DK0568833T3 - Mutanter af humant antithrombin III - Google Patents
Mutanter af humant antithrombin IIIInfo
- Publication number
- DK0568833T3 DK0568833T3 DK93105829T DK93105829T DK0568833T3 DK 0568833 T3 DK0568833 T3 DK 0568833T3 DK 93105829 T DK93105829 T DK 93105829T DK 93105829 T DK93105829 T DK 93105829T DK 0568833 T3 DK0568833 T3 DK 0568833T3
- Authority
- DK
- Denmark
- Prior art keywords
- iii
- mutant
- mutants
- antithrombin iii
- amino acids
- Prior art date
Links
- 101000757319 Homo sapiens Antithrombin-III Proteins 0.000 title abstract 2
- 102000052834 human SERPINC1 Human genes 0.000 title abstract 2
- 229960004336 human antithrombin iii Drugs 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9048892 | 1992-04-10 | ||
| JP03185593A JP3479539B2 (ja) | 1992-04-10 | 1993-02-22 | ヒトアンチトロンビンｉｉｉ変異体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0568833T3 true DK0568833T3 (da) | 2000-09-18 |
Family
ID=26370368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93105829T DK0568833T3 (da) | 1992-04-10 | 1993-04-08 | Mutanter af humant antithrombin III |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5420252A (da) |
| EP (1) | EP0568833B1 (da) |
| JP (1) | JP3479539B2 (da) |
| AT (1) | ATE194624T1 (da) |
| AU (1) | AU655723B2 (da) |
| CA (1) | CA2093575A1 (da) |
| DE (1) | DE69328992T2 (da) |
| DK (1) | DK0568833T3 (da) |
| ES (1) | ES2149788T3 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010638A1 (en) * | 1994-09-30 | 1996-04-11 | Ppl Therapeutics (Scotland) Ltd. | Alpha-1-antitrypsin and antithrombine-iii variants |
| KR20010052345A (ko) | 1998-05-12 | 2001-06-25 | 수잔 씨 복 | 인간 항트롬빈 3 및 그에 관련된 방법 |
| CA2344613A1 (en) | 1998-10-08 | 2000-04-13 | Children's Hospital | Compositions and methods for inhibiting angiogenesis |
| JP4339962B2 (ja) * | 1999-06-23 | 2009-10-07 | 武比古 小出 | ヒトアンチトロンビン変異体 |
| WO2003101398A2 (en) | 2002-05-31 | 2003-12-11 | University Of Utah Research Foundation | Variants of antithrombin iii |
| US20070259809A1 (en) * | 2004-01-09 | 2007-11-08 | Bock Susan C | Methods of Using High Affinity Atiii Variants |
| US8741844B2 (en) * | 2007-07-20 | 2014-06-03 | Universite Paris-Sud Xi | Use of mutated antithrombins for treating or preventing coagulation disorders |
| CA2749772C (en) * | 2009-01-16 | 2018-02-20 | Assistance Publique-Hopitaux De Paris | Mutated antithrombins, a process for preparing the same and their use as drugs |
| TR201809898T4 (tr) | 2009-11-03 | 2018-07-23 | Grifols Therapeutics Llc | Alfa-1 protei̇naz i̇nhi̇bi̇törüne yöneli̇k bi̇leşi̇m, yöntem ve ki̇t. |
| PT2503995T (pt) | 2009-11-24 | 2017-11-23 | Grifols Therapeutics Inc | Métodos de liofilização, composições e kits |
| ES2374054B1 (es) * | 2010-07-03 | 2012-12-26 | Instituto De Salud Carlos Iii | Nuevo inhibidor de serina proteasa y su uso. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185431A (en) | 1988-08-31 | 1993-02-09 | Eisai Co., Ltd. | Recombinant natural killer cell activator |
| DE3901917A1 (de) | 1989-01-24 | 1990-07-26 | Behringwerke Ag | Mutanten von humanem antithrombin iii |
| IE902276A1 (en) | 1989-06-26 | 1991-01-16 | Akzo Nv | Serpin variants |
| US5102995A (en) * | 1989-10-20 | 1992-04-07 | Washington University | Dna encoding modified heparin cofactor ii |
-
1993
- 1993-02-22 JP JP03185593A patent/JP3479539B2/ja not_active Expired - Lifetime
- 1993-04-06 AU AU36761/93A patent/AU655723B2/en not_active Ceased
- 1993-04-07 CA CA002093575A patent/CA2093575A1/en not_active Abandoned
- 1993-04-08 DK DK93105829T patent/DK0568833T3/da active
- 1993-04-08 EP EP93105829A patent/EP0568833B1/en not_active Expired - Lifetime
- 1993-04-08 DE DE69328992T patent/DE69328992T2/de not_active Expired - Lifetime
- 1993-04-08 ES ES93105829T patent/ES2149788T3/es not_active Expired - Lifetime
- 1993-04-08 AT AT93105829T patent/ATE194624T1/de not_active IP Right Cessation
- 1993-04-09 US US08/046,431 patent/US5420252A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2149788T3 (es) | 2000-11-16 |
| JP3479539B2 (ja) | 2003-12-15 |
| US5420252A (en) | 1995-05-30 |
| CA2093575A1 (en) | 1993-10-11 |
| EP0568833B1 (en) | 2000-07-12 |
| EP0568833A1 (en) | 1993-11-10 |
| JPH05339292A (ja) | 1993-12-21 |
| DE69328992T2 (de) | 2000-12-07 |
| AU655723B2 (en) | 1995-01-05 |
| AU3676193A (en) | 1993-10-14 |
| DE69328992D1 (de) | 2000-08-17 |
| ATE194624T1 (de) | 2000-07-15 |
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