ATE194845T1 - Von peptiden abgeleitete komplexbildner für radionuklide - Google Patents

Von peptiden abgeleitete komplexbildner für radionuklide

Info

Publication number
ATE194845T1
ATE194845T1 AT95916539T AT95916539T ATE194845T1 AT E194845 T1 ATE194845 T1 AT E194845T1 AT 95916539 T AT95916539 T AT 95916539T AT 95916539 T AT95916539 T AT 95916539T AT E194845 T1 ATE194845 T1 AT E194845T1
Authority
AT
Austria
Prior art keywords
peptides
complex formers
radionuclides
derived
radionuclides derived
Prior art date
Application number
AT95916539T
Other languages
English (en)
Inventor
Alfred Pollak
Anne Goodbody
Original Assignee
Resolution Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23067872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE194845(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Resolution Pharm Inc filed Critical Resolution Pharm Inc
Application granted granted Critical
Publication of ATE194845T1 publication Critical patent/ATE194845T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT95916539T 1994-07-22 1995-04-28 Von peptiden abgeleitete komplexbildner für radionuklide ATE194845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/279,155 US5662885A (en) 1994-07-22 1994-07-22 Peptide derived radionuclide chelators
PCT/CA1995/000249 WO1996003427A1 (en) 1994-07-22 1995-04-28 Peptide derived radionuclide chelators

Publications (1)

Publication Number Publication Date
ATE194845T1 true ATE194845T1 (de) 2000-08-15

Family

ID=23067872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95916539T ATE194845T1 (de) 1994-07-22 1995-04-28 Von peptiden abgeleitete komplexbildner für radionuklide

Country Status (11)

Country Link
US (3) US5662885A (de)
EP (1) EP0772628B1 (de)
JP (1) JP3753734B2 (de)
CN (1) CN1158133A (de)
AT (1) ATE194845T1 (de)
AU (1) AU700772B2 (de)
CA (1) CA2194551A1 (de)
DE (1) DE69518083T2 (de)
HU (1) HUT77137A (de)
NO (1) NO970273L (de)
WO (1) WO1996003427A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US5804158A (en) * 1995-05-31 1998-09-08 Resolution Pharmaceuticals Inc. Sequestered imaging agents
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
FR2748747B1 (fr) * 1996-05-20 1998-08-07 Centre Nat Rech Scient Particules virales recombinantes comportant un peptide ayant des proprietes de masquage et de demasquage vis-a-vis d'un mecanisme biologique
AU3474997A (en) * 1996-06-10 1998-01-07 G.D. Searle & Co. Radiopharmaceutical compositions capable of localizing at sites of thrombus
JP2002506424A (ja) 1997-04-22 2002-02-26 キュレイター オブ ザ ユニバーシィティ オブ ミズーリ ガストリン受容体−親和性ペプチド結合体
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US6017511A (en) * 1997-05-30 2000-01-25 Resolution Pharmaceuticals Inc. Glycopeptide-chelator conjugates
AU8849398A (en) * 1997-08-21 1999-03-16 Resolution Pharmaceuticals Inc. Combinatorial library
EP1047708B1 (de) * 1997-12-24 2007-09-26 Bracco International B.V. Peptide chelatoren die nach der koordination mit einem metall zu einem vorherrschenden einzel-stereoisomeren führen
US6334996B1 (en) * 1997-12-24 2002-01-01 Resolution Pharmaceuticals Inc. Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center
AU3119199A (en) 1998-04-03 1999-10-25 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
AU763092B2 (en) * 1998-08-31 2003-07-10 Gryphon Sciences Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
EP1141375A4 (de) * 1998-12-14 2002-06-05 Palatin Technologies Inc Kombinatorische bibliotheken von metallopeptiden und ihre anwendung
CA2362860A1 (en) * 1999-02-17 2000-08-24 Bracco International B.V. Immobilized labeling compounds and methods
US6544279B1 (en) 2000-08-09 2003-04-08 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
EP2279757A3 (de) 2000-06-02 2011-08-03 Bracco Suisse SA Arzneimitteln zum Targeting von Endothelzellen
US8263739B2 (en) * 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
CA2429781C (en) * 2000-11-29 2011-01-11 Bracco International B.V. Linkable sialyl lewis x analogs
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
AU2003303714B2 (en) 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
DK1737889T3 (da) 2004-10-19 2011-01-03 Lonza Ag Fremgangsmåde til fastfase-peptidsyntese
EP1700608A1 (de) 2005-03-10 2006-09-13 Schering AG Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette
EP2097111B1 (de) 2006-11-08 2015-07-15 Molecular Insight Pharmaceuticals, Inc. Heterodimere von glutaminsäure
JP5345945B2 (ja) 2006-12-11 2013-11-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニ フィブリン結合ペプチドおよびそのコンジュゲート
US11260133B2 (en) * 2008-02-21 2022-03-01 Sanford-Burnham Medical Research Institute Methods and compositions related to peptides and proteins with C-terminal elements
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
BRPI1015424B1 (pt) 2009-06-22 2022-01-18 Burnham Institute For Medical Research Composição compreendendo um elemento cendr e uma co-composição e composição para uso no reforço da internalização, penetração, ou ambas, de uma co-composição
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en) 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質
US20170319722A1 (en) 2016-04-04 2017-11-09 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
WO2018064597A1 (en) 2016-09-29 2018-04-05 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
WO2018085375A1 (en) 2016-11-01 2018-05-11 Ohio State Innovation Foundation Methods for the iodination of biomolecules
WO2018232345A1 (en) 2017-06-15 2018-12-20 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
WO2020097531A1 (en) 2018-11-08 2020-05-14 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US20200291391A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
US20220218834A1 (en) 2019-05-20 2022-07-14 Ohio State Innovation Foundation Apohemoglobin-haptoglobin complexes and methods of using thereof
US12216122B2 (en) 2019-05-20 2025-02-04 Regeneron Pharmaceuticals, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
CA3227425A1 (en) 2021-07-26 2023-02-02 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
WO2025245032A1 (en) 2024-05-20 2025-11-27 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390528A (en) * 1981-11-16 1983-06-28 Research Corporation Tuftsinyl-tuftsin
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5187264A (en) * 1986-05-28 1993-02-16 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
ATE52516T1 (de) * 1986-05-28 1990-05-15 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US5202109A (en) * 1988-06-10 1993-04-13 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
IT1230712B (it) * 1989-02-10 1991-10-29 Sclavo Spa Composizione per vaccini
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5248764A (en) * 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
IT1232311B (it) * 1989-09-04 1992-01-28 Sclavo Spa Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
US5175257A (en) * 1989-12-29 1992-12-29 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
US5112594A (en) * 1991-04-04 1992-05-12 Mallinckrodt Medical, Inc. Kit for preparing a technetium-99m myocardial imaging agent
EP0570493B1 (de) * 1991-02-08 2000-01-05 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
AU683833B2 (en) * 1992-01-03 1997-11-27 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
EP0710228B1 (de) * 1993-07-19 1998-01-21 Resolution Pharmaceuticals Inc. Hydrazine mit einer n3s konfiguration als radionukleide chelatoren
EP0730472B1 (de) * 1993-11-16 2006-08-02 Bracco International B.V. Immobilisiertes markierungsverfahren
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US5804158A (en) * 1995-05-31 1998-09-08 Resolution Pharmaceuticals Inc. Sequestered imaging agents

Also Published As

Publication number Publication date
EP0772628A1 (de) 1997-05-14
DE69518083T2 (de) 2001-03-22
CN1158133A (zh) 1997-08-27
NO970273D0 (no) 1997-01-21
AU700772B2 (en) 1999-01-14
US5780006A (en) 1998-07-14
US5662885A (en) 1997-09-02
WO1996003427A1 (en) 1996-02-08
HUT77137A (hu) 1998-03-02
DE69518083D1 (de) 2000-08-24
EP0772628B1 (de) 2000-07-19
JPH10502931A (ja) 1998-03-17
CA2194551A1 (en) 1996-02-08
JP3753734B2 (ja) 2006-03-08
US5976495A (en) 1999-11-02
NO970273L (no) 1997-03-12
AU2301195A (en) 1996-02-22

Similar Documents

Publication Publication Date Title
ATE194845T1 (de) Von peptiden abgeleitete komplexbildner für radionuklide
GR3026658T3 (en) Hydrazino-type radionuclide chelators having an n 3?s configuration
DE69417426D1 (de) N2s2-chelatoren des hydrazino-typs
NO991688D0 (no) Administrerbare sammensetninger og fremgangsmÕter til magnetisk resonansavbildning
EA199800025A1 (ru) Стойкие реагенты для получения радиофармпрепаратов
EA200200530A1 (ru) Гетероциклические замещенные пиразолоны
DK0630265T3 (da) Technetium-99m mærkede peptider til afbildning af inflammation
DK0684843T3 (da) Technetium-99m-mærkede peptider til diagnostisk billeddannelse af inflammation
MY128089A (en) Diagnostic imaging contrast agents with extended blood retention
IL125895A0 (en) The use of an image enhancing moiety in the preparation of bioactivated nmr or optical imaging contrat agent from a prodrug
NO975758D0 (no) Heterosykliske frie metylradikaler som bildeforbedrende milder
CA2046654A1 (en) Radiolabeled proteins for diagnostic or therapeutic use
ATE296312T1 (de) Metalkomplexbildner
NZ315505A (en) Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
GR861169B (en) Method for preparing n-(quinolyl) glycinamide derivatives and their application as psychotropes
EA199800101A1 (ru) Комплекс металла с полиаминооксидами и его применение для формирования изображений при диагностике
FI77021B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-imino-pyrrolidiner.
IL152941A0 (en) Fused heterocyclic compounds and kits and pharmaceutical compositions containing the same
ATE207763T1 (de) Liposomensuspensionen als blut-pool- kontrastmittel
KR960700762A (ko) 방사활성 동위원소에 대한 xn_14s_1x' 유형의 킬레이트화제, 그의 금속 착물, 및 그의 진단 및 치료학적 용도(chelators of type xn_1s_1x' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses)
ATE210644T1 (de) Piperidyl-4-substituierte thyrosin-derivate als szintigraphische kontrastmittel zur diagnose von thrombosen
DE60006587D1 (de) Makrozyclische liganden für metallpharmazeutika
IL86722A0 (en) Guanidine-related compounds comprising a tetraphenylborate ion,their preparation and their use
IT1245352B (it) Mezzi di contrasto per imaging cardiaco
MX9605026A (es) Analisis de imagen de diagnostico con complejos de metal.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee