|
EP1958962A3
(en)
|
1997-06-12 |
2013-05-01 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7022479B2
(en)
|
2000-01-24 |
2006-04-04 |
Compound Therapeutics, Inc. |
Sensitive, multiplexed diagnostic assays for protein analysis
|
|
DE60118527D1
(de)
|
2000-01-24 |
2006-05-18 |
Compound Therapeutics Inc |
Sensible und multiplexe diagnostische tests zur proteinanalyse
|
|
AU2001277867B2
(en)
*
|
2000-07-11 |
2006-12-07 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
|
EP2141243A3
(en)
*
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
IL155812A0
(en)
*
|
2000-12-07 |
2003-12-23 |
Lilly Co Eli |
Glp-1 fusion proteins
|
|
US7556925B2
(en)
|
2001-04-04 |
2009-07-07 |
University Of Rochester |
ανβ3 integrin-binding polypeptide monobodies and their use
|
|
EP1456410A2
(en)
*
|
2001-12-11 |
2004-09-15 |
AlgoNomics N.V. |
Method for displaying loops from immunoglobulin domains in different contexts
|
|
SG187991A1
(en)
|
2002-05-02 |
2013-03-28 |
Wyeth Corp |
Calicheamicin derivative-carrier conjugates
|
|
WO2003104418A2
(en)
|
2002-06-06 |
2003-12-18 |
Research Corporation Technologies, Inc. |
Reconstituted polypeptides
|
|
US7083948B1
(en)
|
2002-12-24 |
2006-08-01 |
Immunex Corporation |
Polypeptide purification reagents and methods for their use
|
|
PL2382990T3
(pl)
|
2003-04-30 |
2015-04-30 |
Univ Zuerich |
Sposoby leczenia raka z zastosowaniem immunotoksyny
|
|
GB0407315D0
(en)
|
2003-07-15 |
2004-05-05 |
Cambridge Antibody Tech |
Human antibody molecules
|
|
EP1711196A4
(en)
|
2003-12-05 |
2011-09-14 |
Bristol Myers Squibb Co |
INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
|
|
TR201901929T4
(tr)
|
2005-02-08 |
2019-03-21 |
Genzyme Corp |
TGFBeta'ya antikorlar.
|
|
MX2008012291A
(es)
|
2006-03-27 |
2009-01-12 |
Medimmune Ltd |
Miembro que enlaza al receptor gm-csf.
|
|
CL2007002225A1
(es)
|
2006-08-03 |
2008-04-18 |
Astrazeneca Ab |
Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un
|
|
US8350011B2
(en)
|
2006-08-04 |
2013-01-08 |
Medimmune Limited |
Antibodies to ErbB2
|
|
PL2829551T3
(pl)
|
2006-10-19 |
2018-04-30 |
Csl Limited |
Antagonisty przeciwciała o wysokim powinowactwie wobec receptora alfa 1 interleukiny-13
|
|
MX2009005466A
(es)
|
2006-11-22 |
2009-08-17 |
Adnexus A Bristol Myers Sqibb |
Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i.
|
|
TW200831528A
(en)
|
2006-11-30 |
2008-08-01 |
Astrazeneca Ab |
Compounds
|
|
EP2111228B1
(en)
|
2007-02-02 |
2011-07-20 |
Bristol-Myers Squibb Company |
10Fn3 domain for use in treating diseases associated with inappropriate angiogenesis
|
|
AR065368A1
(es)
|
2007-02-15 |
2009-06-03 |
Astrazeneca Ab |
Anticuerpos para moleculas de ige
|
|
WO2008120101A2
(en)
|
2007-04-02 |
2008-10-09 |
Philogen S.P.A. |
The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases
|
|
AU2008239594B2
(en)
|
2007-04-13 |
2013-10-24 |
Beth Israel Deaconess Medical Center |
Methods for treating cancer resistant to ErbB therapeutics
|
|
EP2559771A3
(en)
|
2007-05-17 |
2013-06-12 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
|
|
EP2167541B1
(en)
|
2007-07-25 |
2012-12-19 |
Philogen S.p.A. |
The ed-a antigen of fibronectin is associated with the neovasculature of tumour metastases
|
|
DK3281952T3
(da)
|
2007-10-30 |
2020-08-03 |
Philogen Spa |
Antigen, der er forbundet med reumatoid artritis
|
|
US8633297B2
(en)
|
2007-10-31 |
2014-01-21 |
Medimmune, Llc |
Protein scaffolds
|
|
US8092804B2
(en)
|
2007-12-21 |
2012-01-10 |
Medimmune Limited |
Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
|
|
KR101759457B1
(ko)
|
2007-12-21 |
2017-07-31 |
메디뮨 리미티드 |
인터루킨-4 수용체 알파(IL-4Rα)에 대한 결합 구성원-173
|
|
WO2009083804A2
(en)
*
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
AU2009213141A1
(en)
|
2008-02-14 |
2009-08-20 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins that bind EGFR
|
|
EA201001734A1
(ru)
|
2008-05-02 |
2011-10-31 |
Новартис Аг |
Улучшенные связывающие молекулы на основе фибронектина и их применение
|
|
WO2009142773A2
(en)
|
2008-05-22 |
2009-11-26 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
AU2009294415B2
(en)
|
2008-09-19 |
2015-09-24 |
Medimmune Llc |
Antibodies directed to DLL4 and uses thereof
|
|
ES2705714T3
(es)
|
2008-10-31 |
2019-03-26 |
Janssen Biotech Inc |
Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
ES2410579T5
(es)
|
2008-12-16 |
2021-10-04 |
Novartis Ag |
Sistemas de despliegue de levaduras
|
|
CA2748158A1
(en)
|
2008-12-23 |
2010-07-01 |
Astrazeneca Ab |
Targeted binding agents directed to .alpha.5.beta.1 and uses thereof
|
|
CA2748401C
(en)
|
2009-01-07 |
2017-09-12 |
Philogen S.P.A. |
Antigens associated with endometriosis
|
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
EP2461832B1
(en)
|
2009-08-05 |
2017-06-28 |
Philogen S.p.A. |
Targeting of bone marrow neovasculature
|
|
WO2011020033A2
(en)
*
|
2009-08-13 |
2011-02-17 |
Massachusetts Institute Of Technology |
Engineered proteins including mutant fibronectin domains
|
|
ES2691717T3
(es)
|
2009-10-30 |
2018-11-28 |
Novartis Ag |
Bibliotecas universales del dominio de unión del lado inferior de tipo iii de la fibronectina de tipo III
|
|
EP2494070A2
(en)
|
2009-10-30 |
2012-09-05 |
Bristol-Myers Squibb Company |
Methods for treating cancer in patients having igf-1r inhibitor resistance
|
|
PL2504364T3
(pl)
|
2009-11-24 |
2017-12-29 |
Medimmune Limited |
Ukierunkowane środki wiążące przeciwko B7-H1
|
|
EA201270662A1
(ru)
|
2009-12-23 |
2013-01-30 |
4-Антибоди Аг |
Связывающие элементы для человеческого цитамегаловируса
|
|
US20130101590A1
(en)
|
2010-04-09 |
2013-04-25 |
Heather A. Arnett |
Btnl9 proteins, nucleic acids, and antibodies and uses thereof
|
|
WO2011130324A1
(en)
|
2010-04-13 |
2011-10-20 |
Medimmune, Llc |
Fibronectin type iii domain-based multimeric scaffolds
|
|
US8569227B2
(en)
|
2010-04-30 |
2013-10-29 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
JP6023703B2
(ja)
|
2010-05-26 |
2016-11-09 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
改善された安定性を有するフィブロネクチンをベースとする足場タンパク質
|
|
CA2809568C
(en)
|
2010-09-01 |
2019-06-11 |
Genzyme Corporation |
Treatment of myocardial infarction using tgf - beta antagonists
|
|
MX2013007067A
(es)
|
2010-12-20 |
2013-11-01 |
Medimmune Ltd |
Anticuerpos anti-il-18 y sus usos.
|
|
WO2012110824A1
(en)
|
2011-02-18 |
2012-08-23 |
Astrazeneca Ab |
Binding agents with specificity for a nucleic acid modification
|
|
EP3415528B1
(en)
|
2011-04-13 |
2021-05-26 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
|
EP2709669A1
(en)
|
2011-05-17 |
2014-03-26 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
EP2710382B1
(en)
|
2011-05-17 |
2017-10-18 |
Bristol-Myers Squibb Company |
Improved methods for the selection of binding proteins
|
|
EP2548891A1
(en)
|
2011-07-18 |
2013-01-23 |
Universiteit Maastricht |
Human monoclonal antibody against the gamma subunit of the acetylcholine receptor for use in the treatment of rhabdomyosarcoma.
|
|
JP6440496B2
(ja)
|
2011-09-27 |
2018-12-19 |
ヤンセン バイオテツク,インコーポレーテツド |
選択的結合表面を有するフィブロネクチンiii型反復ベースのタンパク質スカフォールド
|
|
CA2851322C
(en)
|
2011-10-10 |
2020-03-31 |
Medimmune Limited |
Treatment for rheumatoid arthritis with gm csfr alpha antibodies
|
|
EP3753567A1
(en)
|
2011-10-11 |
2020-12-23 |
Viela Bio, Inc. |
Cd40l-specific tn3-derived scaffolds and methods of use thereof
|
|
EP2766497A1
(en)
|
2011-10-13 |
2014-08-20 |
Bristol-Myers Squibb Company |
Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
|
|
JP2015504038A
(ja)
|
2011-10-31 |
2015-02-05 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
低減した免疫原性を有するフィブロネクチン結合ドメイン
|
|
ES2753135T3
(es)
|
2012-05-07 |
2020-04-07 |
Allergan Inc |
Método de tratamiento de DMAE en pacientes resistentes a terapia anti-VEGF
|
|
EP2875046B2
(en)
|
2012-07-19 |
2025-04-30 |
Amgen Inc. |
Human btnl3 proteins, nucleic acids, and antibodies and uses thereof
|
|
ES2984405T3
(es)
|
2012-09-13 |
2024-10-29 |
Bristol Myers Squibb Co |
Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina
|
|
ES2743423T3
(es)
|
2012-10-03 |
2020-02-19 |
Philogen Spa |
Conjugado de anticuerpos para su uso en el tratamiento de una enfermedad inflamatoria intestinal
|
|
CN104903349B
(zh)
|
2012-11-08 |
2018-10-19 |
十一生物治疗股份有限公司 |
Il-6拮抗剂及其应用
|
|
EP2951206A2
(en)
|
2013-02-01 |
2015-12-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins
|
|
EP2953968B1
(en)
|
2013-02-06 |
2018-07-25 |
Bristol-Myers Squibb Company |
Fibronectin type iii domain proteins with enhanced solubility
|
|
US10065987B2
(en)
|
2013-02-12 |
2018-09-04 |
Bristol-Myers Squibb Company |
High pH protein refolding methods
|
|
EP2968587A2
(en)
|
2013-03-13 |
2016-01-20 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
|
|
WO2014140882A2
(en)
*
|
2013-03-14 |
2014-09-18 |
The Governing Council Of The University Of Toronto |
Scaffolded peptidic libraries and methods of making and screening the same
|
|
GB201307501D0
(en)
|
2013-04-25 |
2013-06-12 |
Univ Aberdeen |
Anti-fungal antibody molecules and uses thereof
|
|
ES2736127T3
(es)
|
2014-03-20 |
2019-12-26 |
Bristol Myers Squibb Co |
Dominios de tipo III de fibronectina de unión a seroalbúmina
|
|
CA2943228C
(en)
|
2014-03-20 |
2023-03-14 |
Bristol-Myers Squibb Company |
Stabilized fibronectin based scaffold molecules
|
|
GB201407852D0
(en)
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
WO2016073894A1
(en)
|
2014-11-07 |
2016-05-12 |
Eleven Biotherapeutics, Inc. |
Therapeutic agents with increased ocular retention
|
|
JP6594438B2
(ja)
|
2014-11-07 |
2019-10-23 |
セセン バイオ, インコーポレイテッド |
改善されたil−6抗体
|
|
KR20170093182A
(ko)
|
2014-12-11 |
2017-08-14 |
인바이오모션 에스.엘. |
인간 c-maf에 대한 결합 구성원
|
|
CN115043943A
(zh)
|
2015-05-15 |
2022-09-13 |
综合医院公司 |
拮抗性抗肿瘤坏死因子受体超家族抗体
|
|
CN108884147B
(zh)
|
2015-09-23 |
2024-02-27 |
百时美施贵宝公司 |
结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子
|
|
CN108290941A
(zh)
|
2015-09-23 |
2018-07-17 |
百时美施贵宝公司 |
快解离速率的血清白蛋白结合性纤连蛋白iii型结构域
|
|
CN108718522A
(zh)
|
2016-02-23 |
2018-10-30 |
赛森生物股份有限公司 |
Il-6拮抗剂制剂及其用途
|
|
WO2017165464A1
(en)
|
2016-03-21 |
2017-09-28 |
Elstar Therapeutics, Inc. |
Multispecific and multifunctional molecules and uses thereof
|
|
KR20180133442A
(ko)
|
2016-04-13 |
2018-12-14 |
비비아 바이오테크 에스.엘. |
생체외 bite 활성화된 t 세포
|
|
JP7274413B2
(ja)
|
2016-09-23 |
2023-05-16 |
マレンゴ・セラピューティクス,インコーポレーテッド |
ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
|
|
CN110225770B
(zh)
|
2016-12-14 |
2022-04-26 |
杨森生物科技公司 |
结合cd8a的纤连蛋白iii型结构域
|
|
EP3554561B1
(en)
|
2016-12-14 |
2023-06-28 |
Janssen Biotech, Inc. |
Cd137 binding fibronectin type iii domains
|
|
EP3554535A4
(en)
|
2016-12-14 |
2020-10-21 |
Janssen Biotech, Inc. |
PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS
|
|
WO2018151820A1
(en)
|
2017-02-16 |
2018-08-23 |
Elstar Therapeutics, Inc. |
Multifunctional molecules comprising a trimeric ligand and uses thereof
|
|
CN110709422B
(zh)
|
2017-04-19 |
2023-12-26 |
马伦戈治疗公司 |
多特异性分子及其用途
|
|
US20200385472A1
(en)
|
2017-04-28 |
2020-12-10 |
Elstar Therapeutics, Inc. |
Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof
|
|
EP3630836A1
(en)
|
2017-05-31 |
2020-04-08 |
Elstar Therapeutics, Inc. |
Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
|
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
|
EP3720881A1
(en)
|
2017-12-08 |
2020-10-14 |
Elstar Therapeutics, Inc. |
Multispecific molecules and uses thereof
|
|
EP3502139A1
(en)
|
2017-12-19 |
2019-06-26 |
Philogen S.p.A. |
Antibodies to tumour antigens
|
|
US12247060B2
(en)
|
2018-01-09 |
2025-03-11 |
Marengo Therapeutics, Inc. |
Calreticulin binding constructs and engineered T cells for the treatment of diseases
|
|
EP3765516A2
(en)
|
2018-03-14 |
2021-01-20 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
EP3765517A1
(en)
|
2018-03-14 |
2021-01-20 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
CA3105448A1
(en)
|
2018-07-03 |
2020-01-09 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
CN113164777B
(zh)
|
2018-09-27 |
2024-12-13 |
马伦戈治疗公司 |
Csf1r/ccr2多特异性抗体
|
|
EP3927746A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
GB2599228B
(en)
|
2019-02-21 |
2024-02-07 |
Marengo Therapeutics Inc |
Multifunctional molecules that bind to T cell related cancer cells and uses thereof
|
|
JP7737306B2
(ja)
|
2019-02-21 |
2025-09-10 |
マレンゴ・セラピューティクス,インコーポレーテッド |
T細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用
|
|
EP3927431A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
CN119039441A
(zh)
|
2019-02-21 |
2024-11-29 |
马伦戈治疗公司 |
与nkp30结合的抗体分子及其用途
|
|
US11781138B2
(en)
|
2019-10-14 |
2023-10-10 |
Aro Biotherapeutics Company |
FN3 domain-siRNA conjugates and uses thereof
|
|
CN119119240A
(zh)
|
2019-10-14 |
2024-12-13 |
Aro生物疗法公司 |
结合cd71的纤维粘连蛋白iii型结构域
|
|
WO2021076543A1
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Epcam binding fibronectin type iii domains
|
|
AU2020416273A1
(en)
|
2020-01-03 |
2022-07-28 |
Marengo Therapeutics, Inc. |
Anti-TCR antibody molecules and uses thereof
|
|
EP4084821A4
(en)
|
2020-01-03 |
2024-04-24 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to cd33 and uses thereof
|
|
CN115843312A
(zh)
|
2020-04-24 |
2023-03-24 |
马伦戈治疗公司 |
结合至t细胞相关癌细胞的多功能性分子及其用途
|
|
AU2021331075A1
(en)
|
2020-08-26 |
2023-04-06 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
GB2616354A
(en)
|
2020-08-26 |
2023-09-06 |
Marengo Therapeutics Inc |
Methods of detecting TRBC1 or TRBC2
|
|
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|
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