ATE196549T1 - Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo - Google Patents

Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo

Info

Publication number
ATE196549T1
ATE196549T1 AT93902713T AT93902713T ATE196549T1 AT E196549 T1 ATE196549 T1 AT E196549T1 AT 93902713 T AT93902713 T AT 93902713T AT 93902713 T AT93902713 T AT 93902713T AT E196549 T1 ATE196549 T1 AT E196549T1
Authority
AT
Austria
Prior art keywords
advanced glycosylation
disclosed
age
vivo
glycosylation endproducts
Prior art date
Application number
AT93902713T
Other languages
English (en)
Inventor
Richard J Bucala
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of ATE196549T1 publication Critical patent/ATE196549T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93902713T 1991-12-20 1992-12-21 Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo ATE196549T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81157991A 1991-12-20 1991-12-20
US07/956,849 US5624804A (en) 1991-12-20 1992-10-01 Immunochemical detection of In vivo advanced glycosylation end products
PCT/US1992/011158 WO1993013421A1 (en) 1991-12-20 1992-12-21 Immunochemical detection of in vivo advanced glycosylation endproducts

Publications (1)

Publication Number Publication Date
ATE196549T1 true ATE196549T1 (de) 2000-10-15

Family

ID=27123501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902713T ATE196549T1 (de) 1991-12-20 1992-12-21 Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo

Country Status (12)

Country Link
US (6) US5624804A (de)
EP (1) EP0623216B1 (de)
JP (1) JPH07502534A (de)
KR (1) KR100257733B1 (de)
CN (1) CN1053964C (de)
AT (1) ATE196549T1 (de)
AU (1) AU681340B2 (de)
CA (1) CA2126209A1 (de)
DE (1) DE69231473T2 (de)
ES (1) ES2150936T3 (de)
PT (1) PT101147A (de)
WO (1) WO1993013421A1 (de)

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US7585512B1 (en) * 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5624804A (en) * 1991-12-20 1997-04-29 The Rockefeller University Immunochemical detection of In vivo advanced glycosylation end products
AU712004B2 (en) * 1993-03-11 1999-10-28 Picower Institute For Medical Research, The Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
US6410598B1 (en) 1994-02-03 2002-06-25 Michael P. Vitek Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
AU692237B2 (en) * 1994-02-03 1998-06-04 Picower Institute For Medical Research, The Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
US5610076A (en) * 1994-04-29 1997-03-11 Alteon Inc. Method for detecting hemoglobin advanced glycosylation endproducts
CA2208411A1 (en) * 1994-12-30 1996-07-11 Alteon, Inc. Monoclonal antibodies specific for advanced glycosylation endproducts in biological samples
US5744318A (en) * 1994-12-30 1998-04-28 Alteon Inc. Monoclonal antibody for the detection of advanced glycosylation endproducts in biological samples
DE69629176T2 (de) * 1995-01-18 2004-06-03 Alteon Inc. Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung
US5811242A (en) * 1995-10-24 1998-09-22 Tokuyama Corporation Marker and reagent for diabetes mellitus and diabetes mellitus complication
US5811401A (en) * 1995-11-30 1998-09-22 The Picower Institute For Medical Research Advanced glycosylation endproducts and methods of use therefor
EP0877943A1 (de) * 1995-12-26 1998-11-18 The Picower Institute For Medical Research Methoden zur messung und behandlung auf grund von endprodukten der fortgeschrittenen glycosylation im tabak und seinen verbrennungsnebenprodukten
WO1997024372A1 (en) * 1995-12-29 1997-07-10 Alteon Inc. 6-(n-carboxymethylamino)caproate, salts thereof and methods of use therefor
US6033862A (en) * 1996-10-30 2000-03-07 Tokuyama Corporation Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications
US6380165B1 (en) 1997-09-19 2002-04-30 The Picower Institute For Medical Research Immunological advanced glycation endproduct crosslink
US6505059B1 (en) 1998-04-06 2003-01-07 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US7899518B2 (en) * 1998-04-06 2011-03-01 Masimo Laboratories, Inc. Non-invasive tissue glucose level monitoring
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ATE283481T1 (de) * 2001-03-22 2004-12-15 Hoffmann La Roche Verfahren zum auffinden von reagenzien und festphasenkomponenten in spezifischen bindungsassays, frei von fortgeschrittenen glykosylierungsendprodukten
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CN100489526C (zh) * 2004-01-16 2009-05-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种人脑红蛋白检测及诊断试剂盒，其制备方法及用途
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EP2369346B1 (de) * 2006-03-24 2014-08-27 Metanomics GmbH Verfahren zur Diagnose von Diabetes Typ II
DE102006026173A1 (de) * 2006-06-06 2007-12-20 Fachhochschule Südwestfalen Verfahren zur nichtinvasiven Diagnose von Diabetes
RU2553225C2 (ru) * 2008-05-23 2015-06-10 Сива Корпорейшн Способ облегчения регенерации
JP5394501B2 (ja) 2009-10-02 2014-01-22 シャープ株式会社 血管状態モニタリング方法
JP5386634B2 (ja) 2010-03-19 2014-01-15 シャープ株式会社 測定結果処理装置、測定システム、測定結果処理方法、制御プログラムおよび記録媒体
ES2725852T3 (es) 2010-09-27 2019-09-27 Siwa Corp Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis
US8721571B2 (en) 2010-11-22 2014-05-13 Siwa Corporation Selective removal of cells having accumulated agents
KR101939401B1 (ko) 2011-11-10 2019-01-16 가천대학교 산학협력단 단핵식세포계 세포의 ａｇｅ-알부민 합성 또는 분비 저해제를 유효성분으로 포함하는 허혈성 심장질환 예방 또는 치료용 조성물
EP3194439B1 (de) 2014-09-19 2022-01-19 Siwa Corporation Anti-age-antikörper zur behandlung von entzündungs- und autoimmunerkrankungen
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
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CN108431044A (zh) * 2015-10-13 2018-08-21 Siwa有限公司 抗age抗体及其使用方法
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US11518801B1 (en) 2017-12-22 2022-12-06 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications
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Also Published As

Publication number Publication date
AU3418793A (en) 1993-07-28
KR100257733B1 (ko) 2000-06-01
CN1053964C (zh) 2000-06-28
US5624804A (en) 1997-04-29
ES2150936T3 (es) 2000-12-16
PT101147A (pt) 1994-03-31
US5629408A (en) 1997-05-13
US5733546A (en) 1998-03-31
DE69231473D1 (de) 2000-10-26
KR940704003A (ko) 1994-12-12
JPH07502534A (ja) 1995-03-16
EP0623216B1 (de) 2000-09-20
CN1079825A (zh) 1993-12-22
US5683887A (en) 1997-11-04
US5712101A (en) 1998-01-27
EP0623216A1 (de) 1994-11-09
US5702704A (en) 1997-12-30
AU681340B2 (en) 1997-08-28
CA2126209A1 (en) 1993-07-08
DE69231473T2 (de) 2001-02-08
WO1993013421A1 (en) 1993-07-08

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