DK0792883T3 - Nye borsyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, der indeholder disse - Google Patents

Nye borsyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, der indeholder disse

Info

Publication number: DK0792883T3
Authority: DK; Denmark
Prior art keywords: optionally substituted; alkyl; phenyl; acid derivatives; processes
Prior art date: 1996-02-27

Application number

DK97400435T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Philippe Gloanec

Christine Lila

Bernard Portevin

Tony Verbeuren

Alain Rupin

Serge Simonet

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-27

Filing date

1997-02-27

Publication date

2001-01-08

1997-02-27 Application filed by Adir filed Critical Adir

2001-01-08 Application granted granted Critical

2001-01-08 Publication of DK0792883T3 publication Critical patent/DK0792883T3/da

Links

KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
MOILFCKRQFQVFS-BDNRQGISSA-N (1r,3s,4r,5r)-4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1[C@@H]2C(C)(C)[C@H]1C[C@H](O)[C@@]2(O)C MOILFCKRQFQVFS-BDNRQGISSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
-1 amino, amidino, guanidino isothioureido iminomethylamino Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK97400435T 1996-02-27 1997-02-27 Nye borsyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, der indeholder disse DK0792883T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9602377A FR2745288B1 (fr)	1996-02-27	1996-02-27	Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
DK0792883T3 true DK0792883T3 (da)	2001-01-08

Family

ID=9489592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97400435T DK0792883T3 (da)	1996-02-27	1997-02-27	Nye borsyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, der indeholder disse

Country Status (17)

Country	Link
US (1)	US5814622A (da)
EP (1)	EP0792883B1 (da)
JP (1)	JPH09227578A (da)
CN (1)	CN1076353C (da)
AT (1)	ATE198203T1 (da)
AU (1)	AU709687B2 (da)
CA (1)	CA2198570C (da)
CY (1)	CY2223B1 (da)
DE (1)	DE69703709T2 (da)
DK (1)	DK0792883T3 (da)
ES (1)	ES2154885T3 (da)
FR (1)	FR2745288B1 (da)
GR (1)	GR3035435T3 (da)
NO (1)	NO308608B1 (da)
NZ (1)	NZ314309A (da)
PT (1)	PT792883E (da)
ZA (1)	ZA971724B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002054931A2 (en) *	2001-01-10	2002-07-18	Bristol Myers Squibb Company P	Alpha-aminoboronic acids prepared by novel synthetic methods
JPWO2003033507A1 (ja) *	2001-10-12	2005-02-03	杏林製薬株式会社	ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬
US7514579B2 (en) *	2002-06-13	2009-04-07	Johns Hopkins University	Boronic chalcone derivatives and uses thereof
AU2003223930A1 (en)	2002-06-14	2003-12-31	Novo Nordisk A/S	Pharmaceutical use of boronic acids and esters thereof
US20060084592A1 (en) *	2002-09-09	2006-04-20	Trigen Limited	Peptide boronic acid inhibitors
US7112572B2 (en) *	2002-09-09	2006-09-26	Trigen Limited	Multivalent metal salts of boronic acids
US20050119226A1 (en) *	2003-09-09	2005-06-02	Trigen Limited	Methods for synthesizing organoboronic compounds and products thereof
US20050282757A1 (en) *	2002-09-09	2005-12-22	Trigen Limited	Peptide boronic acid compounds useful in anticoagulation
US20050176651A1 (en) *	2002-09-09	2005-08-11	Trigen Limited	Peptide boronic acids useful in making salts thereof
GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
JO3598B1 (ar)	2006-10-10	2020-07-05	Infinity Discovery Inc	الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US7838673B2 (en) *	2007-10-16	2010-11-23	Millennium Pharmaceuticals, Inc.	Proteasome inhibitors
CA2707549A1 (en) *	2007-12-03	2009-06-11	Itzik Harosh	Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism
AU2009233711B2 (en)	2008-04-09	2015-02-12	Infinity Pharmaceuticals, Inc	Inhibitors of fatty acid amide hydrolase
US9127083B2 (en)	2009-10-30	2015-09-08	Ntf Therapeutics, Inc.	Neurturin molecules
US8445432B2 (en)	2009-10-30	2013-05-21	Ntf Therapeutics Inc	Neurturin molecules
EP2531511A1 (en)	2010-02-03	2012-12-12	Infinity Pharmaceuticals, Inc.	Fatty acid amide hydrolase inhibitors
US11999757B2 (en)	2017-11-01	2024-06-04	Melinta Subsidiary Corp.	Synthesis of boronate ester derivatives and uses thereof
JP2020079299A (ja) *	2020-02-18	2020-05-28	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) *	1990-08-13	1990-09-26	Sandoz Ltd	Improvements in or relating to organic chemistry
US5563127A (en) *	1993-03-24	1996-10-08	The Dupont Merck Pharmaceutical Company	Boronic acid and ester inhibitors of thrombin
AU6448794A (en) *	1993-03-24	1994-10-11	Du Pont Merck Pharmaceutical Company, The	Boronic acid and ester inhibitors of thrombin
US5574017A (en) *	1994-07-05	1996-11-12	Gutheil; William G.	Antibacterial agents

1996
- 1996-02-27 FR FR9602377A patent/FR2745288B1/fr not_active Expired - Fee Related
1997
- 1997-02-25 NO NO970843A patent/NO308608B1/no unknown
- 1997-02-25 AU AU14888/97A patent/AU709687B2/en not_active Ceased
- 1997-02-26 CA CA002198570A patent/CA2198570C/fr not_active Expired - Fee Related
- 1997-02-26 NZ NZ314309A patent/NZ314309A/en unknown
- 1997-02-27 CN CN97102690A patent/CN1076353C/zh not_active Expired - Fee Related
- 1997-02-27 DK DK97400435T patent/DK0792883T3/da active
- 1997-02-27 US US08/807,569 patent/US5814622A/en not_active Expired - Fee Related
- 1997-02-27 AT AT97400435T patent/ATE198203T1/de not_active IP Right Cessation
- 1997-02-27 ZA ZA9701724A patent/ZA971724B/xx unknown
- 1997-02-27 PT PT97400435T patent/PT792883E/pt unknown
- 1997-02-27 DE DE69703709T patent/DE69703709T2/de not_active Expired - Fee Related
- 1997-02-27 EP EP97400435A patent/EP0792883B1/fr not_active Expired - Lifetime
- 1997-02-27 ES ES97400435T patent/ES2154885T3/es not_active Expired - Lifetime
- 1997-02-27 JP JP9043697A patent/JPH09227578A/ja active Pending
2001
- 2001-02-20 GR GR20010400266T patent/GR3035435T3/el not_active IP Right Cessation
- 2001-05-17 CY CY0100009A patent/CY2223B1/xx unknown

Also Published As

Publication number	Publication date
US5814622A (en)	1998-09-29
ES2154885T3 (es)	2001-04-16
PT792883E (pt)	2001-04-30
NO970843L (no)	1997-08-28
DE69703709D1 (de)	2001-01-25
NZ314309A (en)	1998-07-28
EP0792883A1 (fr)	1997-09-03
ZA971724B (en)	1997-09-04
NO308608B1 (no)	2000-10-02
AU1488897A (en)	1997-09-04
GR3035435T3 (en)	2001-05-31
CY2223B1 (en)	2003-04-18
CN1160716A (zh)	1997-10-01
CN1076353C (zh)	2001-12-19
NO970843D0 (no)	1997-02-25
FR2745288B1 (fr)	1998-04-17
EP0792883B1 (fr)	2000-12-20
ATE198203T1 (de)	2001-01-15
FR2745288A1 (fr)	1997-08-29
JPH09227578A (ja)	1997-09-02
CA2198570C (fr)	2001-08-14
DE69703709T2 (de)	2001-07-12
CA2198570A1 (fr)	1997-08-27
AU709687B2 (en)	1999-09-02

Publication	Publication Date	Title
CY2223B1 (en)	2003-04-18	Novel derivates of boronic acid process for their preparation and pharmaceutical compositions containing them
NO305988B1 (no)	1999-08-30	Nye pyridinforbindelser og farmasoeytiske sammensetninger som inneholder dem
DK0683789T3 (da)	1998-02-09	N-alkyl-2-substituerede ATP-analoger
DK0457686T3 (da)	1994-12-12	Hidtil ukendte aminopiperidin-, aminopyrrolidin- og aminoperhydroazepinderivater, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem
NO306720B1 (no)	1999-12-13	Sykliske ureaer og analoger som er anvendbare som retrovirale proteaseinhibitorer, farmasöytiske preparater omfattende disse og anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
ES8606341A1 (es)	1986-04-16	Un procedimiento para la preparacion de pirazolo piridinas.
DK234388A (da)	1989-01-19	1,4-dihydropyridin-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til deres fremstilling af laegemidler samt beskyttede derivater deraf til anvendelse som udgangsmateriale ved deres fremstilling
DE69324846D1 (de)	1999-06-17	Carbapenemverbindungen als Antibiotika
DE3852008D1 (de)	1994-12-08	Verbindungen.
ES2094324T3 (es)	1997-01-16	Nuevos derivados de pirrolidina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
PL323767A1 (en)	1998-06-22	Novel n-benzylopyrasine compounds, methods of obtaining them and pharmaceutic compositions containing such compounds
NO972943L (no)	1997-12-29	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende dem og deres anvendelse
EP0341081A3 (en)	1990-12-27	Novel amino acid derivatives
FI950818A0 (fi)	1995-02-22	Uudet substituoidut sulfoniamidit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
PT916671E (pt)	2002-06-28	Novos inibidores de metaloproteases processo para a sua preparacao e as suas composicoes farmaceuticas que os contem
GB8823040D0 (en)	1988-11-09	Organic compounds & their use as pharmaceuticals
NO972942D0 (no)	1997-06-23	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse