ATE171067T1 - Verwendung von spiperon als immunsuppressivum und antiinflammatorisches mittel - Google Patents

Verwendung von spiperon als immunsuppressivum und antiinflammatorisches mittel

Info

Publication number
ATE171067T1
ATE171067T1 AT91907118T AT91907118T ATE171067T1 AT E171067 T1 ATE171067 T1 AT E171067T1 AT 91907118 T AT91907118 T AT 91907118T AT 91907118 T AT91907118 T AT 91907118T AT E171067 T1 ATE171067 T1 AT E171067T1
Authority
AT
Austria
Prior art keywords
spiperone
mammal
immunosupressant
inflammatory agent
neuroleptic
Prior art date
Application number
AT91907118T
Other languages
English (en)
Inventor
Richard J Sharpe
Kenneth A Arndt
Stephen J Galli
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of ATE171067T1 publication Critical patent/ATE171067T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91907118T 1990-03-16 1991-03-13 Verwendung von spiperon als immunsuppressivum und antiinflammatorisches mittel ATE171067T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49474090A 1990-03-16 1990-03-16

Publications (1)

Publication Number Publication Date
ATE171067T1 true ATE171067T1 (de) 1998-10-15

Family

ID=23965760

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91907118T ATE171067T1 (de) 1990-03-16 1991-03-13 Verwendung von spiperon als immunsuppressivum und antiinflammatorisches mittel

Country Status (13)

Country Link
US (1) US5290783A (de)
EP (1) EP0520032B1 (de)
JP (1) JPH078792B2 (de)
AT (1) ATE171067T1 (de)
CA (1) CA2077907C (de)
DE (1) DE69130216T2 (de)
DK (1) DK0520032T3 (de)
ES (1) ES2121779T3 (de)
IE (1) IE910882A1 (de)
NZ (1) NZ237422A (de)
PT (1) PT97057A (de)
WO (1) WO1991013622A1 (de)
ZA (1) ZA911932B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
EP0661972A1 (de) * 1991-12-27 1995-07-12 Beth Israel Hospital Verwendung von spiperon und spiperonderivaten als immunsuppressive wirkstoffe
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
CA2159091C (en) * 1993-03-26 2006-12-19 Richard J. Sharpe Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US7226966B2 (en) 2001-08-03 2007-06-05 Nanogram Corporation Structures incorporating polymer-inorganic particle blends
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
EP1080091A1 (de) * 1998-05-18 2001-03-07 Novo Nordisk A/S Neue 1,3,8-triazaspiro[4.5]dekanone mit einer hohen affinität für opioid-rezeptor subtypen
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP2006510586A (ja) * 2002-08-29 2006-03-30 ユニバーシティー オブ サザンプトン 肝疾患治療のための薬剤の調製におけるアポトーシス誘導物質の使用方法
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN102573993A (zh) * 2009-07-31 2012-07-11 Anamar股份公司 治疗炎症的化合物
US8895962B2 (en) 2010-06-29 2014-11-25 Nanogram Corporation Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3155670A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3161644A (en) * 1962-06-22 1964-12-15 Res Lab Dr C Janssen N V 1-benzyl-4-substituted piperidines
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
BE792906A (fr) * 1971-12-18 1973-06-18 Sumitomo Chemical Co Aryl-cetones et leur preparation
US3996363A (en) * 1975-06-13 1976-12-07 E. R. Squibb & Sons, Inc. 2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)alkyl]-1H-benz[de]isoquinolin-1,3(2H)-diones
AU558787B2 (en) * 1981-01-23 1987-02-12 Wellcome Foundation Limited, The Inclusion complexes of cyclodextrins and cardiac clycosides
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH01308274A (ja) * 1987-12-14 1989-12-12 Kyowa Hakko Kogyo Co Ltd 三環式化合物
WO1991002527A1 (en) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists

Also Published As

Publication number Publication date
DE69130216T2 (de) 1999-03-25
JPH078792B2 (ja) 1995-02-01
IE910882A1 (en) 1991-09-25
NZ237422A (en) 1997-06-24
DE69130216D1 (de) 1998-10-22
CA2077907C (en) 1998-06-09
DK0520032T3 (da) 1999-06-14
JPH05506855A (ja) 1993-10-07
ZA911932B (en) 1991-12-24
US5290783A (en) 1994-03-01
CA2077907A1 (en) 1991-09-17
EP0520032A1 (de) 1992-12-30
ES2121779T3 (es) 1998-12-16
EP0520032A4 (en) 1993-02-24
WO1991013622A1 (en) 1991-09-19
EP0520032B1 (de) 1998-09-16
PT97057A (pt) 1991-12-31

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UEP Publication of translation of european patent specification
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