ES2154885T3 - Nuevos derivados de acido boronico, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de acido boronico, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2154885T3
ES2154885T3 ES97400435T ES97400435T ES2154885T3 ES 2154885 T3 ES2154885 T3 ES 2154885T3 ES 97400435 T ES97400435 T ES 97400435T ES 97400435 T ES97400435 T ES 97400435T ES 2154885 T3 ES2154885 T3 ES 2154885T3
Authority
ES
Spain
Prior art keywords
optionally substituted
alkyl
phenyl
boronic acid
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97400435T
Other languages
English (en)
Inventor
Nanteuil Guillaume De
Philippe Gloanec
Christine Lila
Bernard Portevin
Tony Verbeuren
Alain Rupin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2154885T3 publication Critical patent/ES2154885T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTO DE FORMULA (I) EN LA QUE R 1 , R 2 IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO O BIEN R{SUB,1} Y R{SUB,2} FORMAN CON EL ATOMO DE CARBONO QUE LOS LLEVA UN GRUPO CICLOALQUILO, R{SUB,3} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, FENILO O BENCILO, R{SUB,4} REPRESENTA: - UN GRUPO AMINO SUSTITUIDO EVENTUALMENTE, AMIDINO SUSTITUIDO EVENTUALMENTE, GUANIDINO SUSTITUIDO EVENTUALMENTE, ISOTIOUREIDO SUSTITUIDO EVENTUALMENTE, INIMOMETILAMINO SUSTITUIDO EVENTUALMENTE, MERCAPTO SUSTITUIDO POR UN GRUPO HETEROCICLICO O HETEROCICLICO, R{SUB,5} Y R{SUB,6} REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO.
ES97400435T 1996-02-27 1997-02-27 Nuevos derivados de acido boronico, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2154885T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9602377A FR2745288B1 (fr) 1996-02-27 1996-02-27 Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2154885T3 true ES2154885T3 (es) 2001-04-16

Family

ID=9489592

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97400435T Expired - Lifetime ES2154885T3 (es) 1996-02-27 1997-02-27 Nuevos derivados de acido boronico, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (17)

Country Link
US (1) US5814622A (es)
EP (1) EP0792883B1 (es)
JP (1) JPH09227578A (es)
CN (1) CN1076353C (es)
AT (1) ATE198203T1 (es)
AU (1) AU709687B2 (es)
CA (1) CA2198570C (es)
CY (1) CY2223B1 (es)
DE (1) DE69703709T2 (es)
DK (1) DK0792883T3 (es)
ES (1) ES2154885T3 (es)
FR (1) FR2745288B1 (es)
GR (1) GR3035435T3 (es)
NO (1) NO308608B1 (es)
NZ (1) NZ314309A (es)
PT (1) PT792883E (es)
ZA (1) ZA971724B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002054931A2 (en) * 2001-01-10 2002-07-18 Bristol Myers Squibb Company P Alpha-aminoboronic acids prepared by novel synthetic methods
JPWO2003033507A1 (ja) * 2001-10-12 2005-02-03 杏林製薬株式会社 ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬
US7514579B2 (en) * 2002-06-13 2009-04-07 Johns Hopkins University Boronic chalcone derivatives and uses thereof
WO2003105860A1 (en) 2002-06-14 2003-12-24 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
US7371729B2 (en) * 2002-09-09 2008-05-13 Trigen Limited Boronic acid salts useful in parenteral formulations
US20050176651A1 (en) * 2002-09-09 2005-08-11 Trigen Limited Peptide boronic acids useful in making salts thereof
US20050282757A1 (en) * 2002-09-09 2005-12-22 Trigen Limited Peptide boronic acid compounds useful in anticoagulation
US20050119226A1 (en) * 2003-09-09 2005-06-02 Trigen Limited Methods for synthesizing organoboronic compounds and products thereof
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US7838673B2 (en) * 2007-10-16 2010-11-23 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
WO2009071601A1 (en) * 2007-12-03 2009-06-11 Obe Therapy Biotechnology Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism
EP2282742A1 (en) 2008-04-09 2011-02-16 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8445432B2 (en) 2009-10-30 2013-05-21 Ntf Therapeutics Inc Neurturin molecules
US9127083B2 (en) 2009-10-30 2015-09-08 Ntf Therapeutics, Inc. Neurturin molecules
MX361692B (es) 2010-02-03 2018-12-13 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de ácido graso.
AU2018360502B2 (en) 2017-11-01 2024-05-02 Melinta Therapeutics, Llc Synthesis of boronate ester derivatives and uses thereof
JP2020079299A (ja) * 2020-02-18 2020-05-28 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
AU6448794A (en) * 1993-03-24 1994-10-11 Du Pont Merck Pharmaceutical Company, The Boronic acid and ester inhibitors of thrombin
US5574017A (en) * 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents

Also Published As

Publication number Publication date
JPH09227578A (ja) 1997-09-02
EP0792883B1 (fr) 2000-12-20
AU1488897A (en) 1997-09-04
CN1160716A (zh) 1997-10-01
CA2198570A1 (fr) 1997-08-27
FR2745288B1 (fr) 1998-04-17
PT792883E (pt) 2001-04-30
NO970843L (no) 1997-08-28
DK0792883T3 (da) 2001-01-08
US5814622A (en) 1998-09-29
CY2223B1 (en) 2003-04-18
FR2745288A1 (fr) 1997-08-29
GR3035435T3 (en) 2001-05-31
CA2198570C (fr) 2001-08-14
CN1076353C (zh) 2001-12-19
ZA971724B (en) 1997-09-04
AU709687B2 (en) 1999-09-02
DE69703709D1 (de) 2001-01-25
NO970843D0 (no) 1997-02-25
NZ314309A (en) 1998-07-28
EP0792883A1 (fr) 1997-09-03
ATE198203T1 (de) 2001-01-15
DE69703709T2 (de) 2001-07-12
NO308608B1 (no) 2000-10-02

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