ATE104983T1 - Avermectin-ketal-derivate, die als antiparasitenmittel geeignet sind. - Google Patents
Avermectin-ketal-derivate, die als antiparasitenmittel geeignet sind.Info
- Publication number
- ATE104983T1 ATE104983T1 AT9090301638T AT90301638T ATE104983T1 AT E104983 T1 ATE104983 T1 AT E104983T1 AT 9090301638 T AT9090301638 T AT 9090301638T AT 90301638 T AT90301638 T AT 90301638T AT E104983 T1 ATE104983 T1 AT E104983T1
- Authority
- AT
- Austria
- Prior art keywords
- avermectin
- antiparasitic agents
- derivatives useful
- ketal
- ketal derivatives
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 3
- 239000003096 antiparasitic agent Substances 0.000 title abstract 2
- 229940125687 antiparasitic agent Drugs 0.000 title abstract 2
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 2
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31126889A | 1989-02-16 | 1989-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE104983T1 true ATE104983T1 (de) | 1994-05-15 |
Family
ID=23206158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT9090301638T ATE104983T1 (de) | 1989-02-16 | 1990-02-15 | Avermectin-ketal-derivate, die als antiparasitenmittel geeignet sind. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5077308A (de) |
| EP (1) | EP0388019B1 (de) |
| JP (1) | JPH02270880A (de) |
| AT (1) | ATE104983T1 (de) |
| AU (1) | AU623744B2 (de) |
| CA (1) | CA2010078A1 (de) |
| DE (1) | DE69008399T2 (de) |
| DK (1) | DK0388019T3 (de) |
| ES (1) | ES2063256T3 (de) |
| NZ (1) | NZ232422A (de) |
| ZA (1) | ZA901148B (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119649A (en) * | 1995-11-30 | 2002-03-10 | Akzo Nobel Nv | Preparation of Cyclic Kills of History - 3 keto- (5) 10, (-9) 11 steroidadians |
| DE69818093T2 (de) * | 1997-12-03 | 2004-06-09 | Merck & Co., Inc. | Langwirkende, injizierbare, formulierungen enthaltend rizinusöl |
| US6733767B2 (en) | 1998-03-19 | 2004-05-11 | Merck & Co., Inc. | Liquid polymeric compositions for controlled release of bioactive substances |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US20060205681A1 (en) * | 2002-06-21 | 2006-09-14 | Maryam Moaddeb | Homogenous paste formulations |
| US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7531186B2 (en) | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
| WO2008005489A2 (en) | 2006-07-05 | 2008-01-10 | Aventis Agriculture | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
| US8901163B2 (en) | 2007-01-03 | 2014-12-02 | Galderma S.A. | Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound |
| HUE029127T2 (en) | 2007-05-15 | 2017-02-28 | Merial Inc | Arylazol-2-yl-cyanoethylamino compounds, a process for their preparation and use |
| US8097266B2 (en) | 2007-11-26 | 2012-01-17 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| CA2710171C (en) | 2007-12-21 | 2016-02-02 | Merial Limited | The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals |
| WO2010008891A2 (en) * | 2008-06-24 | 2010-01-21 | Merial Limited | Anthelminthic formulations |
| RS58508B1 (sr) | 2008-11-14 | 2019-04-30 | Merial Inc | Enantiomerno obogaćena paraziticidalna jedinjenja ariloazol-2-il cijanoetilamino |
| US8450357B2 (en) * | 2008-11-19 | 2013-05-28 | Merial Limited | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| MX2011005726A (es) | 2008-12-04 | 2011-07-29 | Merial Ltd | Derivados de avermectina y milbemicina dimericos. |
| JP5834006B2 (ja) | 2009-07-30 | 2015-12-16 | メリアル リミテッド | 殺虫性４−アミノ−チエノ［２，３−ｄ］−ピリミジン化合物及びその使用方法 |
| US8846569B2 (en) | 2009-12-04 | 2014-09-30 | Merial Limited | Pesticidal bis-organosulfur compounds |
| ES2569486T3 (es) | 2009-12-17 | 2016-05-11 | Merial, Inc. | Compuestos de dihidroazol antiparasitarios y composiciones que comprenden los mismos |
| WO2011075592A1 (en) | 2009-12-17 | 2011-06-23 | Merial Limited | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| HUE028600T2 (en) | 2010-05-12 | 2016-12-28 | Merial Inc | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| EP2629772B1 (de) | 2010-10-20 | 2016-05-18 | Galderma S.A. | Ivermectin zur behandlung von hämorrhoiden |
| EP2629770B1 (de) | 2010-10-20 | 2016-05-25 | Galderma S.A. | Ivermectin zur behandlung von gehörgangsentzündungen |
| NZ610547A (en) | 2010-11-16 | 2015-07-31 | Merial Ltd | Novel monensin derivatives for the treatment and prevention of protozoal infections |
| NZ612185A (en) | 2010-12-07 | 2015-10-30 | Merial Inc | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| WO2013003505A1 (en) | 2011-06-27 | 2013-01-03 | Merial Limited | Amido-pyridyl ether compounds and compositions and their use against parasites |
| WO2013003168A1 (en) | 2011-06-27 | 2013-01-03 | Merial Limited | Novel insect-repellent coumarin derivatives, syntheses, and methods of use |
| RS61048B1 (sr) | 2011-09-12 | 2020-12-31 | Boehringer Ingelheim Animal Health Usa Inc | Paraziticidne kompozicije koje sadrže izoksazolin aktivni agens, postupak i njihove primene |
| US20130079394A1 (en) | 2011-09-23 | 2013-03-28 | Cnrs (Centre National Recherche Scientifique) | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
| KR102066757B1 (ko) | 2011-11-17 | 2020-01-15 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 아릴 피라졸 및 치환된 이미다졸을 함유하는 조성물, 그의 방법 및 용도 |
| WO2013082373A1 (en) | 2011-12-02 | 2013-06-06 | Merial Limited | Long-acting injectable moxidectin formulations and novel moxidectin crystal forms |
| HUE043949T2 (hu) | 2012-02-06 | 2019-09-30 | Boehringer Ingelheim Animal Health Usa Inc | Szisztémásan ható hatóanyagokat tartalmazó, parazitaellenes, szájon át adagolt állatgyógyászati készítmények, eljárások és alkalmazásuk |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| JP6161173B2 (ja) | 2012-04-20 | 2017-07-12 | メリアル インコーポレイテッド | ベンズイミダゾール誘導体を含む殺寄生虫組成物、その方法及び使用 |
| SG11201503959VA (en) | 2012-11-20 | 2015-06-29 | Merial Inc | Anthelmintic compounds and compositions and method of using thereof |
| PL2950795T3 (pl) | 2013-01-31 | 2018-09-28 | Merial, Inc. | Sposób leczenia i wyleczenia leiszmaniozy z zastosowaniem feksinidazolu |
| US9447084B2 (en) | 2013-11-01 | 2016-09-20 | Merial, Inc. | Antiparisitic and pesticidal isoxazoline compounds |
| CN106455560B (zh) | 2014-04-17 | 2020-12-22 | 勃林格殷格翰动物保健美国公司 | 用于保护动物免受寄生物的丙二腈化合物的用途 |
| US10045979B2 (en) | 2014-05-19 | 2018-08-14 | Merial Inc. | Anthelmintic compounds |
| US9776986B2 (en) | 2014-06-19 | 2017-10-03 | Merial Inc. | Parasiticidal compositions comprising indole derivatives, methods and uses thereof |
| ES2887302T3 (es) | 2014-10-31 | 2021-12-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden fipronil |
| PY1609250A (es) | 2015-02-26 | 2018-03-01 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| SG11201708068PA (en) | 2015-04-08 | 2017-10-30 | Merial Inc | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| CN114891070A (zh) | 2015-05-20 | 2022-08-12 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
| EP3303385A2 (de) | 2015-05-27 | 2018-04-11 | Merial, Inc. | Zusammensetzungen mit antimikrobiellen igy-antikörpern zur behandlung und prävention von störungen und erkrankungen durch die mundgesundheit beeinträchtigende mikroorganismen |
| UY40429A (es) | 2016-02-24 | 2023-10-13 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| EP3525590B1 (de) | 2016-10-14 | 2025-08-20 | Boehringer Ingelheim Vetmedica GmbH | Pestizide und parasitizide vinylisoxazolinverbindungen |
| MX2019005628A (es) | 2016-11-16 | 2019-12-18 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos depsipeptidos antihelminticos. |
| EP3644741B1 (de) | 2017-06-26 | 2023-06-07 | Boehringer Ingelheim Animal Health USA Inc. | Duale aktive parasitizide granulatzusammensetzungen, verfahren und verwendungen davon |
| ES2944616T3 (es) | 2017-08-14 | 2023-06-22 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas |
| EP3749096A1 (de) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasitizide zusammensetzungen mit eprinomectin und praziquantel, verfahren und verwendungen davon |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| NZ776819A (en) | 2019-01-16 | 2023-04-28 | Boehringer Ingelheim Animal Health Usa Inc | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| EP3930684A1 (de) | 2019-03-01 | 2022-01-05 | Boehringer Ingelheim Animal Health USA Inc. | Injizierbare clorsulon-zusammensetzungen, verfahren und ihre verwendung |
| BR112021018631A2 (pt) | 2019-03-19 | 2021-11-23 | Boehringer Ingelheim Animal Health Usa Inc | Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano |
| BR112022000982A2 (pt) | 2019-07-22 | 2022-03-08 | Intervet Int Bv | Forma de dosagem veterinária mastigável macia |
| WO2021242581A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| USRE32006E (en) * | 1977-12-19 | 1985-10-15 | Merck & Co., Inc. | 13-Halo and 13-deoxy C-076 compounds |
| USRE32032E (en) * | 1978-02-10 | 1985-11-19 | Foam Cutting Engineers, Inc. | Method of densifying open-celled polyurethane material |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の５−オキシム誘導体 |
| DE3519834C2 (de) * | 1984-06-05 | 1993-12-16 | American Cyanamid Co | Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen |
| CH666690A5 (de) * | 1984-09-14 | 1988-08-15 | Glaxo Group Ltd | Antibiotisch wirkende verbindungen der makrolidgruppe aus streptomyces-mikroorganismen, ihre herstellung und verwendung. |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| DE3750495T2 (de) * | 1986-07-24 | 1995-02-23 | Beecham Group Plc | Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen. |
| DE3889676D1 (de) * | 1987-02-04 | 1994-06-30 | Ciba Geigy | Mikrobielles Verfahren zur Herstellung von Milbemycin-Derivaten. |
| US4871719A (en) * | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
-
1990
- 1990-02-08 NZ NZ232422A patent/NZ232422A/xx unknown
- 1990-02-14 CA CA002010078A patent/CA2010078A1/en not_active Abandoned
- 1990-02-15 AT AT9090301638T patent/ATE104983T1/de active
- 1990-02-15 DK DK90301638.4T patent/DK0388019T3/da active
- 1990-02-15 EP EP90301638A patent/EP0388019B1/de not_active Expired - Lifetime
- 1990-02-15 DE DE69008399T patent/DE69008399T2/de not_active Expired - Fee Related
- 1990-02-15 ES ES90301638T patent/ES2063256T3/es not_active Expired - Lifetime
- 1990-02-15 AU AU49830/90A patent/AU623744B2/en not_active Ceased
- 1990-02-15 ZA ZA901148A patent/ZA901148B/xx unknown
- 1990-02-16 JP JP2034038A patent/JPH02270880A/ja active Pending
- 1990-07-23 US US07/556,044 patent/US5077308A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5077308A (en) | 1991-12-31 |
| ES2063256T3 (es) | 1995-01-01 |
| EP0388019B1 (de) | 1994-04-27 |
| JPH02270880A (ja) | 1990-11-05 |
| DE69008399T2 (de) | 1994-10-27 |
| DK0388019T3 (da) | 1994-05-24 |
| EP0388019A1 (de) | 1990-09-19 |
| AU4983090A (en) | 1991-08-29 |
| CA2010078A1 (en) | 1990-08-16 |
| DE69008399D1 (de) | 1994-06-01 |
| ZA901148B (en) | 1990-10-31 |
| AU623744B2 (en) | 1992-05-21 |
| NZ232422A (en) | 1992-11-25 |
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