ATE186541T1 - Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung - Google Patents

Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung

Info

Publication number: ATE186541T1
Authority: AT; Austria
Prior art keywords: quillajasaponin; supplement; formulation containing; vaccine formulation; containing same
Prior art date: 1995-04-13

Application number

AT96909390T

Other languages

English (en)

Inventor

Hong-Seob So

Hye-Sung Yoon

Young-Sun Kwon

Joong-Myung Cho

Original Assignee

Lg Chemical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-13

Filing date

1996-04-12

Publication date

1999-11-15

1996-04-12 Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd

1999-11-15 Application granted granted Critical

1999-11-15 Publication of ATE186541T1 publication Critical patent/ATE186541T1/de

Links

PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 title 1
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000013589 supplement Substances 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)

AT96909390T 1995-04-13 1996-04-12 Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung ATE186541T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR19950008590		1995-04-13
KR19950008589		1995-04-13

Publications (1)

Publication Number	Publication Date
ATE186541T1 true ATE186541T1 (de)	1999-11-15

Family

ID=37027969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96909390T ATE186541T1 (de)	1995-04-13	1996-04-12	Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung

Country Status (16)

Country	Link
US (1)	US5817314A (de)
EP (1)	EP0765333B1 (de)
JP (1)	JP2761809B2 (de)
KR (1)	KR0184779B1 (de)
CN (2)	CN1044478C (de)
AR (1)	AR001618A1 (de)
AT (1)	ATE186541T1 (de)
AU (1)	AU678941B2 (de)
BR (1)	BR9606311A (de)
CA (1)	CA2190344C (de)
DE (1)	DE69605094T2 (de)
DK (1)	DK0765333T3 (de)
ES (1)	ES2140837T3 (de)
MX (1)	MX9601378A (de)
TW (1)	TW442293B (de)
WO (1)	WO1996032401A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6080725A (en) *	1997-05-20	2000-06-27	Galenica Pharmaceuticals, Inc.	Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
WO1999010008A1 (en) *	1997-08-29	1999-03-04	Aquila Biopharmaceuticals, Inc.	Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
AU5565599A (en) *	1998-08-14	2000-03-06	Dante J. Marciani	Chemically modified saponins and the use thereof as adjuvants
TW586935B (en) *	1998-09-14	2004-05-11	Kitasato Inst	Saponin-containing vaccine preparation
DE122007000087I1 (de) *	1998-10-16	2008-03-27	Glaxosmithkline Biolog Sa	Adjuvanzsysteme und impfstoffe
EP1235591A1 (de) *	1999-12-08	2002-09-04	Statens Veterinärmedicinska Anstalt	Ginseng pflanzenexrakt-haltige impfstoffadjuvanzien sowie beigefügte amuliniumsalze
US6905712B2 (en) *	1999-12-08	2005-06-14	Statens Veterinarmedicinska Anstalt	Vaccine adjuvants comprising ginseng plant extract and added aluminum salt
US8883170B2 (en) *	2008-09-03	2014-11-11	Western Illinois University Research Foundation	Adjuvant
EP2359702B1 (de)	2010-01-22	2014-06-04	Symrise AG	Solubilisierungsmittel zum Löslichmachen von Polyphenolen, Flavonoiden und/oder Diterpenoidglucosiden
EP2359698B1 (de)	2010-01-22	2013-12-04	Symrise AG	Zusammensetzungen mit einem Tensidsystem mit Saponinen und Lecithin
WO2012077120A2 (en)	2010-12-09	2012-06-14	Y&B Mother's Choice Ltd.	Natural formulations
US9474283B2 (en)	2010-12-09	2016-10-25	Y&B Mother's Choice Ltd.	Formulations comprising saponins and uses thereof
US10434058B2 (en)	2010-12-09	2019-10-08	Y&B Mother's Choice Ltd.	Natural formulations
EP2628398B1 (de)	2012-02-19	2016-09-07	Symrise AG	Stoffgemische
IL229836A0 (en)	2013-12-08	2014-03-31	Y & B Mother S Choice Ltd	Formulations to reduce or suppress irritation to eye tissue
CN105213471A (zh) *	2014-05-29	2016-01-06	江口县苗药生物科技有限公司	一种皂树皮总皂苷的提取工艺
JP2021504424A (ja)	2017-12-01	2021-02-15	グラクソスミスクラインバイオロジカルズソシエテアノニム	サポニン精製
EP3717005A1 (de)	2017-12-01	2020-10-07	GlaxoSmithKline Biologicals S.A.	Saponinextraktion
TWI820099B (zh) *	2018-03-28	2023-11-01	台灣浩鼎生技股份有限公司	新穎皂素佐劑及其評估方法
BR112021024363A2 (pt)	2019-06-05	2022-03-22	Glaxosmithkline Biologicals Sa	Purificação de saponina
CN116355035B (zh) *	2021-12-28	2024-03-12	成都迈科康生物科技有限公司	一种qs21免疫佐剂的制备方法
CN116139265A (zh) *	2023-04-06	2023-05-23	浙江洪晟生物科技股份有限公司	一种含黄芪多糖的兽用纳米乳佐剂及其制备方法和应用
CN119971022A (zh) *	2025-04-15	2025-05-13	北京华诺泰生物医药科技有限公司	一种qs-21复合佐剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057540A (en) *	1987-05-29	1991-10-15	Cambridge Biotech Corporation	Saponin adjuvant
EP0692974B2 (de) *	1993-03-29	2007-05-30	Pfizer Inc.	Multikomponentenimpfstoff aus clostridien, der saponin als adjuvans benutzt

1996
- 1996-04-09 KR KR1019960010630A patent/KR0184779B1/ko not_active Expired - Fee Related
- 1996-04-12 US US08/750,461 patent/US5817314A/en not_active Expired - Fee Related
- 1996-04-12 AR AR33616096A patent/AR001618A1/es not_active Application Discontinuation
- 1996-04-12 WO PCT/KR1996/000053 patent/WO1996032401A1/en not_active Ceased
- 1996-04-12 BR BR9606311A patent/BR9606311A/pt not_active Application Discontinuation
- 1996-04-12 AT AT96909390T patent/ATE186541T1/de not_active IP Right Cessation
- 1996-04-12 CN CN96190306A patent/CN1044478C/zh not_active Expired - Fee Related
- 1996-04-12 AU AU52900/96A patent/AU678941B2/en not_active Ceased
- 1996-04-12 EP EP96909390A patent/EP0765333B1/de not_active Expired - Lifetime
- 1996-04-12 DK DK96909390T patent/DK0765333T3/da active
- 1996-04-12 DE DE69605094T patent/DE69605094T2/de not_active Expired - Fee Related
- 1996-04-12 JP JP8530907A patent/JP2761809B2/ja not_active Expired - Fee Related
- 1996-04-12 ES ES96909390T patent/ES2140837T3/es not_active Expired - Lifetime
- 1996-04-12 MX MX9601378A patent/MX9601378A/es unknown
- 1996-04-12 CA CA002190344A patent/CA2190344C/en not_active Expired - Fee Related
- 1996-05-08 TW TW085105448A patent/TW442293B/zh not_active IP Right Cessation
1998
- 1998-10-13 CN CN98120160A patent/CN1262958A/zh active Pending

Also Published As

Publication number	Publication date
CN1262958A (zh)	2000-08-16
CA2190344C (en)	2001-04-10
CA2190344A1 (en)	1996-10-16
EP0765333A1 (de)	1997-04-02
AU678941B2 (en)	1997-06-12
TW442293B (en)	2001-06-23
BR9606311A (pt)	1997-09-16
CN1149875A (zh)	1997-05-14
DE69605094T2 (de)	2000-07-06
EP0765333B1 (de)	1999-11-10
KR960037694A (ko)	1996-11-19
CN1044478C (zh)	1999-08-04
DK0765333T3 (da)	2000-03-13
KR0184779B1 (ko)	1999-04-01
AU5290096A (en)	1996-10-30
JP2761809B2 (ja)	1998-06-04
DE69605094D1 (de)	1999-12-16
AR001618A1 (es)	1997-11-26
US5817314A (en)	1998-10-06
JPH09510740A (ja)	1997-10-28
MX9601378A (es)	1997-04-30
WO1996032401A1 (en)	1996-10-17
ES2140837T3 (es)	2000-03-01

Legal Events

Date	Code	Title	Description
2000-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE186541T1 (de)	1999-11-15	Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung
IL114759A (en)	1999-10-28	Benzoxazole derivatives and pharmaceutical compositions containing them
DE69509574D1 (de)	1999-06-17	Silikonvesikeln und Einschlussprodukte
DE69618587D1 (de)	2002-02-21	Chinazoline und pharmazeutische zusammensetzungen
FI955042A7 (fi)	1995-11-29	Syklosporiinia sisältävä jauhemainen koostumus
BR9500784A (pt)	1995-10-24	Composto e formulação farmacêutica
BR9504060A (pt)	1996-09-24	Composto e formulação farmacêutica
DK0858325T3 (da)	2002-11-25	Stabil frysetørret farmaceutisk formulering
HU9602188D0 (en)	1996-10-28	Novel carbamate derivative and medicinal composition containing the same
NO954486D0 (no)	1995-11-08	Farmasöytiske formuleringsgrunnlag
EP0950665A4 (de)	2004-05-06	Veränderte physiologisch aktive proteine und medizinische verbindungen, die diese beinhalten
BR9601032A (pt)	1998-01-06	Micropartícula e formulação de vacina de dose única
GB9407386D0 (en)	1994-06-08	Pharmaceutical formulation
GB9402203D0 (en)	1994-03-30	Pharmaceutical formulation
IL115563A0 (en)	1996-01-19	Benzoxazole derivatives and pharmaceutical compositions containing the same
IL112521A0 (en)	1995-05-26	Pharmaceutical formulation
IL131319A0 (en)	2001-01-28	3-Piperidyl-4- oxoquinazoline derivatives and medicinal compositions containing the same
NO981008D0 (no)	1998-03-06	Farmasöytisk formulering
DE69400318D1 (de)	1996-08-29	Silikon enthaltende Hautpflegezusammensetzungen
FI941447A7 (fi)	1994-10-01	Suun kautta annettavat, kapseleina olevat ubidekarenonivalmisteet
GB9405856D0 (en)	1994-05-11	Pharmaceutical formulation
GB9416599D0 (en)	1994-10-12	Pharmaceutical formulation
BR9509688A (pt)	1997-09-30	Composto e composição farmacêutica
GB9504040D0 (en)	1995-04-26	Arylsulfonamide derivative and pharmaceutical composition containing the same
IS5062A (is)	1999-06-01	Lyfjablöndur sem innihalda afleiður N-súlfonýlindólíns