ATE195946T1 - 2-aralkoxy und 2-alkoxy-adenosinderivate als koronarvasodilatoren und antihypertensive stoffe - Google Patents

2-aralkoxy und 2-alkoxy-adenosinderivate als koronarvasodilatoren und antihypertensive stoffe

Info

Publication number: ATE195946T1
Authority: AT; Austria
Prior art keywords: image; oxygen; compounds; group; alkoxy
Prior art date: 1990-02-20

Application number

AT91904813T

Other languages

English (en)

Inventor

Ray A Olsson

Robert D Thompson

Original Assignee

Discovery Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-20

Filing date

1991-02-14

Publication date

2000-09-15

1991-02-14 Application filed by Discovery Therapeutics Inc filed Critical Discovery Therapeutics Inc

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195946T1 publication Critical patent/ATE195946T1/de

Links

239000002220 antihypertensive agent Substances 0.000 title 1
239000003218 coronary vasodilator agent Substances 0.000 title 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 5
229910052760 oxygen Inorganic materials 0.000 abstract 5
239000001301 oxygen Substances 0.000 abstract 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
102000000506 Adenosine A2 Receptors Human genes 0.000 abstract 1
108010041368 Adenosine A2 Receptors Proteins 0.000 abstract 1
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT91904813T 1990-02-20 1991-02-14 2-aralkoxy und 2-alkoxy-adenosinderivate als koronarvasodilatoren und antihypertensive stoffe ATE195946T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/482,282 US5140015A (en)	1990-02-20	1990-02-20	2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
PCT/US1991/001023 WO1991013082A1 (en)	1990-02-20	1991-02-14	2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
CA002074853A CA2074853C (en)	1990-02-20	1992-07-29	2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents

Publications (1)

Publication Number	Publication Date
ATE195946T1 true ATE195946T1 (de)	2000-09-15

Family

ID=25675376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91904813T ATE195946T1 (de)	1990-02-20	1991-02-14	2-aralkoxy und 2-alkoxy-adenosinderivate als koronarvasodilatoren und antihypertensive stoffe

Country Status (9)

Country	Link
US (1)	US5140015A (de)
EP (1)	EP0515514B1 (de)
JP (1)	JP3160611B2 (de)
AT (1)	ATE195946T1 (de)
AU (1)	AU645784B2 (de)
CA (1)	CA2074853C (de)
DE (1)	DE69132389T2 (de)
ES (1)	ES2150903T3 (de)
WO (1)	WO1991013082A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE36494E (en) *	1990-02-20	2000-01-11	Discovery Therapeutics, Inc.	2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
WO1995002604A1 (en) *	1993-07-13	1995-01-26	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	A3 adenosine receptor agonists
US6514949B1 (en)	1994-07-11	2003-02-04	University Of Virginia Patent Foundation	Method compositions for treating the inflammatory response
US5877180A (en) *	1994-07-11	1999-03-02	University Of Virginia Patent Foundation	Method for treating inflammatory diseases with A2a adenosine receptor agonists
US6448235B1 (en)	1994-07-11	2002-09-10	University Of Virginia Patent Foundation	Method for treating restenosis with A2A adenosine receptor agonists
US5817641A (en) *	1994-07-21	1998-10-06	Thomas Jefferson University	Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
US7348315B2 (en)	1995-03-23	2008-03-25	The University Of Connecticut	Methods of treating heart failure with modified ATP, ADP and AMP compounds
US5712258A (en) *	1995-03-23	1998-01-27	The Trustees Of The University Of Pennsylvania	Inotropic ADP and ATP analogues and their pharmaceutical compositions
AU2603197A (en)	1996-04-10	1997-10-29	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Use of an a1 adenosine receptor agonist to treat cerebral ischaemia
TW528755B (en)	1996-12-24	2003-04-21	Glaxo Group Ltd	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
AU740770B2 (en)	1997-06-18	2001-11-15	Aderis Pharmaceuticals, Inc.	Compositions and methods for preventing restenosis following revascularization procedures
US5972903A (en) *	1997-10-07	1999-10-26	Regents Of The University Of California Corporation	Method for promoting angiogenesis using heparin and adenosine
CA2305726A1 (en)	1997-10-07	1999-04-15	Regents Of The University Of California	Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
YU44900A (sh)	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
US6117878A (en) *	1998-02-24	2000-09-12	University Of Virginia	8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
JP3933870B2 (ja)	1998-06-23	2007-06-20	グラクソグループリミテッド	２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体
CA2336967C (en)	1998-07-10	2010-06-29	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	A3 adenosine receptor antagonists
US7427606B2 (en) *	1999-02-01	2008-09-23	University Of Virginia Patent Foundation	Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) *	1999-02-01	2008-05-27	University Of Virginia Patent Foundation	Method to reduce an inflammatory response from arthritis
US6232297B1 (en)	1999-02-01	2001-05-15	University Of Virginia Patent Foundation	Methods and compositions for treating inflammatory response
US6322771B1 (en)	1999-06-18	2001-11-27	University Of Virginia Patent Foundation	Induction of pharmacological stress with adenosine receptor agonists
US7087589B2 (en)	2000-01-14	2006-08-08	The United States Of America As Represented By The Department Of Health And Human Services	Methanocarba cycloakyl nucleoside analogues
GB0003960D0 (en) *	2000-02-18	2000-04-12	Pfizer Ltd	Purine derivatives
US6670334B2 (en)	2001-01-05	2003-12-30	University Of Virginia Patent Foundation	Method and compositions for treating the inflammatory response
NZ556354A (en) *	2001-10-01	2008-10-31	Univ Virginia	2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
CA2465264C (en) *	2001-10-25	2010-09-07	King Pharmaceuticals Research & Development, Inc.	Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
US7342003B2 (en) *	2001-10-25	2008-03-11	King Pharmaceuticals Research And Development, Inc.	Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
WO2004016635A2 (en) *	2002-08-15	2004-02-26	Cv Therapeutics, Inc.	Partial and full agonists of a1 adenosine receptors
GB0228723D0 (en) *	2002-12-09	2003-01-15	Cambridge Biotechnology Ltd	Treatment of pain
GB0305153D0 (en) *	2003-03-07	2003-04-09	Cambridge Biotechnology Ltd	Identification of therapeutic compounds
US20050033044A1 (en) *	2003-05-19	2005-02-10	Bristol-Myers Squibb Pharma Company	Methods for preparing 2-alkynyladenosine derivatives
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2005117910A2 (en) *	2004-05-26	2005-12-15	Inotek Pharmaceuticals Corporation	Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
US7576069B2 (en) *	2004-08-02	2009-08-18	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2006023272A1 (en) *	2004-08-02	2006-03-02	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs having a2a agonist activity
AU2005267706B2 (en) *	2004-08-02	2011-12-08	University Of Virginia Patent Foundation	2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
MX2007003271A (es) *	2004-09-20	2007-06-05	Inotek Pharmaceuticals Corp	Derivados de purina y metodos de uso de los mismos.
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
EA015683B1 (ru) *	2005-11-30	2011-10-31	Инотек Фармасьютикалз Корпорейшн	Производные пурина и способы их применения
WO2007092936A2 (en) *	2006-02-08	2007-08-16	University Of Virginia Patent Foundation	Method to treat gastric lesions
US8178509B2 (en)	2006-02-10	2012-05-15	University Of Virginia Patent Foundation	Method to treat sickle cell disease
US8188063B2 (en) *	2006-06-19	2012-05-29	University Of Virginia Patent Foundation	Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) *	2007-12-20	2011-11-15	University Of Virginia Patent Foundation	Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
EP2274007B1 (de)	2008-03-10	2016-12-14	Cornell University	Modulation der durchlässigkeit der blut-hirn-schranke
US8518957B2 (en)	2009-12-02	2013-08-27	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure
SG182285A1 (en)	2010-01-11	2012-08-30	Inotek Pharmaceuticals Corp	Combination, kit and method of reducing intraocular pressure
EA201290958A1 (ru)	2010-03-26	2013-04-30	Инотек Фармасьютикалз Корпорейшн	Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
BR112014018413A8 (pt)	2012-01-26	2017-07-11	Inotek Pharmaceuticals Corp	Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
CA2903114A1 (en)	2013-03-15	2014-09-25	Inotek Pharmaceuticals Corporation	Ophthalmic formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4826038B1 (de) *	1970-09-25	1973-08-03
BE792155A (fr) *	1971-12-01	1973-05-30	Takeda Chemical Industries Ltd	Nouveaux derives de l'adenosine et leur procede de production
US3903073A (en) *	1973-12-26	1975-09-02	Abbott Lab	2-Substituted adenosine-5{40 {0 carboxylates
JPS5630355B2 (de) *	1974-01-21	1981-07-14
EP0277917A3 (de) *	1987-02-04	1990-03-28	Ciba-Geigy Ag	Bestimmte Derivate von Adenosin-5'-carboxamid
LU87181A1 (fr) *	1987-04-06	1988-11-17	Sandoz Sa	Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments

1990
- 1990-02-20 US US07/482,282 patent/US5140015A/en not_active Ceased
1991
- 1991-02-14 DE DE69132389T patent/DE69132389T2/de not_active Expired - Lifetime
- 1991-02-14 AU AU73255/91A patent/AU645784B2/en not_active Expired
- 1991-02-14 EP EP91904813A patent/EP0515514B1/de not_active Expired - Lifetime
- 1991-02-14 AT AT91904813T patent/ATE195946T1/de not_active IP Right Cessation
- 1991-02-14 JP JP50557191A patent/JP3160611B2/ja not_active Expired - Lifetime
- 1991-02-14 WO PCT/US1991/001023 patent/WO1991013082A1/en not_active Ceased
- 1991-02-14 ES ES91904813T patent/ES2150903T3/es not_active Expired - Lifetime
1992
- 1992-07-29 CA CA002074853A patent/CA2074853C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH05506436A (ja)	1993-09-22
EP0515514A1 (de)	1992-12-02
JP3160611B2 (ja)	2001-04-25
DE69132389D1 (de)	2000-10-05
CA2074853A1 (en)	1994-01-30
EP0515514B1 (de)	2000-08-30
WO1991013082A1 (en)	1991-09-05
CA2074853C (en)	2005-06-07
AU645784B2 (en)	1994-01-27
EP0515514A4 (en)	1993-01-13
AU7325591A (en)	1991-09-18
ES2150903T3 (es)	2000-12-16
DE69132389T2 (de)	2001-01-18
US5140015A (en)	1992-08-18

Legal Events

Date	Code	Title	Description
2001-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE195946T1 (de)	2000-09-15	2-aralkoxy und 2-alkoxy-adenosinderivate als koronarvasodilatoren und antihypertensive stoffe
DK584886D0 (da)	1986-12-05	Vanduoplaeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
ATE114304T1 (de)	1994-12-15	Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate.
DK0409406T3 (da)	1994-02-07	Arylsubstituerede aminderivater, der er anvendelige ved cancerterapi
DK0488513T3 (da)	1996-06-17	Anvendelse af dioxabicyclo(3.3.0)octanderivater til fremstilling af et medikament til inhibering af cholesterolmetabolismen
CO5130006A1 (es)	2002-02-27	Compuestos de pirazina
DK0531091T3 (da)	1995-09-11	Biologisk nedbrydelig copolyester af 4-hydroxyprolin og farmaceutisk præparat indeholdende samme
FI884088A0 (fi)	1988-09-06	Foerfarande foer framstaellning av 17-substituerade androsta-1,4-dien-3-onderivat.
KR900016178A (ko)	1990-11-12	2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
MX15697A (es)	1993-12-01	Derivados heterotetraciclicos de lactama y procesopara su preparacion
DK283189D0 (da)	1989-06-09	Phenothiazinderivater, deres fremstilling og farmaceutiske praeparater deraf
SE8301785L (sv)	1984-06-04	Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning
FR2694557B1 (fr)	1994-09-23	Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique.
DK104488A (da)	1988-08-28	Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem
SE8000138L (sv)	1980-07-18	Nya 3-cyklopentan-1,2'(1'h)-naftalen-derivat, framstellning derav och lekemedel innehallande desamma
KR930700507A (ko)	1993-03-15	살생물성 헤테로폴리시클릭 화합물, 그것의 합성방법 및 그 중간체, 그것들을 포함한 제제, 및 의약품으로서 그것의 사용방법
DK503683D0 (da)	1983-11-03	Fremgangsmade til fremstilling af derivater af gamma-butyrolacton, som er myocardiebeskyttelsesmidler med en antiarytmisk virkning