ATE195733T1 - Als heilmittel nutzbare piperazin verbindungen - Google Patents

Als heilmittel nutzbare piperazin verbindungen

Info

Publication number
ATE195733T1
ATE195733T1 AT94921756T AT94921756T ATE195733T1 AT E195733 T1 ATE195733 T1 AT E195733T1 AT 94921756 T AT94921756 T AT 94921756T AT 94921756 T AT94921756 T AT 94921756T AT E195733 T1 ATE195733 T1 AT E195733T1
Authority
AT
Austria
Prior art keywords
utility
piperazine compounds
receptors
remedies
compounds
Prior art date
Application number
AT94921756T
Other languages
English (en)
Inventor
Kwen-Jen Chang
Michael Joseph Bishop
Dulce Garrido Bubacz
Nutt Robert Walton Mc Jr
Original Assignee
Delta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Pharmaceuticals Inc filed Critical Delta Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE195733T1 publication Critical patent/ATE195733T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Water Treatment By Sorption (AREA)
AT94921756T 1993-07-30 1994-07-29 Als heilmittel nutzbare piperazin verbindungen ATE195733T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9833393A 1993-07-30 1993-07-30
US16987993A 1993-12-17 1993-12-17
PCT/GB1994/001641 WO1995004051A1 (en) 1993-07-30 1994-07-29 Piperazine compounds used in therapy

Publications (1)

Publication Number Publication Date
ATE195733T1 true ATE195733T1 (de) 2000-09-15

Family

ID=26794651

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921756T ATE195733T1 (de) 1993-07-30 1994-07-29 Als heilmittel nutzbare piperazin verbindungen

Country Status (18)

Country Link
US (1) US5552404A (de)
EP (1) EP0711289B1 (de)
JP (1) JPH09501156A (de)
CN (1) CN1054850C (de)
AT (1) ATE195733T1 (de)
AU (1) AU692788B2 (de)
CA (1) CA2168432C (de)
DE (1) DE69425662T2 (de)
DK (1) DK0711289T3 (de)
ES (1) ES2149881T3 (de)
GR (1) GR3034695T3 (de)
HU (1) HU221726B1 (de)
IL (1) IL110512A (de)
MY (1) MY111348A (de)
PT (1) PT711289E (de)
RU (1) RU2133744C1 (de)
TW (1) TW386081B (de)
WO (1) WO1995004051A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US6410537B1 (en) * 1994-09-09 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
US6046200A (en) * 1994-09-09 2000-04-04 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
SE9504662D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6359111B1 (en) 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US6548637B1 (en) 1998-06-18 2003-04-15 Sepracor, Inc. Ligands for opioid receptors
KR100799089B1 (ko) * 1999-12-04 2008-01-29 리서치 디벨럽먼트 파운데이션 에어로졸화된 약물의 침착 증진 조성물
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
US7115664B2 (en) * 2000-03-16 2006-10-03 Sepracor Inc. Peptidomimetic ligands for cellular receptors and ion channels
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
SE0100764D0 (sv) * 2001-03-07 2001-03-07 Astrazeneca Ab New assymetric process
WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence
DK1395567T3 (da) 2001-05-18 2009-04-06 Astrazeneca Ab 4-(phenylpiperazinylmethyl)-benzamidderivater og deres anvendelse til behandling af smerte, angst eller mavetarmslidelser
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
JP2005505575A (ja) * 2001-09-25 2005-02-24 アーデント ファーマスーティカルズ，インコーポレイテッド エナンチオ的に純粋なジアリールメチルピペラジンおよびその利用方法
US7030124B2 (en) * 2001-10-29 2006-04-18 Ardent Pharmaceuticals, Inc. Method of treating depression with delta receptor agonist compounds
US8575169B2 (en) * 2001-10-29 2013-11-05 Versi Group, Llc Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
US6881829B2 (en) * 2002-04-26 2005-04-19 Chimeracom, L.L.C. Chimeric hybrid analgesics
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
ES2298522T3 (es) 2002-05-16 2008-05-16 N.V. Organon Combinacion sinergica de un analgesico opioide y un aine.
CN1202843C (zh) * 2002-06-21 2005-05-25 天大药业(深圳)有限公司 一种戒毒药物组合物及其制备方法和应用
US20060052409A1 (en) * 2002-07-11 2006-03-09 Koji Kawai Therapeutic or preventive agent for nausea/vomiting
US20050241431A1 (en) * 2002-09-27 2005-11-03 Continental Teves Ag & Co. Ohg Adjustable pedal device
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) * 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
TWI317286B (en) 2003-12-31 2009-11-21 Targeting delivery system
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
TW200724144A (en) * 2005-04-14 2007-07-01 Ardent Pharmaceuticals Inc Compositions of novel opioid compounds and method of use thereof
ES2573253T3 (es) 2006-09-20 2016-06-06 The Board Of Regents Of The University Of Texas System Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor
EP3581169A1 (de) 2008-01-22 2019-12-18 The Board Of Regents Of The University Of Texas System Flüchtige anästhesiemittelzusammensetzungen mit extraktiven lösungsmitteln für lokale anästhesie und/oder schmerzlinderung
EA201001644A1 (ru) * 2008-05-20 2011-06-30 Астразенека Аб Способ лечения тревожного большого депрессивного расстройства

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2630435A (en) * 1948-09-09 1953-03-03 Burroughs Wellcome Co N-benzohydryl-n-methyl piperazines and process of preparing same
NL7306771A (de) * 1972-06-02 1973-12-04
ZA82752B (en) * 1981-02-06 1982-12-29 Ucb Sa 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides
DK154078C (da) * 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
US4518711A (en) 1983-05-16 1985-05-21 Gibson-Stephens Institute Conformationally constrained cyclic enkephalin analogs with delta receptor specificity
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
IL78939A (en) 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
CA1321792C (en) * 1987-04-16 1993-08-31 Eli Lilly And Company Piperidine opioid antagonists
US4816586A (en) 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
CA2059127A1 (en) * 1989-06-19 1990-12-20 Oscar William Lever Medicaments useful in cancer therapy and having antihistaminic properties
EP0458160A3 (en) 1990-05-25 1992-03-18 Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents
SE467304B (sv) * 1990-10-31 1992-06-29 Kamewa Ab Styr- och reverseringsanordning foer ett marint straaldriftsaggregat
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds

Also Published As

Publication number Publication date
DE69425662T2 (de) 2001-04-12
CN1054850C (zh) 2000-07-26
TW386081B (en) 2000-04-01
CN1133593A (zh) 1996-10-16
RU2133744C1 (ru) 1999-07-27
CA2168432C (en) 2004-03-23
MY111348A (en) 1999-11-30
AU7235194A (en) 1995-02-28
JPH09501156A (ja) 1997-02-04
US5552404A (en) 1996-09-03
HU221726B1 (hu) 2002-12-28
EP0711289A1 (de) 1996-05-15
DE69425662D1 (de) 2000-09-28
IL110512A0 (en) 1994-10-21
ES2149881T3 (es) 2000-11-16
HU9501982D0 (en) 1995-09-28
PT711289E (pt) 2001-02-28
GR3034695T3 (en) 2001-01-31
DK0711289T3 (da) 2000-11-06
CA2168432A1 (en) 1995-02-09
WO1995004051A1 (en) 1995-02-09
IL110512A (en) 1998-10-30
EP0711289B1 (de) 2000-08-23
HUT72893A (en) 1996-06-28
AU692788B2 (en) 1998-06-18

Similar Documents

Publication Publication Date Title
ATE195733T1 (de) Als heilmittel nutzbare piperazin verbindungen
CA2129046A1 (en) Opioid diarylmethylpiperazines and piperidines
Segal et al. Review of Mindfulness-based Cognitive Therapy for Depression.
ATE132852T1 (de) Tramadol n-oxid, dessen enantiomere und zusammensetzungen davon, und deren verwendung
AU4355693A (en) Ultrafine powder for inhalation and production thereof
HU9700113D0 (en) Substituted pyrimidine compounds and their use
DE69531038D1 (de) Adsorptionskörper enthaltend Aktivkohle, aktiviertes Aluminiumoxid und einen anorganischen Binder und Methode zu dessen Herstellung
NO963675L (no) Prolegemidler av morfolintakykininreseptorantagonister
DE69501591D1 (de) Lactobazillusstämme menschlichen ursprungs, ihre zusammensetzung und deren verwendung
ZA200409814B (en) 3-Z-(1-(4-(N-((4-methyl-piperazin-1-YL)-methylcarbnonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene)-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition.
TW200621753A (en) Pyrimidinylimidazoles and methods of making and using the same
ATE207038T1 (de) Titandioxidteilchen, ihr herstellungsverfahren und ihre verwendung in kosmetika und lacken
ATE539768T1 (de) Kombinationen von metabotropische-glutamat- rezeptor-antagonisten und ihre verwendung zur behandlung von suchtstörungen
GEP20094691B (en) Hydroisoindoline tachykinin receptor antagonists
EP2260843A3 (de) Alpha-MSH und Derivate zur Induktion von Antigentoleranz
WO2003042173A8 (en) Nk1 antagonists
ATE178886T1 (de) 1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten
MA27082A1 (fr) Absorbants et leurs utilisations
TW200621752A (en) Pyrimidinylpyrazoles and methods of making and using the same
DE50312239D1 (de) Beschichtungsstoffe und ihre verwendung zur herstellung schweissbarer beschichtungen
ATE301645T1 (de) Polycyclische thiazolidin-2-yliden amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
BR9713539A (pt) Composições de tratamento de solos, seu processo de prepararo e sua utilização.
DE69628743D1 (de) Levobupivacain und dessen verwendung als anästhetikum bei schwangeren frauen
NO307757B1 (no) Uretanholdige aminosteroidforbindelser, farmasøytisk preparat samt anvendelse
NZ516209A (en) Indoloazepines as vasopressin receptor antagonists

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee