ATE184876T1 - Ethynyl-alanin-aminodiolverbindungen mit piperazinylendgruppe oder piperazinyl-alkylamino- endgruppe zur behandlung von bluthochdruck - Google Patents

Ethynyl-alanin-aminodiolverbindungen mit piperazinylendgruppe oder piperazinyl-alkylamino- endgruppe zur behandlung von bluthochdruck

Info

Publication number: ATE184876T1
Authority: AT; Austria
Prior art keywords: piperazinyl; termination; alkylamino; hypertension; group
Prior art date: 1992-08-14

Application number

AT93919920T

Other languages

English (en)

Inventor

Gunnar J Hanson

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-14

Filing date

1993-08-10

Publication date

1999-10-15

1993-08-10 Application filed by Searle & Co filed Critical Searle & Co

1999-10-15 Application granted granted Critical

1999-10-15 Publication of ATE184876T1 publication Critical patent/ATE184876T1/de

Links

-1 ETHYNYL-ALANINE AMINODIOL COMPOUNDS Chemical class 0.000 title abstract 4
206010020772 Hypertension Diseases 0.000 title abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 3
239000000126 substance Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000001145 hydrido group Chemical group *[H] 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000002461 renin inhibitor Substances 0.000 abstract 1
229940086526 renin-inhibitors Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Peptides Or Proteins (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93919920T 1992-08-14 1993-08-10 Ethynyl-alanin-aminodiolverbindungen mit piperazinylendgruppe oder piperazinyl-alkylamino- endgruppe zur behandlung von bluthochdruck ATE184876T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/930,065 US5298505A (en)	1992-08-14	1992-08-14	Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension

Publications (1)

Publication Number	Publication Date
ATE184876T1 true ATE184876T1 (de)	1999-10-15

Family

ID=25458877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93919920T ATE184876T1 (de)	1992-08-14	1993-08-10	Ethynyl-alanin-aminodiolverbindungen mit piperazinylendgruppe oder piperazinyl-alkylamino- endgruppe zur behandlung von bluthochdruck

Country Status (11)

Country	Link
US (1)	US5298505A (de)
EP (1)	EP0655063B1 (de)
JP (1)	JPH08500115A (de)
AT (1)	ATE184876T1 (de)
AU (1)	AU682319B2 (de)
CA (1)	CA2138521A1 (de)
DE (1)	DE69326555T2 (de)
DK (1)	DK0655063T3 (de)
ES (1)	ES2136667T3 (de)
GR (1)	GR3031861T3 (de)
WO (1)	WO1994004536A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5508466A (en) *	1994-04-13	1996-04-16	G.D. Searle & Co.	Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent
CA2467476A1 (en) *	2001-11-19	2003-05-30	Pharmacia & Upjohn Company	Amino diols useful in the treatment of alzheimer's disease

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
EP0181110A3 (de) *	1984-10-22	1988-05-11	Kissei Pharmaceutical Co. Ltd.	Histidinderivate als Renininhibitoren
SU1676454A3 (ru) *	1984-11-30	1991-09-07	Санкио Компани Лимитед (Фирма)	Способ получени пептидов или их фармацевтически приемлемых солей
DK34086A (da) *	1985-01-23	1986-07-24	Abbott Lab	Peptidylaminodioler
JPS61236770A (ja) *	1985-04-15	1986-10-22	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
JPS6256458A (ja) *	1985-09-04	1987-03-12	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
JPS63503380A (ja) *	1986-01-16	1988-12-08	アボット・ラボラトリーズ	ペプチド類似体
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
US5032577A (en) *	1986-12-31	1991-07-16	Abbott Laboratories	Peptidylaminodiols
US4921855A (en) *	1987-06-22	1990-05-01	Fujisawa Pharmaceutical Co., Ltd.	New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
US5036053A (en) *	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
US4902706A (en) *	1988-07-01	1990-02-20	G. D. Searle & Co.	Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
EP0539976A1 (de) *	1991-10-29	1993-05-05	G.D. Searle & Co.	Ethynyl-Alanin-Amino-Diolderivate zur Behandlung von Hypertonie
US5223535A (en) *	1991-10-29	1993-06-29	G. D. Searle & Co.	Propargyl glycine amino propargyl diol compounds for treatment of hypertension
US5227401A (en) *	1991-10-29	1993-07-13	G. D. Searle & Co.	Ethynyl alanine amino diol compounds for treatment of hypertension

1992
- 1992-08-14 US US07/930,065 patent/US5298505A/en not_active Expired - Fee Related
1993
- 1993-08-10 AT AT93919920T patent/ATE184876T1/de not_active IP Right Cessation
- 1993-08-10 DE DE69326555T patent/DE69326555T2/de not_active Expired - Fee Related
- 1993-08-10 ES ES93919920T patent/ES2136667T3/es not_active Expired - Lifetime
- 1993-08-10 DK DK93919920T patent/DK0655063T3/da active
- 1993-08-10 AU AU49993/93A patent/AU682319B2/en not_active Ceased
- 1993-08-10 WO PCT/US1993/007427 patent/WO1994004536A1/en not_active Ceased
- 1993-08-10 EP EP93919920A patent/EP0655063B1/de not_active Expired - Lifetime
- 1993-08-10 CA CA002138521A patent/CA2138521A1/en not_active Abandoned
- 1993-08-10 JP JP6506331A patent/JPH08500115A/ja active Pending
1999
- 1999-11-17 GR GR990402955T patent/GR3031861T3/el unknown

Also Published As

Publication number	Publication date
EP0655063A1 (de)	1995-05-31
AU682319B2 (en)	1997-10-02
CA2138521A1 (en)	1994-03-03
DK0655063T3 (da)	1999-12-20
AU4999393A (en)	1994-03-15
EP0655063B1 (de)	1999-09-22
GR3031861T3 (en)	2000-02-29
ES2136667T3 (es)	1999-12-01
US5298505A (en)	1994-03-29
DE69326555T2 (de)	2000-02-10
DE69326555D1 (de)	1999-10-28
WO1994004536A1 (en)	1994-03-03
JPH08500115A (ja)	1996-01-09

Legal Events

Date	Code	Title	Description
2000-02-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

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ES2107192T3 (es)	1997-11-16	Compuestos de alquilamino etinil alanina amino diol morfolino/tiomorfolino-terminados utiles como inhibidores de renina.
DK149091C (da)	1986-06-16	Analogifremgangsmaade til fremstilling af peptider indeholdende 2-7 aminosyrerester, desaminodipeptider eller amider deraf med ubiquitin-lignende aktivitet eller farmaceutisk acceptable syreadditionssalte deraf
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EA199800289A1 (ru)	1998-08-27	Производные пептидов
DE3650564D1 (de)	1996-10-02	Dipeptide-Analoge von Aspertam und Verfahren zur deren Herstellung, sowie eine neue Herstellung von Aspertam
FR2555576B1 (fr)	1986-06-13	Derives de n-(methoxyphenacyl)-amine, utilisation notamment en therapeutique et procede de preparation
DE3781691D1 (de)	1992-10-15	Tetrapeptid-hemmstoff zum eintritt in den kreislauf von hemopoietischen stammzellen, verfahren zu deren herstellung und deren anwendungen.
DK0716658T3 (da)	1997-12-22	Glycosylamider af 2-aminocylamino-2-desoxysukkerarter
JPS5283585A (en)	1977-07-12	Novel penicillin derivatives
TH16651A (de)	1995-09-27