ATE184400T1 - Assay für troponin i aus dem herzmuskel - Google Patents

Assay für troponin i aus dem herzmuskel

Info

Publication number
ATE184400T1
ATE184400T1 AT94916788T AT94916788T ATE184400T1 AT E184400 T1 ATE184400 T1 AT E184400T1 AT 94916788 T AT94916788 T AT 94916788T AT 94916788 T AT94916788 T AT 94916788T AT E184400 T1 ATE184400 T1 AT E184400T1
Authority
AT
Austria
Prior art keywords
troponin
assay
heart muscle
cardiac troponin
binding partner
Prior art date
Application number
AT94916788T
Other languages
English (en)
Inventor
Richard W Wicks
Leslie O Zartman
Annette M Vargas
Stacy A Torretti
Original Assignee
Fortron Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fortron Bioscience Inc filed Critical Fortron Bioscience Inc
Application granted granted Critical
Publication of ATE184400T1 publication Critical patent/ATE184400T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT94916788T 1993-05-17 1994-05-16 Assay für troponin i aus dem herzmuskel ATE184400T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6316893A 1993-05-17 1993-05-17

Publications (1)

Publication Number Publication Date
ATE184400T1 true ATE184400T1 (de) 1999-09-15

Family

ID=22047398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94916788T ATE184400T1 (de) 1993-05-17 1994-05-16 Assay für troponin i aus dem herzmuskel

Country Status (8)

Country Link
US (2) US5756682A (de)
EP (1) EP0699306B1 (de)
JP (1) JPH09503050A (de)
AT (1) ATE184400T1 (de)
AU (1) AU689777B2 (de)
CA (1) CA2162121A1 (de)
DE (1) DE69420556T2 (de)
WO (1) WO1994027156A1 (de)

Families Citing this family (45)

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Publication number Priority date Publication date Assignee Title
FR2729759A1 (fr) * 1995-01-19 1996-07-26 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque
FR2729761B1 (fr) * 1995-01-19 1997-12-05 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque
US6165981A (en) * 1995-03-07 2000-12-26 Dade Behring Inc. Stabilizing solutions for proteins and peptides
US6627404B1 (en) * 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US6991907B1 (en) 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6174686B1 (en) 1995-04-18 2001-01-16 Biosite Diagnostics, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
FR2734267B1 (fr) * 1995-05-16 1997-08-01 Pasteur Sanofi Diagnostics Composition stabilisee de troponine pour immunoessais et procede de preparation d'une telle composition stabilisee
DE19548028A1 (de) * 1995-12-21 1997-06-26 Bayer Ag Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten
AU4981897A (en) 1996-10-15 1998-05-11 Navix, Inc. Stabilized conjugates of uncomplexed subunits of multimeric proteins
DE19647927A1 (de) * 1996-11-20 1998-05-28 Bayer Ag Verfahren zur Herstellung einer stabilen Troponin I Präparation und dessen Verwendung als Kalibrator in Immunoassays
FR2756827B1 (fr) * 1996-12-05 1999-01-29 Pasteur Sanofi Diagnostics Composes synthetiques biepitopiques utilisables comme etalons dans les dosages biologiques de la troponine i
US6156521A (en) * 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
WO1998029726A2 (en) * 1996-12-27 1998-07-09 Coulter International Corp. Method of detecting and determining the concentration of total troponin i in a biological sample
US5947124A (en) * 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6248869B1 (en) * 1997-05-29 2001-06-19 Medical Analysis Systems, Inc. Troponin I forms and use of the same
JP2002508839A (ja) * 1997-05-29 2002-03-19 メディカル アナリシス システムズ，インコーポレイテッド 共有結合したトロポニン複合体
US7384751B1 (en) 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
WO2000023585A1 (en) * 1998-10-21 2000-04-27 Spectral Diagnostics, Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
US6190916B1 (en) * 1999-06-29 2001-02-20 Spectral Diagnostics, Inc. Troponin I composition
US7618782B1 (en) * 1999-10-18 2009-11-17 Queen's University At Kingston Methods of diagnosing muscle damage
US7078486B2 (en) 1999-12-10 2006-07-18 Spectral Diagnostics, Inc. Single-chain polypeptides comprising troponin I and troponin C
EP1311860A2 (de) 2000-08-21 2003-05-21 Queen's University At Kingston Verfahren und testkit zur auftrennung und zum nachweis von proteinen in biologischen proben
US6538104B2 (en) 2001-04-27 2003-03-25 Medical Analysis Systems, Inc. Stabilization of cardiac troponin I subunits and complexes
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US7196169B2 (en) 2002-10-11 2007-03-27 Queen's University At Kingston Isolated post-translationally modified mammalian proteins for monitoring and diagnosing muscle damage
US20040096983A1 (en) * 2002-11-14 2004-05-20 Jacobs Merrit N. Wash process for a sample being analyzed
WO2004091476A2 (ja) * 2003-04-16 2004-10-28 Ono Pharmaceutical Co 心臓疾患治療物質のスクリーニング方法および心臓疾患治療医薬組成物
US7473548B2 (en) 2003-04-25 2009-01-06 Medtronic, Inc. Optical detector for enzyme activation
FI20030652A0 (fi) * 2003-04-30 2003-04-30 Susann Eriksson Parannettu immunomääritys
US20050096516A1 (en) * 2003-10-30 2005-05-05 Orhan Soykan Optical detector of organic analyte
US20050164409A1 (en) * 2003-12-10 2005-07-28 Kiernan Urban A. Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins
US20110076697A1 (en) * 2009-04-28 2011-03-31 Innovative Laboratory Technologies, Inc. Lateral-flow immuno-chromatographic assay devices
EP2504466B1 (de) 2009-11-23 2019-11-20 Proxim Diagnostics Corporation Gesteuerte elektrochemische aktivierung von elektroden auf kohlenstoffbasis
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
CN108387744A (zh) 2010-08-26 2018-08-10 弗·哈夫曼-拉罗切有限公司 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途
US9638663B2 (en) 2011-07-25 2017-05-02 Proxim Diagnostics Corporation Cartridge for diagnostic testing
US8603759B2 (en) * 2011-12-06 2013-12-10 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
KR101492696B1 (ko) * 2011-12-09 2015-02-12 경북대학교 산학협력단 심근 트로포닌 ⅰ과 특이적으로 결합하는 폴리펩타이드 및 이의 용도
WO2013088587A1 (ja) * 2011-12-16 2013-06-20 パナソニック株式会社 ヒト心筋由来トロポニンｉに特異的にかつ速やかに結合できる組み換えタンパク質
US8663933B2 (en) 2011-12-16 2014-03-04 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
US8603760B2 (en) * 2011-12-20 2013-12-10 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
US10175250B2 (en) * 2012-06-11 2019-01-08 Gabriela Venturini Da Silva Nitrated cardiac troponin I as a biomarker of cardiac ischemia
KR102328327B1 (ko) 2014-09-26 2021-11-22 소마로직, 인크. 심혈관 위험 사건 예측 및 이의 용도
CN109912713B (zh) * 2019-01-08 2022-09-13 美康生物科技股份有限公司 用于免疫诊断试剂配制的肌钙蛋白i抗体的制备方法及获得的菌株

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US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4912033A (en) * 1985-11-14 1990-03-27 Washington University Creatine kinase MB determination method
GB2200358B (en) * 1987-01-27 1991-02-27 Univ Birmingham Materials for in vivo detection of cardiac damage, and methods for their preparation
DE3922873A1 (de) * 1989-04-25 1990-10-31 Boehringer Mannheim Gmbh Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen
CA2027434C (en) * 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
DE4243648A1 (de) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Herzmuskelnekrosen mittels Antikörper gegen das N-terminale Troponin I-Peptid

Also Published As

Publication number Publication date
CA2162121A1 (en) 1994-11-24
EP0699306A1 (de) 1996-03-06
WO1994027156A1 (en) 1994-11-24
AU6834894A (en) 1994-12-12
DE69420556D1 (de) 1999-10-14
DE69420556T2 (de) 2000-03-23
AU689777B2 (en) 1998-04-09
JPH09503050A (ja) 1997-03-25
US5834220A (en) 1998-11-10
EP0699306B1 (de) 1999-09-08
US5756682A (en) 1998-05-26

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