EE03355B1 - Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine - Google Patents

Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine

Info

Publication number: EE03355B1
Authority: EE; Estonia
Prior art keywords: pct; date; dione; indole; preparation
Prior art date: 1994-09-14

Application number

EE9700052A

Other languages

English (en)

Estonian (et)

Inventor

Moldt Peter

W�tjen Frank

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-14

Filing date

1995-09-12

Publication date

2001-02-15

1995-09-12 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

2001-02-15 Publication of EE03355B1 publication Critical patent/EE03355B1/xx

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000005605 benzo group Chemical group 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EE9700052A 1994-09-14 1995-09-12 Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine EE03355B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK105394		1994-09-14
PCT/EP1995/003593 WO1996008494A1 (en)	1994-09-14	1995-09-12	Indole-2,3-dione-3-oxime derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
EE03355B1 true EE03355B1 (et)	2001-02-15

Family

ID=8100455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700052A EE03355B1 (et)	1994-09-14	1995-09-12	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine

Country Status (12)

Country	Link
US (1)	US5917053A (de)
EP (1)	EP0781284B1 (de)
JP (1)	JP3164371B2 (de)
AT (1)	ATE188700T1 (de)
AU (1)	AU687255B2 (de)
CA (1)	CA2199613C (de)
DE (1)	DE69514532T2 (de)
EE (1)	EE03355B1 (de)
FI (1)	FI112482B (de)
NO (1)	NO308852B1 (de)
NZ (1)	NZ293265A (de)
WO (1)	WO1996008494A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
EP1066037B1 (de) *	1998-03-31	2004-12-29	Neurosearch A/S	Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
DK1183025T3 (da)	1999-05-19	2009-05-04	Painceptor Pharma Corp	Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
EP1255734B1 (de) *	2000-01-24	2006-06-21	NeuroSearch A/S	Isatinderivate mit neurotropen aktivität
US20040063742A1 (en) *	2001-02-15	2004-04-01	Dan Peters	Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
BR0211140A (pt)	2001-07-13	2005-10-25	Upjohn Co	Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
WO2007059608A1 (en)	2005-11-23	2007-05-31	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2008031831A2 (en) *	2006-09-12	2008-03-20	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
ATE157977T1 (de) *	1992-10-13	1997-09-15	Warner Lambert Co	Chinoxalinderivate als eaa antagonisten

1995
- 1995-09-12 AU AU35664/95A patent/AU687255B2/en not_active Ceased
- 1995-09-12 NZ NZ293265A patent/NZ293265A/en unknown
- 1995-09-12 JP JP50990796A patent/JP3164371B2/ja not_active Expired - Fee Related
- 1995-09-12 EP EP95932729A patent/EP0781284B1/de not_active Expired - Lifetime
- 1995-09-12 AT AT95932729T patent/ATE188700T1/de not_active IP Right Cessation
- 1995-09-12 DE DE69514532T patent/DE69514532T2/de not_active Expired - Lifetime
- 1995-09-12 EE EE9700052A patent/EE03355B1/xx not_active IP Right Cessation
- 1995-09-12 WO PCT/EP1995/003593 patent/WO1996008494A1/en not_active Ceased
- 1995-09-12 US US08/809,082 patent/US5917053A/en not_active Expired - Lifetime
- 1995-09-12 CA CA002199613A patent/CA2199613C/en not_active Expired - Fee Related
1997
- 1997-02-21 FI FI970750A patent/FI112482B/fi active
- 1997-02-27 NO NO970904A patent/NO308852B1/no unknown

Also Published As

Publication number	Publication date
FI970750A0 (fi)	1997-02-21
JPH09511524A (ja)	1997-11-18
JP3164371B2 (ja)	2001-05-08
FI970750L (fi)	1997-03-13
AU3566495A (en)	1996-03-29
WO1996008494A1 (en)	1996-03-21
ATE188700T1 (de)	2000-01-15
CA2199613C (en)	2000-02-29
DE69514532T2 (de)	2000-07-06
EP0781284A1 (de)	1997-07-02
NZ293265A (en)	1998-01-26
DE69514532D1 (de)	2000-02-17
AU687255B2 (en)	1998-02-19
FI112482B (fi)	2003-12-15
US5917053A (en)	1999-06-29
NO970904D0 (no)	1997-02-27
NO970904L (no)	1997-04-24
CA2199613A1 (en)	1996-03-21
EP0781284B1 (de)	2000-01-12
NO308852B1 (no)	2000-11-06

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070912

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BG103945A (bg)	2000-07-31	Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
LU91751I2 (fr)	2011-01-04	Asenapin et ses dérivés pharmaceutiquement acceptables (SYCREST®)
UA74391C2 (uk)	2005-12-15	Арил- або гетероарилконденсовані імідазоли як антизапальні і анальгетичні агенти
ES8404990A1 (es)	1984-05-16	Un procedimiento para la preparacion de derivados de prolina.
DK0587088T3 (da)	1996-09-23	Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme
ATE201671T1 (de)	2001-06-15	Chinolon und acridinon derivate zur behandlung der harninkontinenz
DE69516503D1 (de)	2000-05-31	Piperidinderivate mit paf antagonistischer wirkung
ES2135769T3 (es)	1999-11-01	Derivados de isotiourea como inhibidores de no-sintasa.
EE03355B1 (et)	2001-02-15	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine
DE69501359D1 (de)	1998-02-12	Verwendung von Phosphatdiestern zur Behandlung von Erkrankungen der Retina
ATE85334T1 (de)	1993-02-15	Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
DK0628042T3 (da)	2001-11-12	Serotoninerge ergolinderivater
NO833528L (no)	1984-04-02	Fremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutan-derivater
FI955386A0 (fi)	1995-11-08	4-p-fluoribentsoyyli-1-piperidinyyli-propoksi-kromen-4-onijohdannaiset, niiden valmistus ja käyttö psykoosin ja skitsofrenian hoidossa
ES8604843A1 (es)	1986-03-01	Un metodo para la preparacion de un derivado de acetileno
ATE212842T1 (de)	2002-02-15	Quinoxalin-derivate zur behandlung von tinnitus
FI912733A0 (fi)	1991-06-06	Menetelmä terapeuttisesti käyttökelpoisten /(1-aryylipyrrolidin-2-yyli)metyyli/piperatsiinijohdannaisten valmistamiseksi
SE8900725D0 (sv)	1989-03-02	Indolfoereningar och framstaellning daerav