ATE195324T1 - Polysaccharidderivat und wirkstoffträger - Google Patents

Polysaccharidderivat und wirkstoffträger

Info

Publication number
ATE195324T1
ATE195324T1 AT94907702T AT94907702T ATE195324T1 AT E195324 T1 ATE195324 T1 AT E195324T1 AT 94907702 T AT94907702 T AT 94907702T AT 94907702 T AT94907702 T AT 94907702T AT E195324 T1 ATE195324 T1 AT E195324T1
Authority
AT
Austria
Prior art keywords
derivative
polysaccharide
drug
carboxyl groups
tumor
Prior art date
Application number
AT94907702T
Other languages
English (en)
Inventor
Hideo Nogusa
Hiroshi Hamana
Toshiro Yano
Masahiro Kajiki
Keiji Yamamoto
Satoshi Okuno
Shuichi Sugawara
Nobukazu Kashima
Kazuhiro Inoue
Original Assignee
Drug Delivery System Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery System Inst Ltd filed Critical Drug Delivery System Inst Ltd
Application granted granted Critical
Publication of ATE195324T1 publication Critical patent/ATE195324T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT94907702T 1993-02-26 1994-02-28 Polysaccharidderivat und wirkstoffträger ATE195324T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3863593 1993-02-26
PCT/JP1994/000322 WO1994019376A1 (fr) 1993-02-26 1994-02-28 Derive de polysaccharide et vehicule de medicament

Publications (1)

Publication Number Publication Date
ATE195324T1 true ATE195324T1 (de) 2000-08-15

Family

ID=12530705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94907702T ATE195324T1 (de) 1993-02-26 1994-02-28 Polysaccharidderivat und wirkstoffträger

Country Status (11)

Country Link
US (1) US5688931A (de)
EP (1) EP0640622B1 (de)
JP (1) JP2610792B2 (de)
AT (1) ATE195324T1 (de)
CA (1) CA2134348C (de)
DE (1) DE69425464T2 (de)
DK (1) DK0640622T3 (de)
ES (1) ES2149867T3 (de)
GR (1) GR3034416T3 (de)
PT (1) PT640622E (de)
WO (1) WO1994019376A1 (de)

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JP3332735B2 (ja) 1995-08-02 2002-10-07 田辺製薬株式会社 カンプトテシン誘導体
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
WO1997029777A1 (en) * 1996-02-13 1997-08-21 Dainippon Pharmaceutical Co., Ltd. Drug delivery system using galactoxyloglucan
DE69734709D1 (de) 1996-04-15 2005-12-29 Asahi Chemical Ind Arzneimittelkomplexe enthaltend taxan-verbindungen oder steroiden
TW409058B (en) * 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
DE19640207A1 (de) * 1996-09-30 1998-04-02 Bayer Ag Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung)
WO1998014459A1 (de) * 1996-09-30 1998-04-09 Bayer Aktiengesellschaft Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung)
JP3322203B2 (ja) 1997-01-31 2002-09-09 田辺製薬株式会社 医薬組成物
ID23424A (id) * 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
JP2001518556A (ja) * 1997-10-03 2001-10-16 ガレニカ ファーマシューティカルズ， インコーポレイテッド イミン形成ポリサッカライド、その調製、ならびにアジュバントおよび免疫刺激剤としてのその使用
WO1999061061A1 (fr) * 1998-05-22 1999-12-02 Daiichi Pharmaceutical Co., Ltd. Composites medicamenteux
MXPA01004239A (es) * 1998-10-30 2002-06-04 Daiichi Seiyaku Co Compuesto dds y metodo para la medicion del mismo.
JP2003518000A (ja) * 1998-12-11 2003-06-03 コールター ファーマシューティカル，インコーポレイティド プロドラッグ化合物およびその調製方法
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
CN1133654C (zh) * 1999-08-05 2004-01-07 武汉大学 灵芝α-(1→3)-D-葡聚糖羧甲基化衍生物及其用途和制备方法
JP2001081103A (ja) * 1999-09-13 2001-03-27 Denki Kagaku Kogyo Kk ヒアルロン酸結合薬剤
BR0112287A (pt) * 2000-06-29 2003-05-06 Daiichi Seiyaku Co Composto dds e seu método de preparação
US20030092608A1 (en) * 2001-08-21 2003-05-15 Takayuki Kawaguchi Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
TWI313609B (en) * 2001-08-21 2009-08-21 Mitsubishi Tanabe Pharma Corp Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
AU2003216288B2 (en) 2002-02-13 2009-09-24 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
GB2386899B (en) * 2002-03-25 2005-10-26 Johnson & Johnson Medical Ltd Wound dressings comprising chemically modified polysaccharides
CA2500661A1 (en) 2002-10-01 2004-04-15 Chiron Corporation Anti-cancer and anti-infectious disease compositions and methods for using same
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
JP4927536B2 (ja) * 2004-03-05 2012-05-09 電気化学工業株式会社 ヒアルロン酸−メトトレキサート結合体
JP5001645B2 (ja) * 2004-04-02 2012-08-15 電気化学工業株式会社 ヒアルロン酸−メトトレキサート結合体
WO2006028110A1 (ja) 2004-09-07 2006-03-16 Chugai Seiyaku Kabushiki Kaisha 水溶性ヒアルロン酸修飾物の製造方法
MX2007013725A (es) 2005-05-05 2008-04-09 Sensient Flavors Inc Produccion de beta-glucanos y mananos.
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
FR2914305B1 (fr) * 2007-03-29 2009-07-03 Proteins & Peptides Man Dextran fonctionnalise par des amino-acides hydrophobes.
US20120041079A1 (en) * 2006-09-26 2012-02-16 Adocia Dextran functionalized by hydrophobic amino acids
CN1973902B (zh) * 2006-12-12 2010-11-10 东北师范大学 以人参多糖为载体的抗肿瘤药物阿霉素复合物及制备方法
CN101225094A (zh) * 2007-01-18 2008-07-23 天津和美生物技术有限公司 具有抗癌活性的蒽醌四环类化合物
US20090163936A1 (en) * 2007-12-21 2009-06-25 Chunlin Yang Coated Tissue Engineering Scaffold
WO2010042815A2 (en) * 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
WO2010102065A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2011060250A1 (en) * 2009-11-13 2011-05-19 Bend Research, Inc. Cationic dextran polymer derivatives
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
PL2651975T3 (pl) 2010-12-14 2018-04-30 Dso Nat Laboratories Ludzkie przeciwciało monoklonalne o swoistości względem białka e wirusa denga serotypu 1 i jego zastosowania
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
US11135316B2 (en) 2014-01-31 2021-10-05 Washington University Imaging and treatment of pathophysiologic conditions by Cerenkov radiation
US9974870B2 (en) 2014-06-09 2018-05-22 Washington University Compositions and methods for treatment and imaging using nanoparticles
CA2956161A1 (en) 2014-07-23 2016-01-28 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)
WO2016014939A1 (en) 2014-07-24 2016-01-28 Washington University Compositions targeting radiation-induced molecules and methods of use thereof
JP6613300B2 (ja) * 2015-03-31 2019-11-27 キユーピー株式会社 ヒアルロン酸誘導体およびその製造方法、ならびにヒアルロン酸誘導体を含む化粧料、食品組成物および医薬組成物
JP2018531625A (ja) 2015-09-11 2018-11-01 ナセント バイオテック インコーポレイテッド 脳への向上した薬物送達の方法
US11788091B2 (en) 2019-08-21 2023-10-17 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
US12319967B2 (en) 2019-08-21 2025-06-03 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
WO2021155355A1 (en) * 2020-01-31 2021-08-05 The University Of North Carolina At Chapel Hill Nanomaterials for targeted treatment of pulmonary tissue
EP4232605A4 (de) 2020-11-11 2024-09-25 University of Virginia Patent Foundation Verfahren und zusammensetzungen zur diagnose und behandlung von prostatakrebs auf basis von langer nichtcodierender rna, die das lck-gen überlappen, das prostatakrebszellwachstum reguliert

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JPS59220197A (ja) * 1983-05-30 1984-12-11 Snow Brand Milk Prod Co Ltd 新規な含窒素多糖体およびその製造方法
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
JPH0742324B2 (ja) * 1990-08-17 1995-05-10 株式会社デイ・デイ・エス研究所 Ｎ―アセチルカルボキシメチルキトサン誘導体及びその製法
EP0506976B1 (de) * 1990-10-18 1997-04-09 Shiseido Company Limited Kombination von hyaluronsäure mit einem medizinischen bestandteil, und seine herstellung
DK0526649T3 (da) * 1991-02-21 1998-10-07 Drug Delivery System Inst Ltd Carboxymethylmannoglucan og derivater deraf.

Also Published As

Publication number Publication date
CA2134348A1 (en) 1994-08-27
WO1994019376A1 (fr) 1994-09-01
DK0640622T3 (da) 2000-10-23
DE69425464D1 (de) 2000-09-14
CA2134348C (en) 2007-01-02
EP0640622B1 (de) 2000-08-09
JP2610792B2 (ja) 1997-05-14
US5688931A (en) 1997-11-18
ES2149867T3 (es) 2000-11-16
GR3034416T3 (en) 2000-12-29
DE69425464T2 (de) 2001-05-23
EP0640622A4 (de) 1996-07-24
EP0640622A1 (de) 1995-03-01
PT640622E (pt) 2000-11-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee