ATE198203T1 - Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel - Google Patents

Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Info

Publication number
ATE198203T1
ATE198203T1 AT97400435T AT97400435T ATE198203T1 AT E198203 T1 ATE198203 T1 AT E198203T1 AT 97400435 T AT97400435 T AT 97400435T AT 97400435 T AT97400435 T AT 97400435T AT E198203 T1 ATE198203 T1 AT E198203T1
Authority
AT
Austria
Prior art keywords
optionally substituted
alkyl
phenyl
acid derivatives
boronic acid
Prior art date
Application number
AT97400435T
Other languages
English (en)
Inventor
Nanteuil Guillaume De
Philippe Gloanec
Christine Lila
Bernard Portevin
Tony Verbeuren
Alain Rupin
Serge Simonet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE198203T1 publication Critical patent/ATE198203T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97400435T 1996-02-27 1997-02-27 Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel ATE198203T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9602377A FR2745288B1 (fr) 1996-02-27 1996-02-27 Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE198203T1 true ATE198203T1 (de) 2001-01-15

Family

ID=9489592

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97400435T ATE198203T1 (de) 1996-02-27 1997-02-27 Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Country Status (17)

Country Link
US (1) US5814622A (de)
EP (1) EP0792883B1 (de)
JP (1) JPH09227578A (de)
CN (1) CN1076353C (de)
AT (1) ATE198203T1 (de)
AU (1) AU709687B2 (de)
CA (1) CA2198570C (de)
CY (1) CY2223B1 (de)
DE (1) DE69703709T2 (de)
DK (1) DK0792883T3 (de)
ES (1) ES2154885T3 (de)
FR (1) FR2745288B1 (de)
GR (1) GR3035435T3 (de)
NO (1) NO308608B1 (de)
NZ (1) NZ314309A (de)
PT (1) PT792883E (de)
ZA (1) ZA971724B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002243508A1 (en) * 2001-01-10 2002-07-24 Bristol-Myers Squibb Company Patent Department Alpha-aminoboronic acids prepared by novel synthetic methods
JPWO2003033507A1 (ja) * 2001-10-12 2005-02-03 杏林製薬株式会社 ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬
AU2003243594A1 (en) * 2002-06-13 2003-12-31 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
AU2003223930A1 (en) 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
US20050119226A1 (en) * 2003-09-09 2005-06-02 Trigen Limited Methods for synthesizing organoboronic compounds and products thereof
US20050176651A1 (en) * 2002-09-09 2005-08-11 Trigen Limited Peptide boronic acids useful in making salts thereof
US20050288253A1 (en) * 2002-09-09 2005-12-29 Trigen Limited Boronic acid salts
US20050282757A1 (en) * 2002-09-09 2005-12-22 Trigen Limited Peptide boronic acid compounds useful in anticoagulation
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US7838673B2 (en) * 2007-10-16 2010-11-23 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
HRP20160569T1 (hr) * 2007-12-03 2016-07-29 Obe Therapy Biotechnology Boropeptidni inhibitori enteropeptidaze i njihove uporabe u liječenju pretilosti, pretjerane tjelesne težine i/ili bolesti povezane s abnormalnim metabolizmom masti
CA2721060A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8445432B2 (en) 2009-10-30 2013-05-21 Ntf Therapeutics Inc Neurturin molecules
US9127083B2 (en) 2009-10-30 2015-09-08 Ntf Therapeutics, Inc. Neurturin molecules
RU2015143910A (ru) 2010-02-03 2018-12-28 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
SG11202003762VA (en) 2017-11-01 2020-05-28 Melinta Therapeutics Inc Synthesis of boronate ester derivatives and uses thereof
JP2020079299A (ja) * 2020-02-18 2020-05-28 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
WO1994021650A1 (en) * 1993-03-24 1994-09-29 The Du Pont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5574017A (en) * 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents

Also Published As

Publication number Publication date
FR2745288A1 (fr) 1997-08-29
ES2154885T3 (es) 2001-04-16
ZA971724B (en) 1997-09-04
CN1076353C (zh) 2001-12-19
DK0792883T3 (da) 2001-01-08
EP0792883B1 (de) 2000-12-20
AU1488897A (en) 1997-09-04
DE69703709D1 (de) 2001-01-25
AU709687B2 (en) 1999-09-02
CA2198570C (fr) 2001-08-14
CN1160716A (zh) 1997-10-01
PT792883E (pt) 2001-04-30
EP0792883A1 (de) 1997-09-03
JPH09227578A (ja) 1997-09-02
FR2745288B1 (fr) 1998-04-17
CA2198570A1 (fr) 1997-08-27
NO970843D0 (no) 1997-02-25
US5814622A (en) 1998-09-29
DE69703709T2 (de) 2001-07-12
NO970843L (no) 1997-08-28
GR3035435T3 (en) 2001-05-31
NO308608B1 (no) 2000-10-02
NZ314309A (en) 1998-07-28
CY2223B1 (en) 2003-04-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee