ATE192426T1 - Verfahren zur herstellung der valproinsäure - Google Patents

Verfahren zur herstellung der valproinsäure

Info

Publication number: ATE192426T1
Authority: AT; Austria
Prior art keywords: valproic acid; producing; producing valproic; salt; dialkylester
Prior art date: 1996-10-10

Application number

AT97830497T

Other languages

English (en)

Inventor

Mose Santaniello

Carlo Alberto Bagolini

Agostino Uttaro

Silverio Fontana

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-10

Filing date

1997-10-03

Publication date

2000-05-15

1997-10-03 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2000-05-15 Application granted granted Critical

2000-05-15 Publication of ATE192426T1 publication Critical patent/ATE192426T1/de

Links

NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title abstract 4
229960000604 valproic acid Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 2
229940093858 ethyl acetoacetate Drugs 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 abstract 2
CYNYIHKIEHGYOZ-UHFFFAOYSA-N 1-bromopropane Chemical compound CCCBr CYNYIHKIEHGYOZ-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003444 phase transfer catalyst Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)

AT97830497T 1996-10-10 1997-10-03 Verfahren zur herstellung der valproinsäure ATE192426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96RM000688A IT1285801B1 (it)	1996-10-10	1996-10-10	Procedimento migliorato per la preparazione dell'acido valproico

Publications (1)

Publication Number	Publication Date
ATE192426T1 true ATE192426T1 (de)	2000-05-15

Family

ID=11404463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97830497T ATE192426T1 (de)	1996-10-10	1997-10-03	Verfahren zur herstellung der valproinsäure

Country Status (14)

Country	Link
US (1)	US5856569A (de)
EP (1)	EP0835859B1 (de)
JP (1)	JP3983350B2 (de)
KR (1)	KR19980032744A (de)
AT (1)	ATE192426T1 (de)
CA (1)	CA2217836C (de)
DE (1)	DE69701843T2 (de)
DK (1)	DK0835859T3 (de)
ES (1)	ES2146453T3 (de)
GR (1)	GR3034122T3 (de)
IT (1)	IT1285801B1 (de)
PT (1)	PT835859E (de)
TW (1)	TW380134B (de)
ZA (1)	ZA979046B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ540288A (en)	2002-11-22	2009-06-26	Univ Johns Hopkins	Target for therapy of cognitive impairment
ES2865504T3 (es)	2008-10-16	2021-10-15	Univ Johns Hopkins	Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) *	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
CN103183612A (zh) *	2011-12-30	2013-07-03	北大方正集团有限公司	二丙基丙二酸二酯的制备方法
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
MX388586B (es)	2016-12-16	2025-03-20	Idorsia Pharmaceuticals Ltd	Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2442M (fr) *	1962-10-17	1964-04-06	Henry Eugene	L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central.
US4155929A (en) *	1977-05-25	1979-05-22	Labaz	Process for the preparation of an acetonitrile derivative
AT365554B (de) *	1979-04-02	1982-01-25	Gerot Pharmazeutika	Verfahren zur herstellung von di-n-propylmalonsaeure
JPH0662489B2 (ja) *	1985-10-30	1994-08-17	日本合成化学工業株式会社	バルプロ酸の製造法
US5101070A (en) *	1985-10-30	1992-03-31	Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha	Process for preparing valproic acid
JPH0745429B2 (ja) *	1986-11-11	1995-05-17	日本合成化学工業株式会社	バルプロ酸の製造法
US5344975A (en) *	1993-09-03	1994-09-06	Wyckoff Chemical Company, Inc.	Process for production of lower alkanoic acids
US5672746A (en) *	1994-08-30	1997-09-30	American Biogenetic Sciences, Inc.	Antiproliferative and neurotrophic molecules

1996
- 1996-10-10 IT IT96RM000688A patent/IT1285801B1/it active IP Right Grant
1997
- 1997-10-01 US US08/941,722 patent/US5856569A/en not_active Expired - Fee Related
- 1997-10-01 TW TW086114307A patent/TW380134B/zh not_active IP Right Cessation
- 1997-10-03 DK DK97830497T patent/DK0835859T3/da active
- 1997-10-03 EP EP97830497A patent/EP0835859B1/de not_active Expired - Lifetime
- 1997-10-03 DE DE69701843T patent/DE69701843T2/de not_active Expired - Fee Related
- 1997-10-03 PT PT97830497T patent/PT835859E/pt unknown
- 1997-10-03 ES ES97830497T patent/ES2146453T3/es not_active Expired - Lifetime
- 1997-10-03 AT AT97830497T patent/ATE192426T1/de not_active IP Right Cessation
- 1997-10-09 JP JP27714997A patent/JP3983350B2/ja not_active Expired - Lifetime
- 1997-10-09 ZA ZA9709046A patent/ZA979046B/xx unknown
- 1997-10-09 CA CA002217836A patent/CA2217836C/en not_active Expired - Fee Related
- 1997-10-10 KR KR1019970052171A patent/KR19980032744A/ko not_active Ceased
2000
- 2000-08-03 GR GR20000401817T patent/GR3034122T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69701843T2 (de)	2000-10-26
EP0835859B1 (de)	2000-05-03
DE69701843D1 (de)	2000-06-08
CA2217836C (en)	2007-01-09
KR19980032744A (ko)	1998-07-25
JPH10130197A (ja)	1998-05-19
ES2146453T3 (es)	2000-08-01
PT835859E (pt)	2000-09-29
TW380134B (en)	2000-01-21
US5856569A (en)	1999-01-05
DK0835859T3 (da)	2000-09-04
EP0835859A1 (de)	1998-04-15
CA2217836A1 (en)	1998-04-10
ZA979046B (en)	1998-04-23
GR3034122T3 (en)	2000-11-30
ITRM960688A1 (it)	1998-04-10
IT1285801B1 (it)	1998-06-24
JP3983350B2 (ja)	2007-09-26
MX9707714A (es)	1998-06-30

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Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee