ES2149788T3 - Mutantes de antitrombina iii humana. - Google Patents

Mutantes de antitrombina iii humana.

Info

Publication number
ES2149788T3
ES2149788T3 ES93105829T ES93105829T ES2149788T3 ES 2149788 T3 ES2149788 T3 ES 2149788T3 ES 93105829 T ES93105829 T ES 93105829T ES 93105829 T ES93105829 T ES 93105829T ES 2149788 T3 ES2149788 T3 ES 2149788T3
Authority
ES
Spain
Prior art keywords
iii
mutant
antitrombine
mutants
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93105829T
Other languages
English (en)
Inventor
Hiroyuki Kato
Shinji Yoshitake
Suguru Suzuki
Noboru Suzuki
Toshio Seto
Naoko Nagaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2149788T3 publication Critical patent/ES2149788T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTA UN NUEVO MUTANTE DE LA ANTITROMBINA III HUMANA (AT III) QUE TIENE UNA ALTA ACTIVIDAD ANTITROMBINA EN LA AUSENCIA DE HEPARINA Y ES EFECTIVA EN EL TRATAMIENTO DE LAS ENFERMEDADES TROMBOTICAS COMO ANTICOAGULANTE, EL MUTANTE SE OBTIENE MUTANDO LOS AMINOACIDOS EN LA ZONA REACTIVA DE LA ZONA DE UNION DE LA HEPARINA DE LA AT III EN OTROS AMINOACIDOS MEDIANTE EL USO DE TECNOLOGIA DE DNA RECOMBINANTE CON LA UTILIZACION DE UNA CODIFICACION DE DNA PARA LA AT III COMO PLANTILLA. TAMBIEN SE PRESENTA UN METODO PARA LA PRODUCCION EN MASA DEL MUTANTE ANTES DESCRITO MEDIANTE LA INCUBACION DE UN ANFITRION TRANSFORMADO POR UN VECTOR DE EXPRESION QUE TENGA EL CDNA DEL MUTANTE INSERTADO EN EL MISMO.
ES93105829T 1992-04-10 1993-04-08 Mutantes de antitrombina iii humana. Expired - Lifetime ES2149788T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9048892 1992-04-10
JP03185593A JP3479539B2 (ja) 1992-04-10 1993-02-22 ヒトアンチトロンビンｉｉｉ変異体

Publications (1)

Publication Number Publication Date
ES2149788T3 true ES2149788T3 (es) 2000-11-16

Family

ID=26370368

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93105829T Expired - Lifetime ES2149788T3 (es) 1992-04-10 1993-04-08 Mutantes de antitrombina iii humana.

Country Status (9)

Country Link
US (1) US5420252A (es)
EP (1) EP0568833B1 (es)
JP (1) JP3479539B2 (es)
AT (1) ATE194624T1 (es)
AU (1) AU655723B2 (es)
CA (1) CA2093575A1 (es)
DE (1) DE69328992T2 (es)
DK (1) DK0568833T3 (es)
ES (1) ES2149788T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3479495A (en) * 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
KR20010052345A (ko) * 1998-05-12 2001-06-25 수잔 씨 복 인간 항트롬빈 3 및 그에 관련된 방법
WO2000020026A2 (en) 1998-10-08 2000-04-13 Children's Hospital Compositions and methods for inhibiting angiogenesis
JP4339962B2 (ja) 1999-06-23 2009-10-07 武比古 小出 ヒトアンチトロンビン変異体
EP1530629B1 (en) 2002-05-31 2011-08-31 The University of Utah Research Foundation Variants of antithrombin iii
AU2005206806A1 (en) * 2004-01-09 2005-08-04 University Of Utah Research Foundation Methods of using high affinity ATIII variants
DK2175877T3 (da) * 2007-07-20 2012-04-16 Univ Paris Sud Xi Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdomme
WO2010081878A1 (en) * 2009-01-16 2010-07-22 Universite Paris-Sud Xi Mutated antithrombins, a process for preparing the same and their use as drugs
PT2496246T (pt) 2009-11-03 2018-07-31 Grifols Therapeutics Llc Composição, método e kit para o inibidor da alfa-1 protease
RU2540480C2 (ru) 2009-11-24 2015-02-10 Грифольс Терапьютикс Инк. Способы, композиции и наборы для лиофилизации
ES2374054B1 (es) * 2010-07-03 2012-12-26 Instituto De Salud Carlos Iii Nuevo inhibidor de serina proteasa y su uso.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185431A (en) 1988-08-31 1993-02-09 Eisai Co., Ltd. Recombinant natural killer cell activator
DE3901917A1 (de) 1989-01-24 1990-07-26 Behringwerke Ag Mutanten von humanem antithrombin iii
IE902276A1 (en) 1989-06-26 1991-01-16 Akzo Nv Serpin variants
US5102995A (en) * 1989-10-20 1992-04-07 Washington University Dna encoding modified heparin cofactor ii

Also Published As

Publication number Publication date
DE69328992T2 (de) 2000-12-07
JPH05339292A (ja) 1993-12-21
AU655723B2 (en) 1995-01-05
US5420252A (en) 1995-05-30
ATE194624T1 (de) 2000-07-15
EP0568833B1 (en) 2000-07-12
CA2093575A1 (en) 1993-10-11
DE69328992D1 (de) 2000-08-17
DK0568833T3 (da) 2000-09-18
JP3479539B2 (ja) 2003-12-15
EP0568833A1 (en) 1993-11-10
AU3676193A (en) 1993-10-14

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