ES2133542T3 - Benzodiazepinas triciclicas, utilizacion y preparacion. - Google Patents

Benzodiazepinas triciclicas, utilizacion y preparacion.

Info

Publication number
ES2133542T3
ES2133542T3 ES94908289T ES94908289T ES2133542T3 ES 2133542 T3 ES2133542 T3 ES 2133542T3 ES 94908289 T ES94908289 T ES 94908289T ES 94908289 T ES94908289 T ES 94908289T ES 2133542 T3 ES2133542 T3 ES 2133542T3
Authority
ES
Spain
Prior art keywords
sup
hidroxi
alcoxi
ciano
furano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908289T
Other languages
English (en)
Inventor
Rolf Hohlweg
Erik Bardrum Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2133542T3 publication Critical patent/ES2133542T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

BENZACEPINAS QUE TIENEN FORMULA GENERAL (I) EN LA QUE A JUNTO CON LOS ATOMOS DE CARBONO MARCADOS {AL} Y {BE} ES UN ANILLO CICLOPENTENO, CICLOHEXENO, FURANO, DIHIDROFURANO, PIRANO, DIHIDROPIRANO, TIOFENO, OXAZOL, PIROLO, PIRROLINA, TETRAHIDROPIRIDINA O DIOXOL, R{SUP,1} ES H O ALKILO. R{SUP,2} Y R{SUP,3} INDEPENDIENTEMENTE SON H, ALCOXI, HALOGENO, NITRO, CIANO O HIDROXI, O R{SUP,2} Y R{SUP,3} JUNTOS PUEDEN FORMAR UN ANILLO DE FURANO, CICLOPENTENO O DIOXOL Y R{SUP,4} ES H, ALCOXI, NITRO, CIANO, HIDROXI O HALOGENO, O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON UTILES EN EL TRATAMIENTO DE CIERTOS TRASTORNOS EN EL SISTEMA NERVIOSO CENTRAL, POR EJEMPLO SICOSIS, DOLOR, DEPRESION TRASTORNOS DEL SUEÑO, DISQUINESIA, ATAQUES, ENFERMEDAD DE PASRKINSON.
ES94908289T 1993-03-10 1994-02-18 Benzodiazepinas triciclicas, utilizacion y preparacion. Expired - Lifetime ES2133542T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93267A DK26793D0 (da) 1993-03-10 1993-03-10 Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling

Publications (1)

Publication Number Publication Date
ES2133542T3 true ES2133542T3 (es) 1999-09-16

Family

ID=8091615

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908289T Expired - Lifetime ES2133542T3 (es) 1993-03-10 1994-02-18 Benzodiazepinas triciclicas, utilizacion y preparacion.

Country Status (19)

Country Link
US (1) US5512562A (es)
EP (1) EP0688320B1 (es)
JP (1) JP3779319B2 (es)
KR (1) KR960701022A (es)
CN (1) CN1045957C (es)
AT (1) ATE179700T1 (es)
AU (1) AU682494B2 (es)
CA (1) CA2157668C (es)
DE (1) DE69418321T2 (es)
DK (2) DK26793D0 (es)
ES (1) ES2133542T3 (es)
FI (1) FI111944B (es)
GR (1) GR3030864T3 (es)
IL (1) IL108730A (es)
NO (1) NO953543L (es)
NZ (1) NZ262098A (es)
TW (1) TW279861B (es)
WO (1) WO1994020472A1 (es)
ZA (1) ZA941377B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2030197A (en) * 1996-03-08 1997-09-22 Synthelabo 2-aminoethyl-benzofuran derivatives, preparation thereof and therapeutical use thereof
FR2745815B1 (fr) * 1996-03-08 1998-06-26 Synthelabo Derives de benzofurane, leur preparations et compositions pharmaceutiques les comprenant
FR2752840A1 (fr) * 1996-08-29 1998-03-06 Synthelabo Derives de benzothiophene, leur preparation et leur application en therapeutique
US6211173B1 (en) 1997-03-12 2001-04-03 Cenes Limited Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP2002519326A (ja) * 1998-06-30 2002-07-02 イーライ・リリー・アンド・カンパニー セロトニン関連系に効果を有するアゼピン誘導体
DE60206762T2 (de) 2001-07-13 2006-07-13 Pharmacia & Upjohn Co. Llc, Kalamazoo Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden
GB0412314D0 (en) * 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
GB0414795D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Compounds
KR101781789B1 (ko) * 2010-01-27 2017-09-26 에이비 파르마 리미티드. C형 간염 바이러스 억제제로 사용되는 다환 헤테로사이클릭 화합물
JP2016503808A (ja) 2012-12-21 2016-02-08 エイビーティー ホールディング カンパニー セロトニン５−ＨＴ２ｃ受容体リガンドとしてのベンザゼピンおよびその使用
CN105566262B (zh) * 2016-01-11 2017-10-27 华东理工大学 苯并呋喃‑7‑烷基胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255445A (en) * 1980-03-07 1981-03-10 Smithkline Corporation 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
CA1234110A (en) * 1983-08-12 1988-03-15 Joel G. Berger Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
DK157925C (da) * 1985-04-22 1990-08-27 Novo Industri As 2,3,4,5-tetrahydro-1h-3-benzazepinderivater og farmaceutiske praeparater indeholdende disse
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser

Also Published As

Publication number Publication date
IL108730A0 (en) 1994-05-30
US5512562A (en) 1996-04-30
CN1121710A (zh) 1996-05-01
DK26793D0 (da) 1993-03-10
AU682494B2 (en) 1997-10-09
JPH08507498A (ja) 1996-08-13
WO1994020472A1 (en) 1994-09-15
DK0688320T3 (da) 1999-11-01
DE69418321D1 (de) 1999-06-10
NO953543D0 (no) 1995-09-08
TW279861B (es) 1996-07-01
KR960701022A (ko) 1996-02-24
JP3779319B2 (ja) 2006-05-24
NZ262098A (en) 1996-11-26
CN1045957C (zh) 1999-10-27
GR3030864T3 (en) 1999-11-30
CA2157668A1 (en) 1994-09-15
ATE179700T1 (de) 1999-05-15
EP0688320B1 (en) 1999-05-06
EP0688320A1 (en) 1995-12-27
IL108730A (en) 1999-08-17
FI954229A0 (fi) 1995-09-08
ZA941377B (en) 1995-08-28
FI111944B (fi) 2003-10-15
CA2157668C (en) 2006-05-30
DE69418321T2 (de) 1999-12-30
AU6138694A (en) 1994-09-26
NO953543L (no) 1995-09-08
FI954229L (fi) 1995-09-08

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