ATE185811T1 - Verfahren zur herstellung von n-acyl-5- fluorocytidinderivaten - Google Patents

Verfahren zur herstellung von n-acyl-5- fluorocytidinderivaten

Info

Publication number
ATE185811T1
ATE185811T1 AT95112521T AT95112521T ATE185811T1 AT E185811 T1 ATE185811 T1 AT E185811T1 AT 95112521 T AT95112521 T AT 95112521T AT 95112521 T AT95112521 T AT 95112521T AT E185811 T1 ATE185811 T1 AT E185811T1
Authority
AT
Austria
Prior art keywords
acyl
producing
pref
methanol
formula
Prior art date
Application number
AT95112521T
Other languages
English (en)
Inventor
Herbert Robert Brinkmann
Panayiotis Kalaritis
John Francis Morissey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE185811T1 publication Critical patent/ATE185811T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95112521T 1994-08-26 1995-08-09 Verfahren zur herstellung von n-acyl-5- fluorocytidinderivaten ATE185811T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/296,842 US5476932A (en) 1994-08-26 1994-08-26 Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives

Publications (1)

Publication Number Publication Date
ATE185811T1 true ATE185811T1 (de) 1999-11-15

Family

ID=23143805

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95112521T ATE185811T1 (de) 1994-08-26 1995-08-09 Verfahren zur herstellung von n-acyl-5- fluorocytidinderivaten

Country Status (9)

Country Link
US (1) US5476932A (de)
EP (1) EP0698611B1 (de)
JP (1) JP3986574B2 (de)
KR (1) KR100335542B1 (de)
CN (1) CN1053194C (de)
AT (1) ATE185811T1 (de)
DE (1) DE69512851T2 (de)
DK (1) DK0698611T3 (de)
ES (1) ES2138691T3 (de)

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KR100631754B1 (ko) * 2000-08-09 2006-10-09 주식회사 코오롱 Ｎ-알킬옥시카르보닐-5-플루오로사이토신 유도체 및 그의제조방법
DE60326950D1 (de) 2002-05-15 2009-05-14 Janssen Pharmaceutica Nv N-substituierte tricyclische 3-aminopyrazole als pdgf rezeptorenhemmer
ATE402185T1 (de) * 2003-12-22 2008-08-15 Hoffmann La Roche Verfahren für fluorcytidinderivate
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
US20050192433A1 (en) * 2004-02-26 2005-09-01 Mitsui Chemicals, Inc. Metallic salt of N4-acylcytidine derivatives, and a method for producing N4-acylcytidine derivatives using the same
KR101345002B1 (ko) 2005-01-21 2013-12-31 아스텍스 테라퓨틱스 리미티드 제약 화합물
CN120022370A (zh) 2005-02-03 2025-05-23 综合医院公司 治疗吉非替尼耐药性癌症的方法
WO2006103187A2 (en) * 2005-04-01 2006-10-05 F. Hoffmann-La Roche Ag Method for administration of capecitabine
CN100569790C (zh) * 2005-07-15 2009-12-16 上海奥锐特国际贸易有限公司 合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法
US20070104721A1 (en) 2005-11-04 2007-05-10 Wyeth Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
US20080085310A1 (en) * 2006-10-06 2008-04-10 Maria Oksana Bachynsky Capecitabine rapidly disintegrating tablets
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
CN100425617C (zh) * 2006-10-31 2008-10-15 浙江海正药业股份有限公司 一种含氟嘧啶类化合物烷氧羰酰化的方法
ITMI20070435A1 (it) 2007-03-05 2008-09-06 Innovate Biotechnology Srl 2',3'-di-o-acil-5-fluoronucleosidi
WO2009022435A1 (ja) * 2007-08-15 2009-02-19 Japan Absorbent Technology Institute 吸収体製品およびその製造方法
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
KR101013312B1 (ko) * 2007-11-19 2011-02-09 한미홀딩스 주식회사 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
AR064165A1 (es) 2007-12-06 2009-03-18 Richmond Sa Com Ind Y Financie Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009088989A1 (en) * 2008-01-03 2009-07-16 Plus Chemicals, S.A. Process for the preparation of capecitabine
ES2562083T3 (es) * 2008-06-06 2016-03-02 Neurmedix, Inc. Métodos para preparar 17-alquinil-7-hidroxi-esteroides y compuestos relacionados
ES2431355T3 (es) 2008-06-17 2013-11-26 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
DK2326329T3 (en) 2008-08-04 2017-02-20 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
EP4218760A3 (de) 2009-04-06 2023-08-16 Wyeth LLC Behandlungsschema mit neratinib für brustkrebs
WO2011067588A1 (en) 2009-12-04 2011-06-09 Generics [Uk] Limited Cyclic sulphinyl esters of cytidine
WO2011104540A1 (en) 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
CN102260309B (zh) * 2010-05-24 2014-10-22 重庆福安药业(集团)股份有限公司 一种高纯度卡培他滨的制备方法
EP2750683B2 (de) 2011-10-03 2021-01-06 Croda International PLC Nanopartikel, verfahren zu ihrer herstellung und ihre verwendung als träger für amphipatische oder hydrophobe moleküle in der medizin mit verbindungen zur krebsbehandlung und nahrungsmitteln
TWI560195B (en) * 2012-01-13 2016-12-01 Pharmaessentia Corp Novel synthesis of 5-deoxy-5'-fluorocytidine compounds
US9907846B2 (en) 2013-04-01 2018-03-06 Mx Adjuvac Ab Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
CN104926901B (zh) * 2015-06-15 2018-04-20 广安凯特制药有限公司 一种卡培他滨关键中间体的合成方法
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
US11034667B2 (en) 2017-01-09 2021-06-15 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
ES2983284T3 (es) 2018-01-09 2024-10-22 Shuttle Pharmaceuticals Inc Inhibidores selectivos de histona deacetilasa para el tratamiento de enfermedades humanas
KR102708995B1 (ko) 2018-01-10 2024-09-23 누코리온 파마슈티컬스, 인코포레이티드. 포스포르(포스포론)아미다타세탈 및 포스프(온)아탈세탈 화합물
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
CN111801339B (zh) * 2018-01-19 2025-06-24 纽科利制药公司 5-氟尿嘧啶化合物
EP3669890A1 (de) 2018-12-18 2020-06-24 Croda International PLC Filamentöse nanopartikel mit impfstoffadjuvanswirkung
JP7625542B2 (ja) 2019-07-17 2025-02-03 ヌクオリオン ファーマシューティカルズ インコーポレイテッド 環状デオキシリボヌクレオチド化合物
CN115768778A (zh) 2020-04-21 2023-03-07 配体药物公司 苄氧基磷酸(膦酸)酯化合物
CN115605492B (zh) 2020-04-21 2025-09-16 配体制药股份有限公司 核苷酸前药化合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3071512D1 (en) * 1980-09-22 1986-04-24 Towmotor Corp Carriage assembly with shiftable forks
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
TW254946B (de) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines

Also Published As

Publication number Publication date
EP0698611A1 (de) 1996-02-28
JPH0859687A (ja) 1996-03-05
EP0698611B1 (de) 1999-10-20
DE69512851D1 (de) 1999-11-25
DK0698611T3 (da) 2000-03-27
JP3986574B2 (ja) 2007-10-03
KR100335542B1 (ko) 2002-11-08
CN1126726A (zh) 1996-07-17
ES2138691T3 (es) 2000-01-16
CN1053194C (zh) 2000-06-07
DE69512851T2 (de) 2000-05-04
KR960007610A (ko) 1996-03-22
US5476932A (en) 1995-12-19

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UEP Publication of translation of european patent specification