ATE194845T1 - Von peptiden abgeleitete komplexbildner für radionuklide - Google Patents

Von peptiden abgeleitete komplexbildner für radionuklide

Info

Publication number
ATE194845T1
ATE194845T1 AT95916539T AT95916539T ATE194845T1 AT E194845 T1 ATE194845 T1 AT E194845T1 AT 95916539 T AT95916539 T AT 95916539T AT 95916539 T AT95916539 T AT 95916539T AT E194845 T1 ATE194845 T1 AT E194845T1
Authority
AT
Austria
Prior art keywords
peptides
complex formers
radionuclides
derived
radionuclides derived
Prior art date
Application number
AT95916539T
Other languages
English (en)
Inventor
Alfred Pollak
Anne Goodbody
Original Assignee
Resolution Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23067872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE194845(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Resolution Pharm Inc filed Critical Resolution Pharm Inc
Application granted granted Critical
Publication of ATE194845T1 publication Critical patent/ATE194845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT95916539T 1994-07-22 1995-04-28 Von peptiden abgeleitete komplexbildner für radionuklide ATE194845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/279,155 US5662885A (en) 1994-07-22 1994-07-22 Peptide derived radionuclide chelators
PCT/CA1995/000249 WO1996003427A1 (en) 1994-07-22 1995-04-28 Peptide derived radionuclide chelators

Publications (1)

Publication Number Publication Date
ATE194845T1 true ATE194845T1 (de) 2000-08-15

Family

ID=23067872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95916539T ATE194845T1 (de) 1994-07-22 1995-04-28 Von peptiden abgeleitete komplexbildner für radionuklide

Country Status (11)

Country Link
US (3) US5662885A (de)
EP (1) EP0772628B1 (de)
JP (1) JP3753734B2 (de)
CN (1) CN1158133A (de)
AT (1) ATE194845T1 (de)
AU (1) AU700772B2 (de)
CA (1) CA2194551A1 (de)
DE (1) DE69518083T2 (de)
HU (1) HUT77137A (de)
NO (1) NO970273L (de)
WO (1) WO1996003427A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US5804158A (en) * 1995-05-31 1998-09-08 Resolution Pharmaceuticals Inc. Sequestered imaging agents
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
FR2748747B1 (fr) * 1996-05-20 1998-08-07 Centre Nat Rech Scient Particules virales recombinantes comportant un peptide ayant des proprietes de masquage et de demasquage vis-a-vis d'un mecanisme biologique
JP2001504801A (ja) * 1996-06-10 2001-04-10 ジー．ディー．サール アンド カンパニー 血栓サイトに局在化可能な放射性医薬組成物
CA2346154A1 (en) 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
EP0977579B1 (de) 1997-04-22 2009-03-11 Curator Of The University Of Missouri Konjugate aus peptiden, die liganden von gastrinrezeptoren sind
US6017511A (en) * 1997-05-30 2000-01-25 Resolution Pharmaceuticals Inc. Glycopeptide-chelator conjugates
AU8849398A (en) * 1997-08-21 1999-03-16 Resolution Pharmaceuticals Inc. Combinatorial library
US6334996B1 (en) * 1997-12-24 2002-01-01 Resolution Pharmaceuticals Inc. Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center
DE69838490T2 (de) * 1997-12-24 2008-02-07 Bracco International B.V. Peptide chelatoren die nach der koordination mit einem metall zu einem vorherrschenden einzel-stereoisomeren führen
AU3119199A (en) 1998-04-03 1999-10-25 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
CN1325405A (zh) * 1998-08-31 2001-12-05 格莱风科学公司 膜多肽的脂基质协助的化学结合和合成
JP2002536295A (ja) * 1998-12-14 2002-10-29 パラチン テクノロジーズ， インク． 金属ペプチド組合せライブラリ及びその利用法
US7320784B1 (en) * 1999-02-17 2008-01-22 Bracco Imaging S.P.A. Immobilized labeling compounds and methods
US6544279B1 (en) 2000-08-09 2003-04-08 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US8263739B2 (en) * 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
US7422733B2 (en) * 2000-11-29 2008-09-09 Bracco International B.V. Linkable sialyl Lewis X analogs
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
ES2398393T3 (es) 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
AU2003303714B2 (en) 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
ES2396368T3 (es) 2003-03-03 2013-02-21 Dyax Corporation Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
EP1700608A1 (de) 2005-03-10 2006-09-13 Schering AG Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette
EP2097111B1 (de) 2006-11-08 2015-07-15 Molecular Insight Pharmaceuticals, Inc. Heterodimere von glutaminsäure
CN101558081B (zh) 2006-12-11 2014-08-20 伯拉考成像股份公司 用于诊断和治疗应用的纤维蛋白结合肽缀合体
JP2011514160A (ja) * 2008-02-21 2011-05-06 バーナム インスティテュート フォー メディカル リサーチ Ｃ末端エレメントを有するペプチドおよびタンパク質に関する方法および組成物
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
WO2011005540A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
EP3322716B1 (de) 2015-07-15 2025-02-12 California Institute of Technology Il-17f-spezifische einfänger und verfahren zur verwendung
WO2017137477A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
EP3440101B1 (de) 2016-04-04 2021-10-06 Indi Molecular, Inc. Cd8-spezifische einfänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
EP3535278A4 (de) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Verfahren zur jodierung von biomolekülen
WO2018232345A1 (en) 2017-06-15 2018-12-20 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
WO2020097531A1 (en) 2018-11-08 2020-05-14 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US20200291391A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
US12216122B2 (en) 2019-05-20 2025-02-04 Regeneron Pharmaceuticals, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
EP3972646A4 (de) 2019-05-20 2023-06-14 Ohio State Innovation Foundation Apohämoglobin-haptoglobin-komplexe und verfahren zur verwendung davon
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
CA3227425A1 (en) 2021-07-26 2023-02-02 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
WO2025245032A1 (en) 2024-05-20 2025-11-27 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390528A (en) * 1981-11-16 1983-06-28 Research Corporation Tuftsinyl-tuftsin
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE52516T1 (de) * 1986-05-28 1990-05-15 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
US5187264A (en) * 1986-05-28 1993-02-16 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US5202109A (en) * 1988-06-10 1993-04-13 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
IT1230712B (it) * 1989-02-10 1991-10-29 Sclavo Spa Composizione per vaccini
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5248764A (en) * 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
IT1232311B (it) * 1989-09-04 1992-01-28 Sclavo Spa Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
US5175257A (en) * 1989-12-29 1992-12-29 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
US5112594A (en) * 1991-04-04 1992-05-12 Mallinckrodt Medical, Inc. Kit for preparing a technetium-99m myocardial imaging agent
DE69230525T2 (de) * 1991-02-08 2000-06-21 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
CA2127284C (en) * 1992-01-03 2002-02-05 Buck A. Rhodes Protein- and peptide-metal ion pharmaceutical applications
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
ES2114209T3 (es) * 1993-07-19 1998-05-16 Resolution Pharm Inc Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s.
US5789555A (en) * 1993-11-16 1998-08-04 Resolution Pharmaceuticals Inc. Immobilized labelling method
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US5804158A (en) * 1995-05-31 1998-09-08 Resolution Pharmaceuticals Inc. Sequestered imaging agents

Also Published As

Publication number Publication date
AU700772B2 (en) 1999-01-14
NO970273L (no) 1997-03-12
AU2301195A (en) 1996-02-22
DE69518083T2 (de) 2001-03-22
DE69518083D1 (de) 2000-08-24
US5662885A (en) 1997-09-02
CA2194551A1 (en) 1996-02-08
NO970273D0 (no) 1997-01-21
CN1158133A (zh) 1997-08-27
JP3753734B2 (ja) 2006-03-08
WO1996003427A1 (en) 1996-02-08
EP0772628B1 (de) 2000-07-19
EP0772628A1 (de) 1997-05-14
US5780006A (en) 1998-07-14
US5976495A (en) 1999-11-02
HUT77137A (hu) 1998-03-02
JPH10502931A (ja) 1998-03-17

Similar Documents

Publication Publication Date Title
ATE194845T1 (de) Von peptiden abgeleitete komplexbildner für radionuklide
DE69417426D1 (de) N2s2-chelatoren des hydrazino-typs
NO991688L (no) Administrerbare sammensetninger og fremgangsmÕter til magnetisk resonansavbildning
EA199800025A1 (ru) Стойкие реагенты для получения радиофармпрепаратов
AU7261994A (en) Hydrazino-type radionuclide chelators having an n3s configuration
EA200200530A1 (ru) Гетероциклические замещенные пиразолоны
DK0630265T3 (da) Technetium-99m mærkede peptider til afbildning af inflammation
MY128089A (en) Diagnostic imaging contrast agents with extended blood retention
DE69434729D1 (de) TECHNETIUM-99m MARKIERTE PEPTIDE ZUR DIAGNOSTISCHEN BILDERZEUGUNG VON ENTZÜNDUNGEN
IL125895A0 (en) The use of an image enhancing moiety in the preparation of bioactivated nmr or optical imaging contrat agent from a prodrug
DE69326335D1 (de) Technetium-99M-markierte peptide zur Bilderzeugung
NO975758D0 (no) Heterosykliske frie metylradikaler som bildeforbedrende milder
EP0699051A4 (de) Makromolekulares kontrastmittel zur bilderzeugung mittels magnetischer kernresonanz
CA2046654A1 (en) Radiolabeled proteins for diagnostic or therapeutic use
IL175667A (en) Imaging agent which comrises a synthetic caspase-3 inhibitor labeled with an imaging moiety, a radiopharmaceutical composition comprising the same, a kit for the preparation of said composition and a method of diagnosis based thereon
EA199800101A1 (ru) Комплекс металла с полиаминооксидами и его применение для формирования изображений при диагностике
DK204686D0 (da) Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
FI77021B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-imino-pyrrolidiner.
IL152941A0 (en) Fused heterocyclic compounds and kits and pharmaceutical compositions containing the same
ATE207763T1 (de) Liposomensuspensionen als blut-pool- kontrastmittel
KR960700762A (ko) 방사활성 동위원소에 대한 xn_14s_1x' 유형의 킬레이트화제, 그의 금속 착물, 및 그의 진단 및 치료학적 용도(chelators of type xn_1s_1x' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses)
ATE210644T1 (de) Piperidyl-4-substituierte thyrosin-derivate als szintigraphische kontrastmittel zur diagnose von thrombosen
ATE134988T1 (de) Neue vorangeordnete sechszähnige liganden verwendbar in röntgenologischen bildformenden wirkstoffen
DE60006587D1 (de) Makrozyclische liganden für metallpharmazeutika
IT1245352B (it) Mezzi di contrasto per imaging cardiaco

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee