ATE189831T1 - Nicht-radioaktives hybridisations testverfahren und satz - Google Patents
Nicht-radioaktives hybridisations testverfahren und satzInfo
- Publication number
- ATE189831T1 ATE189831T1 AT92924354T AT92924354T ATE189831T1 AT E189831 T1 ATE189831 T1 AT E189831T1 AT 92924354 T AT92924354 T AT 92924354T AT 92924354 T AT92924354 T AT 92924354T AT E189831 T1 ATE189831 T1 AT E189831T1
- Authority
- AT
- Austria
- Prior art keywords
- kit
- test method
- radioactive hybridization
- hybridization test
- radioactive
- Prior art date
Links
- 238000009396 hybridization Methods 0.000 title abstract 2
- 238000010998 test method Methods 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 2
- 241000701806 Human papillomavirus Species 0.000 abstract 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000009395 genetic defect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002853 nucleic acid probe Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/301—Hairpin oligonucleotides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79258591A | 1991-11-14 | 1991-11-14 | |
| PCT/US1992/009604 WO1993010263A1 (en) | 1991-11-14 | 1992-11-12 | Non-radioactive hybridization assay and kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189831T1 true ATE189831T1 (de) | 2000-03-15 |
Family
ID=25157398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92924354T ATE189831T1 (de) | 1991-11-14 | 1992-11-12 | Nicht-radioaktives hybridisations testverfahren und satz |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6228578B1 (de) |
| EP (1) | EP0667918B1 (de) |
| JP (1) | JP3091492B2 (de) |
| AT (1) | ATE189831T1 (de) |
| AU (1) | AU673813B2 (de) |
| DE (1) | DE69230693T2 (de) |
| DK (1) | DK0667918T3 (de) |
| ES (1) | ES2145750T3 (de) |
| FI (1) | FI112095B (de) |
| GR (1) | GR3033345T3 (de) |
| WO (1) | WO1993010263A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981179A (en) * | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
| US6225053B1 (en) * | 1997-12-12 | 2001-05-01 | Digene Corporation | Detection of hepatitis B virus |
| BR9814271A (pt) * | 1997-12-12 | 2001-03-20 | Digene Corp | Determinação de doenças relacionadas com o vìrus do papiloma humano |
| US7399589B2 (en) | 1998-02-06 | 2008-07-15 | Digene Corporation | Immunological detection of RNA:DNA hybrids on microarrays |
| US5994079A (en) * | 1998-02-06 | 1999-11-30 | Digene Corporation | Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function |
| US6686151B1 (en) * | 1998-02-06 | 2004-02-03 | Digene Corporation | Immunological detection of RNA:DNA hybrids on microarrays |
| AU764964B2 (en) * | 1998-11-23 | 2003-09-04 | Usamriid | Purification method and apparatus |
| US6723505B1 (en) * | 1999-08-13 | 2004-04-20 | Nye Colifast As | Method for identification of the indicators of contamination in liquid samples |
| US20040115692A1 (en) * | 2000-04-03 | 2004-06-17 | Cytyc Corporation | Methods, compositions and apparatuses for detecting a target in a preservative solution |
| US7439016B1 (en) | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| US7601497B2 (en) | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| US7494817B2 (en) * | 2000-09-06 | 2009-02-24 | Transnet Yx, Inc. | Methods for genotype screening using magnetic particles |
| DK1337547T3 (da) * | 2000-11-03 | 2014-06-10 | Isis Pharmaceuticals Inc | Nuklease-baseret fremgangsmåde til detektion og kvantificering af oligonukleotider |
| US9261460B2 (en) | 2002-03-12 | 2016-02-16 | Enzo Life Sciences, Inc. | Real-time nucleic acid detection processes and compositions |
| US20050123913A1 (en) * | 2001-08-30 | 2005-06-09 | Emory University | Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays |
| CA2356540A1 (en) * | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| KR20030049802A (ko) * | 2001-12-17 | 2003-06-25 | 권윤정 | 바이오 칩에서 프로브와 시료 핵산의 혼성화 여부를 효소반응으로 구별하는 방법 |
| US9353405B2 (en) | 2002-03-12 | 2016-05-31 | Enzo Life Sciences, Inc. | Optimized real time nucleic acid detection processes |
| US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
| US20030175828A1 (en) * | 2002-03-15 | 2003-09-18 | Lazar James G. | Signal amplification by Hybrid Capture |
| US20030224370A1 (en) * | 2002-05-31 | 2003-12-04 | William Rassman | Method and apparatus for recognizing molecular compounds |
| RU2005118421A (ru) | 2002-11-15 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | 2'-разветвленные нуклеозиды и мутация flaviviridae |
| JP2007528692A (ja) * | 2003-05-28 | 2007-10-18 | メイバン・テクノロジーズ・エルエルシー | 分子化合物を認識する方法及び装置 |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| WO2006096727A2 (en) * | 2005-03-07 | 2006-09-14 | Cellay Llc | Methods for detecting integrated dna |
| US20070037174A1 (en) * | 2005-08-12 | 2007-02-15 | Rampal Jang B | Chemiluminescent generated fluorescent labeling |
| US7732166B2 (en) * | 2005-11-15 | 2010-06-08 | Oncohealth Corporation | Detection method for human pappilomavirus (HPV) and its application in cervical cancer |
| US7972776B2 (en) * | 2005-11-15 | 2011-07-05 | Oncohealth Corporation | Protein chips for HPV detection |
| US20080125333A1 (en) * | 2006-05-31 | 2008-05-29 | Antara Biosciences Inc. | Devices and kits for detecting one or more target agents |
| US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
| US8859218B2 (en) | 2008-06-13 | 2014-10-14 | Oncohealth Corp. | In situ detection of early stages and late stages HPV infection |
| KR100993349B1 (ko) | 2007-02-23 | 2010-11-10 | 주식회사 파나진 | 지지체에 고정된 ｐｎａ 프로브와 표적핵산의 혼성화 효율또는 특이도를 증가시키기 위한 방법, 조성물 및 키트 |
| AU2009238247B2 (en) * | 2008-04-17 | 2014-12-11 | Qiagen Gaithersburg, Inc. | Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid |
| JP5722765B2 (ja) | 2008-04-24 | 2015-05-27 | ニューサウス イノベイションズ ピーティーワイ リミテッド | 藍藻類サキシトキシン遺伝子クラスタおよびシアノトキシンを有する生物の検出 |
| TWI417389B (zh) * | 2008-10-27 | 2013-12-01 | Qiagen Gaithersburg Inc | 於自動平台上之快速結果雜交捕捉法 |
| US8325494B2 (en) | 2009-01-05 | 2012-12-04 | Afl Telecommunications Llc | Universal mounting bracket |
| EP2385979B1 (de) * | 2009-01-28 | 2017-08-16 | QIAGEN Gaithersburg, Inc. | Sequenzspezifisches verfahren zur vorbereitung grossvolumiger proben und assay |
| AU2010242867B2 (en) | 2009-05-01 | 2016-05-12 | Qiagen Gaithersburg, Inc. | A non-target amplification method for detection of RNA splice-forms in a sample |
| CN102449479B (zh) | 2009-05-07 | 2015-11-25 | 安科健康公司 | 鉴别高度或≥cin2用于人乳头瘤病毒(hpv)与hpv相关癌症的早期及晚期检测、筛检和诊断 |
| JP5826752B2 (ja) | 2009-09-14 | 2015-12-02 | キアジェン ゲイサーズバーグ インコーポレイテッド | 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法 |
| JP5819851B2 (ja) | 2010-01-08 | 2015-11-24 | オンコヘルス コーポレーション | Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ |
| CA2787781A1 (en) | 2010-01-29 | 2011-08-04 | Qiagen Gaithersburg, Inc. | Method of determining and confirming the presence of an hpv in a sample |
| ES2615728T3 (es) | 2010-01-29 | 2017-06-08 | Qiagen Gaithersburg, Inc. | Métodos y composiciones para una purificación y un análisis múltiple específico de secuencia de ácidos nucleicos |
| ES2606012T3 (es) * | 2010-02-26 | 2017-03-17 | Ventana Medical Systems, Inc. | Hibridación in situ con sondas PolyTag |
| US9422593B2 (en) | 2010-05-19 | 2016-08-23 | Qiagen Gaithresburg, Inc | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
| CA2799205A1 (en) | 2010-05-25 | 2011-12-01 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
| AU2012220575B2 (en) | 2011-02-24 | 2017-01-12 | Qiagen Gaithersburg, Inc. | Materials and methods for detection of HPV nucleic acid |
| JP6103778B2 (ja) | 2011-11-03 | 2017-03-29 | キアジェン ゲイサーズバーグ インコーポレイテッド | カルボキシル化表面を使用して細胞を固定、単離、および濃縮するための材料および方法 |
| EP3670663B1 (de) | 2014-02-28 | 2024-08-07 | Gen-Probe Incorporated | Verfahren zur isolierung von nukleinsäure aus proben in flüssigkeitsbasierten zytologischen konservierungsmitteln mit formaldehyd |
| GB2559919B (en) | 2014-02-28 | 2018-11-14 | Gen Probe Inc | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| US10356478B2 (en) * | 2015-01-08 | 2019-07-16 | The Directv Group, Inc. | Systems and methods for spotted advertising and control of corresponding user interfaces and transactions via user receiving devices and mobile devices |
| JP7056143B2 (ja) * | 2016-12-27 | 2022-04-19 | 東洋紡株式会社 | 免疫学的測定用組成物および免疫学的測定方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732847A (en) | 1981-06-09 | 1988-03-22 | University Of Hawaii | Monoclonal antibodies for DNA-RNA hybrid complexes and their uses |
| US4623627A (en) | 1983-08-19 | 1986-11-18 | Cetus Corporation | Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same |
| US4743535A (en) | 1984-11-07 | 1988-05-10 | Miles Inc. | Hybridization assay employing labeled probe and anti-hybrid |
| EP0146039A3 (de) * | 1983-12-12 | 1986-08-27 | Miles Inc. | Hybridisierungstest mit Immobilisierung von Hybriden mittels Antihybridbindung |
| CA1253777A (en) | 1984-06-01 | 1989-05-09 | Robert J. Carrico | Nucleic acid hybridization assay employing immobilized rna probes |
| ZA853756B (en) | 1984-06-01 | 1986-01-29 | Miles Lab | Nucleic acid hybridization assay employing immobilized rna probes |
| US4563417A (en) | 1984-08-31 | 1986-01-07 | Miles Laboratories, Inc. | Nucleic acid hybridization assay employing antibodies to intercalation complexes |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| AU558846B2 (en) * | 1985-06-21 | 1987-02-12 | Miles Laboratories Inc. | Solid-phase hydridization assay using anti-hybrid antibodies |
| US4968602A (en) * | 1986-03-05 | 1990-11-06 | Molecular Diagnostics, Inc. | Solution-phase single hybridization assay for detecting polynucleotide sequences |
| GB8712646D0 (en) * | 1987-05-29 | 1987-07-01 | Clayton Found Res | Structural evidence |
| JPH03503476A (ja) * | 1987-07-22 | 1991-08-08 | インペリアル キャンサー リサーチ テクノロジー，リミテッド | 消化方法 |
-
1992
- 1992-11-12 EP EP92924354A patent/EP0667918B1/de not_active Expired - Lifetime
- 1992-11-12 JP JP05509340A patent/JP3091492B2/ja not_active Expired - Lifetime
- 1992-11-12 DE DE69230693T patent/DE69230693T2/de not_active Expired - Lifetime
- 1992-11-12 WO PCT/US1992/009604 patent/WO1993010263A1/en not_active Ceased
- 1992-11-12 AU AU30689/92A patent/AU673813B2/en not_active Expired
- 1992-11-12 ES ES92924354T patent/ES2145750T3/es not_active Expired - Lifetime
- 1992-11-12 DK DK92924354T patent/DK0667918T3/da active
- 1992-11-12 AT AT92924354T patent/ATE189831T1/de active
-
1994
- 1994-01-18 US US08/183,154 patent/US6228578B1/en not_active Expired - Lifetime
- 1994-05-13 FI FI942239A patent/FI112095B/fi not_active IP Right Cessation
-
2000
- 2000-04-26 GR GR20000401030T patent/GR3033345T3/el unknown
-
2001
- 2001-05-07 US US09/850,041 patent/US20020012936A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0667918B1 (de) | 2000-02-16 |
| US6228578B1 (en) | 2001-05-08 |
| DE69230693T2 (de) | 2000-06-15 |
| GR3033345T3 (en) | 2000-09-29 |
| FI942239A0 (fi) | 1994-05-13 |
| ES2145750T3 (es) | 2000-07-16 |
| EP0667918A1 (de) | 1995-08-23 |
| JPH07505759A (ja) | 1995-06-29 |
| DK0667918T3 (da) | 2000-06-05 |
| FI942239L (fi) | 1994-07-06 |
| WO1993010263A1 (en) | 1993-05-27 |
| AU673813B2 (en) | 1996-11-28 |
| JP3091492B2 (ja) | 2000-09-25 |
| AU3068992A (en) | 1993-06-15 |
| US20020012936A1 (en) | 2002-01-31 |
| DE69230693D1 (de) | 2000-03-23 |
| FI112095B (fi) | 2003-10-31 |
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