ATE191856T1 - Knochenersatzmaterial und verfahren zu seiner herstellung - Google Patents

Knochenersatzmaterial und verfahren zu seiner herstellung

Info

Publication number: ATE191856T1
Authority: AT; Austria
Prior art keywords: titanium; producing; alloy; replacement material; apatite
Prior art date: 1993-11-09

Application number

AT95900273T

Other languages

English (en)

Inventor

Tadashi Kokubo

Original Assignee

Found Promotion Ind Science

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-09

Filing date

1994-11-07

Publication date

2000-05-15

1994-11-07 Application filed by Found Promotion Ind Science filed Critical Found Promotion Ind Science

2000-05-15 Application granted granted Critical

2000-05-15 Publication of ATE191856T1 publication Critical patent/ATE191856T1/de

Links

239000000316 bone substitute Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 6
239000000463 material Substances 0.000 abstract 5
229910052719 titanium Inorganic materials 0.000 abstract 5
239000010936 titanium Substances 0.000 abstract 5
239000003513 alkali Substances 0.000 abstract 2
239000000956 alloy Substances 0.000 abstract 2
229910045601 alloy Inorganic materials 0.000 abstract 2
229910052586 apatite Chemical group 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical group [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 abstract 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 abstract 1
230000007704 transition Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)

AT95900273T 1993-11-09 1994-11-07 Knochenersatzmaterial und verfahren zu seiner herstellung ATE191856T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP30465993		1993-11-09
PCT/JP1994/001885 WO1995013100A1 (en)	1993-11-09	1994-11-07	Bone substitute material and process for producing the same

Publications (1)

Publication Number	Publication Date
ATE191856T1 true ATE191856T1 (de)	2000-05-15

Family

ID=17935689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95900273T ATE191856T1 (de)	1993-11-09	1994-11-07	Knochenersatzmaterial und verfahren zu seiner herstellung

Country Status (14)

Country	Link
US (1)	US5609633A (de)
EP (1)	EP0678300B1 (de)
KR (2)	KR0149134B1 (de)
CN (1)	CN1101705C (de)
AT (1)	ATE191856T1 (de)
AU (1)	AU671567B2 (de)
CA (1)	CA2150036C (de)
DE (1)	DE69424035T2 (de)
DK (1)	DK0678300T3 (de)
ES (1)	ES2147831T3 (de)
FI (1)	FI115445B (de)
NO (1)	NO310060B1 (de)
PT (1)	PT678300E (de)
WO (1)	WO1995013100A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843050A (en)	1995-11-13	1998-12-01	Micro Therapeutics, Inc.	Microcatheter
SE513556C2 (sv) *	1997-11-11	2000-10-02	Nobel Biocare Ab	Implantatelement med tunt ytskickt applicerat genom het isostatisk pressning
WO1999030632A1 (en) *	1997-12-18	1999-06-24	Comfort Biomedical, Inc.	Bone augmentation for prosthetic implants and the like
US6214049B1 (en)	1999-01-14	2001-04-10	Comfort Biomedical, Inc.	Method and apparatus for augmentating osteointegration of prosthetic implant devices
ATE235928T1 (de)	1998-09-15	2003-04-15	Isotis Nv	Beschichtungsverfahren von medizinischen implantaten
JP3325529B2 (ja)	1999-01-05	2002-09-17	有限会社相和	生体親和性薄膜を被覆した生体材料
KR20010018331A (ko) *	1999-08-18	2001-03-05	정태섭	알칼리 처리에 의한 생체용 임플란트의 생체활성 부여
JP2002035109A (ja) *	2000-07-21	2002-02-05	Tadashi Kokubo	抗血栓性材料及びその製造方法
KR100431159B1 (ko) *	2001-03-22	2004-05-12	김철생	생체활성 표면을 갖는 Ｔｉ-소재 경조직 대체재료의제조방법
JP4804648B2 (ja) *	2001-05-23	2011-11-02	株式会社神戸製鋼所	骨代替材料
US7291178B2 (en) *	2001-05-29	2007-11-06	Mediteam Dental Ab	Modified oxide
JP4911855B2 (ja) *	2001-10-17	2012-04-04	正小久保	生体親和性に優れた骨代替材料の製造方法
US7132015B2 (en) *	2002-02-20	2006-11-07	University Of Southern California	Materials for dental and biomedical application
US7410502B2 (en) *	2002-04-09	2008-08-12	Numat As	Medical prosthetic devices having improved biocompatibility
RU2313370C2 (ru) *	2002-04-09	2007-12-27	Астра Тек АБ	Медицинские протезы, имеющие улучшенную биологическую совместимость
JP3806061B2 (ja) *	2002-05-21	2006-08-09	富士通株式会社	金属修飾アパタイト含有膜の形成方法、これに用いられるコーティング液、および金属修飾アパタイト含有膜で被覆された部位を有する電子機器
US7740481B2 (en) *	2002-06-21	2010-06-22	Politecnico Di Milano	Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface
US20060122708A1 (en) *	2003-01-10	2006-06-08	Takashi Nakamura	Osteoinductive artificial bone and manufacturing method thereof
CN100367917C (zh) *	2003-04-11	2008-02-13	四川大学	表面骨诱导活性钛接骨板及其制造方法
WO2004103423A1 (en) *	2003-05-21	2004-12-02	Dentium Co., Ltd	Titanium substrate for biocompatible implant coated with hydroxyapatite/titania double layer and a coating method of the same
US7067169B2 (en) *	2003-06-04	2006-06-27	Chemat Technology Inc.	Coated implants and methods of coating
CN100421734C (zh) *	2005-04-26	2008-10-01	中国科学院金属研究所	一种快速制备钛或钛合金表面生物活性涂层的方法
CN101340935B (zh) *	2005-11-14	2013-05-08	拜奥美特3i有限责任公司	于植入物表面上淀积纳米粒子
US20070179618A1 (en) *	2006-01-31	2007-08-02	Sdgi Holdings, Inc.	Intervertebral prosthetic disc
US20070179615A1 (en) *	2006-01-31	2007-08-02	Sdgi Holdings, Inc.	Intervertebral prosthetic disc
WO2007090433A2 (en) *	2006-02-09	2007-08-16	Plus Orthopedics Ag	Purified oxides with novel morphologies formed from ti-alloys
JP5052506B2 (ja) *	2006-04-13	2012-10-17	佐川印刷株式会社	人工骨の製造方法
JP2008080102A (ja) *	2006-08-29	2008-04-10	Nagasaki Univ	インプラント
GB0624423D0 (en) *	2006-12-06	2007-01-17	Univ Brighton	Biomaterials with Functionalised Surfaces
WO2008081861A1 (ja) *	2006-12-28	2008-07-10	Saga University	チタネートでコーティングされた抗菌性部材
WO2008143219A1 (ja) *	2007-05-18	2008-11-27	National University Corporation Okayama University	生体親和性インプラントの製造方法
CA2696954C (en)	2007-08-20	2016-09-13	Smith & Nephew Plc	Implant material with an enlarged implant-to-bone interface layer and method of formation
AU2014268254B2 (en) *	2007-08-20	2015-11-05	Smith & Nephew Plc	Bioactive material
ITTO20070719A1 (it)	2007-10-12	2009-04-13	Torino Politecnico	Superfici di titanio multifunzionali per osteointegrazione.
EP2240116B1 (de)	2008-01-28	2015-07-01	Biomet 3I, LLC	Implantatoberfläche mit erhöhter hydrophilie
WO2009147819A1 (ja)	2008-06-03	2009-12-10	学校法人中部大学	骨修復材料及びその製造方法
IT1390847B1 (it)	2008-07-29	2011-10-19	Milano Politecnico	Trattamento biomimetico a base silicio per l'osteointegrazione di substrati in metallo.
EP2392357B1 (de)	2009-01-30	2016-01-27	Chubu University Educational Foundation	Material für knochenreparatur und verfahren zu seiner herstellung
JP2013508262A (ja)	2009-10-26	2013-03-07	ラトガース，ザステートユニバーシティオブニュージャージー	制御可能なサイズおよび形態を有するハイドロキシアパタイト
US8641418B2 (en)	2010-03-29	2014-02-04	Biomet 3I, Llc	Titanium nano-scale etching on an implant surface
ES2671740T3 (es)	2012-03-20	2018-06-08	Biomet 3I, Llc	Superficie de tratamiento para una superficie de implante
JP2013236700A (ja) *	2012-05-14	2013-11-28	Chube Univ	抗菌性骨修復材料及びその製造方法
WO2013180237A1 (ja) *	2012-05-30	2013-12-05	京セラメディカル株式会社	歯科インプラント
JP6206880B2 (ja) *	2012-08-16	2017-10-04	学校法人中部大学	骨修復材料及びその製造方法
CN105126176B (zh) *	2015-09-21	2018-07-24	高瑞杰	一种用于股骨修复的牡蛎壳生物相容仿生材料以及制备方法
CN109701082B (zh) *	2019-02-22	2021-10-08	九江学院	一种羟基磷灰石-氢氧化钛复合粉体的制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5214095A (en) *	1975-07-23	1977-02-02	Sumitomo Chemical Co	Implant in bone
DD246476A1 (de) *	1986-03-12	1987-06-10	Karl Marx Stadt Tech Hochschul	Einteilige zementfrei verankerbare biokompatible hueftgelenkpfanne
JPS6399867A (ja) *	1986-10-17	1988-05-02	ペルメレツク電極株式会社	リン酸カルシウム化合物被覆複合材及びその製造方法
CA1269898A (en) *	1986-10-17	1990-06-05	Takayuki Shimamune	Process for production of calcium phosphate compound- coated composite material
JPH0373157A (ja) *	1989-05-11	1991-03-28	Sumitomo Metal Ind Ltd	生体活性を示す医療用複合製品
JP3076636B2 (ja) *	1991-09-04	2000-08-14	株式会社アドバンス	複合インプラント

1994
- 1994-11-07 AU AU81157/94A patent/AU671567B2/en not_active Ceased
- 1994-11-07 CN CN94190749A patent/CN1101705C/zh not_active Expired - Lifetime
- 1994-11-07 KR KR1019950702262A patent/KR0149134B1/ko not_active Expired - Lifetime
- 1994-11-07 CA CA002150036A patent/CA2150036C/en not_active Expired - Fee Related
- 1994-11-07 EP EP95900273A patent/EP0678300B1/de not_active Expired - Lifetime
- 1994-11-07 WO PCT/JP1994/001885 patent/WO1995013100A1/ja not_active Ceased
- 1994-11-07 AT AT95900273T patent/ATE191856T1/de active
- 1994-11-07 PT PT95900273T patent/PT678300E/pt unknown
- 1994-11-07 ES ES95900273T patent/ES2147831T3/es not_active Expired - Lifetime
- 1994-11-07 DK DK95900273T patent/DK0678300T3/da active
- 1994-11-07 DE DE69424035T patent/DE69424035T2/de not_active Expired - Lifetime
- 1994-11-07 KR KR1019950702262A patent/KR950704004A/ko active Granted
- 1994-11-09 US US08/338,171 patent/US5609633A/en not_active Expired - Lifetime
1995
- 1995-04-25 NO NO951567A patent/NO310060B1/no not_active IP Right Cessation
- 1995-05-09 FI FI952234A patent/FI115445B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI952234A0 (fi)	1995-05-09
AU671567B2 (en)	1996-08-29
KR950704004A (ko)	1995-11-17
CN1115170A (zh)	1996-01-17
DK0678300T3 (da)	2000-07-17
NO951567D0 (no)	1995-04-25
FI952234L (fi)	1995-05-10
CA2150036A1 (en)	1995-05-18
AU8115794A (en)	1995-05-29
CA2150036C (en)	2001-07-10
WO1995013100A1 (en)	1995-05-18
DE69424035D1 (de)	2000-05-25
DE69424035T2 (de)	2000-12-14
EP0678300B1 (de)	2000-04-19
NO951567L (no)	1995-05-18
CN1101705C (zh)	2003-02-19
PT678300E (pt)	2000-11-30
KR0149134B1 (ko)	1998-10-01
EP0678300A1 (de)	1995-10-25
US5609633A (en)	1997-03-11
ES2147831T3 (es)	2000-10-01
FI115445B (fi)	2005-05-13
EP0678300A4 (de)	1996-04-03
NO310060B1 (no)	2001-05-14

Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2006-10-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
ATE191856T1 (de)	2000-05-15	Knochenersatzmaterial und verfahren zu seiner herstellung
WO1999026674A3 (de)	1999-09-16	Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien
ATE178616T1 (de)	1999-04-15	Verfahren zur herstellung von biologisch aktivem protein (z.b. tgf)
DE69404876D1 (de)	1997-09-18	Verfahren zur Herstellung von, im wesentlichen Silanol-freien Silikonharzpulvern
CA2030518A1 (en)	1990-09-29	Osteoinductive compositions
DE3784060D1 (de)	1993-03-18	Chirurgisches biokompositmaterial und dessen herstellung.
AU6226094A (en)	1995-06-06	Resorbable bioactive phosphate containing cements
EP1230930A3 (de)	2002-11-27	BMP-9 Zusammensetzungen
ATE105539T1 (de)	1994-05-15	Bioreaktives material fuer komposit-prothesen oder -implantaten.
HUP0001138A3 (en)	2002-10-28	Amino acids containing benzodioxane or benzoxazine, pharmaceutical compositions thereof and process for producing the same
DE59108597D1 (de)	1997-04-17	Verfahren zur Herstellung von osteointegrierenden Oberflächen auf Skelettimplantaten sowie Skelettimplantat
CA2467252A1 (en)	2003-05-01	Composite biomaterials
US5482731A (en)	1996-01-09	Method for bonding a calcium phosphate coating to stainless steels and cobalt base alloys for bioactive fixation of artificial implants
FI923561A7 (fi)	1992-08-07	Bioaktiivinen lasikoostumus luuistutteita varten, siitä valmistettuja filamentteja ja valmistusmenetelmä
ATE167232T1 (de)	1998-06-15	Protein mit knochenbildungs-eigenschaften und verfahren zu seiner herstellung
EP0366029A3 (de)	1991-01-09	Knochenersatzmaterial und Knochenzement
DE69425033D1 (de)	2000-08-03	Verfahren zur Sterilisierung einer menschliches, rekombinantes Serum-albumin enthaltenden pharmazeutischen Zusammensetzung
De Groot	1986	Hydroxylapatite coatings for implants in surgery
DE59401009D1 (de)	1996-12-19	Verfahren zur Herstellung von 1,1,1,3,3-Pentafluorpropan
HUT59724A (en)	1992-06-29	Process for producing new thrombosolving material
Borowy et al.	1984	On the Properties of a New Titanium Alloy(TiAl 5 Fe 2. 5) as Implant Material
DE69400342D1 (de)	1996-09-05	Verfahren zur Herstellung von 1,1,1,2-Tetrafluor-2-Chlorethan und Pentafluorethan
EP0493737A3 (de)	1992-12-30	Einen basischen Fibroblastwachstumsfaktor enthaltende Mittel zur Behandlung von Knochenkrankheiten
DE59006616D1 (de)	1994-09-01	Verfahren zur Herstellung von physiologisch verträglichen Oxidschichten auf Skelettimplantaten.
ATE94863T1 (de)	1993-10-15	Verfahren zur herstellung von ''oxoprodukten'' ueber ein plasma und plasmareaktor einschliessende anlage, verwendbar beim verfahren.