ATE195324T1 - Polysaccharidderivat und wirkstoffträger - Google Patents
Polysaccharidderivat und wirkstoffträgerInfo
- Publication number
- ATE195324T1 ATE195324T1 AT94907702T AT94907702T ATE195324T1 AT E195324 T1 ATE195324 T1 AT E195324T1 AT 94907702 T AT94907702 T AT 94907702T AT 94907702 T AT94907702 T AT 94907702T AT E195324 T1 ATE195324 T1 AT E195324T1
- Authority
- AT
- Austria
- Prior art keywords
- derivative
- polysaccharide
- drug
- carboxyl groups
- tumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3863593 | 1993-02-26 | ||
| PCT/JP1994/000322 WO1994019376A1 (fr) | 1993-02-26 | 1994-02-28 | Derive de polysaccharide et vehicule de medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195324T1 true ATE195324T1 (de) | 2000-08-15 |
Family
ID=12530705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94907702T ATE195324T1 (de) | 1993-02-26 | 1994-02-28 | Polysaccharidderivat und wirkstoffträger |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5688931A (de) |
| EP (1) | EP0640622B1 (de) |
| JP (1) | JP2610792B2 (de) |
| AT (1) | ATE195324T1 (de) |
| CA (1) | CA2134348C (de) |
| DE (1) | DE69425464T2 (de) |
| DK (1) | DK0640622T3 (de) |
| ES (1) | ES2149867T3 (de) |
| GR (1) | GR3034416T3 (de) |
| PT (1) | PT640622E (de) |
| WO (1) | WO1994019376A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017901A (en) * | 1995-05-10 | 2000-01-25 | Fidia Advanced Bioplymers S.R.L. | Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions |
| JP3332735B2 (ja) | 1995-08-02 | 2002-10-07 | 田辺製薬株式会社 | カンプトテシン誘導体 |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| JP4259613B2 (ja) * | 1996-02-13 | 2009-04-30 | 大日本住友製薬株式会社 | ガラクトキシログルカンを用いるドラッグ・デリバリー・システム |
| WO1997038727A1 (en) * | 1996-04-15 | 1997-10-23 | Asahi Kasei Kogyo Kabushiki Kaisha | Medicament composite |
| TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) * | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| DE19640207A1 (de) * | 1996-09-30 | 1998-04-02 | Bayer Ag | Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung) |
| CA2267328A1 (en) * | 1996-09-30 | 1998-04-09 | Bayer Aktiengesellschaft | Glycoconjugates from modified camptothecin derivates (20-o-linkage) |
| JP3322203B2 (ja) | 1997-01-31 | 2002-09-09 | 田辺製薬株式会社 | 医薬組成物 |
| ID23424A (id) * | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
| DE69830326T2 (de) * | 1997-10-03 | 2006-02-02 | Galenica Pharmaceuticals, Inc. | Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel |
| EA003398B1 (ru) * | 1998-05-22 | 2003-04-24 | Дайити Фармасьютикал Ко., Лтд. | Лекарственный комплекс c полимерным носителем |
| CN1191093C (zh) * | 1998-10-30 | 2005-03-02 | 第一制药株式会社 | Dds化合物及其测定方法 |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| AU773420B2 (en) * | 1998-12-11 | 2004-05-27 | Medarex, Inc. | Prodrug compounds and process for preparation thereof |
| CN1133654C (zh) * | 1999-08-05 | 2004-01-07 | 武汉大学 | 灵芝α-(1→3)-D-葡聚糖羧甲基化衍生物及其用途和制备方法 |
| JP2001081103A (ja) * | 1999-09-13 | 2001-03-27 | Denki Kagaku Kogyo Kk | ヒアルロン酸結合薬剤 |
| US20030166513A1 (en) * | 2000-06-29 | 2003-09-04 | Akihiro Imura | Dds compound and process for the preparation thereof |
| TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
| US20030216315A1 (en) | 2002-02-13 | 2003-11-20 | Duke University | Modulation of immune response by non-peptide binding stress response polypeptides |
| GB2386899B (en) * | 2002-03-25 | 2005-10-26 | Johnson & Johnson Medical Ltd | Wound dressings comprising chemically modified polysaccharides |
| CA2500661A1 (en) * | 2002-10-01 | 2004-04-15 | Chiron Corporation | Anti-cancer and anti-infectious disease compositions and methods for using same |
| ITPD20020271A1 (it) * | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
| CN1946743B (zh) * | 2004-03-05 | 2010-06-02 | 电气化学工业株式会社 | 透明质酸/甲氨蝶呤化合物 |
| US7807675B2 (en) * | 2004-04-02 | 2010-10-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid-methotrexate conjugate |
| US8143391B2 (en) | 2004-09-07 | 2012-03-27 | Chugai Seiyaku Kabushiki Kaisha | Process for producing water-soluble hyaluronic acid modification |
| MX2007013725A (es) | 2005-05-05 | 2008-04-09 | Sensient Flavors Inc | Produccion de beta-glucanos y mananos. |
| ITPD20050242A1 (it) | 2005-08-03 | 2007-02-04 | Fidia Farmaceutici | Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico |
| FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
| US20120041079A1 (en) * | 2006-09-26 | 2012-02-16 | Adocia | Dextran functionalized by hydrophobic amino acids |
| CN1973902B (zh) * | 2006-12-12 | 2010-11-10 | 东北师范大学 | 以人参多糖为载体的抗肿瘤药物阿霉素复合物及制备方法 |
| CN101225094A (zh) * | 2007-01-18 | 2008-07-23 | 天津和美生物技术有限公司 | 具有抗癌活性的蒽醌四环类化合物 |
| US20090163936A1 (en) * | 2007-12-21 | 2009-06-25 | Chunlin Yang | Coated Tissue Engineering Scaffold |
| WO2010042815A2 (en) * | 2008-10-09 | 2010-04-15 | Duke University | Vhh antibody fragments for use in the detection and treatment of cancer |
| US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
| US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| WO2011060250A1 (en) * | 2009-11-13 | 2011-05-19 | Bend Research, Inc. | Cationic dextran polymer derivatives |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
| US9376486B2 (en) | 2010-12-14 | 2016-06-28 | National University Of Singapore | Human monoclonal antibody with specificity for Dengue virus serotype 1 E protein and uses thereof |
| US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
| WO2015183346A2 (en) | 2014-01-31 | 2015-12-03 | Washington University | Imaging and treatment of pathophysiologic conditions by cerenkov radiation |
| US9974870B2 (en) | 2014-06-09 | 2018-05-22 | Washington University | Compositions and methods for treatment and imaging using nanoparticles |
| CA2956161A1 (en) | 2014-07-23 | 2016-01-28 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72) |
| EP3172222A4 (de) | 2014-07-24 | 2018-03-21 | Washington University | Gegen strahlungsinduzierte moleküle gerichtete zusammensetzungen und verfahren zur verwendung davon |
| US20180086852A1 (en) * | 2015-03-31 | 2018-03-29 | Kewpie Corporation | Hyaluronic Acid Derivative and Manufacturing Method Therefor and Cosmetics, Food Composition, and Pharmaceutical Composition Containing Hyaluronic Acid Derivative |
| EP3347380B1 (de) | 2015-09-11 | 2024-09-25 | Nascent Biotech, Inc. | Verbesserte abgabe von medikamenten an das gehirn |
| US12319967B2 (en) | 2019-08-21 | 2025-06-03 | University Of Virginia Patent Foundation | Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth |
| US11788091B2 (en) | 2019-08-21 | 2023-10-17 | University Of Virginia Patent Foundation | Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth |
| WO2021155355A1 (en) * | 2020-01-31 | 2021-08-05 | The University Of North Carolina At Chapel Hill | Nanomaterials for targeted treatment of pulmonary tissue |
| EP4232605A4 (de) | 2020-11-11 | 2024-09-25 | University of Virginia Patent Foundation | Verfahren und zusammensetzungen zur diagnose und behandlung von prostatakrebs auf basis von langer nichtcodierender rna, die das lck-gen überlappen, das prostatakrebszellwachstum reguliert |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59220197A (ja) * | 1983-05-30 | 1984-12-11 | Snow Brand Milk Prod Co Ltd | 新規な含窒素多糖体およびその製造方法 |
| JP2517760B2 (ja) * | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
| US5463022A (en) * | 1990-08-17 | 1995-10-31 | Drug Delivery System Institute, Ltd. | N-acetylcarboxymethylchitosan derivatives and process for preparation thereof |
| WO1992006714A1 (fr) * | 1990-10-18 | 1992-04-30 | Shiseido Co., Ltd. | Combinaison d'acide hyaluronique avec un ingredient medicinal et sa production |
| JPH0784481B2 (ja) * | 1991-02-21 | 1995-09-13 | 株式会社デイ・デイ・エス研究所 | カルボキシメチルマンノグルカン及びその誘導体 |
-
1994
- 1994-02-28 ES ES94907702T patent/ES2149867T3/es not_active Expired - Lifetime
- 1994-02-28 EP EP94907702A patent/EP0640622B1/de not_active Expired - Lifetime
- 1994-02-28 US US08/325,296 patent/US5688931A/en not_active Expired - Lifetime
- 1994-02-28 DE DE69425464T patent/DE69425464T2/de not_active Expired - Lifetime
- 1994-02-28 JP JP6515876A patent/JP2610792B2/ja not_active Expired - Fee Related
- 1994-02-28 PT PT94907702T patent/PT640622E/pt unknown
- 1994-02-28 CA CA002134348A patent/CA2134348C/en not_active Expired - Fee Related
- 1994-02-28 AT AT94907702T patent/ATE195324T1/de not_active IP Right Cessation
- 1994-02-28 WO PCT/JP1994/000322 patent/WO1994019376A1/ja not_active Ceased
- 1994-02-28 DK DK94907702T patent/DK0640622T3/da active
-
2000
- 2000-09-18 GR GR20000402104T patent/GR3034416T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0640622A1 (de) | 1995-03-01 |
| DK0640622T3 (da) | 2000-10-23 |
| PT640622E (pt) | 2000-11-30 |
| DE69425464D1 (de) | 2000-09-14 |
| EP0640622A4 (de) | 1996-07-24 |
| GR3034416T3 (en) | 2000-12-29 |
| ES2149867T3 (es) | 2000-11-16 |
| DE69425464T2 (de) | 2001-05-23 |
| CA2134348A1 (en) | 1994-08-27 |
| CA2134348C (en) | 2007-01-02 |
| JP2610792B2 (ja) | 1997-05-14 |
| EP0640622B1 (de) | 2000-08-09 |
| WO1994019376A1 (fr) | 1994-09-01 |
| US5688931A (en) | 1997-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |