DK0765333T3 - Quillajasaponinadjuvans og vaccineformulering, der indeholder denne - Google Patents

Quillajasaponinadjuvans og vaccineformulering, der indeholder denne

Info

Publication number: DK0765333T3
Authority: DK; Denmark
Prior art keywords: formulation containing; vaccine formulation; quillajasaponin; adjuvant; quillajasaponin adjuvant
Prior art date: 1995-04-13

Application number

DK96909390T

Other languages

English (en)

Inventor

Hye-Sung Yoon

Hong-Seob So

Young-Sun Kwon

Joong-Myung Cho

Original Assignee

Lg Chemical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-13

Filing date

1996-04-12

Publication date

2000-03-13

1996-04-12 Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd

2000-03-13 Application granted granted Critical

2000-03-13 Publication of DK0765333T3 publication Critical patent/DK0765333T3/da

Links

PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 title 1
239000002671 adjuvant Substances 0.000 title 1
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Immunology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)

DK96909390T 1995-04-13 1996-04-12 Quillajasaponinadjuvans og vaccineformulering, der indeholder denne DK0765333T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
KR19950008589		1995-04-13
KR19950008590		1995-04-13
PCT/KR1996/000053 WO1996032401A1 (en)	1995-04-13	1996-04-12	Quillaja saponin adjuvant and vaccine formulation containing same

Publications (1)

Publication Number	Publication Date
DK0765333T3 true DK0765333T3 (da)	2000-03-13

Family

ID=37027969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96909390T DK0765333T3 (da)	1995-04-13	1996-04-12	Quillajasaponinadjuvans og vaccineformulering, der indeholder denne

Country Status (16)

Country	Link
US (1)	US5817314A (da)
EP (1)	EP0765333B1 (da)
JP (1)	JP2761809B2 (da)
KR (1)	KR0184779B1 (da)
CN (2)	CN1044478C (da)
AR (1)	AR001618A1 (da)
AT (1)	ATE186541T1 (da)
AU (1)	AU678941B2 (da)
BR (1)	BR9606311A (da)
CA (1)	CA2190344C (da)
DE (1)	DE69605094T2 (da)
DK (1)	DK0765333T3 (da)
ES (1)	ES2140837T3 (da)
MX (1)	MX9601378A (da)
TW (1)	TW442293B (da)
WO (1)	WO1996032401A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6080725A (en) *	1997-05-20	2000-06-27	Galenica Pharmaceuticals, Inc.	Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
AU734180B2 (en) *	1997-08-29	2001-06-07	Antigenics Llc	Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
US6262029B1 (en)	1998-08-14	2001-07-17	Galenica Pharmaceuticals, Inc.	Chemically modified saponins and the use thereof as adjuvants
TW586935B (en) *	1998-09-14	2004-05-11	Kitasato Inst	Saponin-containing vaccine preparation
ES2284287T3 (es) *	1998-10-16	2007-11-01	Glaxosmithkline Biologicals S.A.	Sistemas adyuvantes y vacunas.
US6905712B2 (en) *	1999-12-08	2005-06-14	Statens Veterinarmedicinska Anstalt	Vaccine adjuvants comprising ginseng plant extract and added aluminum salt
WO2001041802A1 (en) *	1999-12-08	2001-06-14	Statens Veterinärmedicinska Anstalt	Vaccine adjuvants comprising ginseng plant extract and added aluminium salt
US8883170B2 (en) *	2008-09-03	2014-11-11	Western Illinois University Research Foundation	Adjuvant
EP2359698B1 (en)	2010-01-22	2013-12-04	Symrise AG	Compositions with a surfactant system comprising saponins, and lecithin
EP2359702B1 (en)	2010-01-22	2014-06-04	Symrise AG	Solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides
CN103347529B (zh)	2010-12-09	2016-10-26	Y&B妈妈之选有限公司	包含皂苷的制剂及其用途
US10434058B2 (en)	2010-12-09	2019-10-08	Y&B Mother's Choice Ltd.	Natural formulations
US10064881B2 (en)	2010-12-09	2018-09-04	Y&B Mother's Choice Ltd.	Natural formulations
EP2628398B1 (de)	2012-02-19	2016-09-07	Symrise AG	Stoffgemische
IL229836A0 (en)	2013-12-08	2014-03-31	Y & B Mother S Choice Ltd	Formulations to reduce or suppress irritation to eye tissue
CN105213471A (zh) *	2014-05-29	2016-01-06	江口县苗药生物科技有限公司	一种皂树皮总皂苷的提取工艺
JP2021504424A (ja)	2017-12-01	2021-02-15	グラクソスミスクラインバイオロジカルズソシエテアノニム	サポニン精製
CA3083059A1 (en)	2017-12-01	2019-06-06	Glaxosmithkline Biologicals Sa	Saponin extraction
TWI820099B (zh) *	2018-03-28	2023-11-01	台灣浩鼎生技股份有限公司	新穎皂素佐劑及其評估方法
WO2020245207A1 (en)	2019-06-05	2020-12-10	Glaxosmithkline Biologicals Sa	Saponin purification
CN116355035B (zh) *	2021-12-28	2024-03-12	成都迈科康生物科技有限公司	一种qs21免疫佐剂的制备方法
CN116139265A (zh) *	2023-04-06	2023-05-23	浙江洪晟生物科技股份有限公司	一种含黄芪多糖的兽用纳米乳佐剂及其制备方法和应用
CN119971022A (zh) *	2025-04-15	2025-05-13	北京华诺泰生物医药科技有限公司	一种qs-21复合佐剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057540A (en) *	1987-05-29	1991-10-15	Cambridge Biotech Corporation	Saponin adjuvant
PT692974E (pt) *	1993-03-29	2003-09-30	Pfizer	Vacinas clostridiais com multiplos componentes usando adjuvantes de saponina

1996
- 1996-04-09 KR KR1019960010630A patent/KR0184779B1/ko not_active Expired - Fee Related
- 1996-04-12 DK DK96909390T patent/DK0765333T3/da active
- 1996-04-12 AU AU52900/96A patent/AU678941B2/en not_active Ceased
- 1996-04-12 CN CN96190306A patent/CN1044478C/zh not_active Expired - Fee Related
- 1996-04-12 US US08/750,461 patent/US5817314A/en not_active Expired - Fee Related
- 1996-04-12 EP EP96909390A patent/EP0765333B1/en not_active Expired - Lifetime
- 1996-04-12 AR AR33616096A patent/AR001618A1/es not_active Application Discontinuation
- 1996-04-12 JP JP8530907A patent/JP2761809B2/ja not_active Expired - Fee Related
- 1996-04-12 AT AT96909390T patent/ATE186541T1/de not_active IP Right Cessation
- 1996-04-12 MX MX9601378A patent/MX9601378A/es unknown
- 1996-04-12 CA CA002190344A patent/CA2190344C/en not_active Expired - Fee Related
- 1996-04-12 WO PCT/KR1996/000053 patent/WO1996032401A1/en not_active Ceased
- 1996-04-12 DE DE69605094T patent/DE69605094T2/de not_active Expired - Fee Related
- 1996-04-12 ES ES96909390T patent/ES2140837T3/es not_active Expired - Lifetime
- 1996-04-12 BR BR9606311A patent/BR9606311A/pt not_active Application Discontinuation
- 1996-05-08 TW TW085105448A patent/TW442293B/zh not_active IP Right Cessation
1998
- 1998-10-13 CN CN98120160A patent/CN1262958A/zh active Pending

Also Published As

Publication number	Publication date
EP0765333B1 (en)	1999-11-10
CN1149875A (zh)	1997-05-14
CA2190344C (en)	2001-04-10
MX9601378A (es)	1997-04-30
DE69605094D1 (de)	1999-12-16
ATE186541T1 (de)	1999-11-15
TW442293B (en)	2001-06-23
AR001618A1 (es)	1997-11-26
CN1044478C (zh)	1999-08-04
JP2761809B2 (ja)	1998-06-04
JPH09510740A (ja)	1997-10-28
US5817314A (en)	1998-10-06
CN1262958A (zh)	2000-08-16
KR0184779B1 (ko)	1999-04-01
CA2190344A1 (en)	1996-10-16
EP0765333A1 (en)	1997-04-02
ES2140837T3 (es)	2000-03-01
DE69605094T2 (de)	2000-07-06
AU5290096A (en)	1996-10-30
AU678941B2 (en)	1997-06-12
BR9606311A (pt)	1997-09-16
KR960037694A (ko)	1996-11-19
WO1996032401A1 (en)	1996-10-17

Publication	Publication Date	Title
DK1035865T3 (da)	2008-02-04	HIV-1-Tat eller derivater deraf til profylaktisk og terapeutisk vaccination
NO961160D0 (no)	1996-03-21	Cykliske forbindelser, deres fremstilling og anvendelse
FI955667A7 (fi)	1996-01-12	Adjuvantteja RS-viruksen vastaisia rokotteita varten
NO996133D0 (no)	1999-12-10	Olje-i-vann-vaksinesammensetninger
NO20003302D0 (no)	2000-06-23	Vaksine
DK0811006T3 (da)	2003-08-04	Benzopyranholdige forbindelser og fremgangsmåde til deres anvendelse
DZ2026A1 (fr)	2002-07-21	Compositions vaccinantes.
DK1126876T3 (da)	2007-07-02	Adjuvanssystemer og vacciner
TR199501560A2 (tr)	1996-07-21	Kademeli olarak saliverilen kafein formülasyonu.
DZ1763A1 (fr)	2002-02-17	Composition vaccinantes.
NO307707B1 (no)	2000-05-15	Spiroazabicykliske forbindelser, farmasøytisk preparat inneholdende slike forbindelser og anvendelse derav
DK0729956T3 (da)	2001-11-26	Benzothi9phenforbindelser, emllemprodukter, præparater og fremgangsmåder
NO932915D0 (no)	1993-08-17	Mikroporoest krystallinsk silikoaluminofosfat og fremgangsmaate for fremstilling av dette
DZ2283A1 (fr)	2002-12-25	Composition de vaccin.
NO993731L (no)	1999-09-22	Pyrrolopyrazolopyrimidin-forbindelse og medisin omfattende denne
DE69605094D1 (de)	1999-12-16	Quillajasaponin-zusatz und diesen enthaltende impfstoffformulierung
NO973471D0 (no)	1997-07-28	Transdermal formulering
NO965023L (no)	1996-11-26	Maltitolblanding og fremstilling derav
NO983472D0 (no)	1998-07-28	Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoidene
EP0967993A4 (en)	2001-04-18	ANTI-COCAINE VACCINE
DK0910369T3 (da)	2010-07-26	Benzothiophener, formuleringer indeholdende samme og fremgangsmåder
DK0791591T3 (da)	2001-10-08	Benzothiophener, formuleringer indeholdende samme og fremgangsmåder til deres fremstilling
DE69630611D1 (de)	2003-12-11	Antigenische präparationen
FI933210A7 (fi)	1994-01-21	Vesikauhunvastainen avirulentti rokote
NL300112I2 (nl)	2003-05-01	Vaccin tegen dermatomycosis.