ATE186535T1 - Verfahren zur herstellung von omeprazol - Google Patents
Verfahren zur herstellung von omeprazolInfo
- Publication number
- ATE186535T1 ATE186535T1 AT92202792T AT92202792T ATE186535T1 AT E186535 T1 ATE186535 T1 AT E186535T1 AT 92202792 T AT92202792 T AT 92202792T AT 92202792 T AT92202792 T AT 92202792T AT E186535 T1 ATE186535 T1 AT E186535T1
- Authority
- AT
- Austria
- Prior art keywords
- bridge
- moiety
- reaction
- substituted
- omeprazole
- Prior art date
Links
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960000381 omeprazole Drugs 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- USSBDBZGEDUBHE-UHFFFAOYSA-L magnesium;2-oxidooxycarbonylbenzoate Chemical compound [Mg+2].[O-]OC(=O)C1=CC=CC=C1C([O-])=O USSBDBZGEDUBHE-UHFFFAOYSA-L 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76456491A | 1991-09-20 | 1991-09-20 | |
| US77787391A | 1991-10-15 | 1991-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE186535T1 true ATE186535T1 (de) | 1999-11-15 |
Family
ID=27117485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92202792T ATE186535T1 (de) | 1991-09-20 | 1992-09-12 | Verfahren zur herstellung von omeprazol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5391752A (de) |
| EP (1) | EP0533264B1 (de) |
| JP (1) | JPH0720956B2 (de) |
| KR (1) | KR100242622B1 (de) |
| CN (1) | CN1048729C (de) |
| AT (1) | ATE186535T1 (de) |
| AU (1) | AU649355B2 (de) |
| CA (1) | CA2078517C (de) |
| DE (1) | DE69230278T2 (de) |
| DK (1) | DK0533264T3 (de) |
| ES (1) | ES2143468T3 (de) |
| GR (1) | GR3032619T3 (de) |
| IL (1) | IL103156A (de) |
| MX (1) | MX9205333A (de) |
| NZ (1) | NZ244301A (de) |
| PT (1) | PT533264E (de) |
| WO (1) | WO1993006097A1 (de) |
| YU (1) | YU48291B (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
| CA2136993A1 (en) * | 1992-06-01 | 1993-12-09 | Takeshi Kawakita | Pyridine compound and pharmaceutical use thereof |
| US5504082A (en) * | 1992-06-01 | 1996-04-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and pharmaceutical compostions |
| SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) * | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| CN1053444C (zh) * | 1996-03-20 | 2000-06-14 | 常州市第四制药厂 | 奥美拉唑的一种精制方法 |
| SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| SK283805B6 (sk) | 1996-09-09 | 2004-02-03 | Slovakofarma, A. S. | Spôsob prípravy omeprazolu |
| SE9704183D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
| US6191148B1 (en) | 1998-08-11 | 2001-02-20 | Merck & Co., Inc. | Omerazole process and compositions thereof |
| US6166213A (en) * | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
| US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
| US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| DE19951960C2 (de) | 1999-10-28 | 2002-06-27 | Gruenenthal Gmbh | Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate |
| EP1970374A1 (de) * | 2001-02-02 | 2008-09-17 | Teva Pharmaceutical Industries Ltd. | Verfahren zur Herstellung von substituierten 2-(Pyridin-2-ylmethylsulfinyl)-1H-benzimidazolen |
| KR100783020B1 (ko) * | 2001-03-23 | 2007-12-07 | 동아제약주식회사 | 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법 |
| AU2002321204B2 (en) * | 2001-07-16 | 2008-05-08 | Janssen Pharmaceutica N.V. | Improved process for preparing benzimidazole-type compounds |
| WO2003063840A2 (en) * | 2002-01-25 | 2003-08-07 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
| EP1534278A4 (de) * | 2002-08-01 | 2006-09-06 | Nitromed Inc | Nitrosierte protonenpumpen-hemmer, zusammensetzungen und anwendungsverfahren |
| SE0203092D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Ab | Method for the synthesis of a benzimidazole compound |
| CA2510849A1 (en) | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
| WO2004063188A1 (en) * | 2003-01-15 | 2004-07-29 | Cipla Limited | Paharmaceutical process and compounds prepared thereby |
| WO2004073654A2 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid |
| CA2518999A1 (en) * | 2003-03-12 | 2004-09-23 | Teva Pharmaceutical Industries Ltd | Crystalline and amorphous solids of pantoprazole and processes for their preparation |
| WO2004111029A2 (en) | 2003-06-10 | 2004-12-23 | Teva Pharmaceutical Industries Ltd. | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
| MXPA06000524A (es) * | 2003-07-18 | 2006-08-11 | Santarus Inc | Formulacion farmaceutica y metodo para tratar desordenes gastrointestinales provocados por acido. |
| CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| AR048631A1 (es) * | 2004-04-28 | 2006-05-10 | Altana Pharma Ag | Derivados de dialcoxi-imidazopiridinas, composiciones farmaceuticas que los contienen y usos, |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| WO2006001753A1 (en) | 2004-06-24 | 2006-01-05 | Astrazeneca Ab | New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt |
| GB0525710D0 (en) * | 2005-12-17 | 2006-01-25 | Pliva Hrvatska D O O | An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds |
| WO2008017020A2 (en) * | 2006-08-03 | 2008-02-07 | Dr. Reddy's Laboratories Limited | Process for preparing proton pump inhibitors |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| EP2114919A2 (de) | 2007-01-31 | 2009-11-11 | Krka Tovarna Zdravil, D.D., Novo Mesto | Verfahren zur herstellung von optisch reinem omeprazol durch salzbildung mit einem chiralen amin oder behandlung mit einem enantiomer umwandelnden enzym und chromatographische auftrennung |
| WO2010134099A1 (en) | 2009-05-21 | 2010-11-25 | Cadila Healthcare Limited | One pot process for preparing omeprazole and related compounds |
| CN104203938A (zh) | 2012-01-21 | 2014-12-10 | 朱比兰特生命科学有限公司 | 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4483781A (en) * | 1983-09-02 | 1984-11-20 | The Procter & Gamble Company | Magnesium salts of peroxycarboxylic acids |
| JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| JPS61178919A (ja) * | 1985-02-04 | 1986-08-11 | Banyu Pharmaceut Co Ltd | ベンズイミダゾ−ル誘導体およびそれを含有する医薬 |
| JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
| JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
| FI864046L (fi) * | 1986-10-07 | 1988-04-08 | Farmos Oy | Foerfarande foer framstaellning av en terapeutiskt aktiv foerening. |
| FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
| DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| AU2817989A (en) * | 1987-12-11 | 1989-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzimidazole derivatives |
| SE8804628D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| SE8804629D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
| FR2660313B1 (fr) * | 1990-04-02 | 1992-07-03 | Fournier Ind & Sante | Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
-
1992
- 1992-09-11 WO PCT/US1992/007712 patent/WO1993006097A1/en not_active Ceased
- 1992-09-11 NZ NZ244301A patent/NZ244301A/xx not_active IP Right Cessation
- 1992-09-12 ES ES92202792T patent/ES2143468T3/es not_active Expired - Lifetime
- 1992-09-12 AT AT92202792T patent/ATE186535T1/de not_active IP Right Cessation
- 1992-09-12 DK DK92202792T patent/DK0533264T3/da active
- 1992-09-12 EP EP92202792A patent/EP0533264B1/de not_active Expired - Lifetime
- 1992-09-12 DE DE69230278T patent/DE69230278T2/de not_active Expired - Fee Related
- 1992-09-12 PT PT92202792T patent/PT533264E/pt unknown
- 1992-09-14 JP JP4244822A patent/JPH0720956B2/ja not_active Expired - Fee Related
- 1992-09-14 IL IL10315692A patent/IL103156A/xx not_active IP Right Cessation
- 1992-09-17 CA CA002078517A patent/CA2078517C/en not_active Expired - Fee Related
- 1992-09-18 KR KR1019920016990A patent/KR100242622B1/ko not_active Expired - Fee Related
- 1992-09-18 MX MX9205333A patent/MX9205333A/es not_active IP Right Cessation
- 1992-09-18 AU AU25207/92A patent/AU649355B2/en not_active Ceased
- 1992-09-19 CN CN92110899A patent/CN1048729C/zh not_active Expired - Fee Related
- 1992-10-07 YU YU89492A patent/YU48291B/sh unknown
-
1993
- 1993-02-22 US US08/022,804 patent/US5391752A/en not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400318T patent/GR3032619T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1071169A (zh) | 1993-04-21 |
| DK0533264T3 (da) | 2000-05-15 |
| EP0533264B1 (de) | 1999-11-10 |
| PT533264E (pt) | 2000-05-31 |
| JPH05213936A (ja) | 1993-08-24 |
| JPH0720956B2 (ja) | 1995-03-08 |
| GR3032619T3 (en) | 2000-05-31 |
| CA2078517A1 (en) | 1993-03-21 |
| CN1048729C (zh) | 2000-01-26 |
| IL103156A0 (en) | 1993-02-21 |
| EP0533264A1 (de) | 1993-03-24 |
| AU2520792A (en) | 1993-03-25 |
| MX9205333A (es) | 1993-07-01 |
| KR100242622B1 (ko) | 2000-03-02 |
| KR930006021A (ko) | 1993-04-20 |
| WO1993006097A1 (en) | 1993-04-01 |
| ES2143468T3 (es) | 2000-05-16 |
| IL103156A (en) | 1997-02-18 |
| AU649355B2 (en) | 1994-05-19 |
| YU48291B (sh) | 1998-05-15 |
| DE69230278T2 (de) | 2001-04-05 |
| US5391752A (en) | 1995-02-21 |
| CA2078517C (en) | 2003-11-04 |
| NZ244301A (en) | 1994-08-26 |
| DE69230278D1 (de) | 1999-12-16 |
| YU89492A (sh) | 1995-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |