ATE198203T1 - Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel - Google Patents

Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Info

Publication number: ATE198203T1
Authority: AT; Austria
Prior art keywords: optionally substituted; alkyl; phenyl; acid derivatives; boronic acid
Prior art date: 1996-02-27

Application number

AT97400435T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Philippe Gloanec

Christine Lila

Bernard Portevin

Tony Verbeuren

Alain Rupin

Serge Simonet

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-27

Filing date

1997-02-27

Publication date

2001-01-15

1997-02-27 Application filed by Adir filed Critical Adir

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198203T1 publication Critical patent/ATE198203T1/de

Links

150000001642 boronic acid derivatives Chemical class 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
MOILFCKRQFQVFS-BDNRQGISSA-N (1r,3s,4r,5r)-4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1[C@@H]2C(C)(C)[C@H]1C[C@H](O)[C@@]2(O)C MOILFCKRQFQVFS-BDNRQGISSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
-1 amino, amidino, guanidino isothioureido iminomethylamino Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97400435T 1996-02-27 1997-02-27 Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel ATE198203T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9602377A FR2745288B1 (fr)	1996-02-27	1996-02-27	Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE198203T1 true ATE198203T1 (de)	2001-01-15

Family

ID=9489592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97400435T ATE198203T1 (de)	1996-02-27	1997-02-27	Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Country Status (17)

Country	Link
US (1)	US5814622A (de)
EP (1)	EP0792883B1 (de)
JP (1)	JPH09227578A (de)
CN (1)	CN1076353C (de)
AT (1)	ATE198203T1 (de)
AU (1)	AU709687B2 (de)
CA (1)	CA2198570C (de)
CY (1)	CY2223B1 (de)
DE (1)	DE69703709T2 (de)
DK (1)	DK0792883T3 (de)
ES (1)	ES2154885T3 (de)
FR (1)	FR2745288B1 (de)
GR (1)	GR3035435T3 (de)
NO (1)	NO308608B1 (de)
NZ (1)	NZ314309A (de)
PT (1)	PT792883E (de)
ZA (1)	ZA971724B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002054931A2 (en) *	2001-01-10	2002-07-18	Bristol Myers Squibb Company P	Alpha-aminoboronic acids prepared by novel synthetic methods
JPWO2003033507A1 (ja) *	2001-10-12	2005-02-03	杏林製薬株式会社	ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬
US7514579B2 (en) *	2002-06-13	2009-04-07	Johns Hopkins University	Boronic chalcone derivatives and uses thereof
WO2003105860A1 (en)	2002-06-14	2003-12-24	Novo Nordisk A/S	Pharmaceutical use of boronic acids and esters thereof
US7371729B2 (en) *	2002-09-09	2008-05-13	Trigen Limited	Boronic acid salts useful in parenteral formulations
US20050176651A1 (en) *	2002-09-09	2005-08-11	Trigen Limited	Peptide boronic acids useful in making salts thereof
US20050282757A1 (en) *	2002-09-09	2005-12-22	Trigen Limited	Peptide boronic acid compounds useful in anticoagulation
US20050119226A1 (en) *	2003-09-09	2005-06-02	Trigen Limited	Methods for synthesizing organoboronic compounds and products thereof
US20060084592A1 (en) *	2002-09-09	2006-04-20	Trigen Limited	Peptide boronic acid inhibitors
GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
JO3598B1 (ar)	2006-10-10	2020-07-05	Infinity Discovery Inc	الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US7838673B2 (en) *	2007-10-16	2010-11-23	Millennium Pharmaceuticals, Inc.	Proteasome inhibitors
WO2009071601A1 (en) *	2007-12-03	2009-06-11	Obe Therapy Biotechnology	Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism
EP2282742A1 (de)	2008-04-09	2011-02-16	Infinity Pharmaceuticals, Inc.	Inhibitoren von fettsäureamidhydrolase
US8445432B2 (en)	2009-10-30	2013-05-21	Ntf Therapeutics Inc	Neurturin molecules
US9127083B2 (en)	2009-10-30	2015-09-08	Ntf Therapeutics, Inc.	Neurturin molecules
MX361692B (es)	2010-02-03	2018-12-13	Infinity Pharmaceuticals Inc	Inhibidores de amida hidrolasa de ácido graso.
AU2018360502B2 (en)	2017-11-01	2024-05-02	Melinta Therapeutics, Llc	Synthesis of boronate ester derivatives and uses thereof
JP2020079299A (ja) *	2020-02-18	2020-05-28	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) *	1990-08-13	1990-09-26	Sandoz Ltd	Improvements in or relating to organic chemistry
US5563127A (en) *	1993-03-24	1996-10-08	The Dupont Merck Pharmaceutical Company	Boronic acid and ester inhibitors of thrombin
AU6448794A (en) *	1993-03-24	1994-10-11	Du Pont Merck Pharmaceutical Company, The	Boronic acid and ester inhibitors of thrombin
US5574017A (en) *	1994-07-05	1996-11-12	Gutheil; William G.	Antibacterial agents

1996
- 1996-02-27 FR FR9602377A patent/FR2745288B1/fr not_active Expired - Fee Related
1997
- 1997-02-25 AU AU14888/97A patent/AU709687B2/en not_active Ceased
- 1997-02-25 NO NO970843A patent/NO308608B1/no unknown
- 1997-02-26 CA CA002198570A patent/CA2198570C/fr not_active Expired - Fee Related
- 1997-02-26 NZ NZ314309A patent/NZ314309A/en unknown
- 1997-02-27 AT AT97400435T patent/ATE198203T1/de not_active IP Right Cessation
- 1997-02-27 ES ES97400435T patent/ES2154885T3/es not_active Expired - Lifetime
- 1997-02-27 JP JP9043697A patent/JPH09227578A/ja active Pending
- 1997-02-27 US US08/807,569 patent/US5814622A/en not_active Expired - Fee Related
- 1997-02-27 DE DE69703709T patent/DE69703709T2/de not_active Expired - Fee Related
- 1997-02-27 ZA ZA9701724A patent/ZA971724B/xx unknown
- 1997-02-27 DK DK97400435T patent/DK0792883T3/da active
- 1997-02-27 CN CN97102690A patent/CN1076353C/zh not_active Expired - Fee Related
- 1997-02-27 PT PT97400435T patent/PT792883E/pt unknown
- 1997-02-27 EP EP97400435A patent/EP0792883B1/de not_active Expired - Lifetime
2001
- 2001-02-20 GR GR20010400266T patent/GR3035435T3/el not_active IP Right Cessation
- 2001-05-17 CY CY0100009A patent/CY2223B1/xx unknown

Also Published As

Publication number	Publication date
JPH09227578A (ja)	1997-09-02
EP0792883B1 (de)	2000-12-20
AU1488897A (en)	1997-09-04
CN1160716A (zh)	1997-10-01
CA2198570A1 (fr)	1997-08-27
FR2745288B1 (fr)	1998-04-17
PT792883E (pt)	2001-04-30
NO970843L (no)	1997-08-28
DK0792883T3 (da)	2001-01-08
US5814622A (en)	1998-09-29
ES2154885T3 (es)	2001-04-16
CY2223B1 (en)	2003-04-18
FR2745288A1 (fr)	1997-08-29
GR3035435T3 (en)	2001-05-31
CA2198570C (fr)	2001-08-14
CN1076353C (zh)	2001-12-19
ZA971724B (en)	1997-09-04
AU709687B2 (en)	1999-09-02
DE69703709D1 (de)	2001-01-25
NO970843D0 (no)	1997-02-25
NZ314309A (en)	1998-07-28
EP0792883A1 (de)	1997-09-03
DE69703709T2 (de)	2001-07-12
NO308608B1 (no)	2000-10-02

Legal Events

Date	Code	Title	Description
2001-05-15	UEP	Publication of translation of european patent specification
2005-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE198203T1 (de)	2001-01-15	Neue boronsäure-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
ATE238280T1 (de)	2003-05-15	Verwendung eines pharmazeutisch geeigneten salzes von (3r,2'r)-3-((cyclopentyl- hydroxyphenylacetyl)oxy)-1,1-dimethyl- pyrrolidinium zur herstellung eines arzneimittels
IL108602A0 (en)	1994-05-30	N-alkyl-2-substituted atp analogues, their preparation and pharmaceutical compositions containing them
HU9802850D0 (en)	1999-02-01	Novel aryl propionic acid derivative and pharmaceutical compositions containing it
ATE190612T1 (de)	2000-04-15	Benzopyranverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen zubereitungen
AU4616893A (en)	1994-03-17	New benzopyran compounds, process for their preparation and the pharmaceutical compositions which contain them
DK0553016T3 (da)	1997-12-01	Hidtil ukendte naphtalenamider og -sulfonamider, fremgangsmåder til deres fremstilling samt farmaceutiske midler indeholdende dem
ES493599A0 (es)	1981-06-16	Un procedimiento para la preparacion de derivados de azeti din-2-ona.
EP0188254A3 (en)	1988-10-19	New cephem compounds, processes for preparation thereof and pharmaceutical compositions containing them
GR3020190T3 (en)	1996-09-30	Diclofenac choline salt, a method for the preparation thereof and pharmaceutical compositions containing it
AU6359198A (en)	1998-10-29	New heterocyclic compounds, a process for their preparation and pharmaceutical compositions containing them
DK0571243T3 (da)	1995-12-04	Thiochromanderivater, fremgangsmåder til fremstilling heraf samt farmaceutiske midler indeholdende d isse
AU8038794A (en)	1995-02-23	New eburnane analogues, a process for the preparation thereof and pharmaceutical compositions containing them
IL124353A (en)	2005-06-19	Production of a potassium salt of clavulanic acid
JPS5297934A (en)	1977-08-17	N#-arylsulfonyl-l-argininamides and their salts acceptable as medicine s
PT816358E (pt)	2005-01-31	Amidas de acido 4-amino-2-ureido-pirimidina-5-carboxilico, processos para a sua preparacao, medicamentos contendo estes compostos e sua utilizacao
ATE212634T1 (de)	2002-02-15	Metalloproteaseinhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
AU668398B2 (en)	1996-05-02	New aminoalkylchromones, processes for the preparation thereof, and pharmaceutical compositions containing them
GB8823040D0 (en)	1988-11-09	Organic compounds & their use as pharmaceuticals
DE3782619D1 (de)	1992-12-17	1-hydroxyalkylxanthine, verfahren zu ihrer herstellung und sie enthaltende medikamente.