EE03224B1 - Prolongeeritud toimega süstesuspensioonid ja nende valmistamismeetod - Google Patents

Prolongeeritud toimega süstesuspensioonid ja nende valmistamismeetod

Info

Publication number: EE03224B1
Authority: EE; Estonia
Prior art keywords: prolonged; injection; preparation; release suspension; suspension
Prior art date: 1993-12-09

Application number

EE9600061A

Other languages

English (en)

Inventor

Engel J�rgen

Klokkers-Bethke Karin

Reissmann Thomas

Hilgard Peter

Original Assignee

Asta Medica Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-09

Filing date

1994-11-25

Publication date

1999-10-15

1994-11-25 Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft

1996-06-10 Priority claimed from US08/661,017 external-priority patent/US5773032A/en

1999-10-15 Publication of EE03224B1 publication Critical patent/EE03224B1/et

Links

238000002347 injection Methods 0.000 title 1
239000007924 injection Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
230000002035 prolonged effect Effects 0.000 title 1
239000000725 suspension Substances 0.000 title 1
UCANQOXFIYWYIX-IDEADWEOSA-N (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid Chemical compound OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O UCANQOXFIYWYIX-IDEADWEOSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A61K38/105—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EE9600061A 1993-12-09 1994-11-25 Prolongeeritud toimega süstesuspensioonid ja nende valmistamismeetod EE03224B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4342092A DE4342092B4 (de)	1993-12-09	1993-12-09	Langwirkende Injektionssuspension und Verfahren zur Herstellung
PCT/EP1994/003904 WO1995015767A1 (en)	1993-12-09	1994-11-25	Long-acting injection suspensions and a process for their preparation
US08/661,017 US5773032A (en)	1993-12-09	1996-06-10	Long-acting injection suspensions and a process for their preparation

Publications (1)

Publication Number	Publication Date
EE03224B1 true EE03224B1 (et)	1999-10-15

Family

ID=25931926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600061A EE03224B1 (et)	1993-12-09	1994-11-25	Prolongeeritud toimega süstesuspensioonid ja nende valmistamismeetod

Country Status (26)

Country	Link
EP (1)	EP0732934B1 (et)
JP (1)	JPH09509145A (et)
CN (2)	CN1136916C (et)
AT (1)	ATE310530T1 (et)
AU (1)	AU677748B2 (et)
BR (1)	BR9408272A (et)
CZ (1)	CZ291025B6 (et)
DE (1)	DE4342092B4 (et)
DK (1)	DK0732934T3 (et)
EE (1)	EE03224B1 (et)
EG (1)	EG20787A (et)
ES (1)	ES2251715T3 (et)
FI (1)	FI116121B (et)
HR (1)	HRP940978B1 (et)
HU (1)	HU217081B (et)
IL (1)	IL111928A (et)
LV (1)	LV11596B (et)
NO (1)	NO318984B1 (et)
NZ (1)	NZ277239A (et)
PL (1)	PL186929B1 (et)
RO (1)	RO119343B1 (et)
RS (1)	RS49511B (et)
RU (1)	RU2152222C1 (et)
SK (2)	SK284981B6 (et)
WO (1)	WO1995015767A1 (et)
ZA (1)	ZA949798B (et)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en) *	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
DE69434553T2 (de) *	1993-12-09	2006-08-10	Zentaris Gmbh	Lang wirkende injektionssuspensionen von lhrh-analogen und ein verfahren für ihre herstellung
AU5678398A (en) *	1997-01-29	1998-08-18	Takeda Chemical Industries Ltd.	Sustained-release microspheres, their production and use
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
WO2002047722A1 (en) *	2000-12-15	2002-06-20	Takeda Chemical Industries, Ltd.	Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
TWI332407B (en)	2001-06-29	2010-11-01	Takeda Chemical Industries Ltd	Controlled release composition and method of producting the same
US7098305B2 (en) *	2001-09-06	2006-08-29	Ardana Bioscience Limited	Sustained release of microcrystalline peptide suspensions
EP1674082A1 (de)	2004-12-22	2006-06-28	Zentaris GmbH	Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
TWI481424B (zh)	2006-12-18	2015-04-21	Takeda Pharmaceutical	緩釋性組成物及其製法
US9314509B2 (en)	2009-11-16	2016-04-19	Ipsen Pharma S.A.S.	Pharmaceutical compositions of melanocortin receptor ligands
CN102504018A (zh) *	2011-10-28	2012-06-20	沈阳药科大学	可持续释放的蜂毒肽帕莫酸盐及其制剂
WO2017167180A1 (zh) *	2016-03-29	2017-10-05	上海华汇拓医药科技有限公司	沃替西汀的帕莫酸盐及其晶型
CN108969478A (zh) *	2018-08-29	2018-12-11	江南大学	一种美金刚难溶盐缓释注射剂及其制备方法
CN110003195B (zh) *	2019-05-21	2020-05-26	湖北中医药大学	鲁拉西酮晶体及其制备方法和在注射给药系统中的应用
TWI908864B (zh) *	2020-08-26	2025-12-21	大陸商上海雲晟研新生物科技有限公司	卡利拉嗪藥物組合物、製備方法及應用
CN112569340A (zh) *	2020-12-31	2021-03-30	苏州素仕生物科技有限公司	一种无菌布舍瑞林注射液及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3852422A (en) *	1971-06-26	1974-12-03	Serono Ist Farm	Long-active gonadotropins
NZ181036A (en) *	1975-06-12	1978-12-18	A Schally	Luteinising hormone releasing hormone analogues and intermediates therefor
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
FR2647677B1 (fr) *	1989-05-31	1991-09-27	Roussel Uclaf	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
CH679207A5 (et) *	1989-07-28	1992-01-15	Debiopharm Sa
CH683149A5 (fr) *	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Procédé pour la préparation de microsphères en matériau polymère biodégradable.

1993
- 1993-12-09 DE DE4342092A patent/DE4342092B4/de not_active Expired - Fee Related
1994
- 1994-11-25 RO RO96-01143A patent/RO119343B1/ro unknown
- 1994-11-25 EP EP95903282A patent/EP0732934B1/en not_active Expired - Lifetime
- 1994-11-25 EE EE9600061A patent/EE03224B1/et not_active IP Right Cessation
- 1994-11-25 RU RU96115021/14A patent/RU2152222C1/ru not_active IP Right Cessation
- 1994-11-25 DK DK95903282T patent/DK0732934T3/da active
- 1994-11-25 CN CNB941944050A patent/CN1136916C/zh not_active Expired - Fee Related
- 1994-11-25 CN CNB021593949A patent/CN1248732C/zh not_active Expired - Fee Related
- 1994-11-25 BR BR9408272A patent/BR9408272A/pt not_active Application Discontinuation
- 1994-11-25 WO PCT/EP1994/003904 patent/WO1995015767A1/en not_active Ceased
- 1994-11-25 JP JP7515921A patent/JPH09509145A/ja not_active Ceased
- 1994-11-25 AT AT95903282T patent/ATE310530T1/de not_active IP Right Cessation
- 1994-11-25 AU AU12199/95A patent/AU677748B2/en not_active Ceased
- 1994-11-25 SK SK5090-2005A patent/SK284981B6/sk not_active IP Right Cessation
- 1994-11-25 HU HU9601584A patent/HU217081B/hu not_active IP Right Cessation
- 1994-11-25 SK SK667-96A patent/SK284980B6/sk not_active IP Right Cessation
- 1994-11-25 CZ CZ19961420A patent/CZ291025B6/cs not_active IP Right Cessation
- 1994-11-25 NZ NZ277239A patent/NZ277239A/en not_active IP Right Cessation
- 1994-11-25 ES ES95903282T patent/ES2251715T3/es not_active Expired - Lifetime
- 1994-11-25 PL PL94314913A patent/PL186929B1/pl not_active IP Right Cessation
- 1994-12-07 EG EG77194A patent/EG20787A/xx active
- 1994-12-08 HR HR940978A patent/HRP940978B1/xx not_active IP Right Cessation
- 1994-12-08 ZA ZA949798A patent/ZA949798B/xx unknown
- 1994-12-08 RS YU72194A patent/RS49511B/sr unknown
- 1994-12-08 IL IL11192894A patent/IL111928A/xx not_active IP Right Cessation
1996
- 1996-05-09 NO NO19961877A patent/NO318984B1/no not_active IP Right Cessation
- 1996-06-06 FI FI962354A patent/FI116121B/fi not_active IP Right Cessation
- 1996-07-09 LV LVP-96-226A patent/LV11596B/en unknown

Also Published As

Publication number	Publication date
ATE310530T1 (de)	2005-12-15
CN1136779A (zh)	1996-11-27
NO961877L (no)	1996-05-09
PL186929B1 (pl)	2004-04-30
DE4342092B4 (de)	2007-01-11
HRP940978B1 (en)	2006-08-31
JPH09509145A (ja)	1997-09-16
NO318984B1 (no)	2005-05-30
SK66796A3 (en)	1997-08-06
WO1995015767A1 (en)	1995-06-15
RS49511B (sr)	2006-10-27
AU1219995A (en)	1995-06-27
DK0732934T3 (da)	2006-03-27
FI962354A0 (fi)	1996-06-06
HU217081B (hu)	1999-11-29
PL314913A1 (en)	1996-09-30
BR9408272A (pt)	1996-12-17
DE4342092A1 (de)	1995-06-14
AU677748B2 (en)	1997-05-01
CN1494919A (zh)	2004-05-12
NO961877D0 (no)	1996-05-09
RO119343B1 (ro)	2004-08-30
YU72194A (sh)	1997-03-07
HU9601584D0 (en)	1996-08-28
CN1248732C (zh)	2006-04-05
HK1063746A1 (en)	2005-01-14
LV11596A (lv)	1996-12-20
LV11596B (en)	1997-06-20
IL111928A (en)	1999-11-30
RU2152222C1 (ru)	2000-07-10
FI962354L (fi)	1996-06-06
IL111928A0 (en)	1995-03-15
CZ142096A3 (en)	1996-12-11
CN1136916C (zh)	2004-02-04
FI116121B (fi)	2005-09-30
NZ277239A (en)	1997-03-24
HRP940978A2 (en)	1997-02-28
EP0732934A1 (en)	1996-09-25
ZA949798B (en)	1995-08-18
SK284980B6 (sk)	2006-03-02
ES2251715T3 (es)	2006-05-01
EP0732934B1 (en)	2005-11-23
SK284981B6 (sk)	2006-03-02
EG20787A (en)	2000-02-29
HUT75712A (en)	1997-05-28
CZ291025B6 (cs)	2002-12-11

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-04-15	HC1A	Change of owner name
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2006-10-16	HE1A	Change of address
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20101125

Publication	Publication Date	Title
EE03224B1 (et)	1999-10-15	Prolongeeritud toimega süstesuspensioonid ja nende valmistamismeetod
FI971776A0 (fi)	1997-04-25	Yhdisteet ja koostumukset aktiivisten aineiden antamiseksi
MX9705954A (es)	1998-02-28	Formulaciones y metodos para reducir irritacion de la piel.
DE69740096D1 (de)	2011-02-17	Pharmazeutische Zusammensetzung mit einem Exendin-4-Peptid
ATE203411T1 (de)	2001-08-15	Lagerstabile wässrige pharmazeutische zubereitungen von g-csf
PL325825A1 (en)	1998-08-03	Microemulsion for use as a carrier for administering active compounds
EP0693924A4 (en)	1997-08-06	METHODS OF ADMINISTRATION -i (IN VIVO) OF BIOLOGICAL SUBSTANCES AND COMPOSITIONS USED IN SUCH METHODS
DK0721343T3 (da)	2003-02-17	Farmaceutiske formuleringer omfattende en nervevækstfaktor
ZA982155B (en)	1998-12-01	Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
MXPA02007931A (es)	2004-10-15	Analogos de nucleosido con base monociclica modificada con carboxamidina.
DE69428040D1 (de)	2001-09-27	Orale darreichungsform
DE69422169D1 (de)	2000-01-20	Modifizierte proteine und peptide enthaltende pharmazeutische mittel
CA2178592A1 (en)	1995-06-15	Long-acting injection suspensions and a process for their preparation
UA35611C2 (uk)	2001-04-16	Композиція місцевого застосування для інгібування росту волос у ссавців, спосіб із її використанням та композиція місцевого застосування для доставки водорозчинного фармакологічного засобу до шкіри
BG102514A (en)	1999-04-30	New lh-rh-antagonists of improved effect
MY119896A (en)	2005-08-30	Long-acting injection suspensions and a process for their preparation.
TR199800954T2 (xx)	1998-10-21	Y�ksek i�erikli famsiklovir tabletleri.
AU7533394A (en)	1995-02-28	Antiacid pharmaceutical composition in the form of a suspension based on sucralphate gel
OA09771A (en)	1993-11-30	Asphodelus composition for increasing white blood cell count.
TR199701463T1 (en)	1998-02-21	Sorbin asiti i�eren hidrojel.