ES2152251T3 - Variantes del dominio lectina de la selectina. - Google Patents

Variantes del dominio lectina de la selectina.

Info

Publication number
ES2152251T3
ES2152251T3 ES93910869T ES93910869T ES2152251T3 ES 2152251 T3 ES2152251 T3 ES 2152251T3 ES 93910869 T ES93910869 T ES 93910869T ES 93910869 T ES93910869 T ES 93910869T ES 2152251 T3 ES2152251 T3 ES 2152251T3
Authority
ES
Spain
Prior art keywords
variants
lectin domain
selectin
selectine
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93910869T
Other languages
English (en)
Inventor
David V Erbe
Laurence A Lasky
Leonard G Presta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2152251T3 publication Critical patent/ES2152251T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Non-Volatile Memory (AREA)
  • Semiconductor Memories (AREA)

Abstract

LA INVENCION SE REFIERE A VARIANTES DE LA SELECTINA QUE TIENEN UNA ALTERACION DEL AMINOACIDO EN LA ZONA O ZONAS DE UNA SECUENCIA DE AMINOACIDO DEL DOMINIO DE LA LECTINA DE LA SELECTINA DENTRO DE UNA REGION DEFINIDA POR ZONAS DE UNION RECONOCIDAS POR ANTICUERPOS MONOCLONALES BLOQUEANTES A LA SELECTINA CORRESPONDIENTE INALTERADA EN EL DOMINIO DE LA LECTINA. DENTRO DEL CAMPO DE LA INVENCION TAMBIEN SE ENCUENTRAN SECUENCIAS NUCLEOTIDAS QUE CODIFICAN TALES VARIANTES, VECTORES DE EXPRESION QUE CONTIENEN TALES SECUENCIAS NUCLEOTIDAS Y CELULAS ANFITRIONAS TRANSFORMADAS CON TALES VECTORES DE EXPRESION.
ES93910869T 1992-04-30 1993-04-28 Variantes del dominio lectina de la selectina. Expired - Lifetime ES2152251T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87903692A 1992-04-30 1992-04-30
US95670192A 1992-10-01 1992-10-01

Publications (1)

Publication Number Publication Date
ES2152251T3 true ES2152251T3 (es) 2001-02-01

Family

ID=27128518

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93910869T Expired - Lifetime ES2152251T3 (es) 1992-04-30 1993-04-28 Variantes del dominio lectina de la selectina.

Country Status (12)

Country Link
US (1) US5593882A (es)
EP (1) EP0639224B1 (es)
JP (2) JPH07506253A (es)
AT (1) ATE194168T1 (es)
AU (1) AU674317B2 (es)
CA (1) CA2134756C (es)
DE (1) DE69328928T2 (es)
DK (1) DK0639224T3 (es)
ES (1) ES2152251T3 (es)
GR (1) GR3034447T3 (es)
PT (1) PT639224E (es)
WO (1) WO1993022436A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU707440B2 (en) 1994-03-29 1999-07-08 Celltech Therapeutics Limited Antibodies against E-selectin
US6127524A (en) * 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
US20040096894A1 (en) * 2000-05-19 2004-05-20 Somers William Stuart Crystal structures of P- selectin, P- and E-selectin complexes, and uses thereof
EP1842551A1 (en) * 2000-05-24 2007-10-10 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services E-selectin for treating or preventing stroke
US7897575B2 (en) * 2000-05-24 2011-03-01 The United States Of America As Represented By The Department Of Health And Human Services Treatment and prevention of vascular dementia
BR0116138A (pt) 2000-12-13 2003-09-23 Borean Pharma As Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c
US20040132094A1 (en) * 2000-12-13 2004-07-08 Michael Etzerodt Combinatorial libraries of proteins having the scaffold structure of c-type lectinlike domains
AU2002233658B2 (en) * 2001-02-20 2007-07-12 Summit Glycoresearch Corporation Lectins for analyzing sugar chains and method of using the same
US20040116333A1 (en) * 2001-08-03 2004-06-17 Rong-Hwa Lin Modulators of P-selectin glycoprotein ligand 1
AU2002359815A1 (en) * 2001-12-19 2003-07-09 Immunex Corporation C-type lectin polypeptide, polynucleotide and methods of making and use thereof
US20070244043A1 (en) * 2005-03-10 2007-10-18 Novavax, Inc. Recombinant E-selectin made in insect cells
HUE041957T2 (hu) 2006-12-01 2019-06-28 Novartis Ag Anti-P-szelektin antitestek és eljárások azok alkalmazására gyulladásos betegségek kezelésére
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
EP2195333A1 (en) * 2007-09-12 2010-06-16 Anaphore, Inc. Hsp70-based treatment for autoimmune diseases
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
CN102686606A (zh) * 2009-10-09 2012-09-19 阿纳福公司 结合il-23r的多肽
EP2654781B1 (en) * 2010-12-21 2018-01-24 Selexys Pharmaceuticals Corporation Anti-p-selectin antibodies and methods of their use and identification
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018178991A1 (en) * 2017-03-29 2018-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Purification of an agent of interest
CN121108302A (zh) * 2025-09-22 2025-12-12 渼达(广州)生物科技有限公司 一种重组人Fc和P-选择素的重组蛋白、检测产品及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081034A (en) * 1988-11-14 1992-01-14 Brigham & Women's Hospital Cloned genes which encode elam-1
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
ES2183851T3 (es) * 1990-07-17 2003-04-01 Univ Oklahoma Ligando de gmp-140.

Also Published As

Publication number Publication date
JP2004049234A (ja) 2004-02-19
JPH07506253A (ja) 1995-07-13
AU674317B2 (en) 1996-12-19
DE69328928T2 (de) 2000-11-30
CA2134756A1 (en) 1993-11-11
GR3034447T3 (en) 2000-12-29
ATE194168T1 (de) 2000-07-15
CA2134756C (en) 2010-04-20
EP0639224B1 (en) 2000-06-28
AU4220893A (en) 1993-11-29
DK0639224T3 (da) 2000-10-30
PT639224E (pt) 2000-12-29
DE69328928D1 (de) 2000-08-03
EP0639224A1 (en) 1995-02-22
JP3749529B2 (ja) 2006-03-01
US5593882A (en) 1997-01-14
WO1993022436A1 (en) 1993-11-11

Similar Documents

Publication Publication Date Title
ES2152251T3 (es) Variantes del dominio lectina de la selectina.
ATE215601T1 (de) Rezeptoren der steroid/thyroid superfamilie von rezeptoren
ES2077666T3 (es) Proteina de union a fibronectina y su preparacion.
FI20010060A7 (fi) 5-metoksi-indoli-3-karboksialdehydiamino-(pentyyliamino)metyleeni-hydratsoni
ATE162524T1 (de) Hydrazine mit einer n3s konfiguration als radionukleide chelatoren
CY1118443T1 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοι και χρησεις
BR0011849A (pt) Anticorpos enxertados lm609 melhorados
DK0640135T3 (da) Immunoglobulinbindende proteiner, der er afledt af protein L, og anvendelser af disse
TR199900267T2 (xx) GnRH-L�kotoksin kimeralar�.
PT726955E (pt) Proteinas quimericas compreendendo polipeptidos borrelia: suas utilizacoes
DE69417426D1 (de) N2s2-chelatoren des hydrazino-typs
PT765394E (pt) Lacases myceliophthora purificadas e acidos nucleicos que as codificam
DE69434384D1 (de) Metalkomplexbildner
EA200000144A1 (ru) Направленный цитолиз клеток-мишеней, агенты и композиции, вызывающие цитолиз, и соединения, которые можно использовать для получения этих агентов
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
ATE171212T1 (de) Corticotropin freisetzende rezeptoren des faktor 2
DK0610260T3 (da) Vacciner mod Actinobacillus pleuropneumoniae
DK1279677T3 (da) GD3-mimetiske peptider
ATE442858T1 (de) Nukleinsäureadjuvantien
DE69619808D1 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
DE69840326D1 (de) Steigerung der immunantwort unter verwendung von zielgerichteten molekülen
NO962827L (no) Monoklonale antistoffer mot antigener uttrykt av hematopoietider facilitatoriske celler
DE602006014140D1 (de) Mit scytovirin der domäne 1 verwandte polypeptide
PT714441E (pt) Alergenios recombinantes de cladosporium herbarum
DK551786D0 (da) Rekombinant-dna-sekvens, der koder for aminosyresekvenser i et toksin, expressionssystem omfattende samme og vaertsceller transformeret hermed

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 639224

Country of ref document: ES