ATE199549T1 - Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung - Google Patents

Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Info

Publication number
ATE199549T1
ATE199549T1 AT95903455T AT95903455T ATE199549T1 AT E199549 T1 ATE199549 T1 AT E199549T1 AT 95903455 T AT95903455 T AT 95903455T AT 95903455 T AT95903455 T AT 95903455T AT E199549 T1 ATE199549 T1 AT E199549T1
Authority
AT
Austria
Prior art keywords
group
optionally substituted
pct
amino
halogen atom
Prior art date
Application number
AT95903455T
Other languages
English (en)
Inventor
Jong Chan Son
Ill Young Lee
Byung Il Bae
Jeong Sik Han
Joong Kwon Choi
Yung Bok Chae
Original Assignee
Korea Res Inst Chem Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR2019930028908U external-priority patent/KR0132614Y1/ko
Priority claimed from KR2019930028909U external-priority patent/KR950017498U/ko
Application filed by Korea Res Inst Chem Tech filed Critical Korea Res Inst Chem Tech
Application granted granted Critical
Publication of ATE199549T1 publication Critical patent/ATE199549T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95903455T 1993-12-21 1994-12-20 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung ATE199549T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR2019930028908U KR0132614Y1 (ko) 1993-12-21 1993-12-21 자동차의 좌석 틸트장치
KR2019930028909U KR950017498U (ko) 1993-12-21 1993-12-21 자동차의 스태빌라이저 장착구조
KR19940010264 1994-05-11
KR19940010262 1994-05-11
KR19940010263 1994-05-11
KR1019940029388A KR0151811B1 (ko) 1993-12-21 1994-11-10 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
PCT/KR1994/000178 WO1995018109A1 (en) 1993-12-21 1994-12-20 Novel antiviral 2,4-pyrimidinedione derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
ATE199549T1 true ATE199549T1 (de) 2001-03-15

Family

ID=27555064

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903455T ATE199549T1 (de) 1993-12-21 1994-12-20 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US5747500A (de)
EP (1) EP0736015B1 (de)
JP (1) JP2935573B2 (de)
KR (1) KR0151811B1 (de)
AT (1) ATE199549T1 (de)
AU (1) AU1250295A (de)
DE (1) DE69426836D1 (de)
WO (1) WO1995018109A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
WO1997030979A1 (en) * 1996-02-22 1997-08-28 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
EP0967208B1 (de) * 1998-06-26 2002-08-14 Crompton Vinyl Additives GmbH In 5-Stellung substituierte 6-Aminouracile als Stabilisatoren für halogen-haltige Polymere
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
KR100368891B1 (ko) * 1999-03-04 2003-01-24 한국화학연구원 신규한 항바이러스성 2,4-피리미딘디온 유도체
US6713486B1 (en) * 1999-03-04 2004-03-30 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR100311949B1 (ko) * 1999-03-10 2001-11-02 최승주 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
AU2002248910A1 (en) 2000-11-17 2002-05-27 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines
KR20020074683A (ko) * 2001-03-21 2002-10-04 주식회사 엘지씨아이 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
KR101257378B1 (ko) * 2006-04-19 2013-04-23 삼진제약주식회사 항바이러스성 피리미딘디온 유도체 및 이의 제조 방법
EA200971115A1 (ru) * 2007-06-29 2010-04-30 Корея Рисерч Инститьют Оф Кемикал Текнолоджи Новые ингибиторы обратной транскриптазы вич
KR20100041798A (ko) * 2007-06-29 2010-04-22 한국화학연구원 신규 ｈｉｖ 역전사효소 억제제
KR20100092960A (ko) * 2007-12-21 2010-08-23 한국화학연구원 Ｈｉｖ 역전사 효소 억제제의 제조 방법
SG11201401531RA (en) 2011-11-11 2014-07-30 Pfizer 2-thiopyrimidinones
BR112017022340A2 (pt) 2015-05-05 2018-07-10 Pfizer 2-tiopirimidinonas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730001A (en) * 1986-01-22 1988-03-08 Southern Research Institute Carbocyclic analogues of amino and azido thymidines
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
ATE169915T1 (de) * 1990-02-15 1998-09-15 Takeda Chemical Industries Ltd Pyrimidindionderivate, deren herstellung und verwendung
DE69126469T2 (de) * 1990-03-29 1998-01-29 Mitsubishi Chem Corp Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten
USH1142H (en) * 1990-11-05 1993-02-02 Optically active cyclobutyl pyrimidine

Also Published As

Publication number Publication date
JPH09509405A (ja) 1997-09-22
US5747500A (en) 1998-05-05
KR950017971A (ko) 1995-07-22
WO1995018109A1 (en) 1995-07-06
JP2935573B2 (ja) 1999-08-16
DE69426836D1 (de) 2001-04-12
KR0151811B1 (ko) 1998-10-15
AU1250295A (en) 1995-07-17
EP0736015A1 (de) 1996-10-09
EP0736015B1 (de) 2001-03-07

Similar Documents

Publication Publication Date Title
DE69426836D1 (de) Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung
MX9203762A (es) Administracion de monoaminacridinas en estados deficientes en colinergicos-neuronales.
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
DE69528437D1 (de) Substituierte azaindolylidenderivate und verfahren zu ihrer herstellung
DE69420579D1 (de) 9-HYDROXY-PYRIDO [1,2-a] PYRIMIDIN-4-ON-ETHER-DERIVATE
IL87795A (en) Benzimidazolin-2-oxo- 1-carboxylic acid ester and amide derivatives, their preparation and pharmaceutical compositions containing them
BR1100412A (pt) Composto; método para propiciar tratamento imunomodulador; e composição farmacêutica para tratamento imunomodulador
AU2736088A (en) Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
FI933424A0 (fi) Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyraderivat som antiinflammatoriska medel
HUP0100184A2 (hu) Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
HUP0303204A2 (hu) 1-Metilkarbapenem-származékok és ezeket tartalmazó gyógyszerkészítmények
DK1471059T3 (da) 2,4,6-tris(dineopentyl-4'-aminobenzalmalonat)-s-triazin, fotobeskyttende kosmetiske sammensætninger indeholdende denne forbindelse og anvendelse af den nævnte forbindelse
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
ATE161178T1 (de) Pyrazolpyridine für die behandlung der anämie
ATE246177T1 (de) Katecholhydrazon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten
ATE397609T1 (de) Corticotropinfreisetzungsfaktor antagonisten
DK0720598T3 (da) Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
SE8501988D0 (sv) Iminothiazolidine derivatives
ES2140393T3 (es) Compuestos de penem.
ATE215075T1 (de) Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend
DK0646116T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af bis-aza-bicycliske anxiolytiske midler
EA200200379A3 (ru) Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
MX9708422A (es) Esteres de carbapenemas.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties