DK0698611T3 - Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater - Google Patents

Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater

Info

Publication number: DK0698611T3
Authority: DK; Denmark
Prior art keywords: acyl; preparation; pref; methanol; formula
Prior art date: 1994-08-26

Application number

DK95112521T

Other languages

Danish (da)

English (en)

Inventor

Herbert Robert Brinkmann

Panayiotis Kalaritis

John Francis Morissey

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-26

Filing date

1995-08-09

Publication date

2000-03-27

1995-08-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0698611T3 publication Critical patent/DK0698611T3/da

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 abstract 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 abstract 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal alkoxide Chemical class 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000000908 ammonium hydroxide Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK95112521T 1994-08-26 1995-08-09 Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater DK0698611T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/296,842 US5476932A (en)	1994-08-26	1994-08-26	Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives

Publications (1)

Publication Number	Publication Date
DK0698611T3 true DK0698611T3 (da)	2000-03-27

Family

ID=23143805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95112521T DK0698611T3 (da)	1994-08-26	1995-08-09	Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater

Country Status (9)

Country	Link
US (1)	US5476932A (de)
EP (1)	EP0698611B1 (de)
JP (1)	JP3986574B2 (de)
KR (1)	KR100335542B1 (de)
CN (1)	CN1053194C (de)
AT (1)	ATE185811T1 (de)
DE (1)	DE69512851T2 (de)
DK (1)	DK0698611T3 (de)
ES (1)	ES2138691T3 (de)

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CN108421044A (zh)	2005-02-03	2018-08-21	综合医院公司	治疗吉非替尼耐药性癌症的方法
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CN100569790C (zh) *	2005-07-15	2009-12-16	上海奥锐特国际贸易有限公司	合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法
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AR064165A1 (es)	2007-12-06	2009-03-18	Richmond Sa Com Ind Y Financie	Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
CN101469008B (zh) *	2007-12-29	2013-08-07	上海特化医药科技有限公司	卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009082844A1 (fr) *	2007-12-28	2009-07-09	Topharman Shanghai Co., Ltd	Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009082846A1 (fr) *	2007-12-28	2009-07-09	Topharman Shanghai Co., Ltd.	Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) *	2007-12-28	2009-08-06	Topharman Shanghai Co., Ltd.	Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
WO2009088989A1 (en) *	2008-01-03	2009-07-16	Plus Chemicals, S.A.	Process for the preparation of capecitabine
PL2300489T3 (pl)	2008-06-06	2016-11-30		Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych
CN102641270A (zh)	2008-06-17	2012-08-22	惠氏有限责任公司	含有hki-272和长春瑞滨的抗肿瘤组合
US8669273B2 (en)	2008-08-04	2014-03-11	Wyeth Llc	Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
IL264349B2 (en)	2009-04-06	2024-01-01	Wyeth Llc	Regimen comprising neratinib for the treatment of cancer
WO2011067588A1 (en)	2009-12-04	2011-06-09	Generics [Uk] Limited	Cyclic sulphinyl esters of cytidine
WO2011104540A1 (en)	2010-02-24	2011-09-01	Generics [Uk] Limited	One step process for the preparation of capecitabine
CN102260309B (zh) *	2010-05-24	2014-10-22	重庆福安药业(集团)股份有限公司	一种高纯度卡培他滨的制备方法
JP6050822B2 (ja)	2011-10-03	2016-12-21	モレインクス，エービー	ナノ粒子、ナノ粒子の調製のための処理、および癌治療および食品関連化合物を含む医療分野における両親媒性分子または疎水性分子ための担体としてのナノ粒子の使用
TWI560195B (en) *	2012-01-13	2016-12-01	Pharmaessentia Corp	Novel synthesis of 5-deoxy-5'-fluorocytidine compounds
US9907846B2 (en)	2013-04-01	2018-03-06	Mx Adjuvac Ab	Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
CN104926901B (zh) *	2015-06-15	2018-04-20	广安凯特制药有限公司	一种卡培他滨关键中间体的合成方法
US11584733B2 (en)	2017-01-09	2023-02-21	Shuttle Pharmaceuticals, Inc.	Selective histone deacetylase inhibitors for the treatment of human disease
EP3565549B1 (de)	2017-01-09	2022-03-09	Shuttle Pharmaceuticals, Inc.	Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen
US10435429B2 (en)	2017-10-03	2019-10-08	Nucorion Pharmaceuticals, Inc.	5-fluorouridine monophosphate cyclic triester compounds
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CN111836818B (zh)	2018-01-10	2023-10-31	纽科利制药公司	氨基磷(膦)酸缩醛和磷(膦)酸缩醛化合物
US11427550B2 (en)	2018-01-19	2022-08-30	Nucorion Pharmaceuticals, Inc.	5-fluorouracil compounds
WO2019143860A1 (en) *	2018-01-19	2019-07-25	Nucorion Pharmaceuticals, Inc.	5-fluorouracil compounds
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EP0060245B1 (de) *	1980-09-22	1986-03-19	Caterpillar Industrial Inc.	Hubschlittenanordnung mit verschiebbaren gabeln
CA1327358C (en) *	1987-11-17	1994-03-01	Morio Fujiu	Fluoro cytidine derivatives
AU671491B2 (en) *	1992-12-18	1996-08-29	F. Hoffmann-La Roche Ag	N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (de) *	1992-12-18	1995-08-21	Hoffmann La Roche

1994
- 1994-08-26 US US08/296,842 patent/US5476932A/en not_active Expired - Lifetime
1995
- 1995-08-09 DE DE69512851T patent/DE69512851T2/de not_active Expired - Lifetime
- 1995-08-09 AT AT95112521T patent/ATE185811T1/de active
- 1995-08-09 EP EP95112521A patent/EP0698611B1/de not_active Expired - Lifetime
- 1995-08-09 ES ES95112521T patent/ES2138691T3/es not_active Expired - Lifetime
- 1995-08-09 DK DK95112521T patent/DK0698611T3/da active
- 1995-08-21 JP JP21157995A patent/JP3986574B2/ja not_active Expired - Lifetime
- 1995-08-25 KR KR1019950026517A patent/KR100335542B1/ko not_active Expired - Lifetime
- 1995-08-25 CN CN95109396A patent/CN1053194C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0698611B1 (de)	1999-10-20
ATE185811T1 (de)	1999-11-15
KR100335542B1 (ko)	2002-11-08
CN1053194C (zh)	2000-06-07
JP3986574B2 (ja)	2007-10-03
US5476932A (en)	1995-12-19
KR960007610A (ko)	1996-03-22
ES2138691T3 (es)	2000-01-16
EP0698611A1 (de)	1996-02-28
DE69512851T2 (de)	2000-05-04
DE69512851D1 (de)	1999-11-25
CN1126726A (zh)	1996-07-17
JPH0859687A (ja)	1996-03-05

Publication	Publication Date	Title
DE69512851D1 (de)	1999-11-25	Verfahren zur Herstellung von N-Acyl-5-Fluorocytidinderivaten
AU2003276160A1 (en)	2004-06-30	Method for the production of metal complexes
DE59705405D1 (de)	2001-12-20	Verfahren zur herstellung von fluor enthaltenden verbindungen
DE59810363D1 (de)	2004-01-15	Verfahren zur herstellung von triazolinthion-derivaten
ES2113975T3 (es)	1998-05-16	Azida de tri-alquil superior-estaño y su uso.
DE59106221D1 (de)	1995-09-14	Verfahren zur Herstellung von ungesättigten Ethern.
NO912801L (no)	1992-02-04	Fremgangsmaate for fremstilling av estere og amider og katalysatorsystem til dette.
PT1169326E (pt)	2004-10-29	Novo processo para a preparacao de acido alendronico
FI912336A0 (fi)	1991-05-14	Omaettade polyesterhartser.
DE59309966D1 (de)	2000-04-13	Verfahren zur Herstellung von 2-Chlor-5-aminomethylpyridin
ATE171932T1 (de)	1998-10-15	Verfahren zur herstellung von 4-halo- 2'nitrobutyrophenon
DK0572521T3 (da)	1995-10-02	Opløsningsmiddelfri fremgangsmåde til fremstilling af 1,2:5,6-di-O-isopropyliden-3-O-3-(N,N-dimethylamino-n-propyl)-alfa,D-glucofuranose og 1,2:5,6-di-O-isopropyliden-3-O-heptyl-alfa,D-glucofuranose og selektiv hydrolyse deraf
EP0281154A3 (en)	1989-07-19	Process for producing a siliconcarbide protective coating
ATE251135T1 (de)	2003-10-15	Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
DK709188A (da)	1989-06-23	Fremgangsmaade til fremstilling af et pyrazolderivat
ATA83990A (de)	1991-12-15	Verfahren zur herstellung von n-succinimidylcarbonaten
ATE253553T1 (de)	2003-11-15	Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten
ES477715A1 (es)	1980-04-01	Un procedimiento para la preparacion de 5-fenil-2-oxazol carboximidamidas.
ATE244228T1 (de)	2003-07-15	Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
FI902356L (fi)	1991-11-12	Tieno-triatsolo-diatsepiinijohdosten valmistusmenetelmä
ATE199372T1 (de)	2001-03-15	Verfahren zur herstellung von azacycloalkanderivaten
ATE4503T1 (de)	1983-09-15	Verfahren zur herstellung von substituierten essigsaeurehydraziden.
ES8601179A1 (es)	1985-10-16	Procedimiento para la preparacion de derivados de acido muramico
ATE180473T1 (de)	1999-06-15	Verfahren zur herstellung von 5-(3-tert.- butylamino-2-hydroxypropoxy)-3,4- dihydrocarbostyryl
ES8604396A1 (es)	1986-02-01	Procedimiento para la preparacion de esteres del acido-14,15-dihidro-14 b-hidroxi-(3x,16x)-eburnamenina-14-carboxilico