ES2146453T3 - Procedimiento para producir acido valproico. - Google Patents

Procedimiento para producir acido valproico.

Info

Publication number
ES2146453T3
ES2146453T3 ES97830497T ES97830497T ES2146453T3 ES 2146453 T3 ES2146453 T3 ES 2146453T3 ES 97830497 T ES97830497 T ES 97830497T ES 97830497 T ES97830497 T ES 97830497T ES 2146453 T3 ES2146453 T3 ES 2146453T3
Authority
ES
Spain
Prior art keywords
valproic acid
procedure
produce
salt
dialkylester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97830497T
Other languages
English (en)
Inventor
Mose Santaniello
Carlo Alberto Bagolini
Agostino Uttaro
Silverio Fontana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2146453T3 publication Critical patent/ES2146453T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO MEJORADO DE PRODUCCION DE ACIDO VALPROICO, A PARTIR DE ACETOACETATO DE ETILO, EN EL QUE TANTO LA DIALQUILACION DEL ACETOACETATO DE ETILO CON BROMURO DE PROPILO, COMO LA CONVERSION DEL DIALQUILESTER ASI OBTENIDO, EN LA CORRESPONDIENTE SAL, SE REALIZAN EN UNA SOLA FASE, EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE, Y LA SAL SE CONVIERTE EN ACIDO VALPROICO A UN PH 1-3.
ES97830497T 1996-10-10 1997-10-03 Procedimiento para producir acido valproico. Expired - Lifetime ES2146453T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96RM000688A IT1285801B1 (it) 1996-10-10 1996-10-10 Procedimento migliorato per la preparazione dell'acido valproico

Publications (1)

Publication Number Publication Date
ES2146453T3 true ES2146453T3 (es) 2000-08-01

Family

ID=11404463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97830497T Expired - Lifetime ES2146453T3 (es) 1996-10-10 1997-10-03 Procedimiento para producir acido valproico.

Country Status (14)

Country Link
US (1) US5856569A (es)
EP (1) EP0835859B1 (es)
JP (1) JP3983350B2 (es)
KR (1) KR19980032744A (es)
AT (1) ATE192426T1 (es)
CA (1) CA2217836C (es)
DE (1) DE69701843T2 (es)
DK (1) DK0835859T3 (es)
ES (1) ES2146453T3 (es)
GR (1) GR3034122T3 (es)
IT (1) IT1285801B1 (es)
PT (1) PT835859E (es)
TW (1) TW380134B (es)
ZA (1) ZA979046B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540288A (en) 2002-11-22 2009-06-26 Univ Johns Hopkins Target for therapy of cognitive impairment
ES2865504T3 (es) 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) * 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
CN103183612A (zh) * 2011-12-30 2013-07-03 北大方正集团有限公司 二丙基丙二酸二酯的制备方法
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
MX388586B (es) 2016-12-16 2025-03-20 Idorsia Pharmaceuticals Ltd Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442M (fr) * 1962-10-17 1964-04-06 Henry Eugene L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central.
US4155929A (en) * 1977-05-25 1979-05-22 Labaz Process for the preparation of an acetonitrile derivative
AT365554B (de) * 1979-04-02 1982-01-25 Gerot Pharmazeutika Verfahren zur herstellung von di-n-propylmalonsaeure
JPH0662489B2 (ja) * 1985-10-30 1994-08-17 日本合成化学工業株式会社 バルプロ酸の製造法
US5101070A (en) * 1985-10-30 1992-03-31 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Process for preparing valproic acid
JPH0745429B2 (ja) * 1986-11-11 1995-05-17 日本合成化学工業株式会社 バルプロ酸の製造法
US5344975A (en) * 1993-09-03 1994-09-06 Wyckoff Chemical Company, Inc. Process for production of lower alkanoic acids
US5672746A (en) * 1994-08-30 1997-09-30 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules

Also Published As

Publication number Publication date
DE69701843T2 (de) 2000-10-26
EP0835859B1 (en) 2000-05-03
DE69701843D1 (de) 2000-06-08
ATE192426T1 (de) 2000-05-15
CA2217836C (en) 2007-01-09
KR19980032744A (ko) 1998-07-25
JPH10130197A (ja) 1998-05-19
PT835859E (pt) 2000-09-29
TW380134B (en) 2000-01-21
US5856569A (en) 1999-01-05
DK0835859T3 (da) 2000-09-04
EP0835859A1 (en) 1998-04-15
CA2217836A1 (en) 1998-04-10
ZA979046B (en) 1998-04-23
GR3034122T3 (en) 2000-11-30
ITRM960688A1 (it) 1998-04-10
IT1285801B1 (it) 1998-06-24
JP3983350B2 (ja) 2007-09-26
MX9707714A (es) 1998-06-30

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