08-01 1990-07-30 Verfahren und zusammensetzungen zur verbesserung der symptome von sepsis ATE171042T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38781789A 1989-08-01 1989-08-01

Publications (1)

Publication Number Publication Date
ATE171042T1 true ATE171042T1 (de) 1998-10-15

Family

ID=23531466

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90911485T ATE171042T1 (de) 1989-08-01 1990-07-30 Verfahren und zusammensetzungen zur verbesserung der symptome von sepsis

Country Status (14)

Country Link
US (4) US5730980A (de)
EP (1) EP0485430B1 (de)
JP (1) JP2744130B2 (de)
AT (1) ATE171042T1 (de)
AU (1) AU645515B2 (de)
CA (1) CA2022429C (de)
DE (1) DE69032662T2 (de)
DK (1) DK0485430T3 (de)
ES (1) ES2120948T3 (de)
FI (1) FI920450A7 (de)
GR (1) GR1003164B (de)
IE (1) IE902770A1 (de)
PT (1) PT94869B (de)
WO (1) WO1991001639A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2744130B2 (ja) * 1989-08-01 1998-04-28 スクリップス クリニック アンド リサーチ ファウンデーション 敗血症治療用組成物
DE4029227A1 (de) * 1990-09-14 1992-03-19 Imtox Gmbh Arzneimittel enthaltend cd14
WO1993019772A1 (en) * 1992-04-06 1993-10-14 North Shore University Hospital Research Corporation A novel therapy for treating sepsis using a soluble form of recombinant cd14 myelomonocytic antigen
ATE335072T1 (de) * 1993-05-28 2006-08-15 Scripps Research Inst Methoden für inhibition der cd14-abhängigen zellaktivierung
US5731415A (en) * 1993-06-17 1998-03-24 Xoma Corporation Lipopolysaccharide binding protein derivatives
US5484705A (en) 1994-01-24 1996-01-16 Xoma Corporation Method for quantifying lipopolysaccharide binding protein
US5891618A (en) * 1994-01-24 1999-04-06 Xoma Corporation Method for quantifying LBP in body fluids
ATE308994T1 (de) 1994-09-16 2005-11-15 Scripps Research Inst Gebrauch von antikörpern zur verhinderung von auswirkungen hervorgerufen durch grampositive- und myko-bakterien
WO1996020957A1 (en) * 1994-12-30 1996-07-11 Amgen Inc. Anti-inflammatory cd14 polypeptides
US5766593A (en) * 1994-12-30 1998-06-16 Amgen Inc. Anti-inflammatory CD14 peptides
AU5688596A (en) * 1995-04-13 1996-10-30 Deutsche Om Arzneimittel Gmbh Anti-cd14 antibodies for use in the induction of il-10 secre tion
AU6392996A (en) * 1995-06-19 1997-01-15 Sanna M. Goyert A method for inhibiting bacteremia and bacterial dissemination
PT914144E (pt) * 1996-05-10 2001-05-31 Univ Texas Utilizacoes terapeuticas de produtos de proteinas bip contra a meningococcemia humana
CA2255539C (en) * 1996-05-23 2005-09-27 Xoma Corporation Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma
US6093693A (en) * 1996-11-18 2000-07-25 The Wellesley Hospital Foundation B cell activation
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6991790B1 (en) * 1997-06-13 2006-01-31 Genentech, Inc. Antibody formulation
US5990082A (en) * 1997-10-22 1999-11-23 Xoma Corporation Uses of lipopolysaccharide binding protein
CN1298299A (zh) * 1998-02-07 2001-06-06 英国生物技术药物有限公司 抗菌剂
PL345208A1 (en) * 1998-05-27 2001-12-03 Gemma Biotechnology Ltd The induction of antiobiotic proteins and peptides by lait/scd14-protein
US6974698B1 (en) * 1999-01-15 2005-12-13 The United States Of America As Represented By The Department Of Health And Human Services Methods for delivering biologically active molecules into cells
WO2001022085A1 (en) * 1999-09-17 2001-03-29 Mochida Pharmaceutical Co., Ltd. Method of fractional measurement of soluble cd14 protein
JPWO2002042333A1 (ja) * 2000-11-22 2004-03-25 持田製薬株式会社 Ｃｄ１４／ｔｌｒ結合阻害作用を有する抗ｃｄ１４モノクローナル抗体
US20040063685A1 (en) * 2000-12-08 2004-04-01 Juji Ilzawa Combination Drugs
EP1542721A4 (de) * 2002-06-14 2007-05-02 Centocor Inc Modifizierte "s" antikörper
WO2004103294A2 (en) * 2003-05-15 2004-12-02 Tanox, Inc. Methods and compositions for the prevention and treatment of sepsis
US20060206947A1 (en) * 2005-02-28 2006-09-14 Scallon Bernard J Heterodimeric protein binding compositions
US7696211B2 (en) * 2005-04-29 2010-04-13 Wilson Constance N Methods and pharmaceutical compositions for treating sepsis
WO2006129849A1 (ja) 2005-06-03 2006-12-07 Mochida Pharmaceutical Co., Ltd. 抗ｃｄ１４抗体融合蛋白質
US20170107294A1 (en) * 2014-03-21 2017-04-20 Nordlandssykehuset Hf Anti-cd14 antibodies and uses thereof
AU2018255489B2 (en) 2017-04-21 2024-06-13 Implicit Bioscience Limited CD 14 antagonist antibodies for treating neurodegenerative diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4834976A (en) * 1986-07-03 1989-05-30 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella
JP2744130B2 (ja) * 1989-08-01 1998-04-28 スクリップス クリニック アンド リサーチ ファウンデーション 敗血症治療用組成物

Also Published As

Publication number Publication date
US20020034509A1 (en) 2002-03-21
FI920450A0 (fi) 1992-01-31
WO1991001639A1 (en) 1991-02-21
PT94869A (pt) 1991-04-18
US6495332B2 (en) 2002-12-17
EP0485430A1 (de) 1992-05-20
CA2022429A1 (en) 1991-02-02
IE902770A1 (en) 1991-02-27
EP0485430A4 (en) 1993-03-03
AU6146190A (en) 1991-03-11
DE69032662D1 (de) 1998-10-22
JPH05501399A (ja) 1993-03-18
US6297049B1 (en) 2001-10-02
ES2120948T3 (es) 1998-11-16
DE69032662T2 (de) 1999-03-11
GR1003164B (el) 1999-07-05
EP0485430B1 (de) 1998-09-16
PT94869B (pt) 1997-04-30
US5730980A (en) 1998-03-24
DK0485430T3 (da) 1999-06-14
FI920450A7 (fi) 1992-01-31
CA2022429C (en) 1998-12-01
GR900100582A (el) 1991-12-30
US6045795A (en) 2000-04-04
AU645515B2 (en) 1994-01-20
JP2744130B2 (ja) 1998-04-28

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time