ATE197668T1 - Verwendung von beta-naphthochinonderivaten zur beschleunigung der proliferation der endothelzellen und inhibierung der no-synthasen - Google Patents

Verwendung von beta-naphthochinonderivaten zur beschleunigung der proliferation der endothelzellen und inhibierung der no-synthasen

Info

Publication number: ATE197668T1
Authority: AT; Austria
Prior art keywords: synthases; beta; endothelial cells; derivatives; naphthochinone
Prior art date: 1993-07-02

Application number

AT94401460T

Other languages

English (en)

Inventor

Christian Bloy

Jean-Pierre Cazenave

Bernard Hercelin

Bernard Teisseire

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-02

Filing date

1994-06-28

Publication date

2000-12-15

1994-06-28 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

2000-12-15 Application granted granted Critical

2000-12-15 Publication of ATE197668T1 publication Critical patent/ATE197668T1/de

Links

210000002889 endothelial cell Anatomy 0.000 title abstract 2
230000035755 proliferation Effects 0.000 title abstract 2
125000000614 1,2-naphthoquinonyl group Chemical class C1(C(C(=CC2=CC=CC=C12)*)=O)=O 0.000 abstract 1
102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT94401460T 1993-07-02 1994-06-28 Verwendung von beta-naphthochinonderivaten zur beschleunigung der proliferation der endothelzellen und inhibierung der no-synthasen ATE197668T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308111A FR2707494B1 (fr)	1993-07-02	1993-07-02	Nouvelle utilisation de dérivés de la béta-naphtoquinone ainsi que de leurs sels.

Publications (1)

Publication Number	Publication Date
ATE197668T1 true ATE197668T1 (de)	2000-12-15

Family

ID=9448827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94401460T ATE197668T1 (de)	1993-07-02	1994-06-28	Verwendung von beta-naphthochinonderivaten zur beschleunigung der proliferation der endothelzellen und inhibierung der no-synthasen

Country Status (13)

Country	Link
US (1)	US5478821A (de)
EP (1)	EP0631776B1 (de)
JP (1)	JP3993647B2 (de)
AT (1)	ATE197668T1 (de)
CA (1)	CA2127214C (de)
DE (1)	DE69426316T2 (de)
DK (1)	DK0631776T3 (de)
ES (1)	ES2154285T3 (de)
FR (1)	FR2707494B1 (de)
GR (1)	GR3035059T3 (de)
HU (1)	HU214716B (de)
PT (1)	PT631776E (de)
RU (1)	RU2131246C1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10500129A (ja) *	1994-05-11	1998-01-06	ジェス、オルセン	片頭痛の治療におけるｎｏスカベンジャー、阻害剤または拮抗剤の使用
FR2722507B1 (fr) *	1994-07-12	1996-08-14	Rhone Poulenc Rorer Sa	Adenovirus comportant un gene codant pour une no synthase
WO1997005871A1 (en) *	1995-08-09	1997-02-20	Ontogen Corporation	Nitric oxide synthase (nos) inhibitors
EP0969790A2 (de) *	1997-02-21	2000-01-12	Beiersdorf Aktiengesellschaft	Zubereitungen für die behandlung von rosacea
IT1312537B1 (it) *	1999-04-16	2002-04-22	Euphar Group Srl	Derivati del (-)- verbenone.
JP4989830B2 (ja) *	1999-07-21	2012-08-01	サーントゥルナシオナルドゥラルシェルシュシャーンティフィク	脳によるグルタミン酸塩の放出に対して抑制効果を示す薬剤を製造するためのベータ−ナフトキノン誘導体の使用
US11723907B2 (en)	2017-02-23	2023-08-15	The Cleveland Clinic Foundation	Anti-aging compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2395638A (en) *	1941-03-07	1946-02-26	Research Corp	Hydroxylation of aromatic hydrocarbons
FR924M (de) *	1959-09-26	1961-11-13
US3758520A (en) *	1971-07-23	1973-09-11	C Beaudet	Process for the preparation of beta-naphthoquinone semicarbazone
JPH037806A (ja) *	1989-06-05	1991-01-16	Masamoto Kaneko	廃棄物の処理方法及び装置

1993
- 1993-07-02 FR FR9308111A patent/FR2707494B1/fr not_active Expired - Fee Related
1994
- 1994-06-28 PT PT94401460T patent/PT631776E/pt unknown
- 1994-06-28 AT AT94401460T patent/ATE197668T1/de active
- 1994-06-28 DK DK94401460T patent/DK0631776T3/da active
- 1994-06-28 EP EP94401460A patent/EP0631776B1/de not_active Expired - Lifetime
- 1994-06-28 DE DE69426316T patent/DE69426316T2/de not_active Expired - Lifetime
- 1994-06-28 ES ES94401460T patent/ES2154285T3/es not_active Expired - Lifetime
- 1994-06-30 CA CA002127214A patent/CA2127214C/fr not_active Expired - Fee Related
- 1994-06-30 US US08/269,648 patent/US5478821A/en not_active Expired - Lifetime
- 1994-07-01 RU RU94022756A patent/RU2131246C1/ru not_active IP Right Cessation
- 1994-07-01 HU HU9401977A patent/HU214716B/hu not_active IP Right Cessation
- 1994-07-01 JP JP17158794A patent/JP3993647B2/ja not_active Expired - Fee Related
2000
- 2000-12-13 GR GR20000402747T patent/GR3035059T3/el unknown

Also Published As

Publication number	Publication date
JP3993647B2 (ja)	2007-10-17
US5478821A (en)	1995-12-26
ES2154285T3 (es)	2001-04-01
HUT70507A (en)	1995-10-30
JPH07145129A (ja)	1995-06-06
CA2127214A1 (fr)	1995-01-03
FR2707494B1 (fr)	1995-08-25
DE69426316T2 (de)	2001-05-03
EP0631776B1 (de)	2000-11-22
FR2707494A1 (fr)	1995-01-20
HU9401977D0 (en)	1994-09-28
DE69426316D1 (de)	2000-12-28
RU94022756A (ru)	1996-09-10
GR3035059T3 (en)	2001-03-30
PT631776E (pt)	2001-05-31
RU2131246C1 (ru)	1999-06-10
HU214716B (hu)	1998-05-28
EP0631776A1 (de)	1995-01-04
DK0631776T3 (da)	2001-03-05
CA2127214C (fr)	2004-10-26

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Legal Events

Date	Code	Title	Description
2001-04-15	UEP	Publication of translation of european patent specification
2005-05-15	EEIH	Change in the person of patent owner