DK0520032T3 - Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel - Google Patents

Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Info

Publication number: DK0520032T3
Authority: DK; Denmark
Prior art keywords: spiperone; mammal; immunosuppressive; inflammatory agent; neuroleptic
Prior art date: 1990-03-16

Application number

DK91907118T

Other languages

English (en)

Inventor

J Sharpe Richard

A Arndt Kenneth

J Galli Stephen

Original Assignee

Beth Israel Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-16

Filing date

1991-03-13

Publication date

1999-06-14

1991-03-13 Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0520032T3 publication Critical patent/DK0520032T3/da

Links

DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 title abstract 4
230000001506 immunosuppresive effect Effects 0.000 title abstract 2
229950001675 spiperone Drugs 0.000 title abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229940125721 immunosuppressive agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 2
230000000701 neuroleptic effect Effects 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
102000015554 Dopamine receptor Human genes 0.000 abstract 1
108050004812 Dopamine receptor Proteins 0.000 abstract 1
206010062016 Immunosuppression Diseases 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
208000010247 contact dermatitis Diseases 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK91907118T 1990-03-16 1991-03-13 Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel DK0520032T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49474090A	1990-03-16	1990-03-16
PCT/US1991/001684 WO1991013622A1 (en)	1990-03-16	1991-03-13	Use of spiperone as an immunosuppressant and anti-inflammatory agent

Publications (1)

Publication Number	Publication Date
DK0520032T3 true DK0520032T3 (da)	1999-06-14

Family

ID=23965760

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91907118T DK0520032T3 (da)	1990-03-16	1991-03-13	Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Country Status (13)

Country	Link
US (1)	US5290783A (da)
EP (1)	EP0520032B1 (da)
JP (1)	JPH078792B2 (da)
AT (1)	ATE171067T1 (da)
CA (1)	CA2077907C (da)
DE (1)	DE69130216T2 (da)
DK (1)	DK0520032T3 (da)
ES (1)	ES2121779T3 (da)
IE (1)	IE910882A1 (da)
NZ (1)	NZ237422A (da)
PT (1)	PT97057A (da)
WO (1)	WO1991013622A1 (da)
ZA (1)	ZA911932B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703088A (en) *	1989-08-21	1997-12-30	Beth Israel Deaconess Medical Center, Inc.	Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) *	1990-03-16	1996-11-12	Beth Israel Hospital Association	Use of spiperone derivatives as immunosuppressant agents
EP0661972A1 (en) *	1991-12-27	1995-07-12	Beth Israel Hospital	Use of spiperone or spiperone derivatives as immunosuppressant agents
US5693645A (en) *	1992-12-23	1997-12-02	Beth Israel Deaconess Medical Center, Inc.	Use of spiperone or spiperone derivatives as immunosuppressant agents
CA2159091C (en) *	1993-03-26	2006-12-19	Richard J. Sharpe	Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US7226966B2 (en)	2001-08-03	2007-06-05	Nanogram Corporation	Structures incorporating polymer-inorganic particle blends
US6277991B1 (en)	1998-05-18	2001-08-21	Novo Nordisk A/S	1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
EP1080091A1 (en) *	1998-05-18	2001-03-07	Novo Nordisk A/S	Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
GB0019357D0 (en)	2000-08-07	2000-09-27	Melacure Therapeutics Ab	Novel phenyl guanidines
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
JP2006510586A (ja) *	2002-08-29	2006-03-30	ユニバーシティーオブサザンプトン	肝疾患治療のための薬剤の調製におけるアポトーシス誘導物質の使用方法
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN102573993A (zh) *	2009-07-31	2012-07-11	Anamar股份公司	治疗炎症的化合物
US8895962B2 (en)	2010-06-29	2014-11-25	Nanogram Corporation	Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3155670A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3161644A (en) *	1962-06-22	1964-12-15	Res Lab Dr C Janssen N V	1-benzyl-4-substituted piperidines
US3238216A (en) *	1963-06-20	1966-03-01	Res Lab Dr C Janssen N V	Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
BE792906A (fr) *	1971-12-18	1973-06-18	Sumitomo Chemical Co	Aryl-cetones et leur preparation
US3996363A (en) *	1975-06-13	1976-12-07	E. R. Squibb & Sons, Inc.	2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)alkyl]-1H-benz[de]isoquinolin-1,3(2H)-diones
AU558787B2 (en) *	1981-01-23	1987-02-12	Wellcome Foundation Limited, The	Inclusion complexes of cyclodextrins and cardiac clycosides
US4874766A (en) *	1986-09-22	1989-10-17	Janssen Pharmaceutica N.V.	Method of promoting wound-healing
US4839342A (en) *	1987-09-03	1989-06-13	University Of Georgia Research Foundation, Inc.	Method of increasing tear production by topical administration of cyclosporin
JPH01308274A (ja) *	1987-12-14	1989-12-12	Kyowa Hakko Kogyo Co Ltd	三環式化合物
WO1991002527A1 (en) *	1989-08-21	1991-03-07	Beth Israel Hospital Association	Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists

1991
- 1991-03-13 AT AT91907118T patent/ATE171067T1/de not_active IP Right Cessation
- 1991-03-13 NZ NZ237422A patent/NZ237422A/en unknown
- 1991-03-13 EP EP91907118A patent/EP0520032B1/en not_active Expired - Lifetime
- 1991-03-13 ES ES91907118T patent/ES2121779T3/es not_active Expired - Lifetime
- 1991-03-13 CA CA002077907A patent/CA2077907C/en not_active Expired - Fee Related
- 1991-03-13 DE DE69130216T patent/DE69130216T2/de not_active Expired - Fee Related
- 1991-03-13 WO PCT/US1991/001684 patent/WO1991013622A1/en not_active Ceased
- 1991-03-13 JP JP3506586A patent/JPH078792B2/ja not_active Expired - Lifetime
- 1991-03-13 DK DK91907118T patent/DK0520032T3/da active
- 1991-03-15 PT PT97057A patent/PT97057A/pt not_active Application Discontinuation
- 1991-03-15 IE IE088291A patent/IE910882A1/en unknown
- 1991-03-15 ZA ZA911932A patent/ZA911932B/xx unknown
- 1991-12-27 US US07/815,283 patent/US5290783A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE171067T1 (de)	1998-10-15
DE69130216T2 (de)	1999-03-25
JPH078792B2 (ja)	1995-02-01
IE910882A1 (en)	1991-09-25
NZ237422A (en)	1997-06-24
DE69130216D1 (de)	1998-10-22
CA2077907C (en)	1998-06-09
JPH05506855A (ja)	1993-10-07
ZA911932B (en)	1991-12-24
US5290783A (en)	1994-03-01
CA2077907A1 (en)	1991-09-17
EP0520032A1 (en)	1992-12-30
ES2121779T3 (es)	1998-12-16
EP0520032A4 (en)	1993-02-24
WO1991013622A1 (en)	1991-09-19
EP0520032B1 (en)	1998-09-16
PT97057A (pt)	1991-12-31

Publication	Publication Date	Title
EP0520032A4 (en)	1993-02-24	Use of spiperone as an immunosuppressant and anti-inflammatory agent
AU536192B2 (en)	1984-04-19	Suppressing appetite for calories as carbohydrates
GB2014981B (en)	1982-08-11	Substituted propanolamine and morpholine derivatives
NO995932D0 (no)	1999-12-03	Anvendelse av tiazolidindion-derivater i behandling av polycystiske ovariesyndrom og svangerskapsdiabetes
HN1998000143A (es)	1999-04-09	Tetrahidronaftalenos substituidos y compuestos analogos.
ES507236A0 (es)	1982-09-01	Un procedimiento para preparar una composicion farmaceutica para aplicacion topica, empleada en el tratamiento del acne.
IT1264530B (it)	1996-10-02	Impiego dei polisaccaridi nelle neuropatie atrofico degenerative
MX9202152A (es)	1992-11-01	Derivados del indol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ES2143181T3 (es)	2000-05-01	Derivados biciclicos de isotiourea utiles en terapia.
FI944727L (fi)	1994-10-07	Indolijohdannaisia 5-HT1:n kaltaisina agonisteina
ES458176A1 (es)	1978-04-01	Procedimiento para la preparacion de derivados de indazolil-(4)-oxi-propanolamina.
IT8348947A0 (it)	1983-09-09	Derivati del tiofene, loro preparazione e loro impiego come fungicidi
BR9103481A (pt)	1992-05-12	Composto,estereoisomero,composicao farmaceutica e processo para preparar um composto
JPS5225037A (en)	1977-02-24	Carcinostatic agent
ES9600001A1 (es)	1995-07-16	Procedimiento y composicion para el ondulado permanente del cabello
DK145510C (da)	1983-04-25	Moebel med mindst to i forhold til hinanden drejelige moebeldele,som er indbyrdes forbundet ved hjaelp af mindst en haengselmekanisme
ES2191657T3 (es)	2003-09-16	Azaspiranos inmunomoduladores.
JPS52120132A (en)	1977-10-08	Remedies for nephric diseases
KR910019627A (ko)	1991-12-19	화상 국부치료용 냉각제
FR2335721A1 (fr)	1977-07-15	Cheville, notmment pour l'ameublement
IT1171886B (it)	1987-06-10	Derivati del piridone, loro preparazione e loro impiego come coloranti
IT1141080B (it)	1986-10-01	L'applicazione in terapuetica come agenti analgesici dei derivati del 4,5,6,7-tetraidroisossazolo (5,4-c)piridin-3-ol
FR96337E (fr)	1972-06-16	Dispositif contre l'absorption de goudrons de combustion, et notamment de la nicotine du tabac, par le fumeur, ainsi que l'outil pour le ramonage et l'entretien dudit dispositif.
JPS51131724A (en)	1976-11-16	Method of automatically unfolding folded leaflet with middle leaf or r everse of cover in feeder for book using string
MX9205233A (es)	1993-12-01	Uso de il-5 para tratar tumores solidos.