ATE196549T1 - Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo - Google Patents

Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo

Info

Publication number
ATE196549T1
ATE196549T1 AT93902713T AT93902713T ATE196549T1 AT E196549 T1 ATE196549 T1 AT E196549T1 AT 93902713 T AT93902713 T AT 93902713T AT 93902713 T AT93902713 T AT 93902713T AT E196549 T1 ATE196549 T1 AT E196549T1
Authority
AT
Austria
Prior art keywords
advanced glycosylation
disclosed
age
vivo
glycosylation endproducts
Prior art date
Application number
AT93902713T
Other languages
English (en)
Inventor
Richard J Bucala
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of ATE196549T1 publication Critical patent/ATE196549T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93902713T 1991-12-20 1992-12-21 Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo ATE196549T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81157991A 1991-12-20 1991-12-20
US07/956,849 US5624804A (en) 1991-12-20 1992-10-01 Immunochemical detection of In vivo advanced glycosylation end products
PCT/US1992/011158 WO1993013421A1 (en) 1991-12-20 1992-12-21 Immunochemical detection of in vivo advanced glycosylation endproducts

Publications (1)

Publication Number Publication Date
ATE196549T1 true ATE196549T1 (de) 2000-10-15

Family

ID=27123501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902713T ATE196549T1 (de) 1991-12-20 1992-12-21 Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo

Country Status (12)

Country Link
US (6) US5624804A (de)
EP (1) EP0623216B1 (de)
JP (1) JPH07502534A (de)
KR (1) KR100257733B1 (de)
CN (1) CN1053964C (de)
AT (1) ATE196549T1 (de)
AU (1) AU681340B2 (de)
CA (1) CA2126209A1 (de)
DE (1) DE69231473T2 (de)
ES (1) ES2150936T3 (de)
PT (1) PT101147A (de)
WO (1) WO1993013421A1 (de)

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US5624804A (en) * 1991-12-20 1997-04-29 The Rockefeller University Immunochemical detection of In vivo advanced glycosylation end products
AU712004B2 (en) * 1993-03-11 1999-10-28 Picower Institute For Medical Research, The Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
US6410598B1 (en) 1994-02-03 2002-06-25 Michael P. Vitek Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
JPH09511492A (ja) * 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
US5610076A (en) * 1994-04-29 1997-03-11 Alteon Inc. Method for detecting hemoglobin advanced glycosylation endproducts
US5744318A (en) * 1994-12-30 1998-04-28 Alteon Inc. Monoclonal antibody for the detection of advanced glycosylation endproducts in biological samples
US5892000A (en) * 1994-12-30 1999-04-06 Alteon Inc. Monoclonal antibodies specific for advanced glycosylation endproducts in biological samples
CN1142778C (zh) * 1995-01-18 2004-03-24 奥尔顿有限公司 噻唑鎓化合物用于预防和逆转高级糖基化终产物形成的用途
US5811242A (en) * 1995-10-24 1998-09-22 Tokuyama Corporation Marker and reagent for diabetes mellitus and diabetes mellitus complication
US5811401A (en) * 1995-11-30 1998-09-22 The Picower Institute For Medical Research Advanced glycosylation endproducts and methods of use therefor
JP2000507346A (ja) * 1995-12-26 2000-06-13 ザ ピコワー インスティテュート フォア メディカル リサーチ タバコ及びその燃焼副産物中の高次糖付加最終生成物の存在を基にする測定方法及び治療方法
AU1431397A (en) * 1995-12-29 1997-07-28 Alteon Inc. 6-(n-carboxymethylamino)caproate, salts thereof and methods of use therefor
US6033862A (en) * 1996-10-30 2000-03-07 Tokuyama Corporation Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications
US6380165B1 (en) 1997-09-19 2002-04-30 The Picower Institute For Medical Research Immunological advanced glycation endproduct crosslink
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US20020091324A1 (en) * 1998-04-06 2002-07-11 Nikiforos Kollias Non-invasive tissue glucose level monitoring
US7899518B2 (en) * 1998-04-06 2011-03-01 Masimo Laboratories, Inc. Non-invasive tissue glucose level monitoring
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ATE283481T1 (de) * 2001-03-22 2004-12-15 Hoffmann La Roche Verfahren zum auffinden von reagenzien und festphasenkomponenten in spezifischen bindungsassays, frei von fortgeschrittenen glykosylierungsendprodukten
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CN100489526C (zh) * 2004-01-16 2009-05-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种人脑红蛋白检测及诊断试剂盒，其制备方法及用途
EP1861407A1 (de) * 2005-03-24 2007-12-05 Avanir Pharmaceuticals Thienopyridinonderivate als hemmer des makrophagenmigrationshemmfaktors
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KR20120127543A (ko) 2008-05-23 2012-11-21 시와 코퍼레이션 재생을 촉진하는 방법, 조성물 및 장치
US9060687B2 (en) 2009-10-02 2015-06-23 Sharp Kabushiki Kaisha Device for monitoring blood vessel conditions and method for monitoring same
US9173604B2 (en) 2010-03-19 2015-11-03 Sharp Kabushiki Kaisha Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium
US9649376B2 (en) 2010-09-27 2017-05-16 Siwa Corporation Selective removal of age-modified cells for treatment of atherosclerosis
US8721571B2 (en) 2010-11-22 2014-05-13 Siwa Corporation Selective removal of cells having accumulated agents
KR101939401B1 (ko) * 2011-11-10 2019-01-16 가천대학교 산학협력단 단핵식세포계 세포의 ａｇｅ-알부민 합성 또는 분비 저해제를 유효성분으로 포함하는 허혈성 심장질환 예방 또는 치료용 조성물
RU2721568C2 (ru) 2014-09-19 2020-05-20 Сива Корпорейшн Анти-age антитела для лечения воспаления и аутоиммунных нарушений
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
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RU2766209C2 (ru) * 2015-10-13 2022-02-09 Сива Корпорейшн Антитела к age и способы их применения
JP6553491B2 (ja) * 2015-11-26 2019-07-31 オリエンタル酵母工業株式会社 最終糖化産物（ＡＧＥｓ）が関連する疾患の罹患又はそのリスクを予測する方法
CN109071675A (zh) 2016-02-19 2018-12-21 Siwa有限公司 使用高级糖化终产物(age)的抗体治疗癌症、杀死转移性癌细胞和预防癌症转移的方法和组合物
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US11518801B1 (en) 2017-12-22 2022-12-06 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications
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JP2021534144A (ja) 2018-08-23 2021-12-09 シワ コーポレーション Ａｇｅ修飾細胞を除去するための、抗カルボキシメチルリシン抗体及び超音波
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Also Published As

Publication number Publication date
US5683887A (en) 1997-11-04
AU681340B2 (en) 1997-08-28
JPH07502534A (ja) 1995-03-16
US5733546A (en) 1998-03-31
EP0623216A1 (de) 1994-11-09
US5702704A (en) 1997-12-30
CN1079825A (zh) 1993-12-22
CA2126209A1 (en) 1993-07-08
AU3418793A (en) 1993-07-28
DE69231473T2 (de) 2001-02-08
US5629408A (en) 1997-05-13
DE69231473D1 (de) 2000-10-26
KR100257733B1 (ko) 2000-06-01
US5712101A (en) 1998-01-27
PT101147A (pt) 1994-03-31
CN1053964C (zh) 2000-06-28
US5624804A (en) 1997-04-29
ES2150936T3 (es) 2000-12-16
EP0623216B1 (de) 2000-09-20
KR940704003A (ko) 1994-12-12
WO1993013421A1 (en) 1993-07-08

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