DK0639224T3 - Varianter i lectindomænet af selectin - Google Patents

Varianter i lectindomænet af selectin

Info

Publication number: DK0639224T3
Authority: DK; Denmark
Prior art keywords: selectin; variants; lectin domain; amino acid; nucleotide sequences
Prior art date: 1992-04-30

Application number

DK93910869T

Other languages

English (en)

Inventor

Laurence A Lasky

David V Erbe

Leonard G Presta

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-30

Filing date

1993-04-28

Publication date

2000-10-30

1993-04-28 Application filed by Genentech Inc filed Critical Genentech Inc

2000-10-30 Application granted granted Critical

2000-10-30 Publication of DK0639224T3 publication Critical patent/DK0639224T3/da

Links

102000003800 Selectins Human genes 0.000 title abstract 4
108090000184 Selectins Proteins 0.000 title abstract 4
AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 title abstract 3
102000004856 Lectins Human genes 0.000 title abstract 2
108090001090 Lectins Proteins 0.000 title abstract 2
239000002523 lectin Substances 0.000 title abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000004075 alteration Effects 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Non-Volatile Memory (AREA)
Semiconductor Memories (AREA)

DK93910869T 1992-04-30 1993-04-28 Varianter i lectindomænet af selectin DK0639224T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US87903692A	1992-04-30	1992-04-30
US95670192A	1992-10-01	1992-10-01
PCT/US1993/003987 WO1993022436A1 (en)	1992-04-30	1993-04-28	Lectin domain variants of selectin

Publications (1)

Publication Number	Publication Date
DK0639224T3 true DK0639224T3 (da)	2000-10-30

Family

ID=27128518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93910869T DK0639224T3 (da)	1992-04-30	1993-04-28	Varianter i lectindomænet af selectin

Country Status (12)

Country	Link
US (1)	US5593882A (da)
EP (1)	EP0639224B1 (da)
JP (2)	JPH07506253A (da)
AT (1)	ATE194168T1 (da)
AU (1)	AU674317B2 (da)
CA (1)	CA2134756C (da)
DE (1)	DE69328928T2 (da)
DK (1)	DK0639224T3 (da)
ES (1)	ES2152251T3 (da)
GR (1)	GR3034447T3 (da)
PT (1)	PT639224E (da)
WO (1)	WO1993022436A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2186455A1 (en) *	1994-03-29	1995-10-05	Raymond John Owens	Antibodies against e-selectin
US6127524A (en) *	1996-10-18	2000-10-03	Dade Behring Inc.	Binding molecules and computer-based methods of increasing the binding affinity thereof
EP1282425A4 (en) *	2000-05-19	2004-09-15	Inst Genetics Llc	P-SELECTIN CRYSTAL STRUCTURE, P- AND E-SELECTIN COMPLEXES, AND USE THEREOF
EP1842551A1 (en) *	2000-05-24	2007-10-10	The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services	E-selectin for treating or preventing stroke
US7897575B2 (en) *	2000-05-24	2011-03-01	The United States Of America As Represented By The Department Of Health And Human Services	Treatment and prevention of vascular dementia
EP2284270A3 (en)	2000-12-13	2012-07-25	Anaphore, Inc.	Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
ATE431851T1 (de)	2000-12-13	2009-06-15	Anaphore Inc	Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur
JP3658394B2 (ja) *	2001-02-20	2005-06-08	サミット・グライコリサーチ株式会社	糖鎖解析用レクチン群及びその使用方法
US20040116333A1 (en) *	2001-08-03	2004-06-17	Rong-Hwa Lin	Modulators of P-selectin glycoprotein ligand 1
WO2003054164A2 (en)	2001-12-19	2003-07-03	Immunex Corporation	C-type lectin polypeptide, polynucleotide and methods of making and use thereof
US20070244043A1 (en) *	2005-03-10	2007-10-18	Novavax, Inc.	Recombinant E-selectin made in insect cells
HUE041957T2 (hu)	2006-12-01	2019-06-28	Novartis Ag	Anti-P-szelektin antitestek és eljárások azok alkalmazására gyulladásos betegségek kezelésére
US8945565B2 (en)	2006-12-01	2015-02-03	Selexys Pharmaceuticals Corporation	Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
JP2010538655A (ja) *	2007-09-12	2010-12-16	アナフォアインコーポレイテッド	自己免疫疾患についてのｈｓｐ７０に基づく治療
US20110086806A1 (en) *	2009-10-09	2011-04-14	Anaphore, Inc.	Polypeptides that Bind IL-23R
JP2013507124A (ja) *	2009-10-09	2013-03-04	アナフォアインコーポレイテッド	Ｉｌ−２３ｒを結合するポリペプチド
AU2011349124B2 (en) *	2010-12-21	2016-09-15	Oklahoma Medical Research Foundation	Anti-P-selectin antibodies and methods of their use and identification
US9616114B1 (en)	2014-09-18	2017-04-11	David Gordon Bermudes	Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en)	2015-05-11	2020-06-09	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
AU2018244030B2 (en) *	2017-03-29	2021-10-21	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd	Purification of an agent of interest
CN121108302A (zh) *	2025-09-22	2025-12-12	渼达(广州)生物科技有限公司	一种重组人Fc和P-选择素的重组蛋白、检测产品及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5081034A (en) *	1988-11-14	1992-01-14	Brigham & Women's Hospital	Cloned genes which encode elam-1
US5098833A (en) *	1989-02-23	1992-03-24	Genentech, Inc.	DNA sequence encoding a functional domain of a lymphocyte homing receptor
ATE224911T1 (de) *	1990-07-17	2002-10-15	Univ Oklahoma	Gmp-140 ligand

1993
- 1993-04-28 DE DE69328928T patent/DE69328928T2/de not_active Expired - Lifetime
- 1993-04-28 DK DK93910869T patent/DK0639224T3/da active
- 1993-04-28 ES ES93910869T patent/ES2152251T3/es not_active Expired - Lifetime
- 1993-04-28 WO PCT/US1993/003987 patent/WO1993022436A1/en not_active Ceased
- 1993-04-28 AT AT93910869T patent/ATE194168T1/de active
- 1993-04-28 JP JP5519482A patent/JPH07506253A/ja active Pending
- 1993-04-28 EP EP93910869A patent/EP0639224B1/en not_active Expired - Lifetime
- 1993-04-28 PT PT93910869T patent/PT639224E/pt unknown
- 1993-04-28 AU AU42208/93A patent/AU674317B2/en not_active Expired
- 1993-04-28 CA CA2134756A patent/CA2134756C/en not_active Expired - Lifetime
1994
- 1994-07-13 US US08/274,661 patent/US5593882A/en not_active Expired - Lifetime
2000
- 2000-09-20 GR GR20000402139T patent/GR3034447T3/el unknown
2003
- 2003-06-24 JP JP2003179641A patent/JP3749529B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GR3034447T3 (en)	2000-12-29
EP0639224A1 (en)	1995-02-22
CA2134756A1 (en)	1993-11-11
EP0639224B1 (en)	2000-06-28
JP2004049234A (ja)	2004-02-19
JP3749529B2 (ja)	2006-03-01
PT639224E (pt)	2000-12-29
ES2152251T3 (es)	2001-02-01
AU674317B2 (en)	1996-12-19
ATE194168T1 (de)	2000-07-15
AU4220893A (en)	1993-11-29
DE69328928T2 (de)	2000-11-30
CA2134756C (en)	2010-04-20
JPH07506253A (ja)	1995-07-13
DE69328928D1 (de)	2000-08-03
US5593882A (en)	1997-01-14
WO1993022436A1 (en)	1993-11-11

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