IL99466A - Carbocyclic adenosine analogs and immunosuppressant pharmaceutical compositions containing them - Google Patents

Carbocyclic adenosine analogs and immunosuppressant pharmaceutical compositions containing them

Info

Publication number: IL99466A
Authority: IL; Israel
Prior art keywords: compound; cis; cells; composition according; hydroxy
Prior art date: 1990-09-14

Application number

IL9946691A

Other languages

English (en)

Other versions

IL99466A0 (en

Original Assignee

Marion Merrel Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-14

Filing date

1991-09-12

Publication date

1996-07-23

1991-09-12 Application filed by Marion Merrel Dow Inc filed Critical Marion Merrel Dow Inc

1992-08-18 Publication of IL99466A0 publication Critical patent/IL99466A0/xx

1996-07-23 Publication of IL99466A publication Critical patent/IL99466A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL9946691A 1990-09-14 1991-09-12 Carbocyclic adenosine analogs and immunosuppressant pharmaceutical compositions containing them IL99466A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58228090A	1990-09-14	1990-09-14
US74817291A	1991-08-23	1991-08-23

Publications (2)

Publication Number	Publication Date
IL99466A0 IL99466A0 (en)	1992-08-18
IL99466A true IL99466A (en)	1996-07-23

Family

ID=27078528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9946691A IL99466A (en)	1990-09-14	1991-09-12	Carbocyclic adenosine analogs and immunosuppressant pharmaceutical compositions containing them

Country Status (19)

Country	Link
EP (1)	EP0475411B1 (de)
JP (1)	JP3099280B2 (de)
KR (1)	KR100249111B1 (de)
CN (1)	CN1031132C (de)
AR (1)	AR247566A1 (de)
AT (1)	ATE202106T1 (de)
AU (1)	AU647822B2 (de)
CA (1)	CA2051012C (de)
DE (1)	DE69132632T2 (de)
DK (1)	DK0475411T3 (de)
ES (1)	ES2158840T3 (de)
FI (1)	FI102755B (de)
GR (1)	GR3036577T3 (de)
HU (1)	HU209304B (de)
IE (1)	IE913247A1 (de)
IL (1)	IL99466A (de)
NO (1)	NO179908C (de)
NZ (1)	NZ239750A (de)
PT (1)	PT98943B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5470857A (en) *	1990-09-14	1995-11-28	Marion Merrell Dow Inc.	Carbocyclic nucleoside analogs useful as immunosuppressants
AU642526B2 (en) *	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
CA2084222C (en) *	1991-12-06	2004-04-06	David R. Borcherding	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) *	1992-05-18	1994-03-08	Anthony G. Gristina	Method for nonspecific cellular immune stimulation
BR9307646A (pt)	1992-12-17	1999-05-25	Pfizer	Pirrolopirimidinas como antagonistas de crf
AU677851B2 (en)	1993-06-21	1997-05-08	Merrell Pharmaceuticals Inc.	Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
CN1137274A (zh) *	1993-11-12	1996-12-04	默里尔药物公司	用作免疫抑制剂的6-氧代-核苷
TW282470B (de) *	1993-11-18	1996-08-01	Ajinomoto Kk
ES2109796T3 (es) *	1994-05-03	1998-01-16	Ciba Geigy Ag	Derivados de pirrolopirimidilo con efecto antiproliferante.
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
US6403599B1 (en)	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
US6956047B1 (en)	1995-06-06	2005-10-18	Pfizer Inc.	Corticotropin releasing factor antagonists
US7125880B1 (en)	1995-06-06	2006-10-24	Pfizer Inc.	Corticotropin releasing factor antagonists
CA2397633A1 (en)	2000-01-18	2001-07-26	Pfizer Products Inc.	Corticotropin releasing factor antagonists
CN1871240B (zh) *	2003-08-26	2012-11-07	帝人制药株式会社	吡咯并嘧啶酮衍生物
US8945505B2 (en)	2007-02-02	2015-02-03	Panaphix, Inc.	Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3551428A (en) *	1956-02-10	1970-12-29	Ciba Geigy Corp	New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) *	1974-10-21	1975-11-04	American Cyanamid Co	Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
US4221794A (en) *	1979-06-21	1980-09-09	Newport Pharmaceuticals International, Inc.	Method of imparting immunomodulating and antiviral activity
US4386093A (en) *	1981-09-16	1983-05-31	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	(±)3-Deazaaristeromycin and uses
IN164556B (de) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4859677A (en) *	1987-04-17	1989-08-22	University Of Kansas	Nucleoside analogues having antiviral activity
US4782062A (en) *	1987-05-11	1988-11-01	Merck & Co., Inc.	9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) *	1987-05-19	1988-11-15	Nippon Kayaku Kk	Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) *	1988-11-09	1988-12-14	Wellcome Found	Heterocyclic compounds

1991
- 1991-09-09 CA CA002051012A patent/CA2051012C/en not_active Expired - Lifetime
- 1991-09-09 AU AU83729/91A patent/AU647822B2/en not_active Ceased
- 1991-09-10 AR AR91320625A patent/AR247566A1/es active
- 1991-09-11 PT PT98943A patent/PT98943B/pt not_active IP Right Cessation
- 1991-09-11 NZ NZ239750A patent/NZ239750A/en unknown
- 1991-09-12 AT AT91115485T patent/ATE202106T1/de not_active IP Right Cessation
- 1991-09-12 DK DK91115485T patent/DK0475411T3/da active
- 1991-09-12 IL IL9946691A patent/IL99466A/en not_active IP Right Cessation
- 1991-09-12 DE DE69132632T patent/DE69132632T2/de not_active Expired - Lifetime
- 1991-09-12 ES ES91115485T patent/ES2158840T3/es not_active Expired - Lifetime
- 1991-09-12 EP EP91115485A patent/EP0475411B1/de not_active Expired - Lifetime
- 1991-09-13 NO NO913625A patent/NO179908C/no not_active IP Right Cessation
- 1991-09-13 IE IE324791A patent/IE913247A1/en not_active Application Discontinuation
- 1991-09-13 HU HU912961A patent/HU209304B/hu not_active IP Right Cessation
- 1991-09-13 KR KR1019910015974A patent/KR100249111B1/ko not_active Expired - Fee Related
- 1991-09-13 JP JP03261249A patent/JP3099280B2/ja not_active Expired - Lifetime
- 1991-09-13 FI FI914319A patent/FI102755B/fi active
- 1991-09-14 CN CN91108934A patent/CN1031132C/zh not_active Expired - Fee Related
2001
- 2001-09-11 GR GR20010401434T patent/GR3036577T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100249111B1 (ko)	2000-08-01
FI914319A0 (fi)	1991-09-13
JP3099280B2 (ja)	2000-10-16
FI102755B1 (fi)	1999-02-15
NO913625L (no)	1992-03-16
NO913625D0 (no)	1991-09-13
KR920006357A (ko)	1992-04-27
HU912961D0 (en)	1992-01-28
DK0475411T3 (da)	2001-10-01
AU8372991A (en)	1992-03-19
NO179908B (no)	1996-09-30
IE913247A1 (en)	1992-02-25
PT98943B (pt)	1999-02-26
DE69132632T2 (de)	2002-04-18
GR3036577T3 (en)	2001-12-31
FI914319L (fi)	1992-03-15
HU209304B (en)	1994-04-28
AR247566A1 (es)	1995-01-31
CN1031132C (zh)	1996-02-28
NZ239750A (en)	1994-02-25
ES2158840T3 (es)	2001-09-16
PT98943A (pt)	1992-07-31
CA2051012C (en)	2002-04-02
ATE202106T1 (de)	2001-06-15
EP0475411A1 (de)	1992-03-18
JPH04270282A (ja)	1992-09-25
NO179908C (no)	1997-01-08
FI102755B (fi)	1999-02-15
DE69132632D1 (de)	2001-07-19
AU647822B2 (en)	1994-03-31
EP0475411B1 (de)	2001-06-13
IL99466A0 (en)	1992-08-18
CA2051012A1 (en)	1992-03-15
CN1059909A (zh)	1992-04-01
HUT59138A (en)	1992-04-28

Legal Events

Date	Code	Title
1996-12-05	FF	Patent granted
1997-06-10	KB	Patent renewed
1998-02-22	KB	Patent renewed
2002-05-23	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5244896A (en)	1993-09-14	Carbocyclic adenosine analogs useful as immunosuppressants
EP0475411B1 (de)	2001-06-13	Neue als Immunsuppressiva nützliche karbozyklische Adenosinanaloge
US5514688A (en)	1996-05-07	Carbocyclic adenosine analogs useful as immunosuppressants
US5470857A (en)	1995-11-28	Carbocyclic nucleoside analogs useful as immunosuppressants
US5817672A (en)	1998-10-06	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en)	1998-10-06	Trans cyclopentanyl purine analogs useful as immunosuppressants
EP0475413B1 (de)	1996-06-19	Carbocyklische Nukleosidanaloge als Immunsuppressoren
EP0545413B1 (de)	2000-07-12	Als Immunosuppressiva nützliche Trans-Cyclopentanylpurinanaloge
US6436947B1 (en)	2002-08-20	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5916892A (en)	1999-06-29	Trans cyclopentanyl deazaadenyl analogs useful as immunosuppressants
AU677732B2 (en)	1997-05-01	6-oxo-nucleosides useful as immunosuppressants
EP0472181B1 (de)	1996-10-02	5-Amino-substituierte Adenosinanaloga als Immunsuppressiva