ATE181926T1 - Zunahme der durchlässigkeit der blut-hirn- schranke durch verwendung von durchlässigkeitsfördernden peptiden - Google Patents

Zunahme der durchlässigkeit der blut-hirn- schranke durch verwendung von durchlässigkeitsfördernden peptiden

Info

Publication number
ATE181926T1
ATE181926T1 AT92917463T AT92917463T ATE181926T1 AT E181926 T1 ATE181926 T1 AT E181926T1 AT 92917463 T AT92917463 T AT 92917463T AT 92917463 T AT92917463 T AT 92917463T AT E181926 T1 ATE181926 T1 AT E181926T1
Authority
AT
Austria
Prior art keywords
permeability
blood
brain barrier
molecules
increase
Prior art date
Application number
AT92917463T
Other languages
English (en)
Inventor
John W Kozarich
Gary F Musso
Bernard Malfroy-Camine
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE181926T1 publication Critical patent/ATE181926T1/de

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043Kallidins; Bradykinins; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/18Kallidins; Bradykinins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
AT92917463T 1991-04-23 1992-04-23 Zunahme der durchlässigkeit der blut-hirn- schranke durch verwendung von durchlässigkeitsfördernden peptiden ATE181926T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/690,522 US5268164A (en) 1990-04-23 1991-04-23 Increasing blood-brain barrier permeability with permeabilizer peptides

Publications (1)

Publication Number Publication Date
ATE181926T1 true ATE181926T1 (de) 1999-07-15

Family

ID=24772811

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92917463T ATE181926T1 (de) 1991-04-23 1992-04-23 Zunahme der durchlässigkeit der blut-hirn- schranke durch verwendung von durchlässigkeitsfördernden peptiden

Country Status (12)

Country Link
US (3) US5268164A (de)
EP (2) EP0585412B1 (de)
JP (1) JPH06506942A (de)
KR (1) KR100242597B1 (de)
AT (1) ATE181926T1 (de)
AU (1) AU660465B2 (de)
CA (1) CA2107556C (de)
DE (1) DE69229549T2 (de)
DK (1) DK0585412T3 (de)
ES (1) ES2133326T3 (de)
GR (1) GR3030814T3 (de)
WO (1) WO1992018529A1 (de)

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US5268164A (en) 1993-12-07
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