ATE193542T1 - Verfahren und verbindungen zum screening von presynaptischen calcium kanal inhibitoren - Google Patents

Verfahren und verbindungen zum screening von presynaptischen calcium kanal inhibitoren

Info

Publication number
ATE193542T1
ATE193542T1 AT95941385T AT95941385T ATE193542T1 AT E193542 T1 ATE193542 T1 AT E193542T1 AT 95941385 T AT95941385 T AT 95941385T AT 95941385 T AT95941385 T AT 95941385T AT E193542 T1 ATE193542 T1 AT E193542T1
Authority
AT
Austria
Prior art keywords
methods
compounds
screening
calcium channel
presynaptic calcium
Prior art date
Application number
AT95941385T
Other languages
English (en)
Inventor
William A Catterall
Zu-Hang Sheng
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE193542T1 publication Critical patent/ATE193542T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95941385T 1994-11-10 1995-11-09 Verfahren und verbindungen zum screening von presynaptischen calcium kanal inhibitoren ATE193542T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/337,602 US5623051A (en) 1994-11-10 1994-11-10 Methods and compositions for screening for presynaptic calcium channel blockers
PCT/US1995/014776 WO1996015149A2 (en) 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers

Publications (1)

Publication Number Publication Date
ATE193542T1 true ATE193542T1 (de) 2000-06-15

Family

ID=23321213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941385T ATE193542T1 (de) 1994-11-10 1995-11-09 Verfahren und verbindungen zum screening von presynaptischen calcium kanal inhibitoren

Country Status (8)

Country Link
US (2) US5623051A (de)
EP (1) EP0791013B1 (de)
JP (1) JPH10509945A (de)
AT (1) ATE193542T1 (de)
AU (1) AU4282396A (de)
CA (1) CA2206110A1 (de)
DE (1) DE69517331T2 (de)
WO (1) WO1996015149A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5638972A (en) * 1988-06-17 1997-06-17 Druitt; Rodney Malcolm Linerless closure for carbonated beverage container
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
WO1997020218A1 (en) * 1995-12-01 1997-06-05 The Board Of Trustees Of The Leland Stanford Junior University Calcium channel modulator compositions and methods
CA2267646A1 (en) * 1996-10-07 1998-04-16 President And Fellows Of Harvard College Platelet secretory transport protein
WO1998028419A2 (en) * 1996-12-20 1998-07-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulation of vesicular release
AU6440798A (en) * 1997-02-26 1998-09-18 Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulation of vesicular release
US20050009884A1 (en) * 1997-06-30 2005-01-13 Dreyer Evan B. Calcium blockers to treat proliferative retinal diseases
US6380261B1 (en) * 1997-06-30 2002-04-30 Allergan Sales, Inc. Calcium blockers to treat proliferative vitreoretinopathy
AU8571598A (en) * 1997-07-17 1999-02-10 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6310059B1 (en) 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
JP2002519064A (ja) * 1998-07-02 2002-07-02 インサイト・ファーマスーティカルズ・インコーポレイテッド 神経伝達関連タンパク質
US6686147B1 (en) 1998-07-15 2004-02-03 Ludwig Institute For Cancer Research Cancer associated antigens and uses therefor
EP1230551B1 (de) * 1999-10-13 2005-12-07 The University of British Columbia Verfahren zur identifizierung von verbindungen, die die neuronale aktivität modulieren
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US7049084B2 (en) 2001-05-30 2006-05-23 Ortho-Mcneil Pharmaceutical, Inc. Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore
US20030092039A1 (en) * 2001-08-01 2003-05-15 Third Wave Technologies, Inc. Screening nutraceuticals
WO2003014151A2 (en) * 2001-08-10 2003-02-20 Genset S.A. Human secreted proteins, their encoding polynucleotides, and uses thereof
JP2006526000A (ja) * 2003-05-30 2006-11-16 ニューロームド テクノロジーズ、インク． Ｎ型カルシウムチャネル遮断薬としての３−アミノメチル−ピロリジン
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
KR20140011366A (ko) 2011-03-08 2014-01-28 잘리커스 파마슈티컬즈 리미티드 고체 분산체 제형 및 그의 이용방법
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
JP2017516493A (ja) * 2014-04-04 2017-06-22 フェリジオーニ、マルコ グルタメート興奮毒性により起こる疾患を治療するための細胞透過性ペプチド系

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009834A1 (en) * 1988-04-04 1989-10-19 The Salk Institute Biotechnology/Industrial Associ Calcium channel compositions and methods
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
AU677571B2 (en) * 1991-08-15 1997-05-01 Merck & Co., Inc. Human calcium channel compositions and methods
WO1993013128A1 (en) * 1991-12-30 1993-07-08 Neurex Corporation Methods of producing analgesia and enhancing opiate analgesia
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers

Also Published As

Publication number Publication date
EP0791013B1 (de) 2000-05-31
DE69517331D1 (de) 2000-07-06
EP0791013A2 (de) 1997-08-27
AU4282396A (en) 1996-06-06
WO1996015149A2 (en) 1996-05-23
JPH10509945A (ja) 1998-09-29
US6090631A (en) 2000-07-18
DE69517331T2 (de) 2001-01-04
CA2206110A1 (en) 1996-05-23
US5623051A (en) 1997-04-22
WO1996015149A3 (en) 1996-08-22

Similar Documents

Publication Publication Date Title
ATE193542T1 (de) Verfahren und verbindungen zum screening von presynaptischen calcium kanal inhibitoren
ATE287402T1 (de) Nanomolare, non-peptidische inhibitoren von cathepsin d
DE69709727D1 (de) Parazinon thrombin inhibitoren
DK0873340T3 (da) Heterocyklisk substituerede cyclopentanforbindelser
DK1137941T4 (da) Protein-scaffolds til antistof-mimetika og andre bindingsproteiner
ATE228502T1 (de) Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene
DK0906333T3 (da) Substrater og inhibitorer for proteolytiske enzymer
DE69736646D1 (de) Verfahren zum Zertrennen von Wafern in Einzelchips
TR200102883T2 (tr) Otolog transplantasyon için yöntem, alet ve alet takımı.
DE69710077D1 (de) Verfahren zur erkennung von verbindungen, die die interaktion von rna und rna-bindeproteinen beeinflussen
TR199802676A2 (xx) T�m�rlerin, t�m�rle ilgili hastal�klar�n ve ka�eksinin tedavisi ve �nlenmesi i�in y�ntem.
DK1017684T3 (da) Kontrastmiddel til afbildning af infarkter og nekroser
DE69905273D1 (de) Verfahren und zusammensetzung zur inhibierung der polymerisierung von ethylenisch ungesättigten kohlenwasserstoffen
DE10003866B8 (de) Zusammensetzungen enthaltend stabilisierte Metallocen-Polyolefine, sowie Verfahren zum Stabilisieren von Metallocen-Polyolefinen
DE69719407D1 (de) Verfahren zum Abkühlen von Stahlrohren
DE69808475D1 (de) Aminosäurederivate zur behandlung von schlaganfall
ATE265708T1 (de) Verfahren zur speicherung und zum betrieb von informationseinheiten in einem sicherheitsmodul, und zugehöriges sicherheitsmodul
DE69835376D1 (de) Verfahren zum auffinden von verbindungen zur vorbeugung von infektion oder pathogenizität
ATE194360T1 (de) Verfahren und mittel für die herstellung von bindungsproteinen für inhibitoren von plasmaproteinasen
AR022150A1 (es) Acidos nucleicos derivados de monocitos y composiciones y metodos relacionados
DE69719509D1 (de) Verfahren zum befestigen von auskleidungen in behältern
DE69916404D1 (de) Zusätze und Verfahren zum erhöhen der intrazellulären Kalziumionenkonzentration
DE69409297D1 (de) Verfahren zur Vernetzung von Organosiloxanzusammensetzungen bei Anwesenheit von Vernetzungsinhibitoren
DE69715668D1 (de) N-(pyridinylamino)isoindoline und verwandte verbindungen
DE69932342D1 (de) Verfahren und zusammensetzungen zur hemmung von neoplastischem zellwachstums

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties