IL103156A - Process for the preparation of anti-ulcer pyridylmethyl sulfinyl benzimidazole derivatives - Google Patents

Process for the preparation of anti-ulcer pyridylmethyl sulfinyl benzimidazole derivatives

Info

Publication number
IL103156A
IL103156A IL10315692A IL10315692A IL103156A IL 103156 A IL103156 A IL 103156A IL 10315692 A IL10315692 A IL 10315692A IL 10315692 A IL10315692 A IL 10315692A IL 103156 A IL103156 A IL 103156A
Authority
IL
Israel
Prior art keywords
ulcer
preparation
benzimidazole derivatives
bridge
sulfinyl benzimidazole
Prior art date
Application number
IL10315692A
Other languages
English (en)
Other versions
IL103156A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL103156A0 publication Critical patent/IL103156A0/xx
Publication of IL103156A publication Critical patent/IL103156A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
IL10315692A 1991-09-20 1992-09-14 Process for the preparation of anti-ulcer pyridylmethyl sulfinyl benzimidazole derivatives IL103156A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76456491A 1991-09-20 1991-09-20
US77787391A 1991-10-15 1991-10-15

Publications (2)

Publication Number Publication Date
IL103156A0 IL103156A0 (en) 1993-02-21
IL103156A true IL103156A (en) 1997-02-18

Family

ID=27117485

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10315692A IL103156A (en) 1991-09-20 1992-09-14 Process for the preparation of anti-ulcer pyridylmethyl sulfinyl benzimidazole derivatives

Country Status (18)

Country Link
US (1) US5391752A (de)
EP (1) EP0533264B1 (de)
JP (1) JPH0720956B2 (de)
KR (1) KR100242622B1 (de)
CN (1) CN1048729C (de)
AT (1) ATE186535T1 (de)
AU (1) AU649355B2 (de)
CA (1) CA2078517C (de)
DE (1) DE69230278T2 (de)
DK (1) DK0533264T3 (de)
ES (1) ES2143468T3 (de)
GR (1) GR3032619T3 (de)
IL (1) IL103156A (de)
MX (1) MX9205333A (de)
NZ (1) NZ244301A (de)
PT (1) PT533264E (de)
WO (1) WO1993006097A1 (de)
YU (1) YU48291B (de)

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SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
CA2136993A1 (en) * 1992-06-01 1993-12-09 Takeshi Kawakita Pyridine compound and pharmaceutical use thereof
US5504082A (en) * 1992-06-01 1996-04-02 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and pharmaceutical compostions
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) * 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
CN1053444C (zh) * 1996-03-20 2000-06-14 常州市第四制药厂 奥美拉唑的一种精制方法
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
EP1970374A1 (de) * 2001-02-02 2008-09-17 Teva Pharmaceutical Industries Ltd. Verfahren zur Herstellung von substituierten 2-(Pyridin-2-ylmethylsulfinyl)-1H-benzimidazolen
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
AU2002321204B2 (en) * 2001-07-16 2008-05-08 Janssen Pharmaceutica N.V. Improved process for preparing benzimidazole-type compounds
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
EP1534278A4 (de) * 2002-08-01 2006-09-06 Nitromed Inc Nitrosierte protonenpumpen-hemmer, zusammensetzungen und anwendungsverfahren
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
CA2510849A1 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
WO2004063188A1 (en) * 2003-01-15 2004-07-29 Cipla Limited Paharmaceutical process and compounds prepared thereby
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
CA2518999A1 (en) * 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd Crystalline and amorphous solids of pantoprazole and processes for their preparation
WO2004111029A2 (en) 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
MXPA06000524A (es) * 2003-07-18 2006-08-11 Santarus Inc Formulacion farmaceutica y metodo para tratar desordenes gastrointestinales provocados por acido.
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
AR048631A1 (es) * 2004-04-28 2006-05-10 Altana Pharma Ag Derivados de dialcoxi-imidazopiridinas, composiciones farmaceuticas que los contienen y usos,
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2006001753A1 (en) 2004-06-24 2006-01-05 Astrazeneca Ab New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt
GB0525710D0 (en) * 2005-12-17 2006-01-25 Pliva Hrvatska D O O An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
WO2008017020A2 (en) * 2006-08-03 2008-02-07 Dr. Reddy's Laboratories Limited Process for preparing proton pump inhibitors
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP2114919A2 (de) 2007-01-31 2009-11-11 Krka Tovarna Zdravil, D.D., Novo Mesto Verfahren zur herstellung von optisch reinem omeprazol durch salzbildung mit einem chiralen amin oder behandlung mit einem enantiomer umwandelnden enzym und chromatographische auftrennung
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4483781A (en) * 1983-09-02 1984-11-20 The Procter & Gamble Company Magnesium salts of peroxycarboxylic acids
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS61178919A (ja) * 1985-02-04 1986-08-11 Banyu Pharmaceut Co Ltd ベンズイミダゾ−ル誘導体およびそれを含有する医薬
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
FI864046L (fi) * 1986-10-07 1988-04-08 Farmos Oy Foerfarande foer framstaellning av en terapeutiskt aktiv foerening.
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
SE8804628D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New compounds
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
FR2660313B1 (fr) * 1990-04-02 1992-07-03 Fournier Ind & Sante Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.

Also Published As

Publication number Publication date
CN1071169A (zh) 1993-04-21
DK0533264T3 (da) 2000-05-15
EP0533264B1 (de) 1999-11-10
PT533264E (pt) 2000-05-31
JPH05213936A (ja) 1993-08-24
JPH0720956B2 (ja) 1995-03-08
GR3032619T3 (en) 2000-05-31
CA2078517A1 (en) 1993-03-21
CN1048729C (zh) 2000-01-26
IL103156A0 (en) 1993-02-21
EP0533264A1 (de) 1993-03-24
ATE186535T1 (de) 1999-11-15
AU2520792A (en) 1993-03-25
MX9205333A (es) 1993-07-01
KR100242622B1 (ko) 2000-03-02
KR930006021A (ko) 1993-04-20
WO1993006097A1 (en) 1993-04-01
ES2143468T3 (es) 2000-05-16
AU649355B2 (en) 1994-05-19
YU48291B (sh) 1998-05-15
DE69230278T2 (de) 2001-04-05
US5391752A (en) 1995-02-21
CA2078517C (en) 2003-11-04
NZ244301A (en) 1994-08-26
DE69230278D1 (de) 1999-12-16
YU89492A (sh) 1995-10-03

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Legal Events

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