ATE195944T1 - Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung - Google Patents

Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung

Info

Publication number
ATE195944T1
ATE195944T1 AT95910923T AT95910923T ATE195944T1 AT E195944 T1 ATE195944 T1 AT E195944T1 AT 95910923 T AT95910923 T AT 95910923T AT 95910923 T AT95910923 T AT 95910923T AT E195944 T1 ATE195944 T1 AT E195944T1
Authority
AT
Austria
Prior art keywords
group
chain
liposomes
production
active compounds
Prior art date
Application number
AT95910923T
Other languages
English (en)
Inventor
Yong-Wei Pei
Eric Mayhew
Imran Ahmad
Andrew S Janoff
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ATE195944T1 publication Critical patent/ATE195944T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT95910923T 1994-02-02 1995-02-02 Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung ATE195944T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19029594A 1994-02-02 1994-02-02
PCT/US1995/001490 WO1995021175A1 (en) 1994-02-02 1995-02-02 Pharmaceutically active compounds and liposomes, and methods of use therof

Publications (1)

Publication Number Publication Date
ATE195944T1 true ATE195944T1 (de) 2000-09-15

Family

ID=22700754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95910923T ATE195944T1 (de) 1994-02-02 1995-02-02 Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung

Country Status (14)

Country Link
US (3) US5631394A (de)
EP (2) EP0742789B1 (de)
JP (1) JPH09508900A (de)
AT (1) ATE195944T1 (de)
AU (1) AU691886B2 (de)
CA (1) CA2182485A1 (de)
DE (1) DE69518627T2 (de)
DK (1) DK0742789T3 (de)
ES (1) ES2149350T3 (de)
FI (1) FI116620B (de)
GR (1) GR3034521T3 (de)
NO (1) NO314405B1 (de)
PT (1) PT742789E (de)
WO (1) WO1995021175A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
US6255336B1 (en) 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
AU2588297A (en) * 1996-04-04 1997-10-29 Ortho Pharmaceutical Corporation Liposome-based topical vitamin d formulation
US6274309B1 (en) * 1996-07-26 2001-08-14 Richard Kolesnick Method for the modulation of acid-sphingomyelinase-related apoptosis
CN1055640C (zh) * 1996-11-29 2000-08-23 沃维汉 人降钙素基因相关肽脂质体组合物及其制法
US6982142B2 (en) * 1997-12-01 2006-01-03 John Wayne Cancer Institute Methods for screening therapeutically effective agents
WO2000057916A1 (en) * 1999-03-25 2000-10-05 Center For Molecular Medicine And Immunology Sphingomyelin containing preparation for the enhancement of tumor therapy
US7683044B2 (en) * 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
US7820718B1 (en) * 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
TW502133B (en) 1999-06-10 2002-09-11 Wako Pure Chem Ind Ltd Resist composition, agent and method for reducing substrate dependence thereof
US6682545B1 (en) * 1999-10-06 2004-01-27 The Penn State Research Foundation System and device for preventing restenosis in body vessels
AU1548101A (en) * 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
US6881546B2 (en) * 2000-12-22 2005-04-19 Medlyte, Inc., Sdsu Heart Institute Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US6855830B2 (en) 2001-07-16 2005-02-15 Genzyme Corporation Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
EP1287815A1 (de) * 2001-08-31 2003-03-05 Cosmoferm B.V. Verwendung einer Sphingoidbase zur Inhibierung von Ceramidase-Aktivität
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
EP1601344A2 (de) * 2003-03-07 2005-12-07 Celator Technologies Inc. Verbesserte verabreichung von sphingolipiden
WO2004087097A2 (en) * 2003-03-31 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
KR20060015534A (ko) * 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 성장 억제, 지질 유래된 생활성 화합물의 전신 전달을 위한방법 및 시스템
JP2006527763A (ja) 2003-06-18 2006-12-07 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム スフィンゴ脂質のポリアルキルアミン抱合体
US7906122B2 (en) 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
BRPI0517701A8 (pt) * 2004-11-10 2018-01-23 Genzyme Corp métodos de tratamento de diabetes mellitus
AU2005303389A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
JP4791082B2 (ja) * 2005-05-30 2011-10-12 株式会社クラレ リポソームおよびそれを含む皮膚外用剤
WO2007044748A2 (en) * 2005-10-11 2007-04-19 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
ES2546181T3 (es) * 2006-05-09 2015-09-21 Genzyme Corporation Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8614103B2 (en) 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
WO2008070344A2 (en) 2006-10-27 2008-06-12 Lpath, Inc. Compositions and methods for binding sphingosine-1-phosphate
EP2594565B1 (de) 2007-05-31 2018-10-24 Genzyme Corporation Glukosylceramid-Synthase-Hemmer vom 2-Acylaminpropanol-Typ
KR101640263B1 (ko) 2007-10-05 2016-07-15 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
JP2011529500A (ja) 2008-07-28 2011-12-08 ジェンザイム コーポレーション 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害
CN102271678B (zh) * 2008-10-03 2017-06-30 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂
MY192644A (en) 2009-11-27 2022-08-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
WO2013024843A1 (ja) * 2011-08-15 2013-02-21 国立大学法人 千葉大学 セラミド誘導体およびこれを用いたゴルジ体標識化蛍光プローブ
KR102423002B1 (ko) * 2021-02-17 2022-07-21 주식회사 엘씨에스바이오텍 신규 세라마이드, 그의 제조방법 및 그의 용도
CN121081441A (zh) * 2025-11-07 2025-12-09 中国医学科学院医药生物技术研究所 鞘氨醇在制备预防和/或治疗肺癌药物中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US5030453A (en) * 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes
US5008050A (en) * 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4975282A (en) * 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
FR2637598B1 (fr) * 1988-10-06 1991-10-11 Agronomique Inst Nat Rech Nouveaux sphingophospholipides a inositol, leur obtention, et leur application comme inducteurs de resistance a diverses maladies cryptogamiques chez les vegetaux
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
DE4021082C2 (de) * 1990-07-03 1995-08-17 Hans Dr Lautenschlaeger Hautbehandlungsmittel mit hohen Lipidgehalten unter Verwendung eines Bilayer enthaltenden Systems, Salzen organischer Säuren, Alkohol und Stabilisator
BR9106744A (pt) * 1990-08-13 1993-07-20 Univ Duke Processo para induzir diferenciacao celular,preparacao farmaceutica,composicao e uso de um composto
GB9022921D0 (en) * 1990-10-22 1990-12-05 Unilever Plc Cosmetic composition
GB9100816D0 (en) * 1991-01-15 1991-02-27 Unilever Plc Cosmetic composition
DE4201461A1 (de) * 1992-01-21 1993-07-22 Mueller Schulte Detlef Dr Mittel fuer die selektive tumortherapie auf der basis ferromagnetischer partikel - verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
US5631394A (en) 1997-05-20
JPH09508900A (ja) 1997-09-09
EP1008342A3 (de) 2004-12-29
US5681589A (en) 1997-10-28
FI963045L (fi) 1996-08-01
FI116620B (fi) 2006-01-13
EP0742789B1 (de) 2000-08-30
FI963045A0 (fi) 1996-08-01
DE69518627D1 (de) 2000-10-05
WO1995021175A1 (en) 1995-08-10
EP0742789A1 (de) 1996-11-20
DK0742789T3 (da) 2000-11-13
CA2182485A1 (en) 1995-08-10
AU1871295A (en) 1995-08-21
GR3034521T3 (en) 2000-12-29
US5677337A (en) 1997-10-14
ES2149350T3 (es) 2000-11-01
PT742789E (pt) 2000-12-29
NO314405B1 (no) 2003-03-17
DE69518627T2 (de) 2001-01-11
EP1008342A2 (de) 2000-06-14
NO963224L (no) 1996-09-27
NO963224D0 (no) 1996-08-01
AU691886B2 (en) 1998-05-28

Similar Documents

Publication Publication Date Title
DE69518627D1 (de) Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung
AU689391B2 (en) Cyclic peptide antifungal agents and process for preparation thereof
DE69034202D1 (de) Zwischenprodukte zur Herstellung von non-peptiden retroviralproteasehemmenden Verbindungen
GR3032083T3 (en) Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
UA27220C2 (uk) Спосіб одержання похідних 1-фенілімідазолін-2,5-діону
ZA200108124B (en) Pharmaceutical compounds.
HU9200656D0 (en) Method for producing morpholinyl derivatives of doxorubicine and pharmaceutical preparatives containing said compounds
GR3020190T3 (en) Diclofenac choline salt, a method for the preparation thereof and pharmaceutical compositions containing it
HU900654D0 (en) Process for preparation of new pyrrolidine derivatives and pharmaceutical preparations containing the said compounds
HU9501466D0 (en) Glycopyranoside benzothiophenes
TW287086B (de)
WO2000010992A3 (en) Water-dispersible or water-soluble d-tocotrienol compounds and methods for making therefor
HU9202103D0 (en) Method for producing inosite-phosphate analogues and pharmaceutical preparatives containing these compounds
DE3864336D1 (en) Aromatische thioaether.
ZA927307B (en) Method for treating hypertension
TW275629B (de)
DE69711506D1 (de) Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
AU1287892A (en) Method of inhibiting the progressive development of diabetes mellitus
AU1870783A (en) Nitrosourea derivatives
TW227527B (en) An aniline offshoot condenser's divergent agent and synthesizing method
CA2238710A1 (en) New amino alcohol derivatives, processes for their production and pharmaceutical agents containing these compounds

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee