DK0693077T3 - Antivirusforbindelser - Google Patents

Antivirusforbindelser

Info

Publication number: DK0693077T3
Authority: DK; Denmark
Prior art keywords: pct; nucleoside analog; mono; sec; formula
Prior art date: 1993-04-05

Application number

DK94912709T

Other languages

Danish (da)

English (en)

Inventor

Kjell Torgeir Stokke

Bernt Borretzen

Are Dalen

Finn Myhren

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-05

Filing date

1994-04-05

Publication date

1999-06-14

1994-04-05 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0693077T3 publication Critical patent/DK0693077T3/da

Links

230000002155 anti-virotic effect Effects 0.000 title 1
239000002777 nucleoside Substances 0.000 abstract 3
150000003833 nucleoside derivatives Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002771 monosaccharide derivatives Chemical class 0.000 abstract 1
235000021315 omega 9 monounsaturated fatty acids Nutrition 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Public Health (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Crystals, And After-Treatments Of Crystals (AREA)

DK94912709T 1993-04-05 1994-04-05 Antivirusforbindelser DK0693077T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939307043A GB9307043D0 (en)	1993-04-05	1993-04-05	Chemical compounds
PCT/NO1994/000071 WO1994022887A1 (en)	1993-04-05	1994-04-05	New antiviral compounds

Publications (1)

Publication Number	Publication Date
DK0693077T3 true DK0693077T3 (da)	1999-06-14

Family

ID=10733340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94912709T DK0693077T3 (da)	1993-04-05	1994-04-05	Antivirusforbindelser

Country Status (20)

Country	Link
US (1)	US6153594A (de)
EP (1)	EP0693077B1 (de)
JP (1)	JP3049258B2 (de)
KR (1)	KR100309194B1 (de)
AT (1)	ATE171457T1 (de)
AU (1)	AU685104B2 (de)
CA (1)	CA2158853C (de)
CZ (1)	CZ287755B6 (de)
DE (1)	DE69413529T2 (de)
DK (1)	DK0693077T3 (de)
ES (1)	ES2124883T3 (de)
FI (1)	FI111370B (de)
GB (1)	GB9307043D0 (de)
HU (1)	HU228064B1 (de)
NZ (1)	NZ263888A (de)
PL (1)	PL177263B1 (de)
RU (1)	RU2139884C1 (de)
SK (1)	SK281231B6 (de)
UA (1)	UA41361C2 (de)
WO (1)	WO1994022887A1 (de)

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GB9515279D0 (en) *	1995-07-25	1995-09-20	Norsk Hydro As	Improved therapeutic agents
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
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DE69812934T2 (de) *	1997-01-24	2004-01-29	Conpharma As Oslo	Gemcitabin-derivate
US5891881A (en) *	1997-11-21	1999-04-06	Clarion Pharmaceuticals Inc.	Aminoheterocycle-substituted glycerols
AU1412299A (en) *	1997-11-25	1999-06-15	Protarga, Inc.	Nucleoside analog compositions and uses thereof
EP1095947B1 (de)	1998-07-09	2007-03-14	Sankyo Company Limited	Antibakterielle verbindungen
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US6403564B1 (en)	1998-10-16	2002-06-11	Schering Corporation	Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
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AU2001255495A1 (en) *	2000-04-20	2001-11-07	Schering Corporation	Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection
PY0111577A (es)	2000-05-23	2017-01-02	Idenix Cayman Ltd	Métodos y composiciones para el tratamiento del virus de la hepatitis c
BR0111196A (pt)	2000-05-26	2004-04-06	Idenix Cayman Ltd	Composições e uso das mesmas para tratamento de flavivìrus e pestivìrus
WO2003062388A2 (en) *	2002-01-16	2003-07-31	The Regents Of The University Of California	Inhibition of rna function
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh)	2002-06-28	2008-05-07	埃迪尼克斯(开曼)有限公司	用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
AP2005003213A0 (en)	2002-06-28	2005-03-31	Univ Cagliari	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
US20040077607A1 (en) *	2002-10-21	2004-04-22	Uckun Fatih M.	Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
CA2503890A1 (en) *	2002-11-01	2004-05-13	Evogenix Pty Ltd	Mutagenesis methods using ribavirin and/or rna replicases
RU2005118421A (ru)	2002-11-15	2006-01-20	Айденикс (Кайман) Лимитед (Ky)	2'-разветвленные нуклеозиды и мутация flaviviridae
TWI332507B (en)	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
AU2003300901A1 (en)	2002-12-12	2004-06-30	Idenix (Cayman) Limited	Process for the production of 2'-branched nucleosides
EP1745573A4 (de) *	2003-03-20	2010-05-26	Microbiol Quimica Farmaceutica	Verfahren zur herstellung von 2 -deoxy-beta-l-nukleosiden
KR20060092242A (ko) *	2003-11-03	2006-08-22	코그니스 아이피 매니지먼트 게엠베하	아실 리보뉴클레오시드 및 아실 데옥시리보뉴클레오시드
FR2874016B1 (fr)	2004-06-30	2006-11-24	Centre Nat Rech Scient Cnrse	Nanoparticules de derives de la gemcitabine
US9029345B2 (en) *	2005-03-16	2015-05-12	Case Western Reserve University	Selective inhibitors of translesion DNA replication
WO2006101911A1 (en)	2005-03-16	2006-09-28	Case Western Reserve University	Selective inhibitors of translesion dna replication
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US7781576B2 (en)	2005-12-23	2010-08-24	Idenix Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
US8497292B2 (en)	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
WO2009042766A1 (en) *	2007-09-26	2009-04-02	Mount Sinai School Of Medicine	Azacytidine analogues and uses thereof
US9988680B2 (en)	2011-09-01	2018-06-05	Case Western Reserve University	Non-natural nucleosides as theranostic agents
US9821173B2 (en)	2013-02-08	2017-11-21	Case Western Reserve University	Anti-cancer agents and methods of use

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1993
- 1993-04-05 GB GB939307043A patent/GB9307043D0/en active Pending
1994
- 1994-04-05 WO PCT/NO1994/000071 patent/WO1994022887A1/en not_active Ceased
- 1994-04-05 HU HU9502896A patent/HU228064B1/hu unknown
- 1994-04-05 ES ES94912709T patent/ES2124883T3/es not_active Expired - Lifetime
- 1994-04-05 DE DE69413529T patent/DE69413529T2/de not_active Expired - Lifetime
- 1994-04-05 DK DK94912709T patent/DK0693077T3/da active
- 1994-04-05 RU RU95119386A patent/RU2139884C1/ru active
- 1994-04-05 CA CA002158853A patent/CA2158853C/en not_active Expired - Lifetime
- 1994-04-05 US US08/532,754 patent/US6153594A/en not_active Expired - Lifetime
- 1994-04-05 CZ CZ19952593A patent/CZ287755B6/cs not_active IP Right Cessation
- 1994-04-05 UA UA95104367A patent/UA41361C2/uk unknown
- 1994-04-05 NZ NZ263888A patent/NZ263888A/en not_active IP Right Cessation
- 1994-04-05 AU AU65141/94A patent/AU685104B2/en not_active Expired
- 1994-04-05 PL PL94310970A patent/PL177263B1/pl unknown
- 1994-04-05 SK SK1233-95A patent/SK281231B6/sk not_active IP Right Cessation
- 1994-04-05 JP JP6521952A patent/JP3049258B2/ja not_active Expired - Lifetime
- 1994-04-05 AT AT94912709T patent/ATE171457T1/de active
- 1994-04-05 EP EP94912709A patent/EP0693077B1/de not_active Expired - Lifetime
- 1994-04-05 KR KR1019950704292A patent/KR100309194B1/ko not_active Expired - Fee Related
1995
- 1995-10-04 FI FI954727A patent/FI111370B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT73659A (en)	1996-09-30
UA41361C2 (uk)	2001-09-17
SK281231B6 (sk)	2001-01-18
AU685104B2 (en)	1998-01-15
JP3049258B2 (ja)	2000-06-05
DE69413529D1 (de)	1998-10-29
CA2158853A1 (en)	1994-10-13
HU228064B1 (en)	2012-09-28
ES2124883T3 (es)	1999-02-16
CZ259395A3 (en)	1996-06-12
PL310970A1 (en)	1996-01-22
NZ263888A (en)	1998-05-27
DE69413529T2 (de)	1999-04-29
AU6514194A (en)	1994-10-24
PL177263B1 (pl)	1999-10-29
HK1003437A1 (en)	1998-10-30
HU9502896D0 (en)	1995-11-28
CA2158853C (en)	1999-07-27
FI111370B (fi)	2003-07-15
RU2139884C1 (ru)	1999-10-20
WO1994022887A1 (en)	1994-10-13
EP0693077A1 (de)	1996-01-24
FI954727L (fi)	1995-10-04
EP0693077B1 (de)	1998-09-23
CZ287755B6 (en)	2001-01-17
KR100309194B1 (ko)	2002-06-20
FI954727A0 (fi)	1995-10-04
ATE171457T1 (de)	1998-10-15
GB9307043D0 (en)	1993-05-26
US6153594A (en)	2000-11-28
SK123395A3 (en)	1996-04-03
JPH08508477A (ja)	1996-09-10

Publication	Publication Date	Title
DK0693077T3 (da)	1999-06-14	Antivirusforbindelser
ES2085876T3 (es)	1996-06-16	Derivado de bifenilmetano, su utilizacion y composiciones farmacologicas que contienen el mismo.
ITMI922699A1 (it)	1994-05-26	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
TR200001982T2 (tr)	2001-02-21	Farmasötik vurulu salınımlı oral dozaj şekli.
IT8219610A0 (it)	1982-02-11	Procedimento per minimizzare l'emissione di impurita' da impianti di combustione.
KR920700632A (ko)	1992-08-10	메일라드 반응저해제
EP0642525A1 (de)	1995-03-15	Chemische Verbindungen.
ATE16488T1 (de)	1985-11-15	M-4- und isom-4-derivate, ihre herstellung und diese enthaltende zusammensetzungen.
ES2117976T3 (es)	1998-09-01	Preparacion de derivados n-acetil neuraminicos.
KR0140401B1 (en)	1998-06-01	Anti-bloom triglyceride compositions
ES2143004T3 (es)	2000-05-01	Derivados de la milbemicina, su preparacion y uso.
ES2161759T3 (es)	2001-12-16	Derivados de profarmacos de inhibidores de enzimas con grupos hidroxilo, procedimiento para su preparacion y su utilizacion.
ES466037A1 (es)	1978-10-01	Un procedimiento para preparar derivados de oleandomicina.
DE69028320D1 (de)	1996-10-02	Illudin-analoge, verwendet als antitumormittel
ATE92498T1 (de)	1993-08-15	Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes.
ES8609482A1 (es)	1986-09-01	Un metodo para producir acido dihidrodesoxigriseolico y sa- les y esteres del mismo
ES2074264T3 (es)	1995-09-01	Esteres de aminoacidos de la hidroquinona, su procedimiento de preparacion y composiciones farmaceuticas o cosmeticas que los contienen.
BR9707342A (pt)	1999-07-20	Dihidrobensofurano e compostos correlatod úteis como agentes antiinflamatórios
DE69120670D1 (de)	1996-08-08	Lipo-oligosaccharide als pflanzenspezifisches regulierendes mittel, verfahren zu ihrer herstellung und ihre verwendungen
ATE178334T1 (de)	1999-04-15	Di-lysogangliosidderivate
ES2144993T3 (es)	2000-07-01	Beta-dicetonas sustituidas y su uso en el tratamiento de enfermedades inflamatorias del intestino.
MX9301667A (es)	1993-11-01	Acidos 7-oxo-7h-pirido(1,2,3-de)(1,4)-benzoxacin-6-carboxilicos y sus esteres y medicamentos que los contienen.
ATE73812T1 (de)	1992-04-15	Thionophosphonsaeureester.
DE60003697D1 (de)	2003-08-07	Aktive marine alkaloiden
IT1247510B (it)	1994-12-17	Composizioni terapeutiche ad attivita' anti-hiv costituite da 2',3'-didesossiadenosina e sostanze inibitrici della adenosina-deaminasi